Home Cart Sign in  
Chemical Structure| 1346242-81-6 Chemical Structure| 1346242-81-6

Structure of Erdafitinib
CAS No.: 1346242-81-6

Chemical Structure| 1346242-81-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Erdafitinib inhibits FGFR1 (pIC50 = 9), FGFR2 (pIC50 = 8.5), FGFR3 (pIC50 = 8.5) and FGFR4 (pIC50 = 8.25) and it is a quinoxaline derivative compound.

Synonyms: JNJ-42756493

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Erdafitinib

CAS No. :1346242-81-6
Formula : C25H30N6O2
M.W : 446.54
SMILES Code : CN1N=CC(C2=NC3=CC(N(C4=CC(OC)=CC(OC)=C4)CCNC(C)C)=CC=C3N=C2)=C1
Synonyms :
JNJ-42756493
MDL No. :MFCD28502040
InChI Key :OLAHOMJCDNXHFI-UHFFFAOYSA-N
Pubchem ID :67462786

Safety of Erdafitinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Erdafitinib

RTK

Isoform Comparison

Biological Activity

Target
  • FGFR

In Vitro:

Cell Line
Concentration Treated Time Description References
KB-C2 cells, HEK293/ABCB1 cells 0.06µM, 0.2µM, 0.6µM 72 h Erdafitinib significantly enhanced the accumulation of drugs and inhibited the efflux from ABCB1 overexpressing cells, reversing MDR. PMC7330633

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT06328491 Ovarian Cancer|Steroid Cell Tu... More >>mor, Malignant Less << COMPLETED 2022-08-22 Princess Margaret Cancer Centr... More >>e, Toronto, Ontario, M5G 2M9, Canada Less <<
NCT02699606 Neoplasm PHASE2 COMPLETED 2024-03-15 Beijing, China|Harbin, China|N... More >>anjing, China|Seoul, Korea, Republic of|Kaohsiung, Taiwan|Tainan, Taiwan Less <<
NCT03066687 Healthy PHASE1 COMPLETED 2017-05-12 Celerion, Lincoln, Nebraska, 6... More >>8502, United States Less <<
NCT03825484 Advanced Cancers and FGFR Gene... More >>tic Alterations Less << APPROVED_FOR_MARKETING - -
NCT04917809 Bladder Cancer|Recurrent Bladd... More >>er Cancer|FGFR3 Gene Mutation Less << PHASE2 RECRUITING 2025-08-25 Memorial Sloan Kettering Baski... More >>ng Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, 07920, United States|Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey, 07748, United States|Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, 07645, United States|Memorial Sloan Kettering Commack (Limited Protocol Activities), Commack, New York, 11725, United States|Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison, New York, 10604, United States|Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, 10065, United States|Memorial Sloan Kettering Nassau (Limited Protocol Activities), Uniondale, New York, 11553, United States Less <<
NCT02692677 Healthy PHASE1 COMPLETED 2025-08-16 Madison, Wisconsin, United Sta... More >>tes Less <<
NCT03587363 Hepatic Impairment PHASE1 TERMINATED 2020-12-22 CRS Clinical Research Services... More >> Kiel GmbH, Kiel, 24105, Germany|APEX GmbH, Munchen, 81241, Germany Less <<
NCT04083976 Advanced Solid Tumor PHASE2 ACTIVE_NOT_RECRUITING 2025-03-31 Arizona Oncology Associates, P... More >>C - HOPE, Tucson, Arizona, 85711, United States|Rocky Mountain Cancer Centers, Colorado Springs, Colorado, 80907, United States|Memorial Cancer Institute, Hollywood, Florida, 33021, United States|Cancer Specialists of North Florida, Jacksonville, Florida, 32256, United States|Emory University, Atlanta, Georgia, 30022, United States|Hawaii Cancer Care, 'Aiea, Hawaii, 96701, United States|Maine Medical Center, Scarborough, Maine, 04074, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Henry Ford Hospital, Detroit, Michigan, 48202, United States|Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States|Mount Sinai, New York, New York, 10029, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10128, United States|Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, 28204, United States|Oncology Hematology Care, Cincinnati, Ohio, 45242, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, United States|University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15232, United States|Tennessee Oncology, PLLC, Chattanooga, Tennessee, 37404, United States|Tennessee Oncology, Nashville, Tennessee, 37203, United States|Texas Oncology Baylor Charles A Sammons Cancer Center, Dallas, Texas, 75246, United States|Texas Oncology-Fort Worth Cancer Center, Fort Worth, Texas, 76104, United States|MD Anderson, Houston, Texas, 77030, United States|Oncology Consultants - Texas, Houston, Texas, 77030, United States|Texas Oncology Odessa-West Texas Cancer Center, Odessa, Texas, 79761, United States|Texas Oncology San Antonio Northeast, San Antonio, Texas, 78217, United States|NorthWest Medical Specialties, PLLC, Tacoma, Washington, 98405, United States|Aurora Research Institute, Wauwatosa, Wisconsin, 53226, United States|Hospital Aleman, Buenos Aires, C1118AAT, Argentina|Centro Oncológico Korben, Ciudad Autonoma de Buenos Aires, C1426AGE, Argentina|Instituto Fleni, Ciudad Autonoma de Buenos Aires, C1428AQK, Argentina|CEMIC Saavedra, Ciudad Autonoma de Buenos Aires, C1431FWN, Argentina|Instituto de Investigaciones Metabólicas, Ciudad Autónoma de Buenos Aires, C1012AAR, Argentina|Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Cordoba, 5000, Argentina|Hospital Italiano de La Plata, La Plata Lpl Lpl, 1900, Argentina|Instituto de Investigaciones Clinicas Mar del Plata, Mar Del Plata, Buenos Aires, B7600FZN, Argentina|Hospital Privado de Comunidad, Mar Del Plata, B7602CBM, Argentina|Hospital Universitario Austral, Pilar, 1629, Argentina|Sanatorio Britanico de Rosario, Rosario, 2000, Argentina|ARS Médica, San Salvador De Jujuy, Y4600AFW, Argentina|Flinders Centre for Innovation in Cancer, Adelaide, 5042, Australia|Chris O'Brien Lifehouse, Camperdown, 2050, Australia|St Vincent s Hospital Sydney, Darlinghurst, 2010, Australia|St Vincents Hospital Melbourne, Fitzroy, 3065, Australia|Fiona Stanley Hospital, Murdoch, 6150, Australia|Intergrated Clinical Oncology Network Pty Ltd (ICON), South Brisbane, 4101, Australia|AZ Klina, Brasschaat, 2930, Belgium|UCL Hopital Saint-Luc, Bruxelles, 1200, Belgium|Grand Hopital de Charleroi, site Notre Dame, Charleroi, 6000, Belgium|CHU UCL Namur - Site Dinant, Dinant, 5500, Belgium|UZA, Edegem, 2650, Belgium|AZ Maria Middelares, Gent, 9000, Belgium|UZ Gent, Gent, 9000, Belgium|Jolimont, Haine-Saint-Paul, La Louviere, 7100, Belgium|CHU UCL Namur - Site Sainte Elisabeth, Namur, 5000, Belgium|Cliniques St Pierre, Ottignies, 1340, Belgium|CHU UCL Namur - Site Godinne, Yvoir, 5530, Belgium|Fundacao Pio XII, Barretos, 14784-400, Brazil|Liga Paranaense de Combate ao Cancer, Curitiba, 81520 060, Brazil|Associacao de Combate ao Cancer em Goias - Hospital de Cancer Araujo Jorge, Goiania, 74605-070, Brazil|Associacao Hospital de Caridade Ijui, Ijui, 98700-000, Brazil|Liga Norte Riograndense Contra O Cancer, Natal, 59075-740, Brazil|Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, 90050-170, Brazil|Instituto de Medicina Integral Professor Fernando Figueira, Recife, 50070-550, Brazil|Oncoclinicas Rio de Janeiro S A, Rio de Janeiro, 22250 905, Brazil|Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro, 22281 100, Brazil|Hospital Sao Rafael, Salvador, 41253-190, Brazil|Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, 01246 000, Brazil|Fundacao Antonio Prudente A C Camargo Cancer Center, Sao Paulo, 01509 900, Brazil|Sociedade Beneficente de Senhoras - Hospital Sírio Libanês, S?o Paulo, 01308-901, Brazil|Real e Benemerita Associacao Portuguesa de Beneficencia, S?o Paulo, 01321-001, Brazil|Hospital Das Clinicas Da Faculdade De Medicina Da USP, S?o Paulo, 05410-030, Brazil|GRAACC, S?o Paulo, 4039001, Brazil|Cancer Hospital Chinese Academy of Medical Sciences, Beijing, 100021, China|Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China|Peking University Third Hospital, Beijing, 100191, China|Chinese PLA General Hospital, Beijing, 100853, China|Beijing Luhe Hospital, Capital Medical University, Beijing, 101100, China|Jilin cancer hospital, Changchun, 130012, China|The First Hospital of Jilin University, Changchun, 130021, China|West China Hospital,Sichuan University, Chengdu, 610041, China|Chongqing Southwest Hospital, Chongqing, 400038, China|Third Military Medical University Daping Hospital Cancer Center, Chongqing, 400042, China|Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510289, China|First affiliated Hospital of Zhejiang University, Hangzhou, 310003, China|Zhejiang Cancer Hospital, Hangzhou, 310022, China|Eastern Theater General Hospital, Qinhuai District Medical Area, Nanjing, 210002, China|Ruijin Hospital Shanghai Jiao Tong University, Shanghai, 200025, China|Cancer Hospital, FuDan University, Shanghai, 200032, China|Shanghai Zhongshan Hospital, Shanghai, 200032, China|Huashan Hospital Fudan University, Shanghai, 200040, China|Hopital Saint André, Bordeaux, 33075, France|Centre Francois Baclesse, Caen, 14000, France|Centre Jean Perrin, Clermont Ferrand, 63011, France|Centre Georges Fran?ois Leclerc, Dijon, 21000, France|Centre Oscar Lambret, Lille, 59020, France|Centre Leon Berard, Lyon, 69008, France|Hopital de la Timone, Marseille, 130005, France|Institut Curie, Paris, 75005, France|CHU De Poitiers, Poitiers, 86021, France|Institut de Cancérologie de Lorraine, Vandoeuvre lès Nancy, 54519, France|Institut Gustave Roussy, Villejuif, 94800, France|Charité, Berlin, 10115, Germany|Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden, Dresden, 01307, Germany|Universitaetsklinikum Essen, Essen, 45147, Germany|Universitaetsklinikum Frankfurt, Frankfurt, 60385, Germany|Asklepios Klinik Altona, Hamburg, 22763, Germany|Universitaetsklinikum Heidelberg, Heidelberg, 69120, Germany|Universitaetsklinikum Koeln, K?ln, 50937, Germany|Universitaetsklinikum Leipzig, Leipzig, 04103, Germany|Universit?tsmedizin der Johannes Gutenberg-Universit?t Mainz, Mainz, 55131, Germany|Klinikum rechts der Isar der TU Munchen, München, 81675, Germany|Universitatsklinikum Tubingen, Tübingen, 72076, Germany|Istituto Ortopedico Rizzoli, Bologna, 40136, Italy|ASST Grande Ospedale Metropolitano Niguarda, Milano, 20162, Italy|ASST di Monza, Monza, 20900, Italy|Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli, Napoli, 80138, Italy|Fondazione G Pascale Istituto Nazionale Tumori IRCCS, Napoli, 80138, Italy|Ospedale S. Maria Della Misericordia, Perugia, 06132, Italy|Ospedale Santa Chiara AO Universitaria Pisana, Pisa, 56126, Italy|Azienda Ospedaliera S. Maria Terni, Terni, 5100, Italy|Ospedale Borgo Roma, Verona, 37134, Italy|National Cancer Center Hospital, Chuo Ku, 104 0045, Japan|Hiroshima University Hospital, Hiroshima shi, 734 8551, Japan|National Cancer Center Hospital East, Kashiwa, 277 8577, Japan|National Hospital Organization Shikoku Cancer Center, Matsuyama, 791-0280, Japan|Fujita Health University Hospital, Toyoake, 470-1192, Japan|Severance Hospital Yonsei University Health System, Seoul, 03722, Korea, Republic of|Asan Medical Center, Seoul, 05505, Korea, Republic of|Samsung Medical Center, Seoul, 06351, Korea, Republic of|The Catholic University of Korea Seoul St Marys Hospital, Seoul, 06591, Korea, Republic of|Seoul National University Hospital, Seoul, 3080, Korea, Republic of|Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy, Bydgoszcz, 85-796, Poland|Przychodnia Lekarska KOMED Roman Karaszewski, Konin, 62-500, Poland|Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie, Krakow, 31-501, Poland|Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi, Lodz, 93 513, Poland|Centrum Medyczne Pratia Poznan, Skorzewo, 60-185, Poland|Instytut Matki i Dziecka, Warszawa, 01-211, Poland|Centralny Szpital Kliniczny MSWiA w Warszawie, Warszawa, 02-507, Poland|Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warszawa, 02-781, Poland|Hosp. Univ. Quiron Dexeus, Barcelona, 08028, Spain|Hosp Univ Vall D Hebron, Barcelona, 08035, Spain|Hosp Clinic de Barcelona, Barcelona, 08036, Spain|Hosp. Sant Joan de Deu, Barcelona, 08950, Spain|Inst. Cat. Doncologia-H Duran I Reynals, Hospitalet de Llobregat, Barcelona, 08908, Spain|Hosp. Infantil Univ. Nino Jesus, Madrid, 28009, Spain|Clinica Univ. de Navarra, Madrid, 28027, Spain|Hosp. Univ. Ramon Y Cajal, Madrid, 28034, Spain|Hosp Univ Fund Jimenez Diaz, Madrid, 28040, Spain|Hosp. Univ. 12 de Octubre, Madrid, 28041, Spain|Hosp. Univ. La Paz, Madrid, 28046, Spain|Hosp. Virgen Del Rocio, Sevilla, 41013, Spain|Hosp. Clinico Univ. de Valencia, Valencia, 46010, Spain|Changhua Christian Hospital, Changhua, 50006, Taiwan|E-Da Cancer Hospital, Kaohsiung City, 82445, Taiwan|Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung, 807, Taiwan|Chang Gung Medical Foundation, Kaohsiung, 833, Taiwan|China Medical University Hospital, Taichung, 403, Taiwan|Taichung Veterans General Hospital, Taichung, 40705, Taiwan|Chi Mei Medical Center Yong Kang, Tainan, 710, Taiwan|National Cheng Kung University Hospital, Tainan, 710, Taiwan|Chi Mei Medical Center Liu Ying, Tainan, 736, Taiwan|National Taiwan University Hospital, Taipei, 10002, Taiwan|Taipei Veterans General Hospital, Taipei, 11217, Taiwan|Chang Gung Memorial Hospital Linkou Branch, Taoyuan City, 333, Taiwan|Bristol Royal Hospital for Children, Bristol, BS2 8AE, United Kingdom|Bristol Haematology and Oncology Centre, Bristol, BS2 8ED, United Kingdom|The Christie Nhs Foundation Trust, Manchester, M20 4BX, United Kingdom|Freeman Hospital, Newcastle upon Tyne, NE7 7DN, United Kingdom|Derriford Hospital, Plymouth, PL6 8DH, United Kingdom|The Royal Marsden NHS Trust, Sutton, SM2 5PT, United Kingdom|The Clatterbridge Cancer Centre, Wirral, CH63 4JY, United Kingdom Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.39mL

4.48mL

2.24mL

References

 

Historical Records

Categories