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Chemical Structure| 1126-09-6

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Product Details of Ethyl 4-Piperidinecarboxylate

CAS No. :1126-09-6
Formula : C8H15NO2
M.W : 157.21
SMILES Code : C(OC(C1CCNCC1)=O)C
MDL No. :MFCD00006003
InChI Key :RUJPPJYDHHAEEK-UHFFFAOYSA-N
Pubchem ID :70770

Safety of Ethyl 4-Piperidinecarboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319
Precautionary Statements:P501-P210-P264-P280-P370+P378-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362-P403+P235

Application In Synthesis of Ethyl 4-Piperidinecarboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1126-09-6 ]
  • Downstream synthetic route of [ 1126-09-6 ]

[ 1126-09-6 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 1126-09-6 ]
  • [ 591-50-4 ]
  • [ 94201-40-8 ]
References: [1] Patent: US2006/116368, 2006, A1, . Location in patent: Page/Page column 56; 57.
  • 2
  • [ 1722-12-9 ]
  • [ 1126-09-6 ]
  • [ 111247-60-0 ]
YieldReaction ConditionsOperation in experiment
81% for 18 h; Reflux; Inert atmosphere Method ACompound 1: l-Pyrimidin-2-yl-piperidine-4-carboxylic acid ethyl esterA mixture of 2-chloropyrimidine (2.28g, 20mmol) and ethyl isonipecotate (4.72g, 30mmol) in toluene (10ml) was heated at reflux for 18 h. then cooled to RT. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO3. The organics were separated, dried, and the solvents removed in vacuo. The residue was purified by flash chromatography on silica (eluant: EtOAc/pet. ether 40/60 v/v) to yield the title compound as a colourless oil.Yield = 4.0Og, 81percent. (ESI+): [M+H]+ = 236.0
References: [1] Farmaco, 1993, vol. 48, # 10, p. 1439 - 1445.
[2] Patent: WO2010/97576, 2010, A1, . Location in patent: Page/Page column 39.
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8696 - 8711.
  • 3
  • [ 1126-09-6 ]
  • [ 1208087-83-5 ]
References: [1] Patent: WO2013/41457, 2013, A1, .
 

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