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CAS No. :	4433-63-0
Formula :	C₂H₇BO₂
M.W :	73.89
SMILES Code :	CCB(O)O
MDL No. :	MFCD01074536
InChI Key :	PAVZHTXVORCEHP-UHFFFAOYSA-N
Pubchem ID :	521157

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
2 g	With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene;Reflux; Inert atmosphere;	To a mixture of 4-bromo-3-methoxy-benzaldeyde (5.0 g, 23.38 mmol), ethylboronic acid (5.2 g, 71 mmol) and potassium phosphate (17.3 g, 81.83 mmol) in toluene (100 mL) was added water (10 mL), tricyclohexylphosphine (0.65 g, 2.33 mmol) and palladium (II) acetate (260 mg, 1.16 mmol). The reaction mixture was heated at reflux under argon atmosphere overnight. The reaction was cooled, and then diluted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous sodium sulfate and then concentrated in vacuo. The residue was purified by column chromatography to give 4-ethyl-3-methoxy-benzaldehyde (2 g).
2 g	With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene;Inert atmosphere; Reflux;	Step 1: Preparation of 4-ethyl-3-methoxy-benzaldehyde To a mixture of 4-bromo-3-methoxy-benzalcleyde (5.0 g, 23.38 mmol), ethylboronic acid (5.2 g.71 mmol) and potassium phosphate (17.3 g, 81.83 mmol) in toluene ( 100 ml.) was added water ( 10 mL), tricyclohexylphosphinc (0.65 g, 2.33 mmol) and palladium (II) acetate (260 mg, 1.16 mmol). The reaction mixture was heated at reflux under argon atmosphere overnight. The reaction was cooled, and then diluted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous sodium sulfate and then concentrated in vacuo. The residue was purified by column chromatography to give 4-ethyl-3-methoxy-benzaldehydc (2 g).

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CAS No.: 4433-63-0

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CAS No.: 4433-63-0

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[ 4433-63-0 ] Synthesis Path-Downstream 1~4

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
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H228	Flammable solid
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
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