CAS No. :	42017-89-0
Formula :	C₁₇H₁₅ClO₄
M.W :	318.75
SMILES Code :	CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(O)=O
Synonyms :	FNF acid; NSC 281318; Procetofenic acid
MDL No. :	MFCD00792461
InChI Key :	MQOBSOSZFYZQOK-UHFFFAOYSA-N
Pubchem ID :	64929

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

COS-7 cells	61.0 µM	10 hours	To evaluate the effect of fenofibric acid on PPARγ-LBD-mediated gene transcription activation, results showed that fenofibric acid activated PPARγ-LBD-mediated transactivation with an EC50 of 61.0 µM.	Int J Mol Sci. 2022 Apr 25;23(9):4726.
MCF-7 breast cancer cells	20 µM	24 hours	To evaluate the effect of fenofibric acid on the antitumor effect of paclitaxel, results showed that fenofibric acid did not reduce the antitumor effect of paclitaxel	Brain Behav Immun. 2021 Mar;93:172-185.
A549 non-small cell lung cancer cells	20 µM	24 hours	To evaluate the effect of fenofibric acid on the antitumor effect of paclitaxel, results showed that fenofibric acid did not reduce the antitumor effect of paclitaxel	Brain Behav Immun. 2021 Mar;93:172-185.
AML12 cells	104.7 µM (IC50)	24 hours	To evaluate the toxicity of Mito-FFa on normal cells, results showed Mito-FFa had low toxicity on AML12 cells.	Adv Sci (Weinh). 2023 Jul;10(20):e2300286.
MDA-MB-231 tumor cells	8 µM	24 hours	To evaluate the cytotoxicity of Mito-FFa, results showed Mito-FFa had significant cytotoxicity on MDA-MB-231 cells.	Adv Sci (Weinh). 2023 Jul;10(20):e2300286.
R28 retinal precursor cells	25 µM	24 hours	To evaluate the antioxidant effect of Feno-FA on hypoxia-induced ROS generation, results showed that Feno-FA reduced ROS levels.	Invest Ophthalmol Vis Sci. 2014 May 13;55(7):4568-76.
ARPE-19 cells	100 µM	3 days	To investigate the effect of FA on high glucose and IL-1β-induced fibronectin and collagen IV overexpression. Results showed FA significantly reduced FN and Coll IV expression.	Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6348-54.
CAOV3 ovarian cancer cells	40 µM	48 hours	To evaluate the effect of fenofibric acid on paclitaxel-induced cytotoxicity, results showed that fenofibric acid did not interfere with paclitaxel-induced cell death in CAOV3 cells.	Cancers (Basel). 2020 Dec 29;13(1):69.
SKOV-3 ovarian cancer cells	40 µM	48 hours	To evaluate the effect of fenofibric acid on paclitaxel-induced cytotoxicity, results showed that fenofibric acid did not interfere with paclitaxel-induced cell death in SKOV-3 cells.	Cancers (Basel). 2020 Dec 29;13(1):69.
4T1 tumor cells	8 µM	6 hours	To evaluate the effect of Mito-FFa on mitochondrial function, results showed Mito-FFa significantly increased mtROS generation and caused mitochondrial depolarization.	Adv Sci (Weinh). 2023 Jul;10(20):e2300286.
GL261-Red-FLuc	5, 10, 25, 50 µM	96 hours	To evaluate the cytotoxic effects of PP1 on GL261-Red-FLuc cells. Results showed that PP1 triggered extensive cell death after 96 hours.	Transl Oncol. 2019 Jul;12(7):895-907.
U-87MG	5, 10, 25, 50 µM	96 hours	To evaluate the cytotoxic effects of PP1 on U-87MG cells. Results showed that PP1 triggered extensive cell death after 96 hours.	Transl Oncol. 2019 Jul;12(7):895-907.

C57BL/6J mice	High-fat diet-induced retinal pigment epithelium injury model	Dietary administration	0.1%	Once daily for 1 month	Fenofibrate partially reversed the HFD-induced decrease in ERG c-wave amplitudes and suppressed oxidative injury and inflammatory response in RPE tissues	Drug Des Devel Ther. 2023 Nov 21;17:3439-3452.
C57BL/6J mice	Paclitaxel-induced peripheral neuropathy model	Dietary administration	0.2% and 0.4%	Continued for 4 weeks (before, during and after paclitaxel treatment)	To evaluate the preventive effect of fenofibrate diet on paclitaxel-induced peripheral neuropathy, results showed that fenofibrate diet partially prevented mechanical hypersensitivity, completely prevented cold hypersensitivity, and restored the decrease in sensory nerve action potential amplitude and intra-epidermal nerve fiber density.	Cancers (Basel). 2020 Dec 29;13(1):69.
Transgenic mice	Human apo A-I transgenic mice	Mixed in Mice chow for oral administration	0.5% (wt/wt)	Once daily for 7 days	To investigate the effect of fenofibrate on plasma apo A-I levels and hepatic apo A-I mRNA levels in human apo A-I transgenic mice. Results showed that treatment with 0.5% fenofibrate for 7 days increased plasma human apo A-I levels by 760% and hepatic human apo A-I mRNA levels by 97%.	J Clin Invest. 1996 Jun 1;97(11):2408-16
C57BL/6J mice	Oxygen-induced retinopathy (OIR) model	Intraperitoneal injection	10 mg/kg	Once daily from P12 to P16	To evaluate the protective effect of Feno-FA on retinal apoptosis and oxidative stress in the OIR model, results showed that Feno-FA reduced retinal apoptosis and oxidative stress.	Invest Ophthalmol Vis Sci. 2014 May 13;55(7):4568-76.
C57BL/6J mice	Oxygen-induced retinopathy (OIR) model	Intraperitoneal injection	10 mg/kg	Once daily from P12 to P17	To investigate the effect of PPARα agonist FA on retinal neovascularization and EPC mobilization in the OIR model. Results showed that FA significantly suppressed OIR-induced retinal neovascularization and EPC mobilization.	Invest Ophthalmol Vis Sci. 2014 May 20;55(6):3820-32
C57BL/6J mice	Paclitaxel-induced peripheral neuropathy model	Intraperitoneal injection	150 mg/kg	Once daily for 7 days	To evaluate the preventive and reversal effects of fenofibrate and choline fenofibrate on paclitaxel-induced peripheral neuropathy, results showed that both drugs partially or completely reversed mechanical and cold hypersensitivity and reduced neuroinflammation through PPAR-α activation	Brain Behav Immun. 2021 Mar;93:172-185.
BALB/c mice	4T1 breast tumor model	Intratumoral injection	20, 60, 200 μg/Mice	Single injection	To evaluate the antitumor effect of Mito-FFa in vivo, results showed Mito-FFa significantly inhibited tumor growth and induced CD8+ T cell-dependent immune responses.	Adv Sci (Weinh). 2023 Jul;10(20):e2300286.
Brown Norway rats	Laser-induced choroidal neovascularization (CNV) model	Intraperitoneal injection	25 mg/kg	Once daily for 2 weeks	Evaluate the effects of Feno-FA on laser-induced CNV, results showed Feno-FA significantly reduced vascular leakage and CNV volume	Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5065-5075
C57BL/6NHsd mice	Intracranial glioblastoma model	Oral	50 mg/kg	Daily administration for 14 days	To evaluate the therapeutic effects and toxicity of PP1 in an intracranial glioblastoma model. Results showed that PP1 accumulated in tumor tissues and triggered extensive tumor cell death without significant toxicity.	Transl Oncol. 2019 Jul;12(7):895-907.

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.14mL 0.63mL 0.31mL	15.69mL 3.14mL 1.57mL	31.37mL 6.27mL 3.14mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

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CAS No.: 42017-89-0

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CAS No.: 42017-89-0

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed