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Chemical Structure| 268734-27-6 Chemical Structure| 268734-27-6
Chemical Structure| 268734-27-6

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Product Details of Fmoc-L-3-(9-anthryl)-Ala-OH

CAS No. :268734-27-6
Formula : C32H25NO4
M.W : 487.55
SMILES Code : O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CC4=C5C=CC=CC5=CC6=CC=CC=C46
MDL No. :MFCD00671381
InChI Key :OGLRHZZGDZRSHK-PMERELPUSA-N
Pubchem ID :2761484

Safety of Fmoc-L-3-(9-anthryl)-Ala-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Fmoc-L-3-(9-anthryl)-Ala-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 268734-27-6 ]

[ 268734-27-6 ] Synthesis Path-Downstream   1~5

  • 1
  • Fmoc-His(1-Bzl)-OH [ No CAS ]
  • [ 268734-27-6 ]
  • [ 71989-23-6 ]
  • [ 86123-10-6 ]
  • [ 109425-55-0 ]
  • [ 1213772-61-2 ]
  • 2
  • Fmoc-His(1-Bzl)-OH [ No CAS ]
  • [ 268734-27-6 ]
  • [ 71989-23-6 ]
  • [ 86123-10-6 ]
  • [ 109425-55-0 ]
  • 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan [ No CAS ]
  • [ 1213773-58-0 ]
  • 3
  • Fmoc-His(1-Bzl)-OH [ No CAS ]
  • [ 268734-27-6 ]
  • [ 71989-23-6 ]
  • [ 86123-10-6 ]
  • [ 109425-55-0 ]
  • 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan [ No CAS ]
  • [ 1213772-94-1 ]
  • 4
  • Fmoc-His(1-Bzl)-OH [ No CAS ]
  • [ 268734-27-6 ]
  • [ 86123-10-6 ]
  • [ 109425-55-0 ]
  • 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan [ No CAS ]
  • [ 1213773-27-3 ]
  • 5
  • Fmoc-His(1-Bzl)-OH [ No CAS ]
  • [ 268734-27-6 ]
  • [ 71989-23-6 ]
  • [ 109425-55-0 ]
  • [ 35737-15-6 ]
  • [ 135673-97-1 ]
  • Orn-D-Trp-Cha-Ile-Ala(9-anth)-His(1-Bzl)-NH<SUB>2</SUB> [ No CAS ]
YieldReaction ConditionsOperation in experiment
General procedure: In a reaction vessel, Fmoc-protected Rink amide MBHA resinwas first swelled in DMF for fifteen min. A solution of 20% piperidinein DMF was added and mixture shaken mechanically for15 min resulting in the removal of Fmoc group. The required Fmocprotected amino acids and coupling reagent 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) were placed in amino acid vessels sequentially. DMF was added to theamino acid vessel, which was subsequently added (by positivepressure of N2) to the reaction vessel containing the resin, followedby addition of N,N-diisppropylethylamine (DIEA). After 3 h of mechanicalshaking at ambient temperature, the solvent was drainedand the resin washed with DMF (3 x 5 min) followed by methanol(2 x 5 mL). The cycles of deprotection and coupling were repeatedtill the desired peptide chain length was obtained. The resin-boundpeptide was transferred to a round bottom flask, and simultaneousremoval of resin and protective groups was achieved by using acocktail combination of TFA:triisopropylsilane (TIPS):H2O[95:2.5:2.5] for 3 h. The crude peptide was filtered and purified onpreparative HPLC system, and analyzed using solvent system ofCH3CN-H2O-0.1% CF3COOH in the gradient system: 30 min gradient,30-100% CH3CN-H2O-0.1% CF3COOH at 215 nm.
 

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