HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
| Type | HazMat fee for 500 gram (Estimated) |
| Excepted Quantity | USD 0.00 |
| Limited Quantity | USD 15-60 |
| Inaccessible (Haz class 6.1), Domestic | USD 80+ |
| Inaccessible (Haz class 6.1), International | USD 150+ |
| Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
| Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
L-Cysteine HCl can increase glutathione levels and is important for lung and brain function and liver detoxification.
Synonyms: L-Cysteine(hydrochloride);L-Cysteine HCl
4.5
*For Research Use Only! Not for Human Use. We Do Not Sell to Patients.
Change View
| Size | Price | VIP Price |
DE Stock US Stock |
Asia Stock Global Stock |
In Stock |
| {[ item.pr_size ]}{[ size_append_text(item.pr_size, proInfo.prAm, 'list') ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | {[ item.p_spot_brand_remark ]} 1-2 weeks {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.p_spot_brand_remark ]} 1-2 weeks {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock Inquiry - | Login - + |
Please Login or Create an Account to: See VIP prices and availability
Asia Stock: Ship in 3-5 business days
EU Stock: ship in 0-1 business day
Global Stock: ship in 7-10 days
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
{[ item.p_spot_brand_remark ]}
1-2weeks
Inquiry
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ item.p_spot_brand_remark ]}
1-2weeks
Inquiry
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
Asia Stock: Ship in 3-5 business days
EU Stock: ship in 0-1 business day
Global Stock: ship in 7-10 days
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
| CAS No. : | 52-89-1 |
| Formula : | C3H8ClNO2S |
| M.W : | 157.62 |
| SMILES Code : | N[C@@H](CS)C(O)=O.[H]Cl |
| Synonyms : |
L-Cysteine(hydrochloride);L-Cysteine HCl
|
| English Name : | (R)-2-Amino-3-mercaptopropanoic acid hydrochloride |
| MDL No. : | MFCD00064553 |
| InChI Key : | IFQSXNOEEPCSLW-DKWTVANSSA-N |
| Pubchem ID : | 60960 |
| GHS Pictogram: | |
| Signal Word: | |
| Hazard Statements: | |
| Precautionary Statements: | |
| Class: | |
| UN#: | |
| Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 91% | With potassium acetate In ethanol; water at 20 - 90℃; for 2h; | |
| 91% | With potassium acetate In ethanol; water at 90℃; for 1h; | |
| 90% | With sodium hydrogencarbonate In water; dimethyl sulfoxide at 20℃; |
| 90.9% | In water at 10℃; for 10h; | 1.1; 2.1; 3.1; 4.1; 5.1; 6.1 1. Synthesis of thiazolidine-4-carboxylic acid 5 g (0.14 mol) of L-cysteine hydrochloride, 25 mol of water was added to a 150 mL one-neck flask, and stirred for 5 min.18.3 mL (0.21 mol) of a formaldehyde solution was added thereto, and reacted at 10 ° C for 10 hours.15 mL (0.18 mol) of pyridine was added to the solution, and the mixture was stirred to precipitate a white solid.After cooling, filtration, filter cake V (water): V (ethanol) = 1: 1.1 recrystallized, dried,The white needle crystal thiazolidine-4-carboxylic acid 17.31 was obtained in a yield of 90.9%. |
| 85% | In water for 15h; Ambient temperature; | |
| 80% | With sodium hydroxide In water at 20℃; for 24h; | (R)-Thiazolidine-4-carboxylic acid (4) To a solution of L-cysteine hydrochloride (95 mmol, 16.0 g) in water (10 mL) and 1M NaOH solution (10 mL) was added formaldehyde 37 % in water (11 mL). The mixture was stirred for 24 h at r.t. Next, ethanol (25 mL) and pyridine (12 mL) were added at 0° C. A white solid precipitated and it was filtered and washed with cold ethanol. The white solid product was utilized without further purification. Yield: 80%. M.P. = 195-198 °C. [α]D 20 = -13° (c 1, H2O). 1H NMR (300 MHz, D2O): 4.51 (d, 1H, J = 10.5 Hz); 4.41 (dd, 1H, J = 3.9 Hz; 13.0 Hz); 4.27 (d, 1H, J = 10.2 Hz); 3.25 (dd, 1H, J = 7.5 Hz; 12.3 Hz); 3.25 (dd, 1H, J = 6.0 Hz; 12.0 Hz). |
| 73% | ||
| 70% | In water for 15h; Ambient temperature; | |
| 56% | Stage #1: formaldehyd; l-cysteine hydrochloride In water at 20℃; for 22h; Stage #2: With pyridine In water at 20℃; | |
| With water | ||
| In water at 25℃; | ||
| With sodium hydroxide |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 98% | Triphenylmethanol (3.3 g, 12.7 mmol) was added to a solution of Cysteine chlorydrate (2 g, 12.7 mmol) in TFA (25 mL) and the mixture was stirred for 2 h. After cooling to 0 °C, NaOH 4N and diethyl ether (40 mL) were added until pH 4-5 and then 10percent sodium acetate aqueous solution was added until pH 5-6. The precipitated obtained was filtered, washed with fresh Et2O and finally dried to obtain the desired product (5 g, 98percent yield).1H NMR (DMSO): delta (ppm) 2.35-2.61 (m, 2H, CH2); 2.85-2.98 (m, 1H, CH); 7.2-7.45 (m, 15H, trityl-H).MALDI-TOF MS: m/z364.7 Da [M + H]+, C22H21NO2S, Mol. Wt.: 363.47. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With sodium acetate |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With sulfuric acid |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With sodium hydrogencarbonate anschliessendes Behandeln mit Chlorokohlensaeure-benzylester; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 89% | In N,N-dimethyl-formamide; at 20℃; for 48h; | L-Cysteine hydrochloride (100 g, 0.634 mol) and trityl chloride (270 g, 0.969 mol) were stirred in DMF (400 mL) for 2 days at room temperature. A 10percent sodium acetate solution (3.5 L) was then added dropwise and the white precipitate which formed was filtered and washed with distilled water. Afterward, the residue was stirred in acetone at 50° C. for 30 min after which it was cooled to 0° C. and filtered. The precipitate was washed with a little acetone and diethyl ether and dried in vacuo. S-Trityl-L-cysteine 1b (205 g, 89percent) was obtained as a white powder. 1b: m.p. 192° C. (decomp). 1H NMR (DMSO-d6) delta 2.45 (dd, 1H, J=9 Hz, 12 Hz), 2.58 (dd, 1H, J=4.4 Hz, 12 Hz), 2.91 (m, 1H), 7.22-7.36 (m, 15H); 13C NMR (75.5 MHz, DMSO-d6): delta 33.8, 53.7, 66.4, 127.1, 127.8, 128.1, 128.4, 129.5, 144.5, 168.4. This material was directly used in the next step without further purification. |
| 89% | With sodium acetate; In N,N-dimethyl-formamide; at 20℃; for 48h; | L-Cysteine hydro-chloride (100 g, 0.634 mol) and trityl chloride (270 g, 0.969 mol) were stirred in DMF (400 mL) for 2 days at room temperature. A 10percent sodium acetate solution (3.5 L) was then added dropwise and the white precipitate which formed was filtered and washed with distilled water. Afterward, the residue was stirred in acetone at 50 0C for 30 min after which it was cooled to 00C and filtered. The precipitate was washed with a little acetone and diethyl ether and dried in vacuo. S-Trityl-L-cysteine Ic (205 g, 89percent) was obtained as a white powder. Ic: m.p. 192 °C (decomp) ; 1H NMR (300 MHz, DMSCW5) delta 2.45 (dd, IH, J= 9 Hz, 12 Hz), 2.58 (dd, IH, J= 4.4 Hz, 12 Hz), 2.91 (m, IH), 7.22-7.36 (m, 15H); 13C NMR (75.5 MHz, DMSO- d6): delta 33.8, 53.7, 66.4, 127.1, 127.8, 128.1, 128.4, 129.5, 144.5, 168.4. This material was directly used in the next step without further purification. |
| 78% | In N,N-dimethyl-formamide; at 20℃; for 48h; | Preparation 75: Synthesis of (R)-3-amino-4-tritylsulfanyl-butyric acid methyl ester hydrochloride; (Step 1); L-cysteine hydrochloride (5Og, 284.7mmol) was dissolved in N,N- dimethylformamide (200ml). Trityl chloride (119g, 427.0mmol) was added thereto, and the mixture was stirred for 48 h at room temperature. After completion of the reaction, 10percent sodium acetate (1.5L) was added. The mixture was filtered to give a solid, which was then added to acetone (1.5L), and stirred for 30 min at 50 °C . The insoluble solid was filtered, and dried to give a trityl compound (80g, Yield 78percent). |
| 77% | In N,N-dimethyl-formamide; at 20℃; for 48h; | Synthetic Example 1; (R)-3-Mercapto-2-(5-methyl-4-phenyl-thiazoI-2-yIamino)-propionic acid; Step 1 : S-Trityl-L-cysteine falso known as (R)-2-amino-3- (tritylsulfanyl)propanoic acid); L-Cysteine hydrochloride (5.0 g, 31.7 mmol) and trityl chloride (13.5 g, 48.4 mmol) were stirred in DMF (20 ml) for 48 h at room temperature. A 10percent NaOAc solution (175 mL) was then added, and the precipitate was filtered and washed with water. Afterward, the residue was suspended in acetone and stirred at 50 °C for 30 min, then cooled and filtered. The residue was washed with acetone (cold) and diethyl ether. After drying 8.86 g (77percent) S-trityl-L-cysteine was obtained. |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 84% | With sodium hydroxide In lithium hydroxide monohydrate at 0℃; for 0.5h; | |
| 83.9% | With sodium hydroxide In lithium hydroxide monohydrate at 0℃; | |
| With anhydrous Sodium acetate In tetrahydrofuran |
| With sodium hydroxide | ||
| With sodium hydroxide In lithium hydroxide monohydrate at 0℃; for 0.5h; |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With sodium proprionate In tetrahydrofuran; water |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 90% | In hydrogenchloride for 12h; Heating; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 88% | With sodium ethanolate In ethanol for 0.25h; Ambient temperature; | |
| 88% | Stage #1: l-cysteine hydrochloride With sodium Stage #2: methyl iodide at 20℃; for 0.25h; | (±)-S-methyl-l-cysteine sulfoxide was synthesized as follows L-Cysteine hydrochloride hydrate (21.08g, 0.12mol) was suspended in absolute alcohol (350ml), and cuts of sodium (11g, 0.48mol) were added in 15-min intervals to the solution. After all the sodium had dissolved, methyl iodide (8.3ml, 0.13mol) was added and the mixture was stirred at room temperature for 15min. Water was added to dissolve precipitate, the solution was acidified by 48% aqueous hydroiodic acid to pH 5.0. Diethyl ether (600ml) was added to solubilize a precipitate and the solution was cooled in a refrigerator (8h). Crystalline precipitate was collected by filtration, washed with cold absolute ethanol, then with diethyl ether, and dried. The yield of S-methyl-l-cysteine was 88%. M.p. 219-220°C dec., [a]D25=-32° (c 0.8, H2O). 1H NMR (400MHz, D2O, ppm) δ: 2.13 (s, 3H, CH3); 2.97 (dd, 1H, CH2, J=14.9, 7.7Hz); 3.08 (dd, 1H, CH2, J=14.9, 4.3Hz); 3.92 (dd, 1H, CH, J=7.7, 4.3Hz). ESI-MS (m/z)=136 [M+H]+. |
| With sodium ethanolate at 20℃; for 3h; |
| Stage #1: l-cysteine hydrochloride With sodium methylate In methanol for 1h; Cooling with ice; Stage #2: methyl iodide In deuteromethanol at 20℃; | 2.3.1 (1) S-methyl-L-cysteine (IIIf-1) preparation of The L-cysteine hydrochloride monohydrate (3.1g, 17 . 5mmol) dissolved in MeOH (45 ml) in, under the ice-bath adds by drops 30% of the methanol solution of sodium methoxide (11.2g, 62mmol), reaction 1h rear, methane instillment iodine (0.9 ml, 13. mmol), the reaction temperature-raised to room temperature, TLC detection reaction, 2h end of the reaction, using 10NHCl adjusting the pH value to 5, by adding 40 ml ethyl ether stirring 10 min, filtering, with 60 ml ethyl ether washing, vacuum drying, obtain crude product 4.715 g. | |
| Stage #1: l-cysteine hydrochloride With sodium methylate In methanol at 0℃; for 1h; Stage #2: methyl iodide In methanol at 0 - 20℃; for 2h; | ||
| Stage #1: l-cysteine hydrochloride With sodium methylate In methanol for 1h; Cooling with ice; Stage #2: methyl iodide In methanol at 20℃; for 2h; | 2.3.1 Preparation of S-methyl-L-cysteine (IIIf-1) L-cysteine hydrochloride monohydrate (3.1 g, 17.5 mmol) was dissolved in MeOH (45 mL), and a 30% solution of sodium methoxide in methanol (11.2 g, 62 mmol) was added dropwise under an ice bath,After 1 hour of reaction, methyl iodide (0.9 mL, 13.mmol) was added dropwise, and the temperature was raised to room temperature for reaction.The reaction was detected by TLC. After 2h, the pH was adjusted to 5 with 10N HCl.Add 40 mL of ether and stir for 10 min, filter, and wash the filter cake with 60 mL of ether.Vacuum drying gave 4.715 g of crude product. |

| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| In water; trifluoroacetic acid at 0℃; for 6h; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 95% | With choline chloride; urea In trifluoroacetic acid at 25℃; for 2h; | 4.3. Synthesis of S-trityl-L-cysteine thioethers 5a-c. General procedure in DES General procedure: L-Cysteine hydrochloride (0.5 mmol), alcohol 3c or 3e or 3i (0.5 mmol) and 0.2 mL of trifluoroacetic acid (TFA) were sequentially added to the eutectic mixture ChCl/urea (1.0 g) at roomtemperature under air. After stirring for 2 h at room temperature,2 mL of water were added. An aqueous NaOH solution (4 N) wasthen added dropwise inwater up to a pH of about 5e6. The reaction mixture was extracted three times with EtOAc (5 mL 3). Theresulting organic phase was dried (Na2SO4), filtered, and the volatileswere removed under reduced pressure. The residue was purifiedby flash chromatography (CH2Cl2/CH3OH 9:1) to provide the desired product 5a- |
| (i) BF3-Et2O, AcOH, (ii) aq. NaOAc; Multistep reaction; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 83% | With sodium acetate In ethanol; water at 25℃; for 3h; | |
| 70% | With sodium hydrogencarbonate In water; dimethyl sulfoxide at 20℃; for 12h; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 53% | In ethanol at 20℃; for 1h; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 77% | In ethanol at 20℃; for 12h; |
[ 27829-72-7 ]
[ 52-89-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium hydroxide In water mixing of a concd. aq. soln. of (Coa6)Cl3 with cysteinium chloride and aq. KOH; heating at approx. 65°C; pptn. by addn. of concd. HCl until pH 1 is achieved;; recrystallisation by dissolving in aq. KOH and pptn. with aq. HCl;; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium acetate In methanol; water at 20℃; for 5h; | 10 (R)-2-Pyridin-2-yl-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride monohydrate (492.8 mg, 2.81 mmol) in distilled water (4.3 mL), potassium acetate (338.0 mg, 3.44 mmol) was added. Once the solids went into solution, methanol (4.3 mL) was added followed by pyridine-2- carbaldehyde (322 μL, 3.37 mmol). The reaction was stirred at ambient temperature for 5 hours. The solvent was removed, and no further purification steps were taken. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium acetate In methanol; water at 20℃; | 29 (R)-2-(2-Chloro-pyridin-4-yl)-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride (403.7 mg, 2.56 mmol) in distilled water (4 mL), potassium acetate (306.2 mg, 3.12 mmol) was added. Once the solids went into solution, methanol (4 mL) was added followed by 2-chloro-pyridine-4-carbaldehyde (432.2 mg, 3.06 mmol). Precipitate crashed out of solution within one hour, and the reaction was stirred at ambient temperature overnight. The solvent was removed, and no further purification steps were taken. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium acetate; In methanol; water; at 20℃; | (R)-2-(2-Fluoro-phenyl)-thiazolidine-4-carboxylic acid To a solution of L-cysteine hydrochloride (400 mg, 2.54 mmol) in distilled water (4 mL), potassium acetate (274 mg, 2.79 mmol) was added. Once the solids went into solution, methanol (4 mL) was added followed by 2-fluoro-benzaldehyde (325 muL, 3.06 mmol). The reaction was stirred at ambient temperature overnight. The solvent was removed, and no further purification steps were taken. (R)-2-(2-Fluoro-phenyl)-thiazolidine-3,4-dicarboxylic acid 3-benzyl ester |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium acetate; In methanol; water; at 20℃; for 4h; | (R)-2-Oxazol-5-yl-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride (446.9 mg, 2.84 mmol) in distilled water (4.3 mL), potassium acetate (319.8 mg, 3.26 mmol) was added. Once the solids went into solution, methanol (4.3 mL) was added followed by <strong>[118994-86-8]oxazole-5-carbaldehyde</strong> (339.0 mg, 3.49 mmol). The reaction was stirred at ambient temperature for 4 hours. The solvent was removed, and no further purification steps were taken. (R)-2-Oxazol-5-yl-thiazolidine-3,4-dicarboxylic acid 3-benzyl ester |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With potassium acetate In methanol; water at 20℃; | 49 (R)-2-(2-Hydroxy-pyridin-4-yl)-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride (402.9 mg, 2.56 mmol) in distilled water (4 mL), potassium acetate (281.7 mg, 2.87 mmol) was added. Once the solids went into solution, methanol (4 mL) was added followed by 2-hydroxy-pyridine-4-carbaldehyde (376.4 mg, 3.06 mmol). Precipitate crashed out of solution within one hour, and the reaction was stirred at ambient temperature overnight. The solvent was removed to give the crude product. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With hydrogenchloride In 1,4-dioxane; water at 55 - 65℃; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 38% | With sodium hydrogencarbonate In methanol; aq. phosphate buffer for 72h; Reflux; | General Method A. General procedure: A mixture of a nitrile (2 mmol), L-cysteine hydrochloride (378 mg, 2.4 mmol) and sodium bicarbonate (302 mg, 3.6 mmol) in methanol and phosphate buffer (pH = 6) (12 mL, 1:1) were refluxed for 72 h. After cooling, the mixture was concentrated, basified with 1 N NaOH to pH 10, then washed with ethyl acetate (5 mL x 2). The water phase was acidified with 1 N HCl to pH 2 and extracted with ethyl acetate (10 mL x 3). The organic phases were combined, dried over sodium sulfate and evaporated to give a 2-substituted 4,5-dihydrothiazole-4-carboxylic acid as a white solid or colorless oil. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 98% | With sodium hydrogencarbonate In methanol; aq. phosphate buffer for 72h; Reflux; | General Method A. General procedure: A mixture of a nitrile (2 mmol), L-cysteine hydrochloride (378 mg, 2.4 mmol) and sodium bicarbonate (302 mg, 3.6 mmol) in methanol and phosphate buffer (pH = 6) (12 mL, 1:1) were refluxed for 72 h. After cooling, the mixture was concentrated, basified with 1 N NaOH to pH 10, then washed with ethyl acetate (5 mL x 2). The water phase was acidified with 1 N HCl to pH 2 and extracted with ethyl acetate (10 mL x 3). The organic phases were combined, dried over sodium sulfate and evaporated to give a 2-substituted 4,5-dihydrothiazole-4-carboxylic acid as a white solid or colorless oil. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 93% | Stage #1: 4-n-Octyloxycyanobenzene; l-cysteine hydrochloride With sodium hydrogencarbonate In ethanol for 0.5h; Reflux; Inert atmosphere; Stage #2: With morpholine In ethanol for 12h; Reflux; Inert atmosphere; | General procedure for the synthesis of thiazolines 4a-c General procedure: A solution of L-cysteine hidrochloride (60 mmol;10.8 g), NaHCO3 (60 mmol; 5.3g), the appropriate nitrile(20 mmol) in 85 mL of ethanol was refluxed for 30 min. After, the pH was adjusted to 8.0 by adding a few drops of morpholine, and the reflux was continued for additional 12 h. The ethanol was removed, the residue dissolved in distilled water and acidified to pH 1.5 by adding concentrated HCl. The product was extracted with CH2Cl2 (3 × 50 mL), the organic layers where combined, dried over MgSO4 and the solvent removed under vacuum. The products were obtained with satisfactory purity and were used in the next step without further purification. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 82% | Stage #1: 4-octyloxy-4'-cyanobiphenyl; l-cysteine hydrochloride With sodium hydrogencarbonate In ethanol for 0.5h; Reflux; Inert atmosphere; Stage #2: With morpholine In ethanol for 12h; Reflux; Inert atmosphere; | General procedure for the synthesis of thiazolines 4a-c General procedure: A solution of L-cysteine hidrochloride (60 mmol;10.8 g), NaHCO3 (60 mmol; 5.3g), the appropriate nitrile(20 mmol) in 85 mL of ethanol was refluxed for 30 min. After, the pH was adjusted to 8.0 by adding a few drops of morpholine, and the reflux was continued for additional 12 h. The ethanol was removed, the residue dissolved in distilled water and acidified to pH 1.5 by adding concentrated HCl. The product was extracted with CH2Cl2 (3 × 50 mL), the organic layers where combined, dried over MgSO4 and the solvent removed under vacuum. The products were obtained with satisfactory purity and were used in the next step without further purification. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 70% | With sodium hydroxide In ethanol; water | |
| With sodium acetate In ethanol; water for 4h; | Synthesis of 2-arylthiazolidine-4-carboxylic acids (1a-g) General procedure: To a solution of L-cysteine hydrochloride (0.033 mol)in water (50 mL) was added sodium acetate (0.036 mol) and ethanol (50 mL) with stirring. Then, an appropriatearyl aldehyde (0.017 mol) was added, and the mixture was continuously stirred for at least 4 h.[27,28] The resulting solid product was filtered out and recrystallized from ethanol. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 58 g | Stage #1: l-cysteine hydrochloride With sodium hydroxide In ethanol at 20℃; for 0.0833333h; Stage #2: methyl bromide In ethanol at 20℃; for 6h; | 1 (1) L-cysteine hydrochloride (1 mol) was uniformly dispersed in 3 L of absolute ethanol, then at room temperature, 3.5 mol of sodium hydroxide solution (20 mol / L) was added dropwise with magnetic stirring and stirring was continued for 5 min. Then add 1.1mol of methyl bromide, to maintain a constant temperature reaction for 6h, to form a deoxythiomethyl cysteine sulfoxide (MCS) crude solution. The solution was transferred to a clean container and the pH was adjusted to 5.2 with an acid at 30 ° C. then paced at 4 ° C for 12 h to form white deoxidized MCS crystals. [0047] (2 ) The MCS crystals obtained in step (1) were filtered, dried at 40 ° C, and then redissolved in 10 mL of distilled water containing 1% glacial acetic acid and heated to boiling. The solution was poured into 150 mL of boiling anhydrous ethanol to recrystallize, and the MCS crystals were inverted in the solvent to make the solution cloudy. The solution was allowed to stand at 4 ° C for 12 h and recrystallized. The crystals were filtered and dried at 40 ° C to give about 58 g of pure deoxythiomethyl cysteine sulfoxide (MCS) crystals. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With formaldehyd; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; at -10 - 20℃; | The tert-butoxycarbonyl-N-4-oxo-proline obtained in step S7 and the cysteine hydrochloride were dissolved in a polar proton solvent. Then, carried out reaction again with formaldehyde aqueous solution at -10 ~ 20 C under the action of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and triethylamine , followed by post-treatment to give (2S) - tert-butyl - 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate , standby |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 34% | With potassium hydroxide In methanol at 25℃; for 24h; Inert atmosphere; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| With sodium hydroxide In ethanol; water at 20℃; for 16h; | 5 Example 5: 176g (lM) of L-cysteine hydrochloride was dissolved in an equal amount of water, with 2N sodium hydroxide solution ρΗ = 9, to167 g (1.2 M) of 3-bromopropanol in 167 g of ethanol was added to the liquid and reacted at room temperature for 16 hours. The reaction was completed, with 10wt% hydrochloric acid ρΗ = 5, the solvent was distilled off under reduced pressure to one tenth of the total, to which 1200ml of absolute ethanol was added, stirred at room temperature for a smallWhen, filtered and dried feldstein crude 150g (HPLC98%), the yield of 85%. |
[ 7724-12-1 ]
[ 52-89-1 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 96% | D-Cysteine hydrochloride monohydrate (81.2 mg, 0.462 mmol, 1.1 eq) and 6-amino-cyano- benzothiazole (71 .0 mg, 0.405 mmol, 1 eq) were dissolved in 2:1 MeOH:H20 (1 mL). The resulting solution was allowed to stir at room temperature for 5 mm under a nitrogen atmosphere, after which potassium carbonate (56.5 mg, 0.409 mmol, 1.01 eq) was added. The resulting brightyellow-green solution was allowed to stir for an additional 40 mm, while maintaining an inert atmosphere. Upon consumption of 6-amino-cyanobenzothiazole, as evidenced by TLC analysis, the reaction mixture was diluted with water (4 mL) and washed with EtOAc (1 x 4 mL). The aqueous was then reduced and the resulting precipitate was filtered and washed with cold MeOH (2 x 1 mL). The precipitate was then further purified using reverse phase chromatography elutingwith a gradient of 0-90percent MeOH in water to afford D-aminoluciferin postassium salt as a paleyellow solid (0.123 g, 96percent). [c]ObS: -14° (H20, c = 1). Mp: 111-123°C. 1H-NMR (400 MHz, D20)68.32 (1H, d, J= 8.8 Hz, H-7), 7.79 (1H, s, H-b), 7.55 (1 H, d, J= 8.0 Hz, H-8), 5.72 (1H, m, H-2), 3.8-4.2 (2H, m, H-3). HRMS (ESI+): m/zCalculated for C11H9N302S2K [M+H] 317.9773, found317.9768. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 86% | D-Cysteine hydrochloride monohydrate (30.0 mg, 0.171 mmcl, 1.04 eq) and 2-cyano-6-hydroxy- benzothiazole (29.0 mg, 0.163 mmol, 1 eq) were dissolved in 2:1 MeOH:H20 (1 mL). The resultingsolution was allowed to stir at room temperature for 5 mm under a nitrogen atmosphere, after which potassium carbonate (23.0 mg, 0.164 mmol 1.01 eq) was added. The resulting bright yellow-green solution was allowed to stir for an additional 20 mm, at room temperature, while maintaining the inert atmosphere. Upon consumption of <strong>[939-69-5]2-cyano-6-hydroxybenzothiazole</strong>, as evidenced by TLC analysis, the methanol was removed in vacuo and the remaining aqueoussolution cooled to 0 °C and acidified to pH 3 with 3 M HCI. The aqueous layer was then extracted with EtOAc (5 x 10 mL) and the combined organ ics were dried over Na2SO4, filtered, concentrated in vacuo and purified with column chromatography 3:6:1 DCM:EtOAc:MeOH to provide D-luciferin as a pale yellow solid (39.0 mg, 86 percent). [c]ObS = 290, DMF, c = 1 ([a]1. = -34°, DMF, c = 1). Mp:197-199°C (lit. 196 °C).3 1H-NMR (400 MHz, MeOD) (57.93 (1H, d, J= 8.9 Hz, H-7), 7.35 (iH, d,J= 2.3 Hz, H-b), 7.10 (1H, dd, J= 8.9, 2.3 Hz, H-8), 5.40 (iH, appt, J= 9.0 Hz, H-2), 3.79 (2H, m, H-3) ppm. 13C-NMR (100.6 MHz, CDCI3) oe 172.1 (C-i), 166.2 (C-4), 157.6 (C-9), 157.1 (C-5), 146.8 (C-6), 137.7 (C-il), 124.5 (C-7), 116.8 (C-b), 105.9 (C-8), 78.2 (C-2), 34.5 (C-3) ppm. HAMS (ESI+): m/zCalculated for C11H8N20352 [M+Na] 302.9874, found 302.9868. | |
| 80% | With potassium carbonate; In methanol; dichloromethane; water; for 0.166667h;Cooling with ice; | <strong>[939-69-5]2-cyano-6-hydroxybenzothiazole</strong> (100 mg, 0.57 mmol) was dissolved in DCM:MeOH = 2:3 (10 mL: 15 mL).And pass N2 to the solution.D-cysteine hydrochloride (136 mg, 0.86 mmol) and K2CO3 (119 mg, 0.86 mmol) were dissolved in DI H2O:MeOH = 1:1 (3 mL).The solution was added dropwise to the above <strong>[939-69-5]2-cyano-6-hydroxybenzothiazole</strong>, and the reaction was carried out in the ice bath for 10 min.After the reaction was completed, DCM and MeOH were distilled off under reduced pressure.The pH was then adjusted to 2-3 with a solution of hydrochloric acid (1M) and a yellow precipitate precipitated.The precipitate was filtered and washed with DI H 2 O until the pH became neutral to give D-luciferin crude product.By column chromatography (silica, DCM: MeOH: AcOH, 10:1:1 v/v/v)Purification gave 128 mg of a pale yellow solid.The yield was 80percent. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 95% | With potassium acetate In ethanol; water at 20℃; for 1h; | (2RS,4R)-2-(2-(2-Hydroxyphenyl)thiazol-4-yl)thiazolidine-4-carboxylic acid (HPToxTred-CO2-). 2-(2-Hydroxyphenyl)-thiazole-4-carbaldehyde (1.46 mmol) and potassium acetate(9.71 mmol) were dissolved in a solution of EtOH/H2O (10:3,104 mL) in a round-bottom flask. L-Cysteine-HCl (5.40mmol) was added, and the reaction was stirred at roomtemperature for 1 h. The reaction was washed with hexanes(50 mL), diluted with H2O, and acidified with citric acid to∼pH 2. The aqueous layer was extracted with CH2Cl2 (3 × 75mL). The organic layers were combined and dried overNa2SO4. The solvent was removed in vacuo to afford a yellow/white solid (430 mg, 95%). The product was purified as amixture of epimers and was in agreement with literature valuesfor 1H NMR and 13C NMR.36 HRMS: [M + H]+ 309.0289(calcd), 309.0363 (found). |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 70% | With dipotassium hydrogenphosphate In methanol at 60℃; | (2RS,4R)-2-(2-(2-Hydroxyphenyl)thiazol-4-yl)thiazolidine-4-carboxylic acid (HPToxTred-CO2-). 2-(2-Hydroxyphenyl)-thiazole-4-carbaldehyde (1.46 mmol) and potassium acetate(9.71 mmol) were dissolved in a solution of EtOH/H2O (10:3,104 mL) in a round-bottom flask. L-Cysteine-HCl (5.40mmol) was added, and the reaction was stirred at roomtemperature for 1 h. The reaction was washed with hexanes(50 mL), diluted with H2O, and acidified with citric acid to∼pH 2. The aqueous layer was extracted with CH2Cl2 (3 × 75mL). The organic layers were combined and dried overNa2SO4. The solvent was removed in vacuo to afford a yellow/white solid (430 mg, 95%). The product was purified as amixture of epimers and was in agreement with literature valuesfor 1H NMR and 13C NMR.36 HRMS: [M + H]+ 309.0289(calcd), 309.0363 (found). |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 48% | With triethylamine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃; | Synthesis of polymerisable UV absorber with hydroxyphenyl-benzophenone moiety and an anionic linker (BP15-Cys-MA) L-Cysteine.HCl (2.26 g, 1.5 eq., 14.4 mmol) was added to a solution of 2-(4-benzoyl-3- hydroxyphenoxy)ethyl acrylate (BP15, CAS: 16432-81-8, 3 g, 9.6 mmol) in DMSO (10 ml) and DMF (10 mL) mixture. After solubilizing the components (sonication might be required to enhance L-cysteine solubility) TEA or triethylamine (1.2 mL, 1.0 eq., 9.6 mmol) was added dropwise. The mixture was magnetically stirred at room temperature overnight. The next day the intermediate BP15-Cys precipitated from the solution, which was filtered using Buchner funnel under vacuum. The precipitate was washed with dichloromethane during the filtration process. Successful reaction was indicated by the disappearance of the acrylate peaks (6.0, 6.2 and 6.35 ppm). The intermediate BP15-Cys was then heated in ethanol under reflux for re-crystallization to give 2 g of yellowish solid (yield: 48%). |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 42% | With dihydrogen peroxide; sodium iodide In water at 20℃; for 1h; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 96% | With sodium hydroxide In lithium hydroxide monohydrate at 65℃; for 0.5h; Inert atmosphere; | 1-3; 1-4 Example 2 Step 1. In a nitrogen-filled container, dissolve 100 grams of cysteine hydrochloride monohydrate in 200 ml of water, add 59.3 grams of 3-chloro-1-propanol after the solution is clear, and stir evenly.Step 2. 190 grams of 30% sodium hydroxide solution was added dropwise within 0.5 hours.Step 3. The temperature was raised to 65°C and kept warm.Step 4. After 1 hour, monitor the end point by iodometric method, 3 drops of iodine solution (0.1mol/L) are dark blue.Step 5, adding industrial hydrochloric acid to adjust the pH of the solution to 5.60.Step 6, add 25 grams of copper sulfate 0.2% aqueous solution, continue stirring, and cool down to 35°C.Step 7: Filtration, and the filtrate is introduced into the electrodialysis system.Step 8, energize until the conductivity drops to 30ms/cm, and stop energizing.Step 9. Discharge the material in the light chamber, about 400 ml.After the fresh chamber is emptied, use purified water, divide it into two times, and circulate 200 ml of the fresh chamber for 5 minutes each time, and release it.The fresh chamber discharge and fresh chamber washing water were combined to about 800 ml, and concentrated to about 80 ml under reduced pressure at 65°C.Step 10. Cool to 50°C, and add 250 ml of 95% ethanol.The temperature was lowered to -4°C with stirring, and crystallized for 4 hours.Step 11. Centrifugal material rejection to obtain 120 grams of crude product with a water content of 16%.Step 12. Add 120 grams of purified water to the crude product, heat at 65°C to dissolve, add 0.5 grams of activated carbon, and keep warm for 20 minutes for decolorization.filter.Step 13: About 200 ml of the filtrate is cooled to 50 °C, 1200 ml of ethanol is added, and the temperature is lowered to -4 °C after the addition.Crystallize for 4 hours.Centrifugal rejection to obtain 109 grams of semi-finished products with a water content of 11%.Step 14. Add 300 ml of 95% ethanol to the semi-finished product, and beat for 1 hour.Step 15: centrifugally throw the material, vacuum dry at 60°C to constant weight, pulverize the powder sieve, and obtain 96 grams of finished fudosteine.Yield 96%. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 75 % | With [Ir(dF(CF3)ppy)2(dtbbpy)]PF6; 4-Aminoacetophenone In water at 20℃; Irradiation; Inert atmosphere; Sealed tube; regioselective reaction; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 90 % | With sodium carbonate In ethanol; water at 20℃; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 45 % | With sodium carbonate In ethanol; water at 20℃; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 75 % | Stage #1: 3-fluoro-2-hydroxybenzonitrile; l-cysteine hydrochloride In methanol; aq. phosphate buffer Stage #2: With potassium carbonate In methanol; aq. phosphate buffer at 60℃; | 20 Synthesis of 104.2. To a solution of 3-fluoro-2-hydroxybenzonitrile (104.1, (4.7 g, 34.13 mmol, 1 eq) in MeOH (47 mL) was added L-cysteine (10.76 g, 68.27 mmol, 2 eq, HCI salt) and phosphate buffer (47 mL). The solution was adjusted to pH=6.4 by the addition of solid K2CO3 (5.19 g, 37.55 mmol, 1.1 eq) carefully and the reaction mixture was stirred at 60°C for 12 h. The mixture was concentrated under reduced pressure, and the yellow crude residue was diluted with water (50 mL). The solution was adjusted to pH=2.0 by the addition of solid citric acid. After extraction with dichloromethane (3 x 50 mL), the organic layers were collected, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 6.18 g of 104.2 (75 %, ee value: 100.0%) as a yellow solid. (ES, m/z): [M+l]+242.0. |
| 75 % | Stage #1: 3-fluoro-2-hydroxybenzonitrile; l-cysteine hydrochloride In methanol; aq. phosphate buffer Stage #2: With potassium carbonate In methanol; aq. phosphate buffer at 60℃; | 20 Synthesis of 104.2. To a solution of 3-fluoro-2-hydroxybenzonitrile (104.1, (4.7 g, 34.13 mmol, 1 eq) in MeOH (47 mL) was added L-cysteine (10.76 g, 68.27 mmol, 2 eq, HCI salt) and phosphate buffer (47 mL). The solution was adjusted to pH=6.4 by the addition of solid K2CO3 (5.19 g, 37.55 mmol, 1.1 eq) carefully and the reaction mixture was stirred at 60°C for 12 h. The mixture was concentrated under reduced pressure, and the yellow crude residue was diluted with water (50 mL). The solution was adjusted to pH=2.0 by the addition of solid citric acid. After extraction with dichloromethane (3 x 50 mL), the organic layers were collected, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 6.18 g of 104.2 (75 %, ee value: 100.0%) as a yellow solid. (ES, m/z): [M+l]+242.0. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 73 % | Stage #1: 2-cyano-4-methylphenol; l-cysteine hydrochloride In methanol; aq. phosphate buffer at 25℃; Stage #2: With potassium carbonate In methanol; aq. phosphate buffer at 60℃; | 12 Synthesis of 95.3 To a solution of 2-hydroxy-5-methylbenzonitrile (95.2, 0.7 g, 5.26 mmol, 1 eq) in MeOH (10 mL) was added L-cysteine (1.66 g, 10.51 mmol, 2 eq, HC1 salt) and phosphate buffer (10 mL) at 25°C. The solution was adjusted to pH=6.4 by the addition of solid K2CO3 carefully and the reaction mixture was stirred at 60°C for 2 h. The mixture was concentrated under reduced pressure, and the yellow crude residue was diluted with water (20 mL). The solution was adjusted to pH=2.0 by the addition of solid citric acid. After extraction with di chloromethane (3 x 20 mL), the organic layers were collected, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 1.05 g of 95.3 (73 %, ee value: 95.3 %) as a yellow solid. (ES, m/z): [M+l]+238.1. |
| 73 % | Stage #1: 2-cyano-4-methylphenol; l-cysteine hydrochloride In methanol; aq. phosphate buffer at 25℃; Stage #2: With potassium carbonate In methanol; aq. phosphate buffer at 60℃; | 12 Synthesis of 95.3 To a solution of 2-hydroxy-5-methylbenzonitrile (95.2, 0.7 g, 5.26 mmol, 1 eq) in MeOH (10 mL) was added L-cysteine (1.66 g, 10.51 mmol, 2 eq, HC1 salt) and phosphate buffer (10 mL) at 25°C. The solution was adjusted to pH=6.4 by the addition of solid K2CO3 carefully and the reaction mixture was stirred at 60°C for 2 h. The mixture was concentrated under reduced pressure, and the yellow crude residue was diluted with water (20 mL). The solution was adjusted to pH=2.0 by the addition of solid citric acid. After extraction with di chloromethane (3 x 20 mL), the organic layers were collected, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 1.05 g of 95.3 (73 %, ee value: 95.3 %) as a yellow solid. (ES, m/z): [M+l]+238.1. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 95% | With sodium hydroxide In water Reflux; | 1-7 Example 1 5.0g (15.0mmol, 1.0eq) ethyl 2,4-dioxo-1,3-benzoxazinyloctanoate, 0.25mg (0.0015mmol, 0.01%eq) cysteine hydrochloride, 24.0g (60.0mmol, 4.0eq) 10% sodium hydroxide solution were added to a 250mL three-necked flask and refluxed for 3-4h. The reaction solution was photographed and recorded as shown in Figure 1 (right side). After the reaction was completed, the temperature was lowered to 20-30°C, and 3M dilute hydrochloric acid was carefully added dropwise under stirring to adjust the pH value to 1-3. After stirring for 0.5-1h, the filter cake was filtered and washed with 2×200mL purified water. The filter cake was dried at 55-60°C with air blast for 12-16h to obtain 4.0g off-white solid with a yield of 95%. |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| In methanol at 20℃; for 2h; Inert atmosphere; Irradiation; |
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 26.9% | Stage #1: bis(2-hydroxyethyl) disulfide; l-cysteine hydrochloride With triethylamine In methanol; dichloromethane at 20℃; for 16h; Cooling with ice; Inert atmosphere; Stage #2: di-<i>tert</i>-butyl dicarbonate In methanol; dichloromethane at 20℃; for 4h; | 5 Synthesis of Compound 5-1 Under ice-water bath and nitrogen protection, a solution of triethylamine (1.85 mL, 26.4 mmol, 2.0 eq) and 2-hydroxyethyl disulfide (1.50 g, 13.2 mmol, 1.0 eq) in dichloromethane was added to 18 mL of methanol containing cysteine hydrochloride (1.50 g, 13.2 mmol, 1.0 eq), and the mixture was stirred at room temperature for 16 h. The solution was then cooled to 0 °C, and di-tert-butyl dicarbonate (4.32 g, 19.8 mmol, 1.5 eq) was added. The mixture was stirred at room temperature for 4 h. The reaction was terminated by LC-MS analysis. The reaction solution was directly concentrated and purified by column chromatography (petroleum ether: ethyl acetate = 3:1) to give the compound as a colorless oil (0.9 g, 26.9% yield). |
Tags: L-Cysteine | Endogenous Metabolite | 52-89-1 |
Precautionary Statements-General | |
| Code | Phrase |
| P101 | If medical advice is needed,have product container or label at hand. |
| P102 | Keep out of reach of children. |
| P103 | Read label before use |
Prevention | |
| Code | Phrase |
| P201 | Obtain special instructions before use. |
| P202 | Do not handle until all safety precautions have been read and understood. |
| P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
| P211 | Do not spray on an open flame or other ignition source. |
| P220 | Keep/Store away from clothing/combustible materials. |
| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
| P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
| P230 | Keep wetted |
| P231 | Handle under inert gas. |
| P232 | Protect from moisture. |
| P233 | Keep container tightly closed. |
| P234 | Keep only in original container. |
| P235 | Keep cool |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P244 | Keep reduction valves free from grease and oil. |
| P250 | Do not subject to grinding/shock/friction. |
| P251 | Pressurized container: Do not pierce or burn, even after use. |
| P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P262 | Do not get in eyes, on skin, or on clothing. |
| P263 | Avoid contact during pregnancy/while nursing. |
| P264 | Wash hands thoroughly after handling. |
| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
| P273 | Avoid release to the environment. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P281 | Use personal protective equipment as required. |
| P282 | Wear cold insulating gloves/face shield/eye protection. |
| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
| P313 | Get medical advice/attention. |
| P314 | Get medical advice/attention if you feel unwell. |
| P315 | Get immediate medical advice/attention. |
| P320 | |
| P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
| P321 | |
| P322 | |
| P330 | Rinse mouth. |
| P331 | Do NOT induce vomiting. |
| P332 | IF SKIN irritation occurs: |
| P333 | If skin irritation or rash occurs: |
| P334 | Immerse in cool water/wrap n wet bandages. |
| P335 | Brush off loose particles from skin. |
| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
| P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P342 | If experiencing respiratory symptoms: |
| P350 | Gently wash with plenty of soap and water. |
| P351 | Rinse cautiously with water for several minutes. |
| P352 | Wash with plenty of soap and water. |
| P353 | Rinse skin with water/shower. |
| P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
| P361 | Remove/Take off immediately all contaminated clothing. |
| P362 | Take off contaminated clothing and wash before reuse. |
| P363 | Wash contaminated clothing before reuse. |
| P370 | In case of fire: |
| P371 | In case of major fire and large quantities: |
| P372 | Explosion risk in case of fire. |
| P373 | DO NOT fight fire when fire reaches explosives. |
| P374 | Fight fire with normal precautions from a reasonable distance. |
| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
| P403 | Store in a well-ventilated place. |
| P404 | Store in a closed container. |
| P405 | Store locked up. |
| P406 | Store in corrosive resistant/ container with a resistant inner liner. |
| P407 | Maintain air gap between stacks/pallets. |
| P410 | Protect from sunlight. |
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL


