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Chemical Structure| 627-18-9 Chemical Structure| 627-18-9
Chemical Structure| 627-18-9

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3-Bromopropan-1-ol is a halogenated alcohol compound, commonly used in organic synthesis for the preparation of brominated intermediates.

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Product Details of 3-Bromopropan-1-ol

CAS No. :627-18-9
Formula : C3H7BrO
M.W : 138.99
SMILES Code : OCCCBr
MDL No. :MFCD00002942
InChI Key :RQFUZUMFPRMVDX-UHFFFAOYSA-N
Pubchem ID :12308

Safety of 3-Bromopropan-1-ol

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H302-H318
Precautionary Statements:P210-P264-P270-P280-P301+P312+P330-P305+P351+P338+P310-P370+P378-P403+P235-P501

Application In Synthesis of 3-Bromopropan-1-ol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 627-18-9 ]
  • Downstream synthetic route of [ 627-18-9 ]

[ 627-18-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 57260-71-6 ]
  • [ 627-18-9 ]
  • [ 132710-90-8 ]
YieldReaction ConditionsOperation in experiment
80% With potassium carbonate In acetonitrile at 95℃; for 4 h; Intermediate 121: tert-Butyl 4-(3-hvdroxypropyr)piperazine-l -carboxylate A mixture of tert-butyl piperazine-1 -carboxylate (2.75 g, 14.8 mmol), l-bromo-3- propanol (1.43 mL, 16.2 mmol) and potassium carbonate (2.25 mL, 27.5 mmol) in acetonitrile (75 mL) was heated at 950C for 4 hours. The solvent was removed under reduced pressure, and the residue was taken up in dichloromethane (300 mL) and washed with water, brine, EPO <DP n="118"/>dried over sodium sulfate and concentrated under reduced pressure. Chromatography on silica gel with methanol in dichloromethane (0-10percent) gave a tan solid 2.88 g (80percent yield). MS (ESV 245 (MH+) for C12H24N2O3,1H-NMR TCDCl1) δ: 1.44 (m, 9H); 1.70-1.82 (m, 2H); 2.40-2.53 (m, 2H); 2.62-2.65 (m, 2H); 3.43-3.50 (m, 4H); 2.77 (m, 2H); 3.73-3.82 (m, 2H).
References: [1] Patent: WO2006/134378, 2006, A1, . Location in patent: Page/Page column 116-117.
 

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