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Chemical Structure| 15252-45-6 Chemical Structure| 15252-45-6
Chemical Structure| 15252-45-6

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Hex-5-yn-1-amine is an alkyne-containing amine, used as a reagent in organic synthesis, particularly in the formation of carbon-carbon bonds.

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Hex-5-yn-1-amine

CAS No. :15252-45-6
Formula : C6H11N
M.W : 97.16
SMILES Code : C#CCCCCN
MDL No. :MFCD09923614
InChI Key :ONUHRYKLJYSRMY-UHFFFAOYSA-N
Pubchem ID :10855384

Safety of Hex-5-yn-1-amine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H314
Precautionary Statements:P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501
Class:3(8)
UN#:2924
Packing Group:

Application In Synthesis of Hex-5-yn-1-amine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15252-45-6 ]

[ 15252-45-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15252-45-6 ]
  • [ 24424-99-5 ]
  • [ 151978-58-4 ]
YieldReaction ConditionsOperation in experiment
1.831 g With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20℃; for 2h;Inert atmosphere; N-(5-hexynyl)phthalimide (4.66 g, 20.5 mmol) was dissolved in THF (250 ml) and hydrazine hydrate (410 mmol, 19.8 ml) was added. The obtained solution was refluxed for 3 h, forming a white precipitate after 1h. After the reaction was finished it was cooled down to 8°C and filtered. The filtrate was evaporated to obtain the crude amine 8 as yellow liquid. The crude amine was dissolved in THF (14 ml) and water (14 ml) was added followed by NaHCO3 (2.27 g, 27.0 mmol). The solution was cooled to 0°C and Boc2O (2 M in THF, 8.09 ml; 16.2 mmol) was added via a syringe. The temperature was maintained for 15 min before removing the ice-bath. After 2h at rt the reaction was diluted with EtOAc. It was washed with water, sat. NaHCO3 aq and brine. Drying and evaporation gave a crude oil that was purified on silica with CyHex/EtOAc (92/8) resulting in 1.831g (45percent) 9 as pale yellow oil.
 

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