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Chemical Structure| 2499-95-8 Chemical Structure| 2499-95-8
Chemical Structure| 2499-95-8

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Product Details of Hexyl acrylate

CAS No. :2499-95-8
Formula : C9H16O2
M.W : 156.22
SMILES Code : C=CC(OCCCCCC)=O
MDL No. :MFCD00048881
InChI Key :LNMQRPPRQDGUDR-UHFFFAOYSA-N
Pubchem ID :17259

Safety of Hexyl acrylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H317-H319-H335-H410
Precautionary Statements:P210-P261-P264-P271-P272-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P333+P313-P337+P313-P370+P378-P391-P403+P233-P403+P235-P405-P501

Application In Synthesis of Hexyl acrylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2499-95-8 ]

[ 2499-95-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 6287-82-7 ]
  • [ 2499-95-8 ]
  • [ 1198095-91-8 ]
YieldReaction ConditionsOperation in experiment
77% General procedure: In a pressure tube (glass bomb) a suspension of Pd(OAc)2 (12 mg, 0.05 mmol, 2.5 mol % per Br atom) and dicyclohexyl-(2′,6′-dimethoxybiphenyl-2-yl) phosphine (SPhos) (41 mg, 10 mol %) in DMF (5 mL) was flushed with Ar and stirred at 20 C to give a yellowish or brownish transparent solution. To the stirred solution were added the <strong>[6287-82-7]2,3-dibromobenzothiophene</strong> (15a, 292 mg, 1.0 mmol), Et3N (1.1 mL, 8.0 mmol), and the acrylate (1.25 equiv per Br). The reaction mixture was stirred at 100-130 C for 12-48 h. The solution was cooled to 20 C, poured into H2O and CH2Cl2 (25 mL each), and the organic and the aqueous layer were separated. The latter was extracted with CH2Cl2 (3×25 mL). The combined organic layers were washed with H2O (3×20 mL), dried (Na2SO4), concentrated in vacuo, and passed through a column (silica gel). To a xylene solution (3 mL) of the crude product was added Pd/C (30 mg, 10 mol %). The solution was stirred under reflux for 48 h under argon atmosphere. The reaction mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified by chromatography (flash silica gel, heptanes-EtOAc) to yield the product.
  • 2
  • [ 1003-91-4 ]
  • [ 2499-95-8 ]
  • C22H33BrN2O4 [ No CAS ]
  • C31H48N2O6 [ No CAS ]
  • 3
  • [ 1003-91-4 ]
  • [ 2499-95-8 ]
  • C31H48N2O6 [ No CAS ]
 

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