Home Cart Sign in  
Chemical Structure| 128446-35-5 Chemical Structure| 128446-35-5
Chemical Structure| 128446-35-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

HP-β-CD is used to improve the solubility of lipophilic drugs. It is also an inhibitor of amyloid-β aggregation and Aβ-induced toxicity.

Synonyms: (2-Hydroxypropyl)-β-cyclodextrin; 2-Hydroxypropyl-β-cyclodextrin; VTS-270

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

DE Stock

US Stock

Asia Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Millette, Amira ; van Dijk, Milenna T ; Pokhvisneva, Irina ; Li, Yifei ; Thompson, Rory ; Patel, Sachin , et al.

Abstract: Serum and Glucocorticoid-regulated Kinase 1 (SGK1) is elevated in hippocampal neurons following glucocorticoid exposure and in peripheral blood of depressed patients. However, its mechanistic role in psychopathology and its relevance to the human brain are unknown. To address this gap, we investigated human postmortem brain tissue and found higher SGK1 expression in the hippocampus of depressed suicide decedents compared to healthy subjects who died of natural causes. We observed the highest levels of SGK1 in subjects with reported early life adversity (ELA) – a major risk factor for psychiatric disorders. To determine potential genetic factors underlying increased SGK1 in the hippocampus, we computed expression-based polygenic risk scores (ePRS) for a large population sample from the ABCD study and found that a collection of genetic variants associated with high hippocampal SGK1 expression predicts depression severity and moderates associations between ELA, depressive symptoms, and suicide attempts. Similar to the human brain, hippocampal SGK1 expression was increased in mouse models of ELA, adult chronic stress, and chronic corticosterone exposure, and hippocampal-specific knockdown of SGK1 conferred resilience to stress-induced behavior abnormalities. To test SGK1 as a potential therapeutic target, we injected mice with the small molecule inhibitor, GSK650394, and found that pharmacological inhibition conferred stress resilience, increased adult hippocampal neurogenesis, and rescued stress-induced dentate gyrus hyperactivity. Our cross-species findings reveal a novel role for hippocampal SGK1 in stress resilience, highlight an interaction between ELA and SGK1 on depression and suicide risk, and establish for the first time a functional role for SGK1 in stress-induced psychopathology.

Purchased from AmBeed:

Alternative Products

Product Details of HP-β-CD

CAS No. :128446-35-5
SMILES Code : O[C@@H]1[C@@H](O[C@@H]2O[C@@H](COCC(O)C)[C@H](O[C@@H]3O[C@@H](COCC(O)C)[C@H](O[C@@H]4O[C@@H](COCC(O)C)[C@H]5[C@@H](O)[C@@H]4O)[C@@H](O)[C@@H]3O)[C@@H](O)[C@@H]2O)[C@H](COCC(O)C)O[C@@H](O[C@H]6[C@H](COCC(O)C)O[C@@H](O[C@H]7[C@H](COCC(O)C)O[C@@H](O[C@H]([C@@H](O)[C@@H]8O)[C@H](COCC(O)C)O[C@H]8O5)[C@@H](O)[C@@H]7O)[C@@H](O)[C@@H]6O)[C@H]1O
Synonyms :
(2-Hydroxypropyl)-β-cyclodextrin; 2-Hydroxypropyl-β-cyclodextrin; VTS-270
MDL No. :MFCD00069372

Safety of HP-β-CD

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of HP-β-CD

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 128446-35-5 ]

[ 128446-35-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14252-80-3 ]
  • [ 128446-35-5 ]
  • C18H28N2O*C105H196O56*ClH [ No CAS ]
  • 2
  • [ 128446-35-5 ]
  • [ 17924-92-4 ]
  • C18H22O5*C105H196O56 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In aq. acetate buffer; at 25℃;pH 5; General procedure: Steady-state fluorescence measurements were performed employing a Hitachi F-4500 fluorescencespectrophotometer. Interactions of alpha- and beta-ZOLs with CDs were examined in 0.05 M sodium acetate (pH 5.0), in PBS (pH 7.4), and in 0.05 M sodium borate (pH 10.0) buffers at 25 C, in the presence of air. When testing the effects of CD concentration on the complex formation followed by the enhancement of fluorescence, CDs were applied at concentrations 0, 0.02, 0.05, 0.07, 0.10, 0.20, 0.50, 0.70, 1.0, 1.5 and 2.0 mM together with 2 muM alpha-ZOL or 2 muM beta-ZOL. The fluorescence emission spectra were recorded using the excitation wavelengths of 275 nm or 315 nm (lambdaem = 455 nm). Binding constants (K, with the dimension of dm3/mol) of ZOL-CD complexes were calculated employing the graphical applicationof the Benesi-Hildebrand equation assuming 1:1 stoichiometry: I0/(I-I0)=1/A+1/A x K x [CD]n (1) where I0 and I denote the fluorescence emission intensities of ZOLs in the absence and in the presenceof CDs, respectively; [CD] is the molar concentration of the host molecule, while A is a constant and nis the number of binding sites.
 

Historical Records

Categories