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Chemical Structure| 7531-52-4 Chemical Structure| 7531-52-4
Chemical Structure| 7531-52-4

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L-prolinamide is a proline derivative, commonly found in protein secondary structures, involved in protein synthesis in vivo, with antioxidant and anti-inflammatory effects.

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Product Details of L-Prolinamide

CAS No. :7531-52-4
Formula : C5H10N2O
M.W : 114.15
SMILES Code : O=C(N)[C@H]1NCCC1
MDL No. :MFCD00005253

Safety of L-Prolinamide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of L-Prolinamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7531-52-4 ]

[ 7531-52-4 ] Synthesis Path-Downstream   1~11

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  • [ 1163707-27-4 ]
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  • [ 1166227-08-2 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 18h; Example 6 (S)-pyrrolidine-1 ,2-dicarboxylic acid 2-amide 1-[(2-tert-butyl-4'-methyl- [4,5']bithiazolyl-2'-yl)-amide]; A mixture of imidazole-1-carboxylic acid (2-tert-butyl-4'-methyl-[4,5']bithiazolyl-2'-yl)-amide (40 mg), L-proline amide (20 mg) and triethylamine (0.02 ml) in DMF (1 ml) is allowed to stand at room temperature for 18 hours. Following evaporation of the reaction mixture purification by crystallisation from aqueous methanol gives the title compound as a white solid. Hplc/MS (Method B) RT 2.40 minutes, M+H 394.1 and M-H 392.3.
  • 9
  • C13H17N3OS2 [ No CAS ]
  • [ 530-62-1 ]
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  • [ 141774-70-1 ]
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YieldReaction ConditionsOperation in experiment
95.3% With hydrogenchloride; In water; at 103℃; for 2h; 44.41 g of 1-acetyl-2-pyrrolidinecarboxamide was added to 160 mL of 2N HCl.Raise the temperature to 103 C reflux reaction,During the reaction, the temperature of the system is kept at the micro-reflow state.Co-reacted for 2 hours,After completion of the reaction, the mixture was concentrated to a small volume until crystallization, pH was adjusted to 8, filtered, and dried to give the desired product, L-prolinamide, 31.05 g, yield 95.3%. Detection of D-type isomerismThe purity of the solution was 0.11%, and the purity was determined by high performance liquid chromatography HPLC to be 99.1%.
 

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