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Chemical Structure| 85073-19-4 Chemical Structure| 85073-19-4
Chemical Structure| 85073-19-4

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Synonyms: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

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Watts, Brennan P ; Jamison, Matthew R ; Kapitan, John M ; Huang, Nengjian ; Taylor, Delroy ; Morin, Stephen A

Abstract: The dynamic optical and mechanical properties of cephalopod skin cannot be mimicked using traditional display technologies. Soft materials (and systems thereof ) have the potential to realize cephalopod-like color switching capabilities synthetically. This report describes the fabrication of stretchable arrays of microstructured, stimuli-responsive hydrogels, “synthetic chromatophores,” that emulate the mechano-dynamic action of color change found in cephalopods. By combining multiple layers of these synthetic chromatophores, soft skins with color and pattern morphing capabilities that leverage halftone absorption, optical interference, and microlensing are demonstrated. These skins, made entirely of soft materials, are inherently stretchable and can be programmed to respond to specific environmental stimuli, making them well-suited for applications in soft robotics and human-machine interfaces.

Keywords: chromatophores ; halftones ; hydrogels ; microactuation ; microlens ; moire interference

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Sohn, Sogu ; Momtahan, Nima ; Stevens, Lynn M ; Han, Jiwan ; Liu, Yutong ; Kiker, Meghan T , et al.

Abstract: The human heart’s limited regenerative capacity is a significant barrier to addressing cardiovascular disease (CVD). This is particularly true for cardiac fibrosis, a form of CVD wherein the wound healing process has gone awry. In cardiac fibrosis, excessive scar tissue formation due to dysregulated remodeling of the heart’s extracellular matrix (ECM) results in increased stiffness that reduces cardiac output and can lead to heart failure. This dysregulated ECM deposition is driven by activated cardiac fibroblasts, where cell substrate stiffness is known to play a role in cardiac fibroblast activation. New preclinical models that accurately recapitulate the behavior of activated cardiac fibroblasts are needed to better understand and treat cardiac fibrosis. To this end, we describe a model wherein human induced pluripotent stem cell (hiPSC)-derived cardiac fibroblasts (HCFs) are cultured on 3D printed hydrogels of tunable stiffness, fabricated using dosage controlled digital light processing (DLP). We demonstrate that our model can induce HCF activation in the absence of TGFβ, a key mediator of fibroblast activation, surpassing the activation levels seen with HCFs activated with TGFβ on protein-coated tissue culture plates. Furthermore, combining stiffer hydrogels with TGFβ recapitulates fibroblast activation similar to what is observed in native cardiac tissue. Lastly, by indirectly coculturing HCFs seeded and activated on these stiff hydrogels with hiPSC-derived cardiomyocytes, we demonstrate that the activated HCFs in our cardiac fibrosis model can impair cardiomyocyte function, mimicking the deleterious effects of cardiac fibrosis.

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Luca A. Altevogt ; Rakib H. Sheikh ; Thomas G. Molley ; Joel Yong ; Kang Liang ; Patrick Spicer , et al.

Abstract: The field of 3D biofabrication faces major challenges on the road to printing fully functional tissues and organs. One of them is adding functionality to the newly formed tissue for replicating an active biochemical environment. Native extracellular matrices sequester numerous bioactive species, making the microenvironment biochemically active. On the other hand, most 3D-printed constructs have limited activity, serving merely as mechanical scaffolding. Here we demonstrate active scaffolding through the integration of biocatalytic enzymes within the bioink. Enzymes are an attractive class of biocompatible and substrate-specific bioactive agents that can improve tissue regeneration outcomes. However, the difficulty in the application remains in providing enzymes at the targeted site in adequate amounts over an extended time. In this work, a durable biocatalytic active enzyme bioink for 3D extrusion-based bioprinting is developed by covalently attaching the globular enzyme horseradish peroxidase (HRP) to a gelatin methacrylate (Gel-MA) biopolymer scaffold. Upon introducing methacrylate groups on the surface of the enzyme, it undergoes photo-crosslinking in a post-printing step with the methacrylate groups of Gel-MA without compromising its activity. As a result, HRP becomes a fixed part of the hydrogel network and achieves higher stability inside the gel which results in a higher concentration and catalytic activity for a longer time than solely entrapping the protein inside the hydrogel. We also demonstrate the cytocompatibility of this enzyme bioink and show its printing capabilities for precise applications in the field of tissue engineering. Our approach offers a promising solution to enhance the bioactive properties of 3D-printed constructs, representing a critical step towards achieving functional biofabricated tissues.

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Product Details of LAP

CAS No. :85073-19-4
Formula : C16H16LiO3P
M.W : 294.21
SMILES Code : O=P(C(C1=C(C)C=C(C)C=C1C)=O)(C2=CC=CC=C2)[O-].[Li+]
Synonyms :
Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
MDL No. :MFCD29472537
InChI Key :JUYQFRXNMVWASF-UHFFFAOYSA-M
Pubchem ID :68384915

Safety of LAP

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338
 

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