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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 114798-26-4 Chemical Structure| 114798-26-4

Structure of Losartan
CAS No.: 114798-26-4

Chemical Structure| 114798-26-4

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Losartan is an angiotensin II receptor antagonist that competes with angiotensin II binding to AT1 receptors with an IC50 of 20 nM.

Synonyms: DuP-753

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Citations

Product Citations      Show More

Wang, Zaoming ; Pacheco-Fernández, Idaira ; Carpenter, James E ; Aoyama, Takuma ; Huang, Guoji ; Pournaghshband Isfahani, Ali , et al.

Abstract: The wide presence of pharmaceuticals and personal care products (PPCPs) in water is a major pollution concern even at the part per billion level, which urges their detection and removal. Current research emphasizes the use of microporous materials as adsorbents for pollutant removal but demonstrates the performance at a higher concentration than realistic environmental water due to the absence of efficient detection methods that can be coupled with the removal process. Here we report a pore-networked membrane (PNM) that can simultaneously remove and detect targeted trace-level PPCPs. These PNMs are designed by interconnecting adsorbents within polymer matrices, forming continuous, tunable porous networks that are accessible for PPCPs, thereby offering high selectivity and adsorption capacity. Evaluations across water samples containing 13 pollutants demonstrate the capability of PNMs to selectively adsorb PPCPs for removal and subsequently release them into analysis solution for detection, positioning their promising use in real water treatment workflow.

Purchased from AmBeed:

Wang, Zaoming ; Pacheco-Fernandez, Idaira ; Carpenter, James E. ; Aoyama, Takuma ; Huang, Guoji ; Isfahani, Ali Pournaghshband , et al.

Abstract: The wide presence of pharmaceuticals and personal care products (PPCPs) in water is a major concern regarding current emerging pollution and urges their selective monitoring to establish water quality management. Microporous materials have been developed to extract organic contaminants and further embedded as fillers into polymeric composites like matrix-mixed membranes (MMMs) for practical use. Considering the relatively large mol. size of PPCPs and their slow diffusion in the membrane, the MMM configuration is, however, inadequate for liquid-phase separations Here we report pore-networked membranes (PNMs) based on the concept of interconnecting the microporous fillers within the polymer matrix to form a continuous porous phase. Linked metal-organic polyhedra (MOP) network is designed for the continuous porous phase with tunable micro/mesopores, which are accessible for big PPCP mols. to facilitate their diffusion and adsorption. By contrast to MMMs, PNMs show enhanced stability, capacity and extraction selectivity towards specific pharmaceutical drugs amongst 13 PPCPs in environmental water matrixes at trace-level concentrations

Keywords: Porous materials ; Membranes ; Water contaminants ; Metal-organic polyhedra

Purchased from AmBeed:

Alternative Products

Product Details of Losartan

CAS No. :114798-26-4
Formula : C22H23ClN6O
M.W : 422.91
SMILES Code : OCC1=C(N=C(N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)CCCC)Cl
Synonyms :
DuP-753
MDL No. :MFCD00865831
InChI Key :PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Pubchem ID :3961

Safety of Losartan

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H317-H361-H228
Precautionary Statements:P210-P501-P261-P272-P202-P201-P280-P302+P352-P308+P313-P362+P364-P333+P313-P405
Class:4.1
UN#:1325
Packing Group:

Related Pathways of Losartan

GPCR

Isoform Comparison

Biological Activity

Target
  • AT1 receptor

    AT1 receptor, IC50:20 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
aortic smooth muscle cells 100 μg/ml 24 hours To investigate the effect of Losartan on Smad2 and Erk1/2 phosphorylation, results showed that Losartan inhibited the phosphorylation of Smad2 and Erk1/2 PMC4162309
Mouse peritoneal macrophages 1 μM 6 hours To evaluate the effect of Losartan on IL-6 and TLR4 signaling in macrophages, results showed that Losartan significantly reduced IL-6 and TLR4 mRNA expression. PMC8409338
human podocytes 1 µM 24 hours To investigate the effect of Ang II on LRRC55 expression in podocytes, results showed that Ang II treatment increased LRRC55 expression. PMC7756252
THP-1 cells 10 mg/mL 1 hour Losartan inhibits CCL2-mediated monocyte migration and significantly reduces THP-1 cell migration. PMC8866227
Human peripheral blood mononuclear cells (PBMC) 10 mg/mL 1 hour Losartan significantly inhibits human PBMC migration. PMC8866227
Canine peripheral blood mononuclear cells (PBMC) 10 mg/mL 1 hour Losartan significantly inhibits canine PBMC migration. PMC8866227
Smooth Muscle Cells (SMC) 100 μg/ml 24 hours To study the effect of Losartan on Erk1/2 and Smad2 phosphorylation, results showed that Losartan inhibited Erk1/2 and Smad2 phosphorylation. PMC4162309
THP-1 cells 10 mg/mL 24 hours To assess the transcriptional effects of Losartan on human PBMCs, revealing significant downregulation of genes associated with monocyte chemotaxis and M2 macrophage polarization. PMC8866227
Canine PBMCs 100 ng/mL to 10 mg/mL To evaluate the inhibitory effect of Losartan on CCL2 chemotaxis in canine PBMCs, showing significant suppression of CCL2-mediated monocyte migration. PMC8866227

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Mouse model of Marfan syndrome Drinking water 15 mg/kg Once daily for 21 days Losartan prevented aortic aneurysm in a mouse model of Marfan syndrome and partially reversed noncardiovascular manifestations, such as impaired alveolar septation PMC1482474
Mice cTnT-Q92 transgenic mice model Oral 10 mg/kg Consecutive 7 days Losartan significantly reduced interstitial fibrosis in cTnT-Q92 mice, with a 49% reduction in collagen volume fraction and a 50% reduction in the expression of collagen 1α(I) and transforming growth factor-β1. PMC2779524
mice Fbn1mgR/mgR mouse model drinking water 14.2±5.3 mg·kg⁻¹·d⁻¹ 42±9.6 days To investigate the effect of Losartan on aortic dilatation and survival, results showed that Losartan significantly prolonged the survival of Fbn1mgR/mgR mice and inhibited aortic dilatation PMC4162309
Mouse NF2 CPA model Oral 5 mg/kg/d daily for 3 weeks Losartan prevented tumor-induced hearing loss by reducing fibrosis and inflammatory signaling in the tumor microenvironment and enhanced the efficacy of radiation therapy. PMC8409338
Mice Muscle atrophy model Oral 0.6 g/L from postnatal day 1 to 30 weeks Losartan improved muscle remodeling and protected against muscle atrophy. PMC3140459
Mice BPH mice (hypertensive model) 40 mg/kg/day Once daily, continuous treatment To evaluate the therapeutic effects of Losartan on hypertension-induced deficits in functional hyperemia. Results showed that while Losartan effectively lowered blood pressure, it failed to restore functional hyperemia, likely due to aldosterone breakthrough. PMC8439604
mice Ang II-induced podocyte injury model oral 100 mg/kg/day Once daily, continuous treatment To investigate the effect of Losartan on Ang II-induced podocyte injury, results showed that Losartan suppressed LRRC55 expression and attenuated podocyte injury. PMC7756252
Dogs Spontaneous osteosarcoma lung metastasis model Oral 10 mg/kg/d once daily for 4 weeks Losartan combined with toceranib significantly inhibited lung metastasis in dogs with osteosarcoma, achieving a clinical benefit rate of 50%. PMC8866227
Mice Fbn1C1039G/+ mouse model Drinking water 20 mg/kg Once daily for 9 days Losartan prevented aortic aneurysm in Fbn1C1039G/+ mice and improved the elastic fiber architecture and thickness of the aortic wall, showing no significant difference from wild-type mice PMC1482474
Mice CPA model Oral 5 mg/kg Once daily for 7 days Losartan treatment normalized the TME by reducing neuroinflammatory IL-6/STAT3 signaling and preventing hearing loss PMC8409338
Mice Fbn1mgR/mgR mice Drinking water 0.6 g/liter Starting at 2 weeks of gestation, continued through lactation, and maintained after weaning To study the effect of Losartan on aortic dilatation and survival in Fbn1mgR/mgR mice, results showed that Losartan significantly prolonged the survival of mice and inhibited aortic dilatation. PMC4162309
Mice Muscle atrophy model Oral 40 mg/kg per day Daily, continuous treatment Losartan potassium improved muscle remodeling and protected against muscle atrophy by modulating the TGF-β and IGF-1/Akt/mTOR signaling pathways. PMC3140459
Mice BPH mice (hypertensive model) Oral 100 mg/kg/d or 200 mg/kg/d Once daily for 15 days To evaluate the therapeutic effects of losartan on hypertension-induced deficits in functional hyperemia, it was found that losartan failed to restore functional hyperemia, likely due to aldosterone breakthrough. PMC8439604
Dogs Spontaneous lung metastatic osteosarcoma model Oral 25 mg/kg/d Once daily for 24 weeks To assess the safety and antitumor activity of high-dose Losartan in combination with Toceranib, demonstrating significant clinical benefit in 50% of dogs. PMC8866227
Mice Adriamycin nephropathy model Oral ~100 mg/kg/d Starting at 3 months of age and continued To investigate the effect of losartan potassium on LRRC55 expression and podocyte injury in the adriamycin nephropathy model, results showed that losartan potassium suppressed LRRC55 expression and attenuated podocyte injury. PMC7756252

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00447603 Hypertension Phase 3 Terminated(Achieving site read... More >>iness and enrolling the trial within a reasonable time) Less << - -
NCT01198249 Essential Hypertension Phase 1 Completed - Korea, Republic of ... More >> Severance Hospital Seoul, Korea, Republic of, 120-752 Less <<
NCT02183701 Hypertension Phase 3 Completed - -
NCT00447603 - Terminated(Achieving site read... More >>iness and enrolling the trial within a reasonable time) Less << - -
NCT00942344 Hypertension Phase 2 Completed - Korea, Republic of ... More >> 14 sites in Korea Seoul, Busan, etc., Korea, Republic of Less <<
NCT00720577 Peripheral Arterial Disease Early Phase 1 Completed - -
NCT00593710 Marfan Syndrome Phase 2 Completed - Canada, British Columbia ... More >> Children's Heart Centre, British Columbia's Children's Hospital Vancouver, British Columbia, Canada, V6H 3V4 Less <<
NCT02410005 Diabetic Nephropathies Phase 2 Phase 3 Terminated(Logistic challenges... More >>) Less << - United States, New York ... More >> Weill Cornell Medical College New York, New York, United States, 10021 Qatar Weill Cornell Medical College in Qatar Doha, Qatar, 24144 Hamad Medical Corporation Doha, Qatar Less <<
NCT00683124 Marfan Syndrome Phase 3 Unknown July 2013 Italy ... More >> IRCCS Foundation San Matteo Hospital Recruiting Pavia, Italy, 27100 Contact: Eloisa Arbustini, MD,FESC,FACC    +390382501206    e.arbustini@smatteo.pv.it    Contact: Fabiana I Gambarin, MD    +390382501206    f.gambarin@smatteo.pv.it    Principal Investigator: Eloisa Arbustini, MD,FESC,FACC          Sub-Investigator: Fabiana I Gambarin, MD          Sub-Investigator: Valentina Favalli, Engineer          Sub-Investigator: Alessandra Serio, MD          Sub-Investigator: Mario Regazzi, MD          Sub-Investigator: Catherine Klersy, MD Less <<
NCT00649311 Hypertension Phase 2 Terminated(Poor enrollment; te... More >>rmination not due to safety reasons.) Less << - Taiwan ... More >> Pfizer Investigational Site Kaohsiung, Taiwan Pfizer Investigational Site Taipei, Taiwan Less <<
NCT01431508 Hypertension Phase 4 Completed - -
NCT00090259 Heart Failure Phase 3 Completed - -
NCT00782327 Marfan Syndrome Phase 3 Unknown December 2015 Belgium ... More >> University Hospital Ghent Recruiting Ghent, Belgium, 9000 Principal Investigator: Julie De Backer, MD, PhD Less <<
NCT00565396 Chronic Kidney Insufficiency ... More >> Angiotensin-Converting Enzyme Inhibitors Angiotensin II Type 1 Receptor Blockers Proteinuria Less << Not Applicable Unknown July 2008 China, Jiangsu ... More >> Taizhou People's Hospital Taizhou, Jiangsu, China, 225300 China, Zhejiang The 1st Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou, Zhejiang, China, 310003 Guangxing Hospital Hangzhou, Zhejiang, China, 310007 Shaoyifu Hospital Hangzhou, Zhejiang, China, 310016 Ningbo Lihuili Hospital Ningbo, Zhejiang, China, 315000 Wenling 1st People's Hospital Wenling, Zhejiang, China, 317500 The First affiliated Hospital of Wenzhou Medical College Wenzhou, Zhejiang, China, 325000 Xiangshan People's Hospital Xiangshan, Zhejiang, China, 315700 China Renji Hospital Shanghai, China, 200001 Changzheng Hospital Shanghai, China, 200003 Shanghai 9th People's Hospital Shanghai, China, 200011 Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai, China, 200025 Zhongshan Hospital Shanghai, China, 200032 Huadong Hospital Shanghai, China, 200040 Huashan Shanghai, China, 200040 Shanghai 455 Hospital Shanghai, China, 200052 Shanghai 85 Hospital Shanghai, China, 200052 Tongji Hospital Shanghai, China, 200065 Shanghai 10th People's Hospital Shanghai, China, 200072 Shanghai 1st People's Hospital Shanghai, China, 200080 Shanghai Yangpu District Centre Hospital Shanghai, China, 200090 Xinhua Hospital Shanghai, China, 200092 Shanghai East Hospital Shanghai, China, 200120 Shanghai 6th people's hospital Shanghai, China, 200233 Shanghai Changning District Centre Hospital Shanghai, China, 200336 Changhai Hospital Shanghai, China, 200433 Less <<
NCT01431508 - Completed - -
NCT00090259 - Completed - -
NCT00364988 Type 2 Diabetes ... More >> Diabetic Nephropathy Less << Not Applicable Completed - -
NCT02269176 Hypertension Phase 3 Completed - -
NCT01447654 Hypertrophic Cardiomyopathy Phase 2 Completed - Denmark ... More >> Department of cardiology, Rigshospitalet. Copenhagen, Denmark, 2100 Less <<
NCT01307046 - Completed - -
NCT03357653 Glomerulonephritis, Immunoglob... More >>ulin A (IgA) Less << Phase 3 Not yet recruiting December 31, 2021 -
NCT00763893 Marfan Syndrome Phase 3 Terminated(A similar publicati... More >>on has been released, suggesting a beneficial effect of sartans, and only 15 patients remained to be seen for their visit at 36 months.) Less << - France ... More >> Hôpital Bichat Paris, France, 75018 Less <<
NCT01307046 Hypertension Phase 3 Completed - -
NCT00651235 Marfan Syndrome Phase 2 Unknown June 2011 Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Less <<
NCT00670787 Hypertension Phase 3 Completed - Japan ... More >> Department of Medicine and Clinical Science, Kyushu University Fukuoka City, Fukuoka, Japan, 812-8582 Less <<
NCT01620788 Hypertension Phase 3 Not yet recruiting March 2019 -
NCT02373241 Anemia, Sickle Cell ... More >> Sickle Cell Disease Kidney Disease Hypertension Proteinuria Less << Phase 2 Recruiting April 2020 United States, Alabama ... More >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35223 Contact: Jeffrey D Lebensburger, DO       jlebensburger@peds.uab.edu Less <<
NCT00663377 Heart Failure Phase 4 Completed - -
NCT01305850 Peritoneal Membrane Failure Phase 4 Unknown October 2011 Thailand ... More >> Chulalongkorn University Recruiting Bangkok, Thailand, 10330 Contact: Talerngsak Kanjanabuch, Assist. Prf.    662-2564321 ext 211    golfnephro@hotmail.com    Principal Investigator: Talerngsak Kanjanabuch, Assist. Prf.          Sub-Investigator: Pichaya Tantiyavarong, MD Less <<
NCT02049307 Inflammation ... More >>Fibrosis Less << Phase 2 Active, not recruiting February 2019 United States, California ... More >> UCSF San Francisco, California, United States, 94110 United States, Maryland NIH Clinical Center Bethesda, Maryland, United States, 20892 United States, Minnesota Allina Health Minneapolis, Minnesota, United States, 55407 Hennepin County Medical Center Minneapolis, Minnesota, United States, 55417 Less <<
NCT00739674 Hypertension Phase 3 Completed - -
NCT01149473 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT01982695 Duchenne Muscular Dystrophy (D... More >>MD) Cardiomyopathy Less << Not Applicable Completed - United States, California ... More >> University of California Davis Davis, California, United States United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States United States, Minnesota University of Minnesota St. Paul, Minnesota, United States United States, Missouri St. Louis Children's Hospital St. Louise, Missouri, United States United States, Ohio Nationwide Children's Hospital Columbus, Ohio, United States Less <<
NCT01149473 - Completed - -
NCT00949884 Hypertension Phase 4 Completed - United States, Arizona ... More >> Mesa, Arizona, United States, 85213 Phoenix, Arizona, United States, 85050 United States, California Harbor City, California, United States, 90710 Tustin, California, United States, 92780 Westlake Village, California, United States, 91361 United States, Colorado Pueblo, Colorado, United States, 81001 United States, Florida Deerfield Beach, Florida, United States, 33442 DeLand, Florida, United States, 32720 United States, Indiana South Bend, Indiana, United States, 46614 United States, Kansas Wichita, Kansas, United States, 67205 United States, Louisiana Metairie, Louisiana, United States, 70006 United States, New Mexico Albuquerque, New Mexico, United States, 87108 United States, New York Binghamton, New York, United States, 13701 United States, North Carolina Charlotte, North Carolina, United States, 28209 United States, Ohio Cincinnati, Ohio, United States, 45219 United States, South Carolina Greenville, South Carolina, United States, 29615 United States, Tennessee Bristol, Tennessee, United States, 37620 New Tazewell, Tennessee, United States, 37825 United States, Texas Dallas, Texas, United States, 75230 United States, Virginia Norfolk, Virginia, United States, 23502 Less <<
NCT01127217 Hypertension Phase 3 Completed - Korea, Republic of ... More >> 8 Sites Seoul, Korea, Republic of Less <<
NCT00739674 - Completed - -
NCT01384591 - Completed - -
NCT01041807 - Completed - -
NCT01982695 - Completed - -
NCT03526042 Atherosclerosis ... More >> Lupus Nephritis Less << Not Applicable Recruiting October 31, 2019 Mexico ... More >> Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Recruiting Mexico City, Mexico, 14080 Contact: Juan M Mejia-Vilet, MD,MSc    54870900 ext 4142    jmmejia@hotmail.com    Contact: Luis E Morales-Buenrostro, PhD    54870900 ext 4142    luis_buenrostro@yahoo.com.mx Less <<
NCT00949884 - Completed - -
NCT00940667 Hypertension Phase 3 Completed - Korea, Republic of ... More >> 13 sites in Korea Seoul, Busan, etc., Korea, Republic of Less <<
NCT01384591 Aging Phase 1 Phase 2 Completed - United States, Texas ... More >> University of Texas Medical Branch Galveston, Texas, United States, 77555 Less <<
NCT01321021 Memory, Long-Term ... More >> Memory, Short-Term Less << Not Applicable Completed - Switzerland ... More >> University of Basel, Division of Cognitive Neuroscience Basel, Switzerland, 4055 Less <<
NCT00754429 Ischemic Stroke Phase 4 Completed - -
NCT01224860 Renal Transplant Phase 2 Completed - Italy ... More >> Mario negri Institute - Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Less <<
NCT03217825 Hypertension Phase 2 Recruiting December 2017 Taiwan ... More >> Cvie Therapeutics Limited Recruiting Taipei, Taiwan, 100 Contact: Abby Chang, PhD    +886 2758 6003 ext 108    abbychang@cvie.com Less <<
NCT01964079 Hypertension Phase 4 Completed - Korea, Republic of ... More >> Wonju Severance Christian Hospital Wonju, Gangwon-do, Korea, Republic of, 220-701 Less <<
NCT00701428 Hypertension ... More >>Sleep Apnea Less << Phase 4 Completed - Sweden ... More >> Skaraborg Hospital Skoevde, West Gotaland, Sweden, SE 51485 Less <<
NCT01216878 Hypertension Not Applicable Completed - United States, Missouri ... More >> BioKinetic Clinical Applications, Inc. Springfield, Missouri, United States, 65802 Less <<
NCT00152633 Hypertension Phase 2 Phase 3 Withdrawn(No patient could be ... More >>recruited.) Less << - Germany ... More >> CRC, Med. Klinik 4, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Less <<
NCT01852942 HIV Infection ... More >> HIV Infections Less << Phase 2 Active, not recruiting December 2018 United States, Minnesota ... More >> University of Minnesota, Division of Infectious Diseases Minneapolis, Minnesota, United States, 55455 Less <<
NCT00931710 - Completed - -
NCT00546052 Hypertension ... More >>Metabolic Disorder Less << Phase 3 Completed - -
NCT00931710 Stage 2 Systolic Hypertension Phase 4 Completed - United States, New Jersey ... More >> sites in USA East Hanover, New Jersey, United States Less <<
NCT01277822 Hypertension Phase 4 Completed - -
NCT00546052 - Completed - -
NCT01277822 - Completed - -
NCT01648231 Hypertension Phase 1 Completed - Australia, New South Wales ... More >> GSK Investigational Site Randwick, New South Wales, Australia, 2031 Less <<
NCT01216852 Hypertension Not Applicable Completed - United States, Missouri ... More >> Bio-Kinetic Clinical Applications, Inc. Springfield, Missouri, United States, 65802 Less <<
NCT00940680 Hypertension Phase 3 Completed - Korea, Republic of ... More >> 9 sites in Korea Seoul, Daegu, etc., Korea, Republic of Less <<
NCT02263729 Hamstring Injury Phase 1 Phase 2 Recruiting December 31, 2019 United States, Pennsylvania ... More >> University of Pittsburgh Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: James Irrgang, PT, PhD       irrgangjj@upmc.edu    Principal Investigator: James Irrgang, PT, PhD Less <<
NCT02696564 Emphysema Phase 4 Recruiting January 31, 2021 -
NCT01197014 Healthy Phase 1 Completed - Czech Republic ... More >> CEPHA s.r.o. Pilsen, Czech Republic Less <<
NCT01150461 - Completed - -
NCT00519870 Pulmonary Hypertension Phase 3 Completed - -
NCT00720226 - Completed - -
NCT00723801 - Completed - -
NCT00675987 Obesity Hyper... More >>tension Hyperglycemia Less << Phase 4 Completed - United States, Arkansas ... More >> CAVS Clinical Research Center Little Rock, Arkansas, United States, 72205 United States, California VA San Diego Health Care System San Diego, California, United States, 92161 United States, Florida University of Miami Diabetes Research Institute Miami, Florida, United States, 33136 United States, Indiana Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Massachusetts Brigham and Women's Hospital Cardiovascular Division Boston, Massachusetts, United States, 02115 United States, New York St. Lukes Roosevelt Hospital New York, New York, United States, 10025 United States, Pennsylvania University of Pennsylvania School of Medicine Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas SW Medical Center at Dallas Dallas, Texas, United States, 75390 Hypertension Clinical Pharmacology Baylor Clinic Houston, Texas, United States, 77030 Less <<
NCT01150461 Hypertrophic Cardiomyopathy Phase 2 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT01197001 Healthy Phase 1 Completed - Czech Republic ... More >> CEPHA s.r.o. Pilsen, Czech Republic, CZ-323 00 Less <<
NCT01821729 Pancreatic Cancer Phase 2 Active, not recruiting July 2019 United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT00720226 COPD Emphysem... More >>a Chronic Bronchitis Smoking Less << Phase 4 Completed - United States, Maryland ... More >> Johns Hopkins Asthma and Allergy Center Baltimore, Maryland, United States, 21205 Less <<
NCT01145612 Marfan Syndrome Phase 3 Unknown February 2013 Spain ... More >> Hospital Vall d'Hebron Barcelona, Spain, 08023 Hospital 12 de Octubre Madrid, Spain, 28045 Less <<
NCT01390181 Bicuspid Aortic Valve ... More >> Thoracic Aortic Aneurysm Less << Not Applicable Terminated(Due to low enrollme... More >>nt the decision was made to terminate study prior to final data collection for any individual.) Less << - United States, Michigan ... More >> University of Michigan Ann Arbor, Michigan, United States, 48109 Less <<
NCT00675987 - Completed - -
NCT00723801 Marfan Syndrome Phase 3 Completed - United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT01808196 Eosinophilic Esophagitis ... More >> Connective Tissue Disorders Less << Phase 2 Active, not recruiting August 2018 United States, Ohio ... More >> Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 Less <<
NCT00756938 Hypertension Phase 3 Completed - -
NCT00953680 Hypertension Phase 1 Completed - -
NCT00953680 - Completed - -
NCT01149486 - Completed - -
NCT01603940 Hypertension ... More >>Diabetes Mellitus Less << Phase 4 Completed - Brazil ... More >> Hospital Universitario Pedro Ernesto Rio de Janeiro, RJ, Brazil, 20551030 Less <<
NCT01390181 - Terminated(Due to low enrollme... More >>nt the decision was made to terminate study prior to final data collection for any individual.) Less << - -
NCT00756938 - Completed - -
NCT01603940 - Completed - -
NCT01051219 Nonalcoholic Steatohepatitis PHASE3 COMPLETED 2025-12-14 Plymouth Hospitals NHS Trust, ... More >>Plymouth, Devon, PL6 8DH, United Kingdom|Queen Elizabeth Hospital, Birmingham, B15 2TH, United Kingdom|Cambridge University NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom|Royal Derby Hospital, Derby, United Kingdom|Royal Liverpool & Broadgreen University Hospital, Liverpool, United Kingdom|Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom|Imperial College (St Mary's Site), London, SW7 2AZ, United Kingdom|St George's Hospital, London, United Kingdom|Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE7 7DN, United Kingdom|Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom Less <<
NCT01149486 Healthy Phase 1 Completed - United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less <<
NCT02958631 Hypertension Phase 4 Unknown April 2017 -
NCT00388388 Pre-hypertension ... More >> Pre-diabetes Less << Phase 2 Terminated(Few subjects recrui... More >>ted, sponsor withdrew support.) Less << - Canada, Quebec ... More >> Cardiovascular Prevention Centre, Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Less <<
NCT03763409 Memory Learni... More >>ng Less << Not Applicable Completed - United Kingdom ... More >> Department of Psychiatry, University of Oxford Oxford, United Kingdom, OX37JX Less <<
NCT02212769 Healthy Phase 1 Completed - Korea, Republic of ... More >> Chonbuk National University Hospital Jeonju, Jeollabukdo, Korea, Republic of, 561-712 Less <<
NCT01797926 Hypertension Phase 1 Completed - South Africa ... More >> GSK Investigational Site Bloemfontein,, South Africa, 9301 Less <<
NCT00879879 Precancerous Condition Not Applicable Completed - United States, Ohio ... More >> University of Cincinnati Cincinnati, Ohio, United States, 45267 Less <<
NCT01913470 NAFLD PHASE2 COMPLETED 2025-12-15 Emory University / Children's ... More >>Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less <<
NCT01324752 Drug Interaction Potentiation Phase 1 Completed - United States, California ... More >> ACRI- Phase 1 Anaheim, California, United States, 92801 Less <<
NCT02248961 Arterial Hypertension Phase 3 Completed - Russian Federation ... More >> Federal State Institution "Russian Cardiology Research and Production Complex" of the Ministry of Health and Social Development of the Russian Federation (FSI "Cardiology" Russian Healthcare Ministry) Moscow, Russian Federation Moscow Health Department "City Clinical Hospital № 81" Moscow, Russian Federation State Research Center for Preventive Medicine of Ministry of Health of the Russian gederation Moscow, Russian Federation St. Petersburg State health agency "City Hospital number 38 it. NA Semashko " Pushkin, Russian Federation St. Petersburg State healthcare Institution "City Hospital number 28" "Maximilianovskaya" St. Petersburg, Russian Federation, 190000 Clinical Hospital n. a. St. Luka St. Petersburg, Russian Federation Federal Almazov Medical Research Centre St. Petersburg, Russian Federation St. Petersburg State Healthcare Institution 'Diagnostic Centre #85' St. Petersburg, Russian Federation St. Petersburg State Institution of Health "City Hospital № 15" St. Petersburg, Russian Federation St. Petersburg State Institution of Healthcare "Pokrovskaya City Hospital" St. Petersburg, Russian Federation State Budget Education Institution of Higher Professional Education "North-Western State Medical University named after I.I. Mechnikov" on base St. Petersburg State Institution of Healthcare "Pokrovskaya City Hospital" St. Petersburg, Russian Federation State Budget Education Institution of Higher Professional Education "North-Western State Medical University named after I.I. Mechnikov", the department faculty and hospital care, court number 5 St. Petersburg, Russian Federation Troitsk City Hospital Troitsk, Russian Federation Less <<
NCT00880386 Dyspnea|Lung Cancer|Pulmonary ... More >>Complications|Radiation Fibrosis Less << WITHDRAWN 2025-04-10 -
NCT03626259 Hypertension Phase 4 Recruiting June 14, 2019 Mexico ... More >> Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara Recruiting Guadalajara, Jalisco, Mexico, 44340 Contact: Fernando Grover Paez, PhD    3310585200 ext 33642    fgroverp@hotmail.com Less <<
NCT00879879 - Completed - -
NCT03435939 Cystic Fibrosis EARLY_PHASE1 ACTIVE_NOT_RECRUITING 2025-04-30 University of Kansas Medical C... More >>enter, Kansas City, Kansas, 66160, United States Less <<
NCT01913470 NAFLD PHASE2 COMPLETED 2025-12-15 Emory University / Children's ... More >>Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less <<
NCT01124162 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Montreal, Quebec, Canada, H3X 2H9 Less <<
NCT01124175 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, G1V 2K8 Less <<
NCT01124175 - Completed - -
NCT03603938 Chronic Kidney Disease Patient... More >>s Less << Not Applicable Not yet recruiting December 30, 2023 China, Guangdong ... More >> The fifth affiliated hospital of Sun Yat-sen university Not yet recruiting Zhuhai, Guangdong, China, 519000 Contact: Shaoxuan Liu    0756-2528188    zdwygcp@126.com    Contact: Ye Ming    0756-2528188    zdwygcp@126.com    Principal Investigator: Cheng Wang, Doctor Less <<
NCT03206788 Cystic Fibrosis Phase 2 Recruiting August 10, 2020 United States, Alabama ... More >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: William Harris, MD    205-939-9583    tharris@peds.uab.edu    Principal Investigator: Willian Harris, MD          United States, Florida University of Miami, Miller School of Medicine Recruiting Miami, Florida, United States, 33136 Contact: Maria Tupayachi-Ortiz, MD    305-243-2568    mtupayachiortiz@med.miami.edu    Contact: Eliana Mendes    (305)243-2568    emendes@med.miami.edu    Principal Investigator: Maria Tupayachi-Ortiz, MD          United States, Kansas University of Kansas Not yet recruiting Kansas City, Kansas, United States, 66160 Contact: Carolina Aguiar    913-588-6067    caguiar@kumc.edu    Contact: Kimberly Lovell    (913)588-6067    klovell@kumc.edu    United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Elizabeth P Kramer, MD    513-636-6771    ekramer@cchmc.org    Principal Investigator: Elizabeth Kramer, MD Less <<
NCT03434054 Healthy Volunteers Not Applicable Completed - -
NCT03006952 Diabetic Nephropathies Phase 4 Completed - Iran, Islamic Republic of ... More >> Tehran University of Medical Sciences Tehran, Iran, Islamic Republic of Less <<
NCT02416102 COPD Chronic ... More >>Bronchitis Less << Not Applicable Recruiting May 2019 United States, Florida ... More >> Pulmonary Human Research Laboratory, University of Miami, Miller School of Medicine Recruiting Miami, Florida, United States, 33136 Contact: Eliana Mendes, MD    305-243-2568    emendes@med.miami.edu    Contact: Carolina Aguiar    (305) 243-5545    caguiar2@miami.edu    Principal Investigator: Matthias Salathe, MD Less <<
NCT03632213 Mucopolysaccharidosis IV A ... More >> Mucopolysaccharidosis VI Mucopolysaccharidoses MPS IV A MPS VI MPS - Mucopolysaccharidosis Morquio A Syndrome Morquio Syndrome A Morquio Syndrome Less << Phase 2 Not yet recruiting June 3, 2020 Brazil ... More >> Hospital de Clinicas de Porto Alegre Not yet recruiting Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903 Contact: Marina Zambrano, PhD    +55 51 33596340    marinazambrano@hotmail.com    Contact: Fabiano Poswar, MD    +55 51 33596340    fposwar@hcpa.edu.br    Principal Investigator: Roberto Giugliani, MD, PhD Less <<
NCT01124162 - Completed - -
NCT02232763 Proteinuria Phase 3 Completed - Korea, Republic of ... More >> Seoul National University Children's Hospital Seoul, Korea, Republic of Less <<
NCT02232776 Glomerulonephritis, IGA PHASE3 COMPLETED 2025-04-17 Seoul National University Chil... More >>dren's Hospital, Seoul, Korea, Republic of Less <<
NCT02769130 Pulmonary Vein Stenosis|Childr... More >>en Less << PHASE1|PHASE2 SUSPENDED 2025-05-21 Hospital for Sick Children, To... More >>ronto, Ontario, m5g 0a4, Canada Less <<
NCT03519893 Obesity, Morbid RECRUITING 2025-10-26 St. Olavs University Hospital,... More >> Trondheim, Norway Less <<
NCT02709018 Posttraumatic Stress Disorder Not Applicable Recruiting September 2019 United States, California ... More >> University of California, San Diego Recruiting La Jolla, California, United States, 92037 Contact: Farah D Shaikh, MD, Dr.PH    858-246-0623    fshaikh@ucsd.edu    Contact: Nuzhat A Beg, MD    858-534-7068    nbeg@ucsd.edu    Principal Investigator: Murray B Stein, MD, MPH          United States, District of Columbia George Washington University Recruiting Washington, District of Columbia, United States, 20037 Contact: Nicole Swanson    202-741-2437    loseptsd@gwu.edu    Principal Investigator: Suzan Song, MD, MPH, PhD          United States, Georgia Atlanta Veterans Affairs Medical Center Withdrawn Atlanta, Georgia, United States, 30033 United States, Maryland Walter Reed National Military Medical Center Recruiting Bethesda, Maryland, United States, 20889 Contact: Eva Asabre, MPH    301-295-2381       Contact: Mark Jimerson, BA    (301) 295-0868    eva.asabre.ctr@usuhs.edu    Principal Investigator: James West, MD          United States, Massachusetts McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: Emily Melen, BA    617-855-2511    EMELLEN@MCLEAN.HARVARD.EDU    Principal Investigator: Kerry Ressler, MD, PhD          Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Allyson Blackburn, BA    617-726-3508    ABlackburn1@mgh.harvard.edu    Principal Investigator: Eric Bui, MD, PhD          United States, New York New York University Langone Health Recruiting New York, New York, United States, 10016 Contact: Julia Spandorfer, BA    646-754-4895    Julia.Spandorfer@nyumc.org    Contact: Rebecca Lubin, AB    646-754-7035    Rebecca.Lubin@nyumc.org    Principal Investigator: Naomi Simon, MD, MSc Less <<
NCT03029091 Eosinophilic Esophagitis Phase 2 Recruiting August 2019 United States, California ... More >> University of California, San Diego Recruiting La Jolla, California, United States, 92093 Contact: Lea Jacinto    858-246-2144    ljacinto@ucsd.edu    Principal Investigator: Seema Aceves, M.D., PhD          United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60208 Contact: Angelika Zalewski    312-695-4054    angelika.zalewski@northwestern.edu    Principal Investigator: Ikuo Hirano, M.D.          United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Heather Foote    513-803-1155    Heather.Foote@cchmc.org    Principal Investigator: J. Pablo Abonia, MD Less <<
NCT01989078 Sickle Cell Disease EARLY_PHASE1 COMPLETED 2025-12-16 Grady Health Systems, Atlanta,... More >> Georgia, 30303, United States|Children's Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less <<
NCT03692013 Hypertension,Nephropathy PHASE4 UNKNOWN 2023-12-01 -
NCT03396523 Healthy Not Applicable Recruiting December 31, 2018 China, Sichuan ... More >> University of Electronic Science and Technology of China Recruiting Chengdu, Sichuan, China, 611731 Contact: Weihua Zhao, Master    611731    zarazhao.uestc@outlook.com Less <<
NCT02238457 Heart Failure Phase 4 Withdrawn(Difficulty recruitin... More >>g patients) Less << - -
NCT03467217 NAFLD - Nonalcoholic Fatty Liv... More >>er Disease Less << Phase 2 Recruiting August 30, 2019 United States, California ... More >> University of California, San Diego Recruiting San Diego, California, United States, 92103 Contact: Janis Durelle    619-543-5226    jdurelle@ucsd.edu    Principal Investigator: Jeffrey Schwimmer, MD          University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Camille Langlois    415-476-1756    Camille.Langlois@ucsf.edu    Principal Investigator: Philip Rosenthal, MD          United States, Georgia Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Miriam Vos, MD, MSPH    404-727-1463    Mvos@emory.edu    Contact: Rebecca Cleeton    (404) 727-5383    rcleeto@emory.edu    Principal Investigator: Miriam Vos, MD, PhD          United States, Illinois Northwestern Univ-Ann & Robert H. Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60611-2605 Contact: Joy Ito    312-227-4559    jito@luriechildrens.org    Contact: Mary Riordan    (312) 227.4558    mriordan@luriechildrens.org    Principal Investigator: Mark Fishbein, MD          United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202 Contact: Ann Klipsch    317-274-9605    aeye@iupui.edu    Contact: Laura Walker    (317) 944-4490    walkerlk@iu.edu    Principal Investigator: Jean Molleston, MD          United States, Missouri St. Louis University Recruiting Saint Louis, Missouri, United States, 63104 Contact: Theresa Cattoor, BSN,MA,CCRC    314-977-9335    theresa.cattoor@health.slu.edu    Principal Investigator: Ajay Jain, MD          United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Elena Reynoso    212-305-6274    er2564@columbia.edu    Principal Investigator: Joel Lavine, MD, PhD          United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229-3039 Contact: April Carr    513-803-7744    april.carr@cchmc.org    Contact: Kimberlee Bernstein, BS, CCRP    (513)636-4406    Kimberlee.bernstein@cchmc.org    Principal Investigator: Stavra Xanthakos, MD          United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Tamir Miloh, MD    832-822-3648    tamiloh@texaschildrens.org    Contact: Alicia Lawson    (832) 824-3848    alicia.lawson@bcm.edu    Principal Investigator: Tamir Miloh, MD          United States, Washington University of Washington Recruiting Seattle, Washington, United States, 98195 Contact: Melissa Young    206-987-1037    melissa.young@seattlechildrens.org    Sub-Investigator: Niviann Blondet, MD          Principal Investigator: Karen Murray, MD Less <<
NCT03459911 Healthy Phase 1 Completed - India ... More >> Clinical Unit, Reliance Life Sciences Pvt. Ltd. Mumbai, Maharashtra, India, 400 701 Less <<
NCT00813722 Blood Pressure Phase 4 Unknown June 2009 Brazil ... More >> Sao Paulo University Sao Paulo, Brazil, 05403-900 University of Sao Paulo Sao Paulo, Brazil, 05405-000 Less <<
NCT00381134 Diabetes Kidn... More >>ey Disease Hypertension Less << Phase 2 Completed - United States, Texas ... More >> The University of Texas Southwestern Medical Center Dallas, Texas, United States, 75230 Less <<
NCT03461003 Pediatric Hypertension Phase 4 Recruiting January 2020 United States, Texas ... More >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS    713-500-5670    joyce.p.samuel@uth.tmc.edu Less <<
NCT01443039 Obesity Phase 1 Completed - France ... More >> Unit of internal medicine A, Lariboisière Hospital Paris, France, 75010 Less <<
NCT03147092 Hypertension ... More >>Blood Pressure Less << Early Phase 1 Not yet recruiting June 30, 2021 -
NCT00889447 - Completed - United States, Maryland ... More >> Johns Hopkins Asthma and Allergy Center Baltimore, Maryland, United States, 21224 Less <<
NCT02232880 Hypertension Phase 2 Terminated(failure to recruit) - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-6602 Less <<
NCT00480805 Type 2 Diabetes Mellitus ... More >> Hypertension Less << Phase 3 Completed - -
NCT01086722 Morbid Obesity ... More >> Overweight Less << Phase 1 Phase 2 Completed - Spain ... More >> Hospital del Mar Barcelona, Spain, 08003 IMIM-Hospital del Mar Barcelona, Spain, 08003 Less <<
NCT03563287 Obesity, Morbid ... More >> Bariatric Surgery Candidate Less << Not Applicable Completed - Finland ... More >> University of Eastern Finland Kuopio, Finland Less <<
NCT01774656 Heart Failure NYHA Class III ... More >> Heart Failure NYHA Class IV Less << Phase 4 Recruiting December 2017 United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Terry Blanton, BSN, RN       mtblan02@louisville.edu    Principal Investigator: Emma Birks, MD, PhD          United States, Nebraska University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Stacy Flickbohm, RN    402-559-5127    stacy.fickbohm@unmc.edu    Contact: Natalie Kamtz    402-559-3293    natalie.kamtz@unmc.edu    Principal Investigator: Brian D Lowes, MD, PhD          United States, New York Montefiore Medical Center Recruiting New York, New York, United States, 10467 Contact: Auris Brown       aubrowne@montefiore.org    Contact: Johanna Oviedo    718-920-8780    joviedo@montefiore.org    Principal Investigator: Snehal Patel, MD          United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Barb Gus, RN BSN CCRC    216-445-6552    GUSB@ccf.org    Principal Investigator: Maria Mountis, D.O.          United States, Pennsylvania University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Judith Marble       Judith.Marble@uphs.upenn.edu    Principal Investigator: J E Rame, MD          United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Ashley Elmer       ashley.elmer@hsc.utah.edu    Principal Investigator: Craig Selzman, MD Less <<
NCT00555217 Kidney Disease ... More >> Nephropathy Type 2 Diabetes Less << Phase 3 Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << - -
NCT03354143 Hypertension Phase 2 Recruiting October 31, 2022 United States, Texas ... More >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Principal Investigator: Rong Zhang, Ph.D.          Principal Investigator: Wanpen Vongpatanasin, MD Less <<
NCT02246257 Rheumatoid Arthritis ... More >> Cardiovascular Diseases Less << Not Applicable Recruiting September 2020 Denmark ... More >> Department of Rheumathology, Frederiksberg and Bispebjerg univeristy Hospital Recruiting Frederiksberg, Region Of Copenhagen, Denmark, 2000 Contact: Annemarie Lyng Svesson, MD, PhD    004528555126    lyng.annemarie@gmail.com    Contact: Torkell J Ellingsen, MD, PhD, Professor    004565413523    torkell.ellingsen@rsyd.dk Less <<
NCT00378443 Glomerulonephritis, IGA Not Applicable Unknown - -
NCT00922311 IgA Nephropathy Phase 4 Completed - China ... More >> Department of Medicine, The University of Hong Kong Hong Kong, China Queen Mary Hospital Hong Kong, China Less <<
NCT02232880 - Terminated(failure to recruit) - -
NCT03109288 Multiple Sclerosis Phase 1 Phase 2 Recruiting June 1, 2030 United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-411-1222 ext TTY8664111010    prpl@cc.nih.gov Less <<
NCT00446862 - Completed - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294-0006 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Illinois Feinberg School of Medicine, Northwestern University Chicago, Illinois, United States, 60614 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Slovenia General Hospital Slovenj Gradec Ljubljana, Gradec, Slovenia, 1 Less <<
NCT00555217 - Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << - -
NCT02387554 Hypertension(HTN) Phase 1 Completed - Korea, Republic of ... More >> Seoul National University Bundang Hospital Bundang, Gyeonggi, Korea, Republic of Less <<
NCT02056743 Healthy Phase 1 Completed - Korea, Republic of ... More >> Clinical Trial Center of Chonbuk National University Hospital Jeonju, Jeollabuk-do, Korea, Republic of Less <<
NCT01368185 - Completed - -
NCT00530595 Cardiovascular Disease Not Applicable Completed - -
NCT02387554 - Completed - -
NCT01368185 - Completed - -
NCT00907374 - Completed - -
NCT00907374 Microalbuminuria Not Applicable Completed - United States, California ... More >> Charles Drew University Los Angeles, California, United States, 90059 Less <<
NCT02620306 Chronic Kidney Disease Phase 3 Recruiting December 2020 Korea, Republic of ... More >> Severance hospital Recruiting Seoul, Korea, Republic of Contact: Sungha Park    02-2228-8455    shpark0530@yuhs.ac Less <<
NCT00814255 - Completed - -
NCT02900729 Hypertension Phase 3 Unknown February 2018 China, Hunan ... More >> The Third Xiangya Hospital of Central South University Not yet recruiting Changsha, Hunan, China Contact: Zhihui Zhang, Dr.       zhangzhihui0869@126.com    Contact: Xiaoyan Wang, Dr.          China, Shanghai Zhongshan Hospital affiliated to Fu Dan University Not yet recruiting Shanghai, Shanghai, China, 200032 Contact: Junbo Ge, Dr.       ge.junbo@zs-hospital.sh.cn    Contact: Li Shen, Dr.       shen.li@zs-hospital.sh.cn    Changhai Hospital affiliated to Second Military Medical University Not yet recruiting Shanghai, Shanghai, China Contact: Xianxian Zhao, Dr.       13601713431@163.com    Contact: Zhifu Guo, Dr.          Putuo Hospital affiliated to Shanghai Traditional Chinese Medicine University Not yet recruiting Shanghai, Shanghai, China Contact: Zongjun Liu, Dr.       lzj72@126.com    Contact: Jia Shi, Dr.          Shanghai Chest Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Weiyi Fang, Dr.       fwychest@163.com    Contact: Shaofeng Guan, Dr.       gsf@qq.com    Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Changqian Wang, Dr.       wcqian@hotmail.com    Contact: Zhaofang Yin, Dr.       13072103901@163.com    Shanghai Sixth People's Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Jingbo Li, Dr.       jbli@medmail.com.cn    Contact: Yesheng Pan, Dr.       panyesheng@163.com    Tongji Hospital affiliated to Tongji University Not yet recruiting Shanghai, Shanghai, China Contact: Xuebo Liu, Dr.       lxb70@hotmail.com    Contact: Yang Liu, Dr.       961165@sina.com    Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine Chongming Branch Not yet recruiting Shanghai, Shanghai, China Contact: Yingmin Lu, Dr.       lymkk@sohu.com    Contact: Shuxin Hou, Dr.       1461396934@qq.com    China, Zhejiang Sir Run Run Shaw Hospital affiliated to Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China Contact: Guosheng Fu, Dr.       fugs@medmail.com.cn    Contact: Chenyang Jiang, Dr.          The Second Hospital affiliated to Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China Contact: Jianan Wang, Dr.       wang_jian_an@tom.com    Contact: Jun Jiang, Dr.       drjayj@Hotmail.com    Taizhou Hospital Not yet recruiting Taizhou, Zhejiang, China Contact: Jianjun Jiang, Dr.       taizhoujiangjj@163.com    Contact: Yafei Mi, Dr.          The First Hospital affiliated to Wenzhou Medical College Not yet recruiting Wenzhou, Zhejiang, China Contact: Weijian Huang, Dr.       weijianhuang69@yahoo.com.cn    Contact: Zhouqing Huang, Dr.       susiehzq@126.com Less <<
NCT02166398 Healthy Phase 1 Completed - Korea, Republic of ... More >> Seoul National University Hospital Seoul, Jongno-gu, Korea, Republic of, 110-744 Less <<
NCT02521233 Essential Arterial Hypertensio... More >>n Less << Phase 3 Withdrawn(Sponsor decision) August 2017 -
NCT00502242 Kidney Transplant Phase 4 Completed - -
NCT00502242 - Completed - -
NCT03082014 Cerebral Small Vessel Diseases Phase 3 Recruiting September 30, 2020 Germany ... More >> Insitute for Stroke and Dementia Research Not yet recruiting Munich, Germany, 81377 Contact: Martin Dichgans, Prof.    +49 89 4400 ext 46019       Contact: Anna Kopczak, MD    +49 89 4400 ext 46125       Netherlands Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands, 6202 AZ Contact: Robert van Oostenbrugge, Prof.          Contact: Julie Staals, MD, PhD          Sub-Investigator: Danielle Kerkhofs          University Medical Center Utrecht Not yet recruiting Utrecht, Netherlands, 3584 CX Contact: Geert Jan Biessels, Prof.          Contact: Hilde van den Brink, MD          United Kingdom Nuffield Department of Clinical Neurosciences Recruiting Oxford, England, United Kingdom, OX1 2JD Contact: Peter Rothwell, Prof.          Contact: Alastair Webb, MD, PhD          Centre for Clinical Brain Sciences Not yet recruiting Edinburgh, Scotland, United Kingdom, EH16 4SB Contact: Joanna Wardlaw, Prof.          Contact: Fergus Doubal, MD, PhD Less <<
NCT00814255 Focal Segmental Glomeruloscler... More >>osis Less << Phase 2 Completed - United States, Florida ... More >> University of Miami Miami, Florida, United States, 33136 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104 United States, New York Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 NYU Langone Medical Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Ohio State University Columbus, Ohio, United States, 43205 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97239 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Texas Tech University El Paso, Texas, United States, 79905 Canada, Alberta University of Alberta Edmonton, Alberta, Canada, T6G 2R7 Less <<
NCT01299376 Hypertension Phase 3 Completed - -
NCT03666351 Aortic Stenosis ... More >> Aortic Regurgitation Hypertension LVM Left Ventricular Hypertrophy Less << Phase 4 Recruiting January 31, 2022 Korea, Republic of ... More >> 10 Institutions Including Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: kang Less <<
NCT01299376 - Completed - -
NCT01361087 Marfan Syndrome Phase 3 Withdrawn(No outside recruitme... More >>nt of subjects from Main Atenolol VS Losartan NIH study) Less << - United States, Illinois ... More >> Children's Memorial Hospital Chicago Chicago, Illinois, United States, 60614 Less <<
NCT01570569 Healthy Phase 1 Completed - -
NCT02760615 Colitis, Ulcerative ... More >> Crohn Disease Less << Phase 4 Recruiting July 29, 2019 United States, California ... More >> WCCT Recruiting Cypress, California, United States, 90630 United States, Florida QPS MRA Recruiting Miami, Florida, United States, 33143 Less <<
NCT01233635 Atrial Fibrillation Phase 4 Terminated(inadequate enrollme... More >>nt rate) Less << - United States, Pennsylvania ... More >> UPMC CVI Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00275639 Liver Transplant Recipients Phase 4 Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT02278471 Hypertension ... More >>Hyperlipidemia Less << Phase 2 Completed - United States, Alabama ... More >> Franklin Primary Health Center Mobile, Alabama, United States, 36603 Less <<
NCT03295734 Hypertension ... More >>Aging Sedentary Lifestyle Less << Phase 2 Recruiting September 2022 United States, Alabama ... More >> UAB Center for Exercise Medicine Recruiting Birmingham, Alabama, United States, 35205 Contact: Sara Harper, PhD    205-996-3005    saharper@uabmc.edu Less <<
NCT02188121 Serious Mental Illness ... More >> Schizophrenia Schizoaffective Disorder Bipolar Disorder Cardiovascular Disease Major Depressive Disorder Psychosis NOS Less << Phase 4 Recruiting December 2020 United States, Massachusetts ... More >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Principal Investigator: Dost Ongur, MD PhD Less <<
NCT01011062 Insulin Resistance ... More >> Type 2 Diabetes Less << Not Applicable Completed - Czech Republic ... More >> Diabetes Center, Institute of Clinical and Experimental Medicine Prague, Czech Republic, 14021 Less <<
NCT01198496 Hypertension ... More >>Stroke Blood Pressure Less << Phase 4 Recruiting December 2019 Japan ... More >> Jichi Medical Univercity Recruiting Shimotsuke, Tochigi, Japan, 329-0498 Contact: Kazuyuki Shimada, MD       kazuyuki@jichi.ac.jp    Principal Investigator: Kazuomi Kario, MD Less <<
NCT00001741 Cardiovascular Disease PHASE1 COMPLETED 2025-04-03 National Heart, Lung and Blood... More >> Institute (NHLBI), Bethesda, Maryland, 20892, United States Less <<
NCT00234858 Hypertension ... More >>Metabolic Syndrome Less << Phase 4 Completed - -
NCT00541684 Hypertension Phase 3 Completed - -
NCT00159692 Hypertension Phase 4 Completed - -
NCT02560805 Stress Disorders, Post-Traumat... More >>ic Less << Phase 2 Recruiting August 2020 United States, Georgia ... More >> Atlanta VA Medical Center Recruiting Decatur, Georgia, United States, 30033 Contact: Melanie Kankam, MS    404-321-6111 ext 7040    melanie.l.jefferson@emory.edu    Principal Investigator: Jeanie Park, MD Less <<
NCT00280215 Hyperoxaluria Phase 3 Withdrawn(Inadequate number of... More >> patients, lack of funding) Less << - -
NCT00155064 Hyperaldosteronism Phase 4 Completed - Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan Less <<
NCT00143949 Type 1 Diabetes Phase 2 Completed - Canada, Ontario ... More >> Mt Sinai Hospital, University of Toronto (Clinical Ctr) Toronto, Ontario, Canada, M5G 1X5 Canada, Quebec Royal Victoria Hospital, McGill University (Data Center) Montreal, Quebec, Canada, H3A 1A1 Montreal Childrens Hospital, McGill University (Clinical Ctr) Montreal, Quebec, Canada, H3H 1P3 Less <<
NCT00467831 Hermansky-Pudlak Syndrome (HPS... More >>) Pulmonary Fibrosis Oculocutaneous Albinism Platelet Storage Pool Deficiency Metabolic Disease Less << Phase 1 Phase 2 Terminated(insufficient enroll... More >>ment) Less << - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00467831 - Terminated(insufficient enroll... More >>ment) Less << - -
NCT01115426 IGA Glomerulonephritis Phase 4 Completed - Italy ... More >> "Mater Domini" Hospital Catanzaro, Calabria, Italy, 88100 Less <<
NCT02916602 Hypertension Phase 3 Completed - Korea, Republic of ... More >> Seoul National University Bundang Hospital Seongnam, Gyeonggi-Do, Korea, Republic of, 463-707 Less <<
NCT02704494 Diabetic Nephropathy Early Phase 1 Completed - Iran, Islamic Republic of ... More >> Shahid Motahhari Clinic, Shiraz University of Medical Sciences Shiraz, Fars, Iran, Islamic Republic of Less <<
NCT02676466 Inflammation Phase 2 Completed - United States, Florida ... More >> University of Florida Gainesville, Florida, United States, 32611 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts Tufts University Boston, Massachusetts, United States, 02111 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27157 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT02121041 Hypertension Not Applicable Completed - United States, North Carolina ... More >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Less <<
NCT00805311 Carotid Artery Stenosis ... More >> Atherosclerosis Stroke Less << Phase 4 Terminated(Due to the clear ad... More >>vantage of carotid endarterectomy) Less << - Russian Federation ... More >> Russian Cardiology Research and Production Center Moscow, Russian Federation, 121552 Russian Cardiology Research and Production Center Moscow, Russian Federation Less <<
NCT01187862 Cytochrome Ph... More >>armacokinetics Less << Phase 1 Completed - Switzerland ... More >> University Hospital Basel, Switzerland, 4031 Less <<
NCT01891513 - Completed - United States, Florida ... More >> UF Institute on Aging Clinical and Translational Research Building Gainesville, Florida, United States, 32611 Less <<
NCT00456963 Diabetes Mellitus ... More >> Hypertension Less << Phase 4 Terminated(Because of delay in... More >> approval of the protocol by a number of Ethics Commitees the trial was terminated on March 4, 2010. No patient had received any study drug.) Less << - Italy ... More >> Istituto Auxologico Italiano. Milan, Italy, 20145 Less <<
NCT00402194 Obesity|Insulin Resistance|Imp... More >>aired Glucose Tolerance|Pre-diabetes Less << COMPLETED 2025-03-12 Indiana University Hospital GC... More >>RC, Indianapolis, Indiana, 46202, United States Less <<
NCT03505853 Acute Intermittent Porphyria (... More >>AIP) Acute Hepatic Porphyria (AHP) Porphyria, Acute Intermittent Acute Porphyria Less << Phase 1 Active, not recruiting January 2019 Sweden ... More >> Clinical Trial Site Stockholm, Sweden Less <<
NCT02744456 Hypertension ... More >>High Blood Pressure Less << Phase 2 Completed - United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Less <<
NCT00402194 Obesity|Insulin Resistance|Imp... More >>aired Glucose Tolerance|Pre-diabetes Less << COMPLETED 2025-03-12 Indiana University Hospital GC... More >>RC, Indianapolis, Indiana, 46202, United States Less <<
NCT02063100 Glomerulonephritis ... More >> Proteinuria Less << Phase 4 Unknown - -
NCT02121041 - Completed - -
NCT02235909 Hypertension Phase 3 Recruiting August 2020 -
NCT01934569 Healthy Phase 1 Completed - Belgium ... More >> Pfizer Investigational Site Brussels, Belgium, B-1070 Less <<
NCT00092209 Hypertension Phase 3 Completed - -
NCT03335904 Sleep Disordered Breathing ... More >> Hypoxia Respiration; Sleep Disorder Chemoreceptor Apnea Less << Phase 4 Recruiting January 2020 Canada, British Columbia ... More >> University of British Columbia Recruiting Kelowna, British Columbia, Canada, V1V 1V7 Contact: Glen Foster, PhD    12508078224    glen.foster@ubc.ca Less <<
NCT00886600 - Completed - -
NCT01210430 Postural Tachycardia Syndrome Early Phase 1 Completed - United States, New York ... More >> New York Medical College/Bradhurst building Hawthorne, New York, United States, 10532 Less <<
NCT00981747 Idiopathic Pulmonary Fibrosis ... More >> Pulmonary Fibrosis Less << Phase 2 Phase 3 Terminated(Funding was withdra... More >>wn.) Less << - United States, Iowa ... More >> University of Iowa Hospitals and Clinics Iowa City, Iowa, United States, 52246 Less <<
NCT02504606 Hypertension Phase 1 Completed - -
NCT00981747 - Terminated(Funding was withdra... More >>wn.) Less << - -
NCT00981929 Cytochrome P450 Phenotype and ... More >>Genotype Metrics Less << Not Applicable Terminated(Unexpected non-seri... More >>ous adverse events) Less << January 2011 Denmark ... More >> University of Southern Denmark, Clinical Pharmacology Odense, Fyn, Denmark, D-5000 Less <<
NCT00398541 Hypertension Phase 3 Completed - -
NCT00886600 Hypertension Phase 3 Completed - -
NCT00994617 Hypertension, Resistant to Con... More >>ventional Therapy Essential Hypertension Less << Phase 4 Unknown December 2014 United Kingdom ... More >> Professor Morris Brown Recruiting Cambridge, Cambridgeshire, United Kingdom, CB22QQ Contact: Jackie Salsbury, Nursing    01223 586878    js811@medschl.cam.ac.uk    NHS Ayrshire Recruiting Ayrshire, United Kingdom Principal Investigator: Dr E Spalding          University Hospitals Birmingham NHS Foundation Trust Recruiting Birmingham, United Kingdom Principal Investigator: Dr U Martin          NHS Tayside/University of Dundee Recruiting Dundee, United Kingdom Principal Investigator: Prof T MacDonald          NHS Lothian/University of Edinburgh Recruiting Edinburgh, United Kingdom Principal Investigator: Prof D Webb          NHS Greater Glasgow and Clyde/University of Glasgow Recruiting Glasgow, United Kingdom Principal Investigator: Dr S Padmanabhan          Ixworth GP Practice Recruiting Ixworth, United Kingdom Principal Investigator: Dr J Cannon          University Hospitals of Leicester NHS Trust Recruiting Leicester, United Kingdom Principal Investigator: Dr A Stanley          Barts and the London School of Medicine and Dentistry Recruiting London, United Kingdom Contact: Prof M Caulfield          Principal Investigator: Prof M Caulfield          Guys and St Thomas' NHS Foundation Trust Recruiting London, United Kingdom Principal Investigator: Prof K Cruickshank          Imperial College Healthcare NHS Trust Recruiting London, United Kingdom Principal Investigator: Prof P Sever          Central Manchester University Hospitals NHS Foundation Trust Recruiting Manchester, United Kingdom Principal Investigator: Dr H Soran          Norfolk and Norwich University Hospital NHS Trust Recruiting Norwich, United Kingdom Principal Investigator: Dr S Myint-Khin Less <<
NCT01806324 Hypertension ... More >>Hyperlipidemia Less << Phase 1 Completed - United States, Maryland ... More >> Baltimore, Maryland, United States, 21201 Less <<
NCT00284128 Hypertension Phase 2 Phase 3 Completed - -
NCT02521246 Essential Arterial Hypertensio... More >>n Less << Phase 3 Withdrawn(Sponsor decision) August 2017 -
NCT00774904 Diabetic Nephropathy COMPLETED 2025-11-07 Shanghai No.3 people's hospita... More >>l, Shanghai, 201900, China Less <<
NCT01281787 Lung Cancer A... More >>trial Fibrillation Less << Phase 3 Completed - Italy ... More >> European Institute of Oncology Milan, Italy, 20141 Less <<
NCT01675362 Kidney Calculi Phase 4 Completed - Egypt ... More >> Urology and Nephrology Center Mansoura, Egypt, 35516 Less <<
NCT01845688 Idiopathic Membranous Nephropa... More >>thy Less << Not Applicable Unknown September 2016 China, Shanghai ... More >> Shanghai University of Traditional Chinese Medicine Shanghai, Shanghai, China, 200032 Less <<
NCT01271374 Hypertension Phase 4 Unknown December 2011 United States, Georgia ... More >> Atlanta Clinical Research Center Tucker, Georgia, United States, 30084 Less <<
NCT01637623 Severe Obstructive Sleep Apnea... More >> (Apnea Hypopnea Index > 30 Events/Hour) Hypertension Less << Phase 2 Completed - United States, Wisconsin ... More >> Aurora Bay Care Green Bay, Wisconsin, United States, 54308 Gundersen Lutheran La Crosse, Wisconsin, United States, 54601 University of Wisconsin Madison Madison, Wisconsin, United States, 53705 Marshfield Clinic Marshfield, Wisconsin, United States, 54449 Less <<
NCT00198562 Hypertension Phase 4 Unknown March 2012 Japan ... More >> National Cardiovascular Center Suita, Osaka, Japan, 565-8565 Less <<
NCT00561704 Obese Type 2 ... More >>Diabetes Diabetic Nephropathy Glucose Metabolism Angiotensin II Type 1 Receptor Blockers Less << Not Applicable Completed - -
NCT01692717 Healthy Subjects Phase 1 Unknown May 2013 Brazil ... More >> LAL Clínica Pesquisa e Desenvolvimento Ltda Not yet recruiting Valinhos, São Paulo, Brazil Contact: Alexandre Frederico, physician    55 19 38716399    alexandre@lalclinica.com.br Less <<
NCT00971165 Hypertension ... More >>Cardiovascular Disease Less << Phase 3 Completed - Brazil ... More >> Hospital de Clínicas de Porto Alegre, UFRGS Porto Alegre, RS, Brazil, 90035 903 Hospital de Clínicas de Porto Alegre Porto Alegre, RS, Brazil, 90035-903 Less <<
NCT03604003 Chronic Kidney Disease Not Applicable Not yet recruiting December 30, 2023 -
NCT02294539 Hypertension Phase 4 Completed - Korea, Republic of ... More >> Kyung Hee University Hospital at Gangdong Seoul, Korea, Republic of Less <<
NCT00400218 Hypertension Phase 3 Completed - -
NCT02190318 Chronic Renal Disease Not Applicable Unknown December 2015 China, Hunan ... More >> Recruiting Changsha, Hunan, China, 410000 Contact: Hong Liu, MD,phD    86-0731-85292057    liuh0618@163.com    Principal Investigator: Hong Liu, MD,phD Less <<
NCT01292694 Hypertension ... More >>Pure Autonomic Failure Multiple System Atrophy Less << Phase 1 Terminated(Could not enroll en... More >>ough participants, and lost funding.) Less << - United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37232 Less <<
NCT03371823 Cardiovascular Diseases ... More >> Hypertension Less << Phase 4 Recruiting December 31, 2019 United States, Delaware ... More >> University of Delaware Recruiting Newark, Delaware, United States, 19716 Contact: Megan Wenner, PhD    302-831-7343    mwenner@udel.edu    Contact: Joshua C Hobson, MS    302-831-8137    jhobson@udel.edu Less <<
NCT01302691 Hypertension Phase 3 Completed - -
NCT01234922 Hypertension ... More >>Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 2 Terminated(slow accrual) - United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less <<
NCT01302691 - Completed - -
NCT01234922 - Terminated(slow accrual) - -
NCT01276613 Pancreatic Cancer Early Phase 1 Active, not recruiting January 2019 United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT02768948 Diabetic Nephropathy Not Applicable Recruiting July 2019 France ... More >> CHU de Nice Recruiting Nice, France, 06000 Contact: Guillaume FAVRE, PH       favre.g@chu-nice.fr Less <<
NCT00369538 Proteinuria H... More >>ypertension End Stage Renal Disease Less << Phase 4 Suspended(principle investigat... More >>or moved, new investigators will join, insurance expired - project needs to be re-examined by an ethic committee) Less << - France ... More >> Service de Néphrologie, Hôpital Civil, Hôpitaux Universitaires Strasbourg, France, 67091 Less <<
NCT03578042 Hypertension Phase 4 Recruiting December 30, 2019 Lebanon ... More >> Hotel Dieu de France Hospital Recruiting Beirut, Lebanon, Beirut Contact: Rabih R Azar, MD, MPH    +9611615300 ext 9408    razar@usj.edu.lb Less <<
NCT02795910 Diabetes Mellitus ... More >> Hypertension Heart Failure Ischemic Heart Disease Cerebrovascular Disease Less << Not Applicable Active, not recruiting March 31, 2019 Brazil ... More >> Florianopolis City Health Department Florianopolis, Santa Catarina, Brazil, 88.040-400 Less <<
NCT03610217 Scleroderma, Systemic ... More >> Sclerosis, Systemic Less << Not Applicable Not yet recruiting October 2021 Canada, Ontario ... More >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC    15196466332    Janet.Pope@sjhc.london.on.ca    Contact: Andreu Fernandez-Codina    151964661023    doccodina@gmail.com Less <<
NCT01405794 Healthy Phase 1 Phase 2 Completed - United States, Utah ... More >> University of Utah Salt Lake City, Utah, United States, 84112-5820 Less <<
NCT02817360 Heart Diseases ... More >> Diabetes Mellitus, Type 2 Less << Phase 4 Recruiting February 2021 Austria ... More >> Internistische Ordination Recruiting Mödling, Niederösterreich, Austria, 2340 Contact: Christian Feinböck, MD    +43 2236 869 142    office@dr-feinboeck.at    Contact: Christiane Feinböck    +43 2236 869 142    office@dr-feinboeck.at    Sub-Investigator: Egbert Seyfried, MD          Principal Investigator: Christian Feinböck, MD          Klinischen Abteilung für Endokrinologie und Diabetologie MU Graz Recruiting Graz, Steiermark, Austria, 8036 Contact: Harald Sourij    +43-316-385-80363    ha.sourij@medunigraz.at    Contact: Michael Zink    +43-680-128-5120    m.zink@medunigraz.at    Sub-Investigator: Julia Mader, MD Prof          Sub-Investigator: Eva Novak, MD          Sub-Investigator: Caren Sourij, MD          Konventhospital der Barmherzigen Brüder Abteilung für Innere Medizin Recruiting Linz, Upper Austria, Austria, 4021 Contact: Martin Clodi, Prof.Dr.       martin.clodi@bblinz.at    Principal Investigator: Martin Clodi, Prof.Dr.          Sub-Investigator: Michael Resl, Dr.          Krankenanstalt Rudolfstiftung, 1. Medizinische Abteilung Recruiting Vienna, Austria, 1030 Contact: Bernhard Ludvik, Prof.Dr.    +43 1 711 65 ext 2107    bernhard.ludvik@wienkav.at    Principal Investigator: Bernhard Ludvik, Prof.Dr.          Sub-Investigator: Eva-Christina Krzizek, Dr.          Sub-Investigator: Johanna Brix, Dr.          Sub-Investigator: Astrid Feder, Dr.          Sub-Investigator: Florian Hoellerl, Dr.          Medical University of Vienna Univ.Clinic for Internal Medicine II Department of Cardiology Recruiting Vienna, Austria, 1090 Contact: Martin Huelsmann, Doz.Dr.    +43 1 40400 ext 46140    martin.huelsmann@meduniwien.ac.at    Principal Investigator: Martin Huelsmann, Doz.Dr.          Sub-Investigator: Raphael Wurm, Dr.          Univ. Klinik für Innere Medizin III Med. Uni Wien Recruiting Vienna, Austria, 1090 Contact: Anton Luger, Prof.Dr.    00 43 1 40400 ext 43100    anton.luger@meduniwien.ac.at    Principal Investigator: Anton Luger, Prof.Dr.          Sub-Investigator: Michael Krebs, Prof.Dr.          Universitätsklinik für Augenheilkunde und Optometrie Medizinische Universität Wien Recruiting Vienna, Austria, 1090 Contact: Sonja Prager, Dr.    +43 1 40400 ext 79470    sonja.prager@meduniwien.ac.at    Principal Investigator: Sonja Prager, Dr.          Sub-Investigator: Julia Hafner, Dr.          Diabetes & Stoffwechselambulanz Gesundheitszentrum Wien Süd Recruiting Vienna, Austria, 1100 Contact: Helmut Brath, OA Dr.    +43 1 60122 ext 4264    helmut.brath@wgkk.at    Principal Investigator: Helmut Brath, OA Dr.          3. Med. Abtlg., KH Hietzing mit Neurologischem Zentrum Rosenhügel Recruiting Vienna, Austria, 1130 Contact: Rudolf Prager, Prof.Dr.    +43 1 80110 ext 2351    rudolf.prager@wienkav.at    Principal Investigator: Rudolf Prager, Prof.Dr.          Sub-Investigator: Slobodan Peric, Dr.          Zentrum für Klinische Studien Recruiting Wien, Austria, 1060 Contact: Ursula Hanusch, MD    +43 1 266 21 91    dr.hanusch@dieinternistin.com    Contact: Michaela Mauritz    +43 1 266 21 91    office@dieinternistin.com    Sub-Investigator: Marita Spak, MD          Netherlands Maastricht University Medical Center; Dep. Cardiology Recruiting Maastricht, Netherlands, 6202 Contact: Hans-Peter Brunner-La Rocca, MD Prof    +31 43-3877097    hp.brunnerlarocca@mumc.nl    Contact: Mireille Spanjers    +31 43-3877099    m.spanjers@mumc.nl    Sub-Investigator: Nick Marks, MD          Sub-Investigator: Wouter Robaeys, MD          New Zealand Christchurch Heart Institute Recruiting Christchurch, New Zealand, 8140 Contact: Richard Troughton, MD Prof    +64 3 364 1063    Richard.Troughton@cdhb.health.nz    Contact: Lorraine Skelton    +64 3 364 1063    lorraine.skelton@cdhb@health.nz    Principal Investigator: Richard Troughton, MD Prof Less <<
NCT00673790 Hypertension Phase 4 Completed - -
NCT01715584 Hypertension Phase 4 Recruiting December 31, 2019 Canada, Ontario ... More >> London Health Sciences Centre - Victoria Campus Recruiting London, Ontario, Canada, N6A 5W9 Contact: Craig J Railton, MD, PhD    519 685 8500 ext 58525    Craig.Railton@lhsc.on.ca    Principal Investigator: Craig J Railton, MD, PhD          Sub-Investigator: Jonathan Fairbairn, BSc          Sub-Investigator: George Nicoloau, MD          Sub-Investigator: Robert Gros, PhD          Sub-Investigator: Jason Franklin, MD          Sub-Investigator: John Yoo, MD          Sub-Investigator: Kevin Fung, MD          Sub-Investigator: Anthony Nichols, MD          Sub-Investigator: Danielle McNeil, MD Less <<
NCT03502031 Renal Insufficiency, Chronic ... More >> Diabetic Nephropathy Type 2 Less << Phase 4 Recruiting December 2020 United States, Georgia ... More >> NephroNet Recruiting Buford, Georgia, United States, 30518 Contact: James A Tumlin, MD    770-490-9203    jamestumlinmdnephronet@gmail.com    Contact: Julie Moss    404-790-0267    jmoss@nephronet.com Less <<
NCT00684489 Hypertension Not Applicable Completed - -
NCT01405794 - Completed - -
NCT01377285 Chronic Renal Failure Phase 4 Unknown December 2018 Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Tun-Jun Tsai, M.D.; PhD    00886-2-23123456 ext 63953    tjtsai@ntuh.gov.tw    Contact: Yung-Ming Chen, M.D.    00886-2-23123456 ext 65993    chenym@ntuh.gov.tw    Principal Investigator: Tun-Jun Tsai, M.D.; PhD Less <<
NCT02386917 Obesity Not Applicable Active, not recruiting December 2019 Norway ... More >> HVestfold Tønsberg, Vestfold, Norway, 3103 Less <<
NCT01371747 Chronic Kidney Disease ... More >> Hypertension Hyperkalemia Less << Phase 2 Completed - -
NCT00721877 Healthy, no Evidence of Diseas... More >>e Less << Phase 1 Completed - United States, Arizona ... More >> Arizona Cancer Center - Tucson Tucson, Arizona, United States, 85724-5024 Less <<
NCT02355821 Osteopenia Ar... More >>terial Hypertension Less << Not Applicable Completed - Russian Federation ... More >> National Research Center for Preventive Medicine Moscow, Russian Federation, 101000 Less <<
NCT02832973 Hypertension Resistant to Conv... More >>entional Therapy Less << Phase 4 Recruiting March 2018 Brazil ... More >> Juan Carlos Yugar-Toledo Recruiting São José do Rio Preto, São Paulo, Brazil, 15090000 Contact: Juan C Yugar-Toledo, MD, PhD    +55-17-32271899    yugarjuan@uol.com.br    Contact: Elizabeth DE Cestario, MD    +55-17-997186562    cesatrio@cardiol.br Less <<
NCT01805362 Chronic Kidney Disease Not Applicable Unknown February 2017 France ... More >> Department of Nephrology, Nice University Hospital Recruiting Nice, France, 06000 Contact: vincent Esnault, MD       esnault.v@chu-nice.fr    Principal Investigator: Vincent Esnault, MD Less <<
NCT02913664 Cognitively Normal Older Adult... More >>s Hypertension Subjective Cognitive Decline Family History of Alzheimer's Disease Less << Phase 2 Phase 3 Recruiting September 2022 United States, Kansas ... More >> University of Kansas Medical Center Research Institute Recruiting Kansas City, Kansas, United States, 66160 Contact: Angela VanSciver    913-945-5029    avansciver@kumc.edu    Principal Investigator: Jeffrey Burns, MD          United States, Louisiana Pennington Biomedical Research Center Recruiting Baton Rouge, Louisiana, United States, 70808 Contact: Sara Goff    225-763-0910    sara.goff@pbrc.edu    Principal Investigator: Jeffrey Keller, PhD          United States, Missouri Washington University in St. Louis Recruiting Saint Louis, Missouri, United States, 63110 Contact: Monica Sewell    314-286-2716    sewellm@wustl.edu    Principal Investigator: Ellen Binder, MD          United States, Texas UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Lauren Braunfeld, BS    214-345-7134    LaurenBraunfeld@texashealth.org    Contact: Ann Jacob, BSN    214-345-4665    AnnJacob@TexasHealth.org    Principal Investigator: Rong Zhang, PhD Less <<
NCT00354328 - Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT00498537 Diabetic Nephropathy Not Applicable Completed - United States, Ohio ... More >> VA Medical Center, Dayton Dayton, Ohio, United States, 45428 Less <<
NCT01371747 - Completed - -
NCT00961207 Microalbuminuria ... More >> Macroalbuminuric Diabetic Nephropathy Diabetes Proteinuria Albuminuria Less << Phase 4 Terminated(Altitude trial whic... More >>h used similar drugs was terminated due to increased ADR.) Less << - United States, Illinois ... More >> John H Stroger Hospital of Cook County Chicago, Illinois, United States, 60612 Less <<
NCT00274105 Hypertension ... More >>Coronary Arteriosclerosis Less << Phase 4 Terminated - Germany ... More >> Universitätsklinikum Charité Berlin, Germany, 10117 Med. Hochschule Hannover Hannover, Germany, 30623 Less <<
NCT01180413 Essential Hypertension ... More >> High Blood Pressure Less << Phase 4 Completed - Denmark ... More >> Aarhus University Hospital - dept. cardiology (A) Aarhus, Denmark, 8000 Less <<
NCT01230216 Coronary Artery Disease ... More >> Hypertension Less << Phase 4 Terminated(Slow patients enrol... More >>lment) Less << - Japan ... More >> Division of Cardiology, Kyoto University Hospital Kyoto, Japan, 6066-8507 Less <<
NCT01715207 Marfan Syndrome Phase 3 Completed - Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less <<
NCT01015937 Diabetic Nephropathy ... More >> Proteinuria Less << Not Applicable Completed - Iran, Islamic Republic of ... More >> Clinic Shiraz, Fars, Iran, Islamic Republic of, 098 Less <<
NCT01715207 - Completed - -
NCT03276598 Hypertension ... More >>Pharmacogenetics Less << Phase 4 Completed - Finland ... More >> Helsinki University Central Hospital Helsinki, Finland Less <<
NCT03417388 Coronary Artery Disease Phase 4 Recruiting December 30, 2022 United States, California ... More >> Cedars-Sinai Heart Institute Recruiting Los Angeles, California, United States, 90048 Contact: Sophie Yoo, MS    310-423-3300    jihye.yoo@cshs.org    Principal Investigator: Chrisandra Shufelt, MD          LA BioMedical Recruiting Torrance, California, United States, 90502 Principal Investigator: Matthew Budoff, MD          United States, Florida Family Medicine at Eastside Community Practice Recruiting Gainesville, Florida, United States, 32206 Family Medicine at Hampton Oaks Medical Plaza (Adults and Peds) Recruiting Gainesville, Florida, United States, 32607 Internal Medicine at Tower Hill Recruiting Gainesville, Florida, United States, 32607 Family Medicine at Haile Plantation (Adults & Peds) Recruiting Gainesville, Florida, United States, 32608 Cardiovascular Clinic at UF Health UF Recruiting Gainesville, Florida, United States, 32610 Internal Medicine at UF Health Medical Plaza Recruiting Gainesville, Florida, United States, 32610 UF Health at the University of Florida Recruiting Gainesville, Florida, United States, 32610 Cardiology West at Doctors Park Recruiting Gainesville, Florida, United States, 32611 Family Medicine at 4th Ave Recruiting Gainesville, Florida, United States, 32611 Family Medicine at Old Town (Adults and Peds) Recruiting Gainesville, Florida, United States, 32680 Baptist Health Recruiting Jacksonville, Florida, United States, 32207 Principal Investigator: Ruple Galani, MD          Naval Hospital Jacksonville Recruiting Jacksonville, Florida, United States, 32214 UF Primary Care at Lake City SW Recruiting Lake City, Florida, United States, 32024 UF Primary Care at Lake City West Recruiting Lake City, Florida, United States, 32024 Novel Clinical Research Recruiting Miami, Florida, United States, 33186 Contact: Heber L Varela, MD    786-773-2737       Daytona Heart Group Recruiting Multiple Locations, Florida, United States, 32114 Contact: Glenn Rayos, MD    386-258-8722       Ocala Research Institute Inc. Recruiting Ocala, Florida, United States, 34480 Contact: Rakesh Prashad, MD    352-412-5989       Orlando Health Recruiting Orlando, Florida, United States, 32806 Principal Investigator: Arnold Einhorn, MD          Naval Hospital Pensacola Recruiting Pensacola, Florida, United States, 32512 Principal Investigator: Carrie Gray, MD          Florida Hospital Tampa - Pepin Heart Institute Recruiting Tampa, Florida, United States, 33613 Contact: Charles R Lambert, MD    813-615-7527       Interventional Cardiac Consultants Recruiting Tampa, Florida, United States, 33613 Contact: Carlos J Bayron, MD    727-842-9526       United States, Kentucky University of Kentucky Recruiting Lexington, Kentucky, United States, 40506 Principal Investigator: Gretchen Wells, MD Less <<
NCT00223717 Hypertension Phase 1 Completed - United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37232 Less <<
NCT01878045 - Enrolling by invitation January 25, 2035 United States, Arizona ... More >> NIDDK, Phoenix Phoenix, Arizona, United States, 85014 Less <<
NCT00572403 - Completed - Canada, Ontario ... More >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Less <<
NCT04340557 SARS-CoV Infection PHASE4 COMPLETED 2020-06-13 Sharp Grossmont Hospital, La M... More >>esa, California, 91942, United States|Sharp Chula Vista Medical Center, San Diego, California, 91911, United States|Sharp Memorial Hospital, San Diego, California, 92123, United States Less <<
NCT05012631 Sickle Cell Disease|Diffuse My... More >>ocardial Fibrosis Less << PHASE2 RECRUITING 2026-12-31 Cincinnati Children's Hospital... More >> Medical Center, Cincinnati, Ohio, 45229, United States Less <<
NCT01479439 Nephropathy|Sickle Cell Anemia PHASE2 COMPLETED 2025-12-15 University of Illinois at Chic... More >>ago, Chicago, Illinois, 60612, United States|University of Louisville, Louisville, Kentucky, 40201, United States|NHLBI, Bethesda, Maryland, 20892, United States|Akron Children's Hospital, Akron, Ohio, 44308, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|University of Cincinnati, Cincinnati, Ohio, 45229, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|University of Texas Southwestern, Dallas, Texas, 75390, United States|Texas Children's Hospital, Houston, Texas, 77030, United States Less <<
NCT03951142 Glioblastoma|Brain Metastases PHASE2 ENROLLING_BY_INVITATION 2024-12-31 Oslo University Hospital, Oslo... More >>, 0372, Norway Less <<
NCT04335123 COVID-19 PHASE1 COMPLETED 2020-08-17 University of Kansas Medical C... More >>enter, Kansas City, Kansas, 66160, United States Less <<
NCT05157464 Arthrofibrosis PHASE4 WITHDRAWN 2024-12-31 NYU Langone Health, New York, ... More >>New York, 10016, United States Less <<
NCT00298714 Chronic Hepatitis C|Liver Fibr... More >>osis Less << PHASE4 COMPLETED 2025-01-06 -
NCT06333522 Arthrofibrosis of Knee PHASE4 WITHDRAWN 2026-01-01 NYU Langone Health, New York, ... More >>New York, 10016, United States Less <<
NCT05243446 Renal Transplant Failure|Cardi... More >>ovascular Complication Less << UNKNOWN 2023-12-31 Medical University, Gdansk, 80... More >>-952, Poland Less <<
NCT00001534 Hypertrophic Cardiomyopathy|Le... More >>ft Ventricular Hypertrophy|Myocardial Ischemia Less << COMPLETED 2025-04-03 National Heart, Lung and Blood... More >> Institute (NHLBI), Bethesda, Maryland, 20892, United States Less <<
NCT06135493 Peripheral Neuropathy Due to C... More >>hemotherapy Less << PHASE2 RECRUITING 2025-03-30 Breast Cancer Comprehensive Ce... More >>nter of the National Cancer Institute, Cairo University, Cairo, Egypt Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.82mL

2.36mL

1.18mL

23.65mL

4.73mL

2.36mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories