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Structure of Losartan
CAS No.: 114798-26-4
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Losartan is an angiotensin II receptor antagonist that competes with angiotensin II binding to AT1 receptors with an IC50 of 20 nM.
Synonyms: DuP-753
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
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Wang, Zaoming ; Pacheco-Fernández, Idaira ; Carpenter, James E ; Aoyama, Takuma ; Huang, Guoji ; Pournaghshband Isfahani, Ali , et al.
Abstract: The wide presence of pharmaceuticals and personal care products (PPCPs) in water is a major pollution concern even at the part per billion level, which urges their detection and removal. Current research emphasizes the use of microporous materials as adsorbents for pollutant removal but demonstrates the performance at a higher concentration than realistic environmental water due to the absence of efficient detection methods that can be coupled with the removal process. Here we report a pore-networked membrane (PNM) that can simultaneously remove and detect targeted trace-level PPCPs. These PNMs are designed by interconnecting adsorbents within polymer matrices, forming continuous, tunable porous networks that are accessible for PPCPs, thereby offering high selectivity and adsorption capacity. Evaluations across water samples containing 13 pollutants demonstrate the capability of PNMs to selectively adsorb PPCPs for removal and subsequently release them into analysis solution for detection, positioning their promising use in real water treatment workflow.
Show More >
Pore-networked membrane for trace-level molecular separations in environmental water
Wang, Zaoming ; Pacheco-Fernandez, Idaira ; Carpenter, James E. ; Aoyama, Takuma ; Huang, Guoji ; Isfahani, Ali Pournaghshband , et al.
Abstract: The wide presence of pharmaceuticals and personal care products (PPCPs) in water is a major concern regarding current emerging pollution and urges their selective monitoring to establish water quality management. Microporous materials have been developed to extract organic contaminants and further embedded as fillers into polymeric composites like matrix-mixed membranes (MMMs) for practical use. Considering the relatively large mol. size of PPCPs and their slow diffusion in the membrane, the MMM configuration is, however, inadequate for liquid-phase separations Here we report pore-networked membranes (PNMs) based on the concept of interconnecting the microporous fillers within the polymer matrix to form a continuous porous phase. Linked metal-organic polyhedra (MOP) network is designed for the continuous porous phase with tunable micro/mesopores, which are accessible for big PPCP mols. to facilitate their diffusion and adsorption. By contrast to MMMs, PNMs show enhanced stability, capacity and extraction selectivity towards specific pharmaceutical drugs amongst 13 PPCPs in environmental water matrixes at trace-level concentrations
Show More >
Keywords: Porous materials ; Membranes ; Water contaminants ; Metal-organic polyhedra
Show More >
CAS No. : | 114798-26-4 |
Formula : | C22H23ClN6O |
M.W : | 422.91 |
SMILES Code : | OCC1=C(N=C(N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)CCCC)Cl |
Synonyms : |
DuP-753
|
MDL No. : | MFCD00865831 |
InChI Key : | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
Pubchem ID : | 3961 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H317-H361-H228 |
Precautionary Statements: | P210-P501-P261-P272-P202-P201-P280-P302+P352-P308+P313-P362+P364-P333+P313-P405 |
Class: | 4.1 |
UN#: | 1325 |
Packing Group: | Ⅲ |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
aortic smooth muscle cells | 100 μg/ml | 24 hours | To investigate the effect of Losartan on Smad2 and Erk1/2 phosphorylation, results showed that Losartan inhibited the phosphorylation of Smad2 and Erk1/2 | PMC4162309 |
Mouse peritoneal macrophages | 1 μM | 6 hours | To evaluate the effect of Losartan on IL-6 and TLR4 signaling in macrophages, results showed that Losartan significantly reduced IL-6 and TLR4 mRNA expression. | PMC8409338 |
human podocytes | 1 µM | 24 hours | To investigate the effect of Ang II on LRRC55 expression in podocytes, results showed that Ang II treatment increased LRRC55 expression. | PMC7756252 |
THP-1 cells | 10 mg/mL | 1 hour | Losartan inhibits CCL2-mediated monocyte migration and significantly reduces THP-1 cell migration. | PMC8866227 |
Human peripheral blood mononuclear cells (PBMC) | 10 mg/mL | 1 hour | Losartan significantly inhibits human PBMC migration. | PMC8866227 |
Canine peripheral blood mononuclear cells (PBMC) | 10 mg/mL | 1 hour | Losartan significantly inhibits canine PBMC migration. | PMC8866227 |
Smooth Muscle Cells (SMC) | 100 μg/ml | 24 hours | To study the effect of Losartan on Erk1/2 and Smad2 phosphorylation, results showed that Losartan inhibited Erk1/2 and Smad2 phosphorylation. | PMC4162309 |
THP-1 cells | 10 mg/mL | 24 hours | To assess the transcriptional effects of Losartan on human PBMCs, revealing significant downregulation of genes associated with monocyte chemotaxis and M2 macrophage polarization. | PMC8866227 |
Canine PBMCs | 100 ng/mL to 10 mg/mL | To evaluate the inhibitory effect of Losartan on CCL2 chemotaxis in canine PBMCs, showing significant suppression of CCL2-mediated monocyte migration. | PMC8866227 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | Mouse model of Marfan syndrome | Drinking water | 15 mg/kg | Once daily for 21 days | Losartan prevented aortic aneurysm in a mouse model of Marfan syndrome and partially reversed noncardiovascular manifestations, such as impaired alveolar septation | PMC1482474 |
Mice | cTnT-Q92 transgenic mice model | Oral | 10 mg/kg | Consecutive 7 days | Losartan significantly reduced interstitial fibrosis in cTnT-Q92 mice, with a 49% reduction in collagen volume fraction and a 50% reduction in the expression of collagen 1α(I) and transforming growth factor-β1. | PMC2779524 |
mice | Fbn1mgR/mgR mouse model | drinking water | 14.2±5.3 mg·kg⁻¹·d⁻¹ | 42±9.6 days | To investigate the effect of Losartan on aortic dilatation and survival, results showed that Losartan significantly prolonged the survival of Fbn1mgR/mgR mice and inhibited aortic dilatation | PMC4162309 |
Mouse | NF2 CPA model | Oral | 5 mg/kg/d | daily for 3 weeks | Losartan prevented tumor-induced hearing loss by reducing fibrosis and inflammatory signaling in the tumor microenvironment and enhanced the efficacy of radiation therapy. | PMC8409338 |
Mice | Muscle atrophy model | Oral | 0.6 g/L | from postnatal day 1 to 30 weeks | Losartan improved muscle remodeling and protected against muscle atrophy. | PMC3140459 |
Mice | BPH mice (hypertensive model) | 40 mg/kg/day | Once daily, continuous treatment | To evaluate the therapeutic effects of Losartan on hypertension-induced deficits in functional hyperemia. Results showed that while Losartan effectively lowered blood pressure, it failed to restore functional hyperemia, likely due to aldosterone breakthrough. | PMC8439604 | |
mice | Ang II-induced podocyte injury model | oral | 100 mg/kg/day | Once daily, continuous treatment | To investigate the effect of Losartan on Ang II-induced podocyte injury, results showed that Losartan suppressed LRRC55 expression and attenuated podocyte injury. | PMC7756252 |
Dogs | Spontaneous osteosarcoma lung metastasis model | Oral | 10 mg/kg/d | once daily for 4 weeks | Losartan combined with toceranib significantly inhibited lung metastasis in dogs with osteosarcoma, achieving a clinical benefit rate of 50%. | PMC8866227 |
Mice | Fbn1C1039G/+ mouse model | Drinking water | 20 mg/kg | Once daily for 9 days | Losartan prevented aortic aneurysm in Fbn1C1039G/+ mice and improved the elastic fiber architecture and thickness of the aortic wall, showing no significant difference from wild-type mice | PMC1482474 |
Mice | CPA model | Oral | 5 mg/kg | Once daily for 7 days | Losartan treatment normalized the TME by reducing neuroinflammatory IL-6/STAT3 signaling and preventing hearing loss | PMC8409338 |
Mice | Fbn1mgR/mgR mice | Drinking water | 0.6 g/liter | Starting at 2 weeks of gestation, continued through lactation, and maintained after weaning | To study the effect of Losartan on aortic dilatation and survival in Fbn1mgR/mgR mice, results showed that Losartan significantly prolonged the survival of mice and inhibited aortic dilatation. | PMC4162309 |
Mice | Muscle atrophy model | Oral | 40 mg/kg per day | Daily, continuous treatment | Losartan potassium improved muscle remodeling and protected against muscle atrophy by modulating the TGF-β and IGF-1/Akt/mTOR signaling pathways. | PMC3140459 |
Mice | BPH mice (hypertensive model) | Oral | 100 mg/kg/d or 200 mg/kg/d | Once daily for 15 days | To evaluate the therapeutic effects of losartan on hypertension-induced deficits in functional hyperemia, it was found that losartan failed to restore functional hyperemia, likely due to aldosterone breakthrough. | PMC8439604 |
Dogs | Spontaneous lung metastatic osteosarcoma model | Oral | 25 mg/kg/d | Once daily for 24 weeks | To assess the safety and antitumor activity of high-dose Losartan in combination with Toceranib, demonstrating significant clinical benefit in 50% of dogs. | PMC8866227 |
Mice | Adriamycin nephropathy model | Oral | ~100 mg/kg/d | Starting at 3 months of age and continued | To investigate the effect of losartan potassium on LRRC55 expression and podocyte injury in the adriamycin nephropathy model, results showed that losartan potassium suppressed LRRC55 expression and attenuated podocyte injury. | PMC7756252 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00447603 | Hypertension | Phase 3 | Terminated(Achieving site read... More >>iness and enrolling the trial within a reasonable time) Less << | - | - |
NCT01198249 | Essential Hypertension | Phase 1 | Completed | - | Korea, Republic of ... More >> Severance Hospital Seoul, Korea, Republic of, 120-752 Less << |
NCT02183701 | Hypertension | Phase 3 | Completed | - | - |
NCT00447603 | - | Terminated(Achieving site read... More >>iness and enrolling the trial within a reasonable time) Less << | - | - | |
NCT00942344 | Hypertension | Phase 2 | Completed | - | Korea, Republic of ... More >> 14 sites in Korea Seoul, Busan, etc., Korea, Republic of Less << |
NCT00720577 | Peripheral Arterial Disease | Early Phase 1 | Completed | - | - |
NCT00593710 | Marfan Syndrome | Phase 2 | Completed | - | Canada, British Columbia ... More >> Children's Heart Centre, British Columbia's Children's Hospital Vancouver, British Columbia, Canada, V6H 3V4 Less << |
NCT02410005 | Diabetic Nephropathies | Phase 2 Phase 3 | Terminated(Logistic challenges... More >>) Less << | - | United States, New York ... More >> Weill Cornell Medical College New York, New York, United States, 10021 Qatar Weill Cornell Medical College in Qatar Doha, Qatar, 24144 Hamad Medical Corporation Doha, Qatar Less << |
NCT00683124 | Marfan Syndrome | Phase 3 | Unknown | July 2013 | Italy ... More >> IRCCS Foundation San Matteo Hospital Recruiting Pavia, Italy, 27100 Contact: Eloisa Arbustini, MD,FESC,FACC +390382501206 e.arbustini@smatteo.pv.it Contact: Fabiana I Gambarin, MD +390382501206 f.gambarin@smatteo.pv.it Principal Investigator: Eloisa Arbustini, MD,FESC,FACC Sub-Investigator: Fabiana I Gambarin, MD Sub-Investigator: Valentina Favalli, Engineer Sub-Investigator: Alessandra Serio, MD Sub-Investigator: Mario Regazzi, MD Sub-Investigator: Catherine Klersy, MD Less << |
NCT00649311 | Hypertension | Phase 2 | Terminated(Poor enrollment; te... More >>rmination not due to safety reasons.) Less << | - | Taiwan ... More >> Pfizer Investigational Site Kaohsiung, Taiwan Pfizer Investigational Site Taipei, Taiwan Less << |
NCT01431508 | Hypertension | Phase 4 | Completed | - | - |
NCT00090259 | Heart Failure | Phase 3 | Completed | - | - |
NCT00782327 | Marfan Syndrome | Phase 3 | Unknown | December 2015 | Belgium ... More >> University Hospital Ghent Recruiting Ghent, Belgium, 9000 Principal Investigator: Julie De Backer, MD, PhD Less << |
NCT00565396 | Chronic Kidney Insufficiency ... More >> Angiotensin-Converting Enzyme Inhibitors Angiotensin II Type 1 Receptor Blockers Proteinuria Less << | Not Applicable | Unknown | July 2008 | China, Jiangsu ... More >> Taizhou People's Hospital Taizhou, Jiangsu, China, 225300 China, Zhejiang The 1st Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou, Zhejiang, China, 310003 Guangxing Hospital Hangzhou, Zhejiang, China, 310007 Shaoyifu Hospital Hangzhou, Zhejiang, China, 310016 Ningbo Lihuili Hospital Ningbo, Zhejiang, China, 315000 Wenling 1st People's Hospital Wenling, Zhejiang, China, 317500 The First affiliated Hospital of Wenzhou Medical College Wenzhou, Zhejiang, China, 325000 Xiangshan People's Hospital Xiangshan, Zhejiang, China, 315700 China Renji Hospital Shanghai, China, 200001 Changzheng Hospital Shanghai, China, 200003 Shanghai 9th People's Hospital Shanghai, China, 200011 Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai, China, 200025 Zhongshan Hospital Shanghai, China, 200032 Huadong Hospital Shanghai, China, 200040 Huashan Shanghai, China, 200040 Shanghai 455 Hospital Shanghai, China, 200052 Shanghai 85 Hospital Shanghai, China, 200052 Tongji Hospital Shanghai, China, 200065 Shanghai 10th People's Hospital Shanghai, China, 200072 Shanghai 1st People's Hospital Shanghai, China, 200080 Shanghai Yangpu District Centre Hospital Shanghai, China, 200090 Xinhua Hospital Shanghai, China, 200092 Shanghai East Hospital Shanghai, China, 200120 Shanghai 6th people's hospital Shanghai, China, 200233 Shanghai Changning District Centre Hospital Shanghai, China, 200336 Changhai Hospital Shanghai, China, 200433 Less << |
NCT01431508 | - | Completed | - | - | |
NCT00090259 | - | Completed | - | - | |
NCT00364988 | Type 2 Diabetes ... More >> Diabetic Nephropathy Less << | Not Applicable | Completed | - | - |
NCT02269176 | Hypertension | Phase 3 | Completed | - | - |
NCT01447654 | Hypertrophic Cardiomyopathy | Phase 2 | Completed | - | Denmark ... More >> Department of cardiology, Rigshospitalet. Copenhagen, Denmark, 2100 Less << |
NCT01307046 | - | Completed | - | - | |
NCT03357653 | Glomerulonephritis, Immunoglob... More >>ulin A (IgA) Less << | Phase 3 | Not yet recruiting | December 31, 2021 | - |
NCT00763893 | Marfan Syndrome | Phase 3 | Terminated(A similar publicati... More >>on has been released, suggesting a beneficial effect of sartans, and only 15 patients remained to be seen for their visit at 36 months.) Less << | - | France ... More >> Hôpital Bichat Paris, France, 75018 Less << |
NCT01307046 | Hypertension | Phase 3 | Completed | - | - |
NCT00651235 | Marfan Syndrome | Phase 2 | Unknown | June 2011 | Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Less << |
NCT00670787 | Hypertension | Phase 3 | Completed | - | Japan ... More >> Department of Medicine and Clinical Science, Kyushu University Fukuoka City, Fukuoka, Japan, 812-8582 Less << |
NCT01620788 | Hypertension | Phase 3 | Not yet recruiting | March 2019 | - |
NCT02373241 | Anemia, Sickle Cell ... More >> Sickle Cell Disease Kidney Disease Hypertension Proteinuria Less << | Phase 2 | Recruiting | April 2020 | United States, Alabama ... More >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35223 Contact: Jeffrey D Lebensburger, DO jlebensburger@peds.uab.edu Less << |
NCT00663377 | Heart Failure | Phase 4 | Completed | - | - |
NCT01305850 | Peritoneal Membrane Failure | Phase 4 | Unknown | October 2011 | Thailand ... More >> Chulalongkorn University Recruiting Bangkok, Thailand, 10330 Contact: Talerngsak Kanjanabuch, Assist. Prf. 662-2564321 ext 211 golfnephro@hotmail.com Principal Investigator: Talerngsak Kanjanabuch, Assist. Prf. Sub-Investigator: Pichaya Tantiyavarong, MD Less << |
NCT02049307 | Inflammation ... More >>Fibrosis Less << | Phase 2 | Active, not recruiting | February 2019 | United States, California ... More >> UCSF San Francisco, California, United States, 94110 United States, Maryland NIH Clinical Center Bethesda, Maryland, United States, 20892 United States, Minnesota Allina Health Minneapolis, Minnesota, United States, 55407 Hennepin County Medical Center Minneapolis, Minnesota, United States, 55417 Less << |
NCT00739674 | Hypertension | Phase 3 | Completed | - | - |
NCT01149473 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT01982695 | Duchenne Muscular Dystrophy (D... More >>MD) Cardiomyopathy Less << | Not Applicable | Completed | - | United States, California ... More >> University of California Davis Davis, California, United States United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States United States, Minnesota University of Minnesota St. Paul, Minnesota, United States United States, Missouri St. Louis Children's Hospital St. Louise, Missouri, United States United States, Ohio Nationwide Children's Hospital Columbus, Ohio, United States Less << |
NCT01149473 | - | Completed | - | - | |
NCT00949884 | Hypertension | Phase 4 | Completed | - | United States, Arizona ... More >> Mesa, Arizona, United States, 85213 Phoenix, Arizona, United States, 85050 United States, California Harbor City, California, United States, 90710 Tustin, California, United States, 92780 Westlake Village, California, United States, 91361 United States, Colorado Pueblo, Colorado, United States, 81001 United States, Florida Deerfield Beach, Florida, United States, 33442 DeLand, Florida, United States, 32720 United States, Indiana South Bend, Indiana, United States, 46614 United States, Kansas Wichita, Kansas, United States, 67205 United States, Louisiana Metairie, Louisiana, United States, 70006 United States, New Mexico Albuquerque, New Mexico, United States, 87108 United States, New York Binghamton, New York, United States, 13701 United States, North Carolina Charlotte, North Carolina, United States, 28209 United States, Ohio Cincinnati, Ohio, United States, 45219 United States, South Carolina Greenville, South Carolina, United States, 29615 United States, Tennessee Bristol, Tennessee, United States, 37620 New Tazewell, Tennessee, United States, 37825 United States, Texas Dallas, Texas, United States, 75230 United States, Virginia Norfolk, Virginia, United States, 23502 Less << |
NCT01127217 | Hypertension | Phase 3 | Completed | - | Korea, Republic of ... More >> 8 Sites Seoul, Korea, Republic of Less << |
NCT00739674 | - | Completed | - | - | |
NCT01384591 | - | Completed | - | - | |
NCT01041807 | - | Completed | - | - | |
NCT01982695 | - | Completed | - | - | |
NCT03526042 | Atherosclerosis ... More >> Lupus Nephritis Less << | Not Applicable | Recruiting | October 31, 2019 | Mexico ... More >> Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Recruiting Mexico City, Mexico, 14080 Contact: Juan M Mejia-Vilet, MD,MSc 54870900 ext 4142 jmmejia@hotmail.com Contact: Luis E Morales-Buenrostro, PhD 54870900 ext 4142 luis_buenrostro@yahoo.com.mx Less << |
NCT00949884 | - | Completed | - | - | |
NCT00940667 | Hypertension | Phase 3 | Completed | - | Korea, Republic of ... More >> 13 sites in Korea Seoul, Busan, etc., Korea, Republic of Less << |
NCT01384591 | Aging | Phase 1 Phase 2 | Completed | - | United States, Texas ... More >> University of Texas Medical Branch Galveston, Texas, United States, 77555 Less << |
NCT01321021 | Memory, Long-Term ... More >> Memory, Short-Term Less << | Not Applicable | Completed | - | Switzerland ... More >> University of Basel, Division of Cognitive Neuroscience Basel, Switzerland, 4055 Less << |
NCT00754429 | Ischemic Stroke | Phase 4 | Completed | - | - |
NCT01224860 | Renal Transplant | Phase 2 | Completed | - | Italy ... More >> Mario negri Institute - Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Less << |
NCT03217825 | Hypertension | Phase 2 | Recruiting | December 2017 | Taiwan ... More >> Cvie Therapeutics Limited Recruiting Taipei, Taiwan, 100 Contact: Abby Chang, PhD +886 2758 6003 ext 108 abbychang@cvie.com Less << |
NCT01964079 | Hypertension | Phase 4 | Completed | - | Korea, Republic of ... More >> Wonju Severance Christian Hospital Wonju, Gangwon-do, Korea, Republic of, 220-701 Less << |
NCT00701428 | Hypertension ... More >>Sleep Apnea Less << | Phase 4 | Completed | - | Sweden ... More >> Skaraborg Hospital Skoevde, West Gotaland, Sweden, SE 51485 Less << |
NCT01216878 | Hypertension | Not Applicable | Completed | - | United States, Missouri ... More >> BioKinetic Clinical Applications, Inc. Springfield, Missouri, United States, 65802 Less << |
NCT00152633 | Hypertension | Phase 2 Phase 3 | Withdrawn(No patient could be ... More >>recruited.) Less << | - | Germany ... More >> CRC, Med. Klinik 4, University of Erlangen-Nürnberg Erlangen, Germany, 91054 Less << |
NCT01852942 | HIV Infection ... More >> HIV Infections Less << | Phase 2 | Active, not recruiting | December 2018 | United States, Minnesota ... More >> University of Minnesota, Division of Infectious Diseases Minneapolis, Minnesota, United States, 55455 Less << |
NCT00931710 | - | Completed | - | - | |
NCT00546052 | Hypertension ... More >>Metabolic Disorder Less << | Phase 3 | Completed | - | - |
NCT00931710 | Stage 2 Systolic Hypertension | Phase 4 | Completed | - | United States, New Jersey ... More >> sites in USA East Hanover, New Jersey, United States Less << |
NCT01277822 | Hypertension | Phase 4 | Completed | - | - |
NCT00546052 | - | Completed | - | - | |
NCT01277822 | - | Completed | - | - | |
NCT01648231 | Hypertension | Phase 1 | Completed | - | Australia, New South Wales ... More >> GSK Investigational Site Randwick, New South Wales, Australia, 2031 Less << |
NCT01216852 | Hypertension | Not Applicable | Completed | - | United States, Missouri ... More >> Bio-Kinetic Clinical Applications, Inc. Springfield, Missouri, United States, 65802 Less << |
NCT00940680 | Hypertension | Phase 3 | Completed | - | Korea, Republic of ... More >> 9 sites in Korea Seoul, Daegu, etc., Korea, Republic of Less << |
NCT02263729 | Hamstring Injury | Phase 1 Phase 2 | Recruiting | December 31, 2019 | United States, Pennsylvania ... More >> University of Pittsburgh Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: James Irrgang, PT, PhD irrgangjj@upmc.edu Principal Investigator: James Irrgang, PT, PhD Less << |
NCT02696564 | Emphysema | Phase 4 | Recruiting | January 31, 2021 | - |
NCT01197014 | Healthy | Phase 1 | Completed | - | Czech Republic ... More >> CEPHA s.r.o. Pilsen, Czech Republic Less << |
NCT01150461 | - | Completed | - | - | |
NCT00519870 | Pulmonary Hypertension | Phase 3 | Completed | - | - |
NCT00720226 | - | Completed | - | - | |
NCT00723801 | - | Completed | - | - | |
NCT00675987 | Obesity Hyper... More >>tension Hyperglycemia Less << | Phase 4 | Completed | - | United States, Arkansas ... More >> CAVS Clinical Research Center Little Rock, Arkansas, United States, 72205 United States, California VA San Diego Health Care System San Diego, California, United States, 92161 United States, Florida University of Miami Diabetes Research Institute Miami, Florida, United States, 33136 United States, Indiana Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Massachusetts Brigham and Women's Hospital Cardiovascular Division Boston, Massachusetts, United States, 02115 United States, New York St. Lukes Roosevelt Hospital New York, New York, United States, 10025 United States, Pennsylvania University of Pennsylvania School of Medicine Philadelphia, Pennsylvania, United States, 19104 United States, Texas University of Texas SW Medical Center at Dallas Dallas, Texas, United States, 75390 Hypertension Clinical Pharmacology Baylor Clinic Houston, Texas, United States, 77030 Less << |
NCT01150461 | Hypertrophic Cardiomyopathy | Phase 2 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT01197001 | Healthy | Phase 1 | Completed | - | Czech Republic ... More >> CEPHA s.r.o. Pilsen, Czech Republic, CZ-323 00 Less << |
NCT01821729 | Pancreatic Cancer | Phase 2 | Active, not recruiting | July 2019 | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less << |
NCT00720226 | COPD Emphysem... More >>a Chronic Bronchitis Smoking Less << | Phase 4 | Completed | - | United States, Maryland ... More >> Johns Hopkins Asthma and Allergy Center Baltimore, Maryland, United States, 21205 Less << |
NCT01145612 | Marfan Syndrome | Phase 3 | Unknown | February 2013 | Spain ... More >> Hospital Vall d'Hebron Barcelona, Spain, 08023 Hospital 12 de Octubre Madrid, Spain, 28045 Less << |
NCT01390181 | Bicuspid Aortic Valve ... More >> Thoracic Aortic Aneurysm Less << | Not Applicable | Terminated(Due to low enrollme... More >>nt the decision was made to terminate study prior to final data collection for any individual.) Less << | - | United States, Michigan ... More >> University of Michigan Ann Arbor, Michigan, United States, 48109 Less << |
NCT00675987 | - | Completed | - | - | |
NCT00723801 | Marfan Syndrome | Phase 3 | Completed | - | United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less << |
NCT01808196 | Eosinophilic Esophagitis ... More >> Connective Tissue Disorders Less << | Phase 2 | Active, not recruiting | August 2018 | United States, Ohio ... More >> Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229-3039 Less << |
NCT00756938 | Hypertension | Phase 3 | Completed | - | - |
NCT00953680 | Hypertension | Phase 1 | Completed | - | - |
NCT00953680 | - | Completed | - | - | |
NCT01149486 | - | Completed | - | - | |
NCT01603940 | Hypertension ... More >>Diabetes Mellitus Less << | Phase 4 | Completed | - | Brazil ... More >> Hospital Universitario Pedro Ernesto Rio de Janeiro, RJ, Brazil, 20551030 Less << |
NCT01390181 | - | Terminated(Due to low enrollme... More >>nt the decision was made to terminate study prior to final data collection for any individual.) Less << | - | - | |
NCT00756938 | - | Completed | - | - | |
NCT01603940 | - | Completed | - | - | |
NCT01051219 | Nonalcoholic Steatohepatitis | PHASE3 | COMPLETED | 2025-12-14 | Plymouth Hospitals NHS Trust, ... More >>Plymouth, Devon, PL6 8DH, United Kingdom|Queen Elizabeth Hospital, Birmingham, B15 2TH, United Kingdom|Cambridge University NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom|Royal Derby Hospital, Derby, United Kingdom|Royal Liverpool & Broadgreen University Hospital, Liverpool, United Kingdom|Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, United Kingdom|Imperial College (St Mary's Site), London, SW7 2AZ, United Kingdom|St George's Hospital, London, United Kingdom|Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE7 7DN, United Kingdom|Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom Less << |
NCT01149486 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 Less << |
NCT02958631 | Hypertension | Phase 4 | Unknown | April 2017 | - |
NCT00388388 | Pre-hypertension ... More >> Pre-diabetes Less << | Phase 2 | Terminated(Few subjects recrui... More >>ted, sponsor withdrew support.) Less << | - | Canada, Quebec ... More >> Cardiovascular Prevention Centre, Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Less << |
NCT03763409 | Memory Learni... More >>ng Less << | Not Applicable | Completed | - | United Kingdom ... More >> Department of Psychiatry, University of Oxford Oxford, United Kingdom, OX37JX Less << |
NCT02212769 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Chonbuk National University Hospital Jeonju, Jeollabukdo, Korea, Republic of, 561-712 Less << |
NCT01797926 | Hypertension | Phase 1 | Completed | - | South Africa ... More >> GSK Investigational Site Bloemfontein,, South Africa, 9301 Less << |
NCT00879879 | Precancerous Condition | Not Applicable | Completed | - | United States, Ohio ... More >> University of Cincinnati Cincinnati, Ohio, United States, 45267 Less << |
NCT01913470 | NAFLD | PHASE2 | COMPLETED | 2025-12-15 | Emory University / Children's ... More >>Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less << |
NCT01324752 | Drug Interaction Potentiation | Phase 1 | Completed | - | United States, California ... More >> ACRI- Phase 1 Anaheim, California, United States, 92801 Less << |
NCT02248961 | Arterial Hypertension | Phase 3 | Completed | - | Russian Federation ... More >> Federal State Institution "Russian Cardiology Research and Production Complex" of the Ministry of Health and Social Development of the Russian Federation (FSI "Cardiology" Russian Healthcare Ministry) Moscow, Russian Federation Moscow Health Department "City Clinical Hospital № 81" Moscow, Russian Federation State Research Center for Preventive Medicine of Ministry of Health of the Russian gederation Moscow, Russian Federation St. Petersburg State health agency "City Hospital number 38 it. NA Semashko " Pushkin, Russian Federation St. Petersburg State healthcare Institution "City Hospital number 28" "Maximilianovskaya" St. Petersburg, Russian Federation, 190000 Clinical Hospital n. a. St. Luka St. Petersburg, Russian Federation Federal Almazov Medical Research Centre St. Petersburg, Russian Federation St. Petersburg State Healthcare Institution 'Diagnostic Centre #85' St. Petersburg, Russian Federation St. Petersburg State Institution of Health "City Hospital № 15" St. Petersburg, Russian Federation St. Petersburg State Institution of Healthcare "Pokrovskaya City Hospital" St. Petersburg, Russian Federation State Budget Education Institution of Higher Professional Education "North-Western State Medical University named after I.I. Mechnikov" on base St. Petersburg State Institution of Healthcare "Pokrovskaya City Hospital" St. Petersburg, Russian Federation State Budget Education Institution of Higher Professional Education "North-Western State Medical University named after I.I. Mechnikov", the department faculty and hospital care, court number 5 St. Petersburg, Russian Federation Troitsk City Hospital Troitsk, Russian Federation Less << |
NCT00880386 | Dyspnea|Lung Cancer|Pulmonary ... More >>Complications|Radiation Fibrosis Less << | WITHDRAWN | 2025-04-10 | - | |
NCT03626259 | Hypertension | Phase 4 | Recruiting | June 14, 2019 | Mexico ... More >> Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara Recruiting Guadalajara, Jalisco, Mexico, 44340 Contact: Fernando Grover Paez, PhD 3310585200 ext 33642 fgroverp@hotmail.com Less << |
NCT00879879 | - | Completed | - | - | |
NCT03435939 | Cystic Fibrosis | EARLY_PHASE1 | ACTIVE_NOT_RECRUITING | 2025-04-30 | University of Kansas Medical C... More >>enter, Kansas City, Kansas, 66160, United States Less << |
NCT01913470 | NAFLD | PHASE2 | COMPLETED | 2025-12-15 | Emory University / Children's ... More >>Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less << |
NCT01124162 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... More >> Anapharm Inc. Montreal, Quebec, Canada, H3X 2H9 Less << |
NCT01124175 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... More >> Anapharm Inc. Sainte-Foy, Quebec, Canada, G1V 2K8 Less << |
NCT01124175 | - | Completed | - | - | |
NCT03603938 | Chronic Kidney Disease Patient... More >>s Less << | Not Applicable | Not yet recruiting | December 30, 2023 | China, Guangdong ... More >> The fifth affiliated hospital of Sun Yat-sen university Not yet recruiting Zhuhai, Guangdong, China, 519000 Contact: Shaoxuan Liu 0756-2528188 zdwygcp@126.com Contact: Ye Ming 0756-2528188 zdwygcp@126.com Principal Investigator: Cheng Wang, Doctor Less << |
NCT03206788 | Cystic Fibrosis | Phase 2 | Recruiting | August 10, 2020 | United States, Alabama ... More >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: William Harris, MD 205-939-9583 tharris@peds.uab.edu Principal Investigator: Willian Harris, MD United States, Florida University of Miami, Miller School of Medicine Recruiting Miami, Florida, United States, 33136 Contact: Maria Tupayachi-Ortiz, MD 305-243-2568 mtupayachiortiz@med.miami.edu Contact: Eliana Mendes (305)243-2568 emendes@med.miami.edu Principal Investigator: Maria Tupayachi-Ortiz, MD United States, Kansas University of Kansas Not yet recruiting Kansas City, Kansas, United States, 66160 Contact: Carolina Aguiar 913-588-6067 caguiar@kumc.edu Contact: Kimberly Lovell (913)588-6067 klovell@kumc.edu United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Elizabeth P Kramer, MD 513-636-6771 ekramer@cchmc.org Principal Investigator: Elizabeth Kramer, MD Less << |
NCT03434054 | Healthy Volunteers | Not Applicable | Completed | - | - |
NCT03006952 | Diabetic Nephropathies | Phase 4 | Completed | - | Iran, Islamic Republic of ... More >> Tehran University of Medical Sciences Tehran, Iran, Islamic Republic of Less << |
NCT02416102 | COPD Chronic ... More >>Bronchitis Less << | Not Applicable | Recruiting | May 2019 | United States, Florida ... More >> Pulmonary Human Research Laboratory, University of Miami, Miller School of Medicine Recruiting Miami, Florida, United States, 33136 Contact: Eliana Mendes, MD 305-243-2568 emendes@med.miami.edu Contact: Carolina Aguiar (305) 243-5545 caguiar2@miami.edu Principal Investigator: Matthias Salathe, MD Less << |
NCT03632213 | Mucopolysaccharidosis IV A ... More >> Mucopolysaccharidosis VI Mucopolysaccharidoses MPS IV A MPS VI MPS - Mucopolysaccharidosis Morquio A Syndrome Morquio Syndrome A Morquio Syndrome Less << | Phase 2 | Not yet recruiting | June 3, 2020 | Brazil ... More >> Hospital de Clinicas de Porto Alegre Not yet recruiting Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903 Contact: Marina Zambrano, PhD +55 51 33596340 marinazambrano@hotmail.com Contact: Fabiano Poswar, MD +55 51 33596340 fposwar@hcpa.edu.br Principal Investigator: Roberto Giugliani, MD, PhD Less << |
NCT01124162 | - | Completed | - | - | |
NCT02232763 | Proteinuria | Phase 3 | Completed | - | Korea, Republic of ... More >> Seoul National University Children's Hospital Seoul, Korea, Republic of Less << |
NCT02232776 | Glomerulonephritis, IGA | PHASE3 | COMPLETED | 2025-04-17 | Seoul National University Chil... More >>dren's Hospital, Seoul, Korea, Republic of Less << |
NCT02769130 | Pulmonary Vein Stenosis|Childr... More >>en Less << | PHASE1|PHASE2 | SUSPENDED | 2025-05-21 | Hospital for Sick Children, To... More >>ronto, Ontario, m5g 0a4, Canada Less << |
NCT03519893 | Obesity, Morbid | RECRUITING | 2025-10-26 | St. Olavs University Hospital,... More >> Trondheim, Norway Less << | |
NCT02709018 | Posttraumatic Stress Disorder | Not Applicable | Recruiting | September 2019 | United States, California ... More >> University of California, San Diego Recruiting La Jolla, California, United States, 92037 Contact: Farah D Shaikh, MD, Dr.PH 858-246-0623 fshaikh@ucsd.edu Contact: Nuzhat A Beg, MD 858-534-7068 nbeg@ucsd.edu Principal Investigator: Murray B Stein, MD, MPH United States, District of Columbia George Washington University Recruiting Washington, District of Columbia, United States, 20037 Contact: Nicole Swanson 202-741-2437 loseptsd@gwu.edu Principal Investigator: Suzan Song, MD, MPH, PhD United States, Georgia Atlanta Veterans Affairs Medical Center Withdrawn Atlanta, Georgia, United States, 30033 United States, Maryland Walter Reed National Military Medical Center Recruiting Bethesda, Maryland, United States, 20889 Contact: Eva Asabre, MPH 301-295-2381 Contact: Mark Jimerson, BA (301) 295-0868 eva.asabre.ctr@usuhs.edu Principal Investigator: James West, MD United States, Massachusetts McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Contact: Emily Melen, BA 617-855-2511 EMELLEN@MCLEAN.HARVARD.EDU Principal Investigator: Kerry Ressler, MD, PhD Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Allyson Blackburn, BA 617-726-3508 ABlackburn1@mgh.harvard.edu Principal Investigator: Eric Bui, MD, PhD United States, New York New York University Langone Health Recruiting New York, New York, United States, 10016 Contact: Julia Spandorfer, BA 646-754-4895 Julia.Spandorfer@nyumc.org Contact: Rebecca Lubin, AB 646-754-7035 Rebecca.Lubin@nyumc.org Principal Investigator: Naomi Simon, MD, MSc Less << |
NCT03029091 | Eosinophilic Esophagitis | Phase 2 | Recruiting | August 2019 | United States, California ... More >> University of California, San Diego Recruiting La Jolla, California, United States, 92093 Contact: Lea Jacinto 858-246-2144 ljacinto@ucsd.edu Principal Investigator: Seema Aceves, M.D., PhD United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60208 Contact: Angelika Zalewski 312-695-4054 angelika.zalewski@northwestern.edu Principal Investigator: Ikuo Hirano, M.D. United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Heather Foote 513-803-1155 Heather.Foote@cchmc.org Principal Investigator: J. Pablo Abonia, MD Less << |
NCT01989078 | Sickle Cell Disease | EARLY_PHASE1 | COMPLETED | 2025-12-16 | Grady Health Systems, Atlanta,... More >> Georgia, 30303, United States|Children's Healthcare of Atlanta, Atlanta, Georgia, 30322, United States Less << |
NCT03692013 | Hypertension,Nephropathy | PHASE4 | UNKNOWN | 2023-12-01 | - |
NCT03396523 | Healthy | Not Applicable | Recruiting | December 31, 2018 | China, Sichuan ... More >> University of Electronic Science and Technology of China Recruiting Chengdu, Sichuan, China, 611731 Contact: Weihua Zhao, Master 611731 zarazhao.uestc@outlook.com Less << |
NCT02238457 | Heart Failure | Phase 4 | Withdrawn(Difficulty recruitin... More >>g patients) Less << | - | - |
NCT03467217 | NAFLD - Nonalcoholic Fatty Liv... More >>er Disease Less << | Phase 2 | Recruiting | August 30, 2019 | United States, California ... More >> University of California, San Diego Recruiting San Diego, California, United States, 92103 Contact: Janis Durelle 619-543-5226 jdurelle@ucsd.edu Principal Investigator: Jeffrey Schwimmer, MD University of California, San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Camille Langlois 415-476-1756 Camille.Langlois@ucsf.edu Principal Investigator: Philip Rosenthal, MD United States, Georgia Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Miriam Vos, MD, MSPH 404-727-1463 Mvos@emory.edu Contact: Rebecca Cleeton (404) 727-5383 rcleeto@emory.edu Principal Investigator: Miriam Vos, MD, PhD United States, Illinois Northwestern Univ-Ann & Robert H. Lurie Children's Hospital of Chicago Recruiting Chicago, Illinois, United States, 60611-2605 Contact: Joy Ito 312-227-4559 jito@luriechildrens.org Contact: Mary Riordan (312) 227.4558 mriordan@luriechildrens.org Principal Investigator: Mark Fishbein, MD United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202 Contact: Ann Klipsch 317-274-9605 aeye@iupui.edu Contact: Laura Walker (317) 944-4490 walkerlk@iu.edu Principal Investigator: Jean Molleston, MD United States, Missouri St. Louis University Recruiting Saint Louis, Missouri, United States, 63104 Contact: Theresa Cattoor, BSN,MA,CCRC 314-977-9335 theresa.cattoor@health.slu.edu Principal Investigator: Ajay Jain, MD United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Elena Reynoso 212-305-6274 er2564@columbia.edu Principal Investigator: Joel Lavine, MD, PhD United States, Ohio Cincinnati Children's Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229-3039 Contact: April Carr 513-803-7744 april.carr@cchmc.org Contact: Kimberlee Bernstein, BS, CCRP (513)636-4406 Kimberlee.bernstein@cchmc.org Principal Investigator: Stavra Xanthakos, MD United States, Texas Texas Children's Hospital Recruiting Houston, Texas, United States, 77030 Contact: Tamir Miloh, MD 832-822-3648 tamiloh@texaschildrens.org Contact: Alicia Lawson (832) 824-3848 alicia.lawson@bcm.edu Principal Investigator: Tamir Miloh, MD United States, Washington University of Washington Recruiting Seattle, Washington, United States, 98195 Contact: Melissa Young 206-987-1037 melissa.young@seattlechildrens.org Sub-Investigator: Niviann Blondet, MD Principal Investigator: Karen Murray, MD Less << |
NCT03459911 | Healthy | Phase 1 | Completed | - | India ... More >> Clinical Unit, Reliance Life Sciences Pvt. Ltd. Mumbai, Maharashtra, India, 400 701 Less << |
NCT00813722 | Blood Pressure | Phase 4 | Unknown | June 2009 | Brazil ... More >> Sao Paulo University Sao Paulo, Brazil, 05403-900 University of Sao Paulo Sao Paulo, Brazil, 05405-000 Less << |
NCT00381134 | Diabetes Kidn... More >>ey Disease Hypertension Less << | Phase 2 | Completed | - | United States, Texas ... More >> The University of Texas Southwestern Medical Center Dallas, Texas, United States, 75230 Less << |
NCT03461003 | Pediatric Hypertension | Phase 4 | Recruiting | January 2020 | United States, Texas ... More >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joyce P Samuel, MD, MS 713-500-5670 joyce.p.samuel@uth.tmc.edu Less << |
NCT01443039 | Obesity | Phase 1 | Completed | - | France ... More >> Unit of internal medicine A, Lariboisière Hospital Paris, France, 75010 Less << |
NCT03147092 | Hypertension ... More >>Blood Pressure Less << | Early Phase 1 | Not yet recruiting | June 30, 2021 | - |
NCT00889447 | - | Completed | - | United States, Maryland ... More >> Johns Hopkins Asthma and Allergy Center Baltimore, Maryland, United States, 21224 Less << | |
NCT02232880 | Hypertension | Phase 2 | Terminated(failure to recruit) | - | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-6602 Less << |
NCT00480805 | Type 2 Diabetes Mellitus ... More >> Hypertension Less << | Phase 3 | Completed | - | - |
NCT01086722 | Morbid Obesity ... More >> Overweight Less << | Phase 1 Phase 2 | Completed | - | Spain ... More >> Hospital del Mar Barcelona, Spain, 08003 IMIM-Hospital del Mar Barcelona, Spain, 08003 Less << |
NCT03563287 | Obesity, Morbid ... More >> Bariatric Surgery Candidate Less << | Not Applicable | Completed | - | Finland ... More >> University of Eastern Finland Kuopio, Finland Less << |
NCT01774656 | Heart Failure NYHA Class III ... More >> Heart Failure NYHA Class IV Less << | Phase 4 | Recruiting | December 2017 | United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Terry Blanton, BSN, RN mtblan02@louisville.edu Principal Investigator: Emma Birks, MD, PhD United States, Nebraska University of Nebraska Medical Center Recruiting Omaha, Nebraska, United States, 68198 Contact: Stacy Flickbohm, RN 402-559-5127 stacy.fickbohm@unmc.edu Contact: Natalie Kamtz 402-559-3293 natalie.kamtz@unmc.edu Principal Investigator: Brian D Lowes, MD, PhD United States, New York Montefiore Medical Center Recruiting New York, New York, United States, 10467 Contact: Auris Brown aubrowne@montefiore.org Contact: Johanna Oviedo 718-920-8780 joviedo@montefiore.org Principal Investigator: Snehal Patel, MD United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Barb Gus, RN BSN CCRC 216-445-6552 GUSB@ccf.org Principal Investigator: Maria Mountis, D.O. United States, Pennsylvania University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Judith Marble Judith.Marble@uphs.upenn.edu Principal Investigator: J E Rame, MD United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Ashley Elmer ashley.elmer@hsc.utah.edu Principal Investigator: Craig Selzman, MD Less << |
NCT00555217 | Kidney Disease ... More >> Nephropathy Type 2 Diabetes Less << | Phase 3 | Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << | - | - |
NCT03354143 | Hypertension | Phase 2 | Recruiting | October 31, 2022 | United States, Texas ... More >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Principal Investigator: Rong Zhang, Ph.D. Principal Investigator: Wanpen Vongpatanasin, MD Less << |
NCT02246257 | Rheumatoid Arthritis ... More >> Cardiovascular Diseases Less << | Not Applicable | Recruiting | September 2020 | Denmark ... More >> Department of Rheumathology, Frederiksberg and Bispebjerg univeristy Hospital Recruiting Frederiksberg, Region Of Copenhagen, Denmark, 2000 Contact: Annemarie Lyng Svesson, MD, PhD 004528555126 lyng.annemarie@gmail.com Contact: Torkell J Ellingsen, MD, PhD, Professor 004565413523 torkell.ellingsen@rsyd.dk Less << |
NCT00378443 | Glomerulonephritis, IGA | Not Applicable | Unknown | - | - |
NCT00922311 | IgA Nephropathy | Phase 4 | Completed | - | China ... More >> Department of Medicine, The University of Hong Kong Hong Kong, China Queen Mary Hospital Hong Kong, China Less << |
NCT02232880 | - | Terminated(failure to recruit) | - | - | |
NCT03109288 | Multiple Sclerosis | Phase 1 Phase 2 | Recruiting | June 1, 2030 | United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Less << |
NCT00446862 | - | Completed | - | United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294-0006 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Illinois Feinberg School of Medicine, Northwestern University Chicago, Illinois, United States, 60614 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Slovenia General Hospital Slovenj Gradec Ljubljana, Gradec, Slovenia, 1 Less << | |
NCT00555217 | - | Terminated(It was stopped prim... More >>arily because of safety concerns along with low conditional power to detect a treatment effect on the primary outcome.) Less << | - | - | |
NCT02387554 | Hypertension(HTN) | Phase 1 | Completed | - | Korea, Republic of ... More >> Seoul National University Bundang Hospital Bundang, Gyeonggi, Korea, Republic of Less << |
NCT02056743 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Clinical Trial Center of Chonbuk National University Hospital Jeonju, Jeollabuk-do, Korea, Republic of Less << |
NCT01368185 | - | Completed | - | - | |
NCT00530595 | Cardiovascular Disease | Not Applicable | Completed | - | - |
NCT02387554 | - | Completed | - | - | |
NCT01368185 | - | Completed | - | - | |
NCT00907374 | - | Completed | - | - | |
NCT00907374 | Microalbuminuria | Not Applicable | Completed | - | United States, California ... More >> Charles Drew University Los Angeles, California, United States, 90059 Less << |
NCT02620306 | Chronic Kidney Disease | Phase 3 | Recruiting | December 2020 | Korea, Republic of ... More >> Severance hospital Recruiting Seoul, Korea, Republic of Contact: Sungha Park 02-2228-8455 shpark0530@yuhs.ac Less << |
NCT00814255 | - | Completed | - | - | |
NCT02900729 | Hypertension | Phase 3 | Unknown | February 2018 | China, Hunan ... More >> The Third Xiangya Hospital of Central South University Not yet recruiting Changsha, Hunan, China Contact: Zhihui Zhang, Dr. zhangzhihui0869@126.com Contact: Xiaoyan Wang, Dr. China, Shanghai Zhongshan Hospital affiliated to Fu Dan University Not yet recruiting Shanghai, Shanghai, China, 200032 Contact: Junbo Ge, Dr. ge.junbo@zs-hospital.sh.cn Contact: Li Shen, Dr. shen.li@zs-hospital.sh.cn Changhai Hospital affiliated to Second Military Medical University Not yet recruiting Shanghai, Shanghai, China Contact: Xianxian Zhao, Dr. 13601713431@163.com Contact: Zhifu Guo, Dr. Putuo Hospital affiliated to Shanghai Traditional Chinese Medicine University Not yet recruiting Shanghai, Shanghai, China Contact: Zongjun Liu, Dr. lzj72@126.com Contact: Jia Shi, Dr. Shanghai Chest Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Weiyi Fang, Dr. fwychest@163.com Contact: Shaofeng Guan, Dr. gsf@qq.com Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Changqian Wang, Dr. wcqian@hotmail.com Contact: Zhaofang Yin, Dr. 13072103901@163.com Shanghai Sixth People's Hospital affiliated to Shanghai Jiao Tong University Not yet recruiting Shanghai, Shanghai, China Contact: Jingbo Li, Dr. jbli@medmail.com.cn Contact: Yesheng Pan, Dr. panyesheng@163.com Tongji Hospital affiliated to Tongji University Not yet recruiting Shanghai, Shanghai, China Contact: Xuebo Liu, Dr. lxb70@hotmail.com Contact: Yang Liu, Dr. 961165@sina.com Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine Chongming Branch Not yet recruiting Shanghai, Shanghai, China Contact: Yingmin Lu, Dr. lymkk@sohu.com Contact: Shuxin Hou, Dr. 1461396934@qq.com China, Zhejiang Sir Run Run Shaw Hospital affiliated to Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China Contact: Guosheng Fu, Dr. fugs@medmail.com.cn Contact: Chenyang Jiang, Dr. The Second Hospital affiliated to Zhejiang University Not yet recruiting Hangzhou, Zhejiang, China Contact: Jianan Wang, Dr. wang_jian_an@tom.com Contact: Jun Jiang, Dr. drjayj@Hotmail.com Taizhou Hospital Not yet recruiting Taizhou, Zhejiang, China Contact: Jianjun Jiang, Dr. taizhoujiangjj@163.com Contact: Yafei Mi, Dr. The First Hospital affiliated to Wenzhou Medical College Not yet recruiting Wenzhou, Zhejiang, China Contact: Weijian Huang, Dr. weijianhuang69@yahoo.com.cn Contact: Zhouqing Huang, Dr. susiehzq@126.com Less << |
NCT02166398 | Healthy | Phase 1 | Completed | - | Korea, Republic of ... More >> Seoul National University Hospital Seoul, Jongno-gu, Korea, Republic of, 110-744 Less << |
NCT02521233 | Essential Arterial Hypertensio... More >>n Less << | Phase 3 | Withdrawn(Sponsor decision) | August 2017 | - |
NCT00502242 | Kidney Transplant | Phase 4 | Completed | - | - |
NCT00502242 | - | Completed | - | - | |
NCT03082014 | Cerebral Small Vessel Diseases | Phase 3 | Recruiting | September 30, 2020 | Germany ... More >> Insitute for Stroke and Dementia Research Not yet recruiting Munich, Germany, 81377 Contact: Martin Dichgans, Prof. +49 89 4400 ext 46019 Contact: Anna Kopczak, MD +49 89 4400 ext 46125 Netherlands Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands, 6202 AZ Contact: Robert van Oostenbrugge, Prof. Contact: Julie Staals, MD, PhD Sub-Investigator: Danielle Kerkhofs University Medical Center Utrecht Not yet recruiting Utrecht, Netherlands, 3584 CX Contact: Geert Jan Biessels, Prof. Contact: Hilde van den Brink, MD United Kingdom Nuffield Department of Clinical Neurosciences Recruiting Oxford, England, United Kingdom, OX1 2JD Contact: Peter Rothwell, Prof. Contact: Alastair Webb, MD, PhD Centre for Clinical Brain Sciences Not yet recruiting Edinburgh, Scotland, United Kingdom, EH16 4SB Contact: Joanna Wardlaw, Prof. Contact: Fergus Doubal, MD, PhD Less << |
NCT00814255 | Focal Segmental Glomeruloscler... More >>osis Less << | Phase 2 | Completed | - | United States, Florida ... More >> University of Miami Miami, Florida, United States, 33136 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Boston Children's Hospital Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55901 United States, Missouri Children's Mercy Hospital Kansas City, Missouri, United States, 64108 Cardinal Glennon Children's Medical Center Saint Louis, Missouri, United States, 63104 United States, New York Steven and Alexandra Cohen Children's Medical Center of New York New Hyde Park, New York, United States, 11040 NYU Langone Medical Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28207 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Ohio State University Columbus, Ohio, United States, 43205 United States, Oregon Doernbecher Children's Hospital Portland, Oregon, United States, 97239 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Texas Tech University El Paso, Texas, United States, 79905 Canada, Alberta University of Alberta Edmonton, Alberta, Canada, T6G 2R7 Less << |
NCT01299376 | Hypertension | Phase 3 | Completed | - | - |
NCT03666351 | Aortic Stenosis ... More >> Aortic Regurgitation Hypertension LVM Left Ventricular Hypertrophy Less << | Phase 4 | Recruiting | January 31, 2022 | Korea, Republic of ... More >> 10 Institutions Including Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: kang Less << |
NCT01299376 | - | Completed | - | - | |
NCT01361087 | Marfan Syndrome | Phase 3 | Withdrawn(No outside recruitme... More >>nt of subjects from Main Atenolol VS Losartan NIH study) Less << | - | United States, Illinois ... More >> Children's Memorial Hospital Chicago Chicago, Illinois, United States, 60614 Less << |
NCT01570569 | Healthy | Phase 1 | Completed | - | - |
NCT02760615 | Colitis, Ulcerative ... More >> Crohn Disease Less << | Phase 4 | Recruiting | July 29, 2019 | United States, California ... More >> WCCT Recruiting Cypress, California, United States, 90630 United States, Florida QPS MRA Recruiting Miami, Florida, United States, 33143 Less << |
NCT01233635 | Atrial Fibrillation | Phase 4 | Terminated(inadequate enrollme... More >>nt rate) Less << | - | United States, Pennsylvania ... More >> UPMC CVI Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT00275639 | Liver Transplant Recipients | Phase 4 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT02278471 | Hypertension ... More >>Hyperlipidemia Less << | Phase 2 | Completed | - | United States, Alabama ... More >> Franklin Primary Health Center Mobile, Alabama, United States, 36603 Less << |
NCT03295734 | Hypertension ... More >>Aging Sedentary Lifestyle Less << | Phase 2 | Recruiting | September 2022 | United States, Alabama ... More >> UAB Center for Exercise Medicine Recruiting Birmingham, Alabama, United States, 35205 Contact: Sara Harper, PhD 205-996-3005 saharper@uabmc.edu Less << |
NCT02188121 | Serious Mental Illness ... More >> Schizophrenia Schizoaffective Disorder Bipolar Disorder Cardiovascular Disease Major Depressive Disorder Psychosis NOS Less << | Phase 4 | Recruiting | December 2020 | United States, Massachusetts ... More >> McLean Hospital Recruiting Belmont, Massachusetts, United States, 02478 Principal Investigator: Dost Ongur, MD PhD Less << |
NCT01011062 | Insulin Resistance ... More >> Type 2 Diabetes Less << | Not Applicable | Completed | - | Czech Republic ... More >> Diabetes Center, Institute of Clinical and Experimental Medicine Prague, Czech Republic, 14021 Less << |
NCT01198496 | Hypertension ... More >>Stroke Blood Pressure Less << | Phase 4 | Recruiting | December 2019 | Japan ... More >> Jichi Medical Univercity Recruiting Shimotsuke, Tochigi, Japan, 329-0498 Contact: Kazuyuki Shimada, MD kazuyuki@jichi.ac.jp Principal Investigator: Kazuomi Kario, MD Less << |
NCT00001741 | Cardiovascular Disease | PHASE1 | COMPLETED | 2025-04-03 | National Heart, Lung and Blood... More >> Institute (NHLBI), Bethesda, Maryland, 20892, United States Less << |
NCT00234858 | Hypertension ... More >>Metabolic Syndrome Less << | Phase 4 | Completed | - | - |
NCT00541684 | Hypertension | Phase 3 | Completed | - | - |
NCT00159692 | Hypertension | Phase 4 | Completed | - | - |
NCT02560805 | Stress Disorders, Post-Traumat... More >>ic Less << | Phase 2 | Recruiting | August 2020 | United States, Georgia ... More >> Atlanta VA Medical Center Recruiting Decatur, Georgia, United States, 30033 Contact: Melanie Kankam, MS 404-321-6111 ext 7040 melanie.l.jefferson@emory.edu Principal Investigator: Jeanie Park, MD Less << |
NCT00280215 | Hyperoxaluria | Phase 3 | Withdrawn(Inadequate number of... More >> patients, lack of funding) Less << | - | - |
NCT00155064 | Hyperaldosteronism | Phase 4 | Completed | - | Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan Less << |
NCT00143949 | Type 1 Diabetes | Phase 2 | Completed | - | Canada, Ontario ... More >> Mt Sinai Hospital, University of Toronto (Clinical Ctr) Toronto, Ontario, Canada, M5G 1X5 Canada, Quebec Royal Victoria Hospital, McGill University (Data Center) Montreal, Quebec, Canada, H3A 1A1 Montreal Childrens Hospital, McGill University (Clinical Ctr) Montreal, Quebec, Canada, H3H 1P3 Less << |
NCT00467831 | Hermansky-Pudlak Syndrome (HPS... More >>) Pulmonary Fibrosis Oculocutaneous Albinism Platelet Storage Pool Deficiency Metabolic Disease Less << | Phase 1 Phase 2 | Terminated(insufficient enroll... More >>ment) Less << | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00467831 | - | Terminated(insufficient enroll... More >>ment) Less << | - | - | |
NCT01115426 | IGA Glomerulonephritis | Phase 4 | Completed | - | Italy ... More >> "Mater Domini" Hospital Catanzaro, Calabria, Italy, 88100 Less << |
NCT02916602 | Hypertension | Phase 3 | Completed | - | Korea, Republic of ... More >> Seoul National University Bundang Hospital Seongnam, Gyeonggi-Do, Korea, Republic of, 463-707 Less << |
NCT02704494 | Diabetic Nephropathy | Early Phase 1 | Completed | - | Iran, Islamic Republic of ... More >> Shahid Motahhari Clinic, Shiraz University of Medical Sciences Shiraz, Fars, Iran, Islamic Republic of Less << |
NCT02676466 | Inflammation | Phase 2 | Completed | - | United States, Florida ... More >> University of Florida Gainesville, Florida, United States, 32611 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts Tufts University Boston, Massachusetts, United States, 02111 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27157 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT02121041 | Hypertension | Not Applicable | Completed | - | United States, North Carolina ... More >> University of North Carolina Chapel Hill, North Carolina, United States, 27599 Less << |
NCT00805311 | Carotid Artery Stenosis ... More >> Atherosclerosis Stroke Less << | Phase 4 | Terminated(Due to the clear ad... More >>vantage of carotid endarterectomy) Less << | - | Russian Federation ... More >> Russian Cardiology Research and Production Center Moscow, Russian Federation, 121552 Russian Cardiology Research and Production Center Moscow, Russian Federation Less << |
NCT01187862 | Cytochrome Ph... More >>armacokinetics Less << | Phase 1 | Completed | - | Switzerland ... More >> University Hospital Basel, Switzerland, 4031 Less << |
NCT01891513 | - | Completed | - | United States, Florida ... More >> UF Institute on Aging Clinical and Translational Research Building Gainesville, Florida, United States, 32611 Less << | |
NCT00456963 | Diabetes Mellitus ... More >> Hypertension Less << | Phase 4 | Terminated(Because of delay in... More >> approval of the protocol by a number of Ethics Commitees the trial was terminated on March 4, 2010. No patient had received any study drug.) Less << | - | Italy ... More >> Istituto Auxologico Italiano. Milan, Italy, 20145 Less << |
NCT00402194 | Obesity|Insulin Resistance|Imp... More >>aired Glucose Tolerance|Pre-diabetes Less << | COMPLETED | 2025-03-12 | Indiana University Hospital GC... More >>RC, Indianapolis, Indiana, 46202, United States Less << | |
NCT03505853 | Acute Intermittent Porphyria (... More >>AIP) Acute Hepatic Porphyria (AHP) Porphyria, Acute Intermittent Acute Porphyria Less << | Phase 1 | Active, not recruiting | January 2019 | Sweden ... More >> Clinical Trial Site Stockholm, Sweden Less << |
NCT02744456 | Hypertension ... More >>High Blood Pressure Less << | Phase 2 | Completed | - | United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Less << |
NCT00402194 | Obesity|Insulin Resistance|Imp... More >>aired Glucose Tolerance|Pre-diabetes Less << | COMPLETED | 2025-03-12 | Indiana University Hospital GC... More >>RC, Indianapolis, Indiana, 46202, United States Less << | |
NCT02063100 | Glomerulonephritis ... More >> Proteinuria Less << | Phase 4 | Unknown | - | - |
NCT02121041 | - | Completed | - | - | |
NCT02235909 | Hypertension | Phase 3 | Recruiting | August 2020 | - |
NCT01934569 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Pfizer Investigational Site Brussels, Belgium, B-1070 Less << |
NCT00092209 | Hypertension | Phase 3 | Completed | - | - |
NCT03335904 | Sleep Disordered Breathing ... More >> Hypoxia Respiration; Sleep Disorder Chemoreceptor Apnea Less << | Phase 4 | Recruiting | January 2020 | Canada, British Columbia ... More >> University of British Columbia Recruiting Kelowna, British Columbia, Canada, V1V 1V7 Contact: Glen Foster, PhD 12508078224 glen.foster@ubc.ca Less << |
NCT00886600 | - | Completed | - | - | |
NCT01210430 | Postural Tachycardia Syndrome | Early Phase 1 | Completed | - | United States, New York ... More >> New York Medical College/Bradhurst building Hawthorne, New York, United States, 10532 Less << |
NCT00981747 | Idiopathic Pulmonary Fibrosis ... More >> Pulmonary Fibrosis Less << | Phase 2 Phase 3 | Terminated(Funding was withdra... More >>wn.) Less << | - | United States, Iowa ... More >> University of Iowa Hospitals and Clinics Iowa City, Iowa, United States, 52246 Less << |
NCT02504606 | Hypertension | Phase 1 | Completed | - | - |
NCT00981747 | - | Terminated(Funding was withdra... More >>wn.) Less << | - | - | |
NCT00981929 | Cytochrome P450 Phenotype and ... More >>Genotype Metrics Less << | Not Applicable | Terminated(Unexpected non-seri... More >>ous adverse events) Less << | January 2011 | Denmark ... More >> University of Southern Denmark, Clinical Pharmacology Odense, Fyn, Denmark, D-5000 Less << |
NCT00398541 | Hypertension | Phase 3 | Completed | - | - |
NCT00886600 | Hypertension | Phase 3 | Completed | - | - |
NCT00994617 | Hypertension, Resistant to Con... More >>ventional Therapy Essential Hypertension Less << | Phase 4 | Unknown | December 2014 | United Kingdom ... More >> Professor Morris Brown Recruiting Cambridge, Cambridgeshire, United Kingdom, CB22QQ Contact: Jackie Salsbury, Nursing 01223 586878 js811@medschl.cam.ac.uk NHS Ayrshire Recruiting Ayrshire, United Kingdom Principal Investigator: Dr E Spalding University Hospitals Birmingham NHS Foundation Trust Recruiting Birmingham, United Kingdom Principal Investigator: Dr U Martin NHS Tayside/University of Dundee Recruiting Dundee, United Kingdom Principal Investigator: Prof T MacDonald NHS Lothian/University of Edinburgh Recruiting Edinburgh, United Kingdom Principal Investigator: Prof D Webb NHS Greater Glasgow and Clyde/University of Glasgow Recruiting Glasgow, United Kingdom Principal Investigator: Dr S Padmanabhan Ixworth GP Practice Recruiting Ixworth, United Kingdom Principal Investigator: Dr J Cannon University Hospitals of Leicester NHS Trust Recruiting Leicester, United Kingdom Principal Investigator: Dr A Stanley Barts and the London School of Medicine and Dentistry Recruiting London, United Kingdom Contact: Prof M Caulfield Principal Investigator: Prof M Caulfield Guys and St Thomas' NHS Foundation Trust Recruiting London, United Kingdom Principal Investigator: Prof K Cruickshank Imperial College Healthcare NHS Trust Recruiting London, United Kingdom Principal Investigator: Prof P Sever Central Manchester University Hospitals NHS Foundation Trust Recruiting Manchester, United Kingdom Principal Investigator: Dr H Soran Norfolk and Norwich University Hospital NHS Trust Recruiting Norwich, United Kingdom Principal Investigator: Dr S Myint-Khin Less << |
NCT01806324 | Hypertension ... More >>Hyperlipidemia Less << | Phase 1 | Completed | - | United States, Maryland ... More >> Baltimore, Maryland, United States, 21201 Less << |
NCT00284128 | Hypertension | Phase 2 Phase 3 | Completed | - | - |
NCT02521246 | Essential Arterial Hypertensio... More >>n Less << | Phase 3 | Withdrawn(Sponsor decision) | August 2017 | - |
NCT00774904 | Diabetic Nephropathy | COMPLETED | 2025-11-07 | Shanghai No.3 people's hospita... More >>l, Shanghai, 201900, China Less << | |
NCT01281787 | Lung Cancer A... More >>trial Fibrillation Less << | Phase 3 | Completed | - | Italy ... More >> European Institute of Oncology Milan, Italy, 20141 Less << |
NCT01675362 | Kidney Calculi | Phase 4 | Completed | - | Egypt ... More >> Urology and Nephrology Center Mansoura, Egypt, 35516 Less << |
NCT01845688 | Idiopathic Membranous Nephropa... More >>thy Less << | Not Applicable | Unknown | September 2016 | China, Shanghai ... More >> Shanghai University of Traditional Chinese Medicine Shanghai, Shanghai, China, 200032 Less << |
NCT01271374 | Hypertension | Phase 4 | Unknown | December 2011 | United States, Georgia ... More >> Atlanta Clinical Research Center Tucker, Georgia, United States, 30084 Less << |
NCT01637623 | Severe Obstructive Sleep Apnea... More >> (Apnea Hypopnea Index > 30 Events/Hour) Hypertension Less << | Phase 2 | Completed | - | United States, Wisconsin ... More >> Aurora Bay Care Green Bay, Wisconsin, United States, 54308 Gundersen Lutheran La Crosse, Wisconsin, United States, 54601 University of Wisconsin Madison Madison, Wisconsin, United States, 53705 Marshfield Clinic Marshfield, Wisconsin, United States, 54449 Less << |
NCT00198562 | Hypertension | Phase 4 | Unknown | March 2012 | Japan ... More >> National Cardiovascular Center Suita, Osaka, Japan, 565-8565 Less << |
NCT00561704 | Obese Type 2 ... More >>Diabetes Diabetic Nephropathy Glucose Metabolism Angiotensin II Type 1 Receptor Blockers Less << | Not Applicable | Completed | - | - |
NCT01692717 | Healthy Subjects | Phase 1 | Unknown | May 2013 | Brazil ... More >> LAL Clínica Pesquisa e Desenvolvimento Ltda Not yet recruiting Valinhos, São Paulo, Brazil Contact: Alexandre Frederico, physician 55 19 38716399 alexandre@lalclinica.com.br Less << |
NCT00971165 | Hypertension ... More >>Cardiovascular Disease Less << | Phase 3 | Completed | - | Brazil ... More >> Hospital de Clínicas de Porto Alegre, UFRGS Porto Alegre, RS, Brazil, 90035 903 Hospital de Clínicas de Porto Alegre Porto Alegre, RS, Brazil, 90035-903 Less << |
NCT03604003 | Chronic Kidney Disease | Not Applicable | Not yet recruiting | December 30, 2023 | - |
NCT02294539 | Hypertension | Phase 4 | Completed | - | Korea, Republic of ... More >> Kyung Hee University Hospital at Gangdong Seoul, Korea, Republic of Less << |
NCT00400218 | Hypertension | Phase 3 | Completed | - | - |
NCT02190318 | Chronic Renal Disease | Not Applicable | Unknown | December 2015 | China, Hunan ... More >> Recruiting Changsha, Hunan, China, 410000 Contact: Hong Liu, MD,phD 86-0731-85292057 liuh0618@163.com Principal Investigator: Hong Liu, MD,phD Less << |
NCT01292694 | Hypertension ... More >>Pure Autonomic Failure Multiple System Atrophy Less << | Phase 1 | Terminated(Could not enroll en... More >>ough participants, and lost funding.) Less << | - | United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37232 Less << |
NCT03371823 | Cardiovascular Diseases ... More >> Hypertension Less << | Phase 4 | Recruiting | December 31, 2019 | United States, Delaware ... More >> University of Delaware Recruiting Newark, Delaware, United States, 19716 Contact: Megan Wenner, PhD 302-831-7343 mwenner@udel.edu Contact: Joshua C Hobson, MS 302-831-8137 jhobson@udel.edu Less << |
NCT01302691 | Hypertension | Phase 3 | Completed | - | - |
NCT01234922 | Hypertension ... More >>Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 2 | Terminated(slow accrual) | - | United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less << |
NCT01302691 | - | Completed | - | - | |
NCT01234922 | - | Terminated(slow accrual) | - | - | |
NCT01276613 | Pancreatic Cancer | Early Phase 1 | Active, not recruiting | January 2019 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT02768948 | Diabetic Nephropathy | Not Applicable | Recruiting | July 2019 | France ... More >> CHU de Nice Recruiting Nice, France, 06000 Contact: Guillaume FAVRE, PH favre.g@chu-nice.fr Less << |
NCT00369538 | Proteinuria H... More >>ypertension End Stage Renal Disease Less << | Phase 4 | Suspended(principle investigat... More >>or moved, new investigators will join, insurance expired - project needs to be re-examined by an ethic committee) Less << | - | France ... More >> Service de Néphrologie, Hôpital Civil, Hôpitaux Universitaires Strasbourg, France, 67091 Less << |
NCT03578042 | Hypertension | Phase 4 | Recruiting | December 30, 2019 | Lebanon ... More >> Hotel Dieu de France Hospital Recruiting Beirut, Lebanon, Beirut Contact: Rabih R Azar, MD, MPH +9611615300 ext 9408 razar@usj.edu.lb Less << |
NCT02795910 | Diabetes Mellitus ... More >> Hypertension Heart Failure Ischemic Heart Disease Cerebrovascular Disease Less << | Not Applicable | Active, not recruiting | March 31, 2019 | Brazil ... More >> Florianopolis City Health Department Florianopolis, Santa Catarina, Brazil, 88.040-400 Less << |
NCT03610217 | Scleroderma, Systemic ... More >> Sclerosis, Systemic Less << | Not Applicable | Not yet recruiting | October 2021 | Canada, Ontario ... More >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC 15196466332 Janet.Pope@sjhc.london.on.ca Contact: Andreu Fernandez-Codina 151964661023 doccodina@gmail.com Less << |
NCT01405794 | Healthy | Phase 1 Phase 2 | Completed | - | United States, Utah ... More >> University of Utah Salt Lake City, Utah, United States, 84112-5820 Less << |
NCT02817360 | Heart Diseases ... More >> Diabetes Mellitus, Type 2 Less << | Phase 4 | Recruiting | February 2021 | Austria ... More >> Internistische Ordination Recruiting Mödling, Niederösterreich, Austria, 2340 Contact: Christian Feinböck, MD +43 2236 869 142 office@dr-feinboeck.at Contact: Christiane Feinböck +43 2236 869 142 office@dr-feinboeck.at Sub-Investigator: Egbert Seyfried, MD Principal Investigator: Christian Feinböck, MD Klinischen Abteilung für Endokrinologie und Diabetologie MU Graz Recruiting Graz, Steiermark, Austria, 8036 Contact: Harald Sourij +43-316-385-80363 ha.sourij@medunigraz.at Contact: Michael Zink +43-680-128-5120 m.zink@medunigraz.at Sub-Investigator: Julia Mader, MD Prof Sub-Investigator: Eva Novak, MD Sub-Investigator: Caren Sourij, MD Konventhospital der Barmherzigen Brüder Abteilung für Innere Medizin Recruiting Linz, Upper Austria, Austria, 4021 Contact: Martin Clodi, Prof.Dr. martin.clodi@bblinz.at Principal Investigator: Martin Clodi, Prof.Dr. Sub-Investigator: Michael Resl, Dr. Krankenanstalt Rudolfstiftung, 1. Medizinische Abteilung Recruiting Vienna, Austria, 1030 Contact: Bernhard Ludvik, Prof.Dr. +43 1 711 65 ext 2107 bernhard.ludvik@wienkav.at Principal Investigator: Bernhard Ludvik, Prof.Dr. Sub-Investigator: Eva-Christina Krzizek, Dr. Sub-Investigator: Johanna Brix, Dr. Sub-Investigator: Astrid Feder, Dr. Sub-Investigator: Florian Hoellerl, Dr. Medical University of Vienna Univ.Clinic for Internal Medicine II Department of Cardiology Recruiting Vienna, Austria, 1090 Contact: Martin Huelsmann, Doz.Dr. +43 1 40400 ext 46140 martin.huelsmann@meduniwien.ac.at Principal Investigator: Martin Huelsmann, Doz.Dr. Sub-Investigator: Raphael Wurm, Dr. Univ. Klinik für Innere Medizin III Med. Uni Wien Recruiting Vienna, Austria, 1090 Contact: Anton Luger, Prof.Dr. 00 43 1 40400 ext 43100 anton.luger@meduniwien.ac.at Principal Investigator: Anton Luger, Prof.Dr. Sub-Investigator: Michael Krebs, Prof.Dr. Universitätsklinik für Augenheilkunde und Optometrie Medizinische Universität Wien Recruiting Vienna, Austria, 1090 Contact: Sonja Prager, Dr. +43 1 40400 ext 79470 sonja.prager@meduniwien.ac.at Principal Investigator: Sonja Prager, Dr. Sub-Investigator: Julia Hafner, Dr. Diabetes & Stoffwechselambulanz Gesundheitszentrum Wien Süd Recruiting Vienna, Austria, 1100 Contact: Helmut Brath, OA Dr. +43 1 60122 ext 4264 helmut.brath@wgkk.at Principal Investigator: Helmut Brath, OA Dr. 3. Med. Abtlg., KH Hietzing mit Neurologischem Zentrum Rosenhügel Recruiting Vienna, Austria, 1130 Contact: Rudolf Prager, Prof.Dr. +43 1 80110 ext 2351 rudolf.prager@wienkav.at Principal Investigator: Rudolf Prager, Prof.Dr. Sub-Investigator: Slobodan Peric, Dr. Zentrum für Klinische Studien Recruiting Wien, Austria, 1060 Contact: Ursula Hanusch, MD +43 1 266 21 91 dr.hanusch@dieinternistin.com Contact: Michaela Mauritz +43 1 266 21 91 office@dieinternistin.com Sub-Investigator: Marita Spak, MD Netherlands Maastricht University Medical Center; Dep. Cardiology Recruiting Maastricht, Netherlands, 6202 Contact: Hans-Peter Brunner-La Rocca, MD Prof +31 43-3877097 hp.brunnerlarocca@mumc.nl Contact: Mireille Spanjers +31 43-3877099 m.spanjers@mumc.nl Sub-Investigator: Nick Marks, MD Sub-Investigator: Wouter Robaeys, MD New Zealand Christchurch Heart Institute Recruiting Christchurch, New Zealand, 8140 Contact: Richard Troughton, MD Prof +64 3 364 1063 Richard.Troughton@cdhb.health.nz Contact: Lorraine Skelton +64 3 364 1063 lorraine.skelton@cdhb@health.nz Principal Investigator: Richard Troughton, MD Prof Less << |
NCT00673790 | Hypertension | Phase 4 | Completed | - | - |
NCT01715584 | Hypertension | Phase 4 | Recruiting | December 31, 2019 | Canada, Ontario ... More >> London Health Sciences Centre - Victoria Campus Recruiting London, Ontario, Canada, N6A 5W9 Contact: Craig J Railton, MD, PhD 519 685 8500 ext 58525 Craig.Railton@lhsc.on.ca Principal Investigator: Craig J Railton, MD, PhD Sub-Investigator: Jonathan Fairbairn, BSc Sub-Investigator: George Nicoloau, MD Sub-Investigator: Robert Gros, PhD Sub-Investigator: Jason Franklin, MD Sub-Investigator: John Yoo, MD Sub-Investigator: Kevin Fung, MD Sub-Investigator: Anthony Nichols, MD Sub-Investigator: Danielle McNeil, MD Less << |
NCT03502031 | Renal Insufficiency, Chronic ... More >> Diabetic Nephropathy Type 2 Less << | Phase 4 | Recruiting | December 2020 | United States, Georgia ... More >> NephroNet Recruiting Buford, Georgia, United States, 30518 Contact: James A Tumlin, MD 770-490-9203 jamestumlinmdnephronet@gmail.com Contact: Julie Moss 404-790-0267 jmoss@nephronet.com Less << |
NCT00684489 | Hypertension | Not Applicable | Completed | - | - |
NCT01405794 | - | Completed | - | - | |
NCT01377285 | Chronic Renal Failure | Phase 4 | Unknown | December 2018 | Taiwan ... More >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Tun-Jun Tsai, M.D.; PhD 00886-2-23123456 ext 63953 tjtsai@ntuh.gov.tw Contact: Yung-Ming Chen, M.D. 00886-2-23123456 ext 65993 chenym@ntuh.gov.tw Principal Investigator: Tun-Jun Tsai, M.D.; PhD Less << |
NCT02386917 | Obesity | Not Applicable | Active, not recruiting | December 2019 | Norway ... More >> HVestfold Tønsberg, Vestfold, Norway, 3103 Less << |
NCT01371747 | Chronic Kidney Disease ... More >> Hypertension Hyperkalemia Less << | Phase 2 | Completed | - | - |
NCT00721877 | Healthy, no Evidence of Diseas... More >>e Less << | Phase 1 | Completed | - | United States, Arizona ... More >> Arizona Cancer Center - Tucson Tucson, Arizona, United States, 85724-5024 Less << |
NCT02355821 | Osteopenia Ar... More >>terial Hypertension Less << | Not Applicable | Completed | - | Russian Federation ... More >> National Research Center for Preventive Medicine Moscow, Russian Federation, 101000 Less << |
NCT02832973 | Hypertension Resistant to Conv... More >>entional Therapy Less << | Phase 4 | Recruiting | March 2018 | Brazil ... More >> Juan Carlos Yugar-Toledo Recruiting São José do Rio Preto, São Paulo, Brazil, 15090000 Contact: Juan C Yugar-Toledo, MD, PhD +55-17-32271899 yugarjuan@uol.com.br Contact: Elizabeth DE Cestario, MD +55-17-997186562 cesatrio@cardiol.br Less << |
NCT01805362 | Chronic Kidney Disease | Not Applicable | Unknown | February 2017 | France ... More >> Department of Nephrology, Nice University Hospital Recruiting Nice, France, 06000 Contact: vincent Esnault, MD esnault.v@chu-nice.fr Principal Investigator: Vincent Esnault, MD Less << |
NCT02913664 | Cognitively Normal Older Adult... More >>s Hypertension Subjective Cognitive Decline Family History of Alzheimer's Disease Less << | Phase 2 Phase 3 | Recruiting | September 2022 | United States, Kansas ... More >> University of Kansas Medical Center Research Institute Recruiting Kansas City, Kansas, United States, 66160 Contact: Angela VanSciver 913-945-5029 avansciver@kumc.edu Principal Investigator: Jeffrey Burns, MD United States, Louisiana Pennington Biomedical Research Center Recruiting Baton Rouge, Louisiana, United States, 70808 Contact: Sara Goff 225-763-0910 sara.goff@pbrc.edu Principal Investigator: Jeffrey Keller, PhD United States, Missouri Washington University in St. Louis Recruiting Saint Louis, Missouri, United States, 63110 Contact: Monica Sewell 314-286-2716 sewellm@wustl.edu Principal Investigator: Ellen Binder, MD United States, Texas UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Lauren Braunfeld, BS 214-345-7134 LaurenBraunfeld@texashealth.org Contact: Ann Jacob, BSN 214-345-4665 AnnJacob@TexasHealth.org Principal Investigator: Rong Zhang, PhD Less << |
NCT00354328 | - | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << | |
NCT00498537 | Diabetic Nephropathy | Not Applicable | Completed | - | United States, Ohio ... More >> VA Medical Center, Dayton Dayton, Ohio, United States, 45428 Less << |
NCT01371747 | - | Completed | - | - | |
NCT00961207 | Microalbuminuria ... More >> Macroalbuminuric Diabetic Nephropathy Diabetes Proteinuria Albuminuria Less << | Phase 4 | Terminated(Altitude trial whic... More >>h used similar drugs was terminated due to increased ADR.) Less << | - | United States, Illinois ... More >> John H Stroger Hospital of Cook County Chicago, Illinois, United States, 60612 Less << |
NCT00274105 | Hypertension ... More >>Coronary Arteriosclerosis Less << | Phase 4 | Terminated | - | Germany ... More >> Universitätsklinikum Charité Berlin, Germany, 10117 Med. Hochschule Hannover Hannover, Germany, 30623 Less << |
NCT01180413 | Essential Hypertension ... More >> High Blood Pressure Less << | Phase 4 | Completed | - | Denmark ... More >> Aarhus University Hospital - dept. cardiology (A) Aarhus, Denmark, 8000 Less << |
NCT01230216 | Coronary Artery Disease ... More >> Hypertension Less << | Phase 4 | Terminated(Slow patients enrol... More >>lment) Less << | - | Japan ... More >> Division of Cardiology, Kyoto University Hospital Kyoto, Japan, 6066-8507 Less << |
NCT01715207 | Marfan Syndrome | Phase 3 | Completed | - | Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less << |
NCT01015937 | Diabetic Nephropathy ... More >> Proteinuria Less << | Not Applicable | Completed | - | Iran, Islamic Republic of ... More >> Clinic Shiraz, Fars, Iran, Islamic Republic of, 098 Less << |
NCT01715207 | - | Completed | - | - | |
NCT03276598 | Hypertension ... More >>Pharmacogenetics Less << | Phase 4 | Completed | - | Finland ... More >> Helsinki University Central Hospital Helsinki, Finland Less << |
NCT03417388 | Coronary Artery Disease | Phase 4 | Recruiting | December 30, 2022 | United States, California ... More >> Cedars-Sinai Heart Institute Recruiting Los Angeles, California, United States, 90048 Contact: Sophie Yoo, MS 310-423-3300 jihye.yoo@cshs.org Principal Investigator: Chrisandra Shufelt, MD LA BioMedical Recruiting Torrance, California, United States, 90502 Principal Investigator: Matthew Budoff, MD United States, Florida Family Medicine at Eastside Community Practice Recruiting Gainesville, Florida, United States, 32206 Family Medicine at Hampton Oaks Medical Plaza (Adults and Peds) Recruiting Gainesville, Florida, United States, 32607 Internal Medicine at Tower Hill Recruiting Gainesville, Florida, United States, 32607 Family Medicine at Haile Plantation (Adults & Peds) Recruiting Gainesville, Florida, United States, 32608 Cardiovascular Clinic at UF Health UF Recruiting Gainesville, Florida, United States, 32610 Internal Medicine at UF Health Medical Plaza Recruiting Gainesville, Florida, United States, 32610 UF Health at the University of Florida Recruiting Gainesville, Florida, United States, 32610 Cardiology West at Doctors Park Recruiting Gainesville, Florida, United States, 32611 Family Medicine at 4th Ave Recruiting Gainesville, Florida, United States, 32611 Family Medicine at Old Town (Adults and Peds) Recruiting Gainesville, Florida, United States, 32680 Baptist Health Recruiting Jacksonville, Florida, United States, 32207 Principal Investigator: Ruple Galani, MD Naval Hospital Jacksonville Recruiting Jacksonville, Florida, United States, 32214 UF Primary Care at Lake City SW Recruiting Lake City, Florida, United States, 32024 UF Primary Care at Lake City West Recruiting Lake City, Florida, United States, 32024 Novel Clinical Research Recruiting Miami, Florida, United States, 33186 Contact: Heber L Varela, MD 786-773-2737 Daytona Heart Group Recruiting Multiple Locations, Florida, United States, 32114 Contact: Glenn Rayos, MD 386-258-8722 Ocala Research Institute Inc. Recruiting Ocala, Florida, United States, 34480 Contact: Rakesh Prashad, MD 352-412-5989 Orlando Health Recruiting Orlando, Florida, United States, 32806 Principal Investigator: Arnold Einhorn, MD Naval Hospital Pensacola Recruiting Pensacola, Florida, United States, 32512 Principal Investigator: Carrie Gray, MD Florida Hospital Tampa - Pepin Heart Institute Recruiting Tampa, Florida, United States, 33613 Contact: Charles R Lambert, MD 813-615-7527 Interventional Cardiac Consultants Recruiting Tampa, Florida, United States, 33613 Contact: Carlos J Bayron, MD 727-842-9526 United States, Kentucky University of Kentucky Recruiting Lexington, Kentucky, United States, 40506 Principal Investigator: Gretchen Wells, MD Less << |
NCT00223717 | Hypertension | Phase 1 | Completed | - | United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37232 Less << |
NCT01878045 | - | Enrolling by invitation | January 25, 2035 | United States, Arizona ... More >> NIDDK, Phoenix Phoenix, Arizona, United States, 85014 Less << | |
NCT00572403 | - | Completed | - | Canada, Ontario ... More >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Less << | |
NCT04340557 | SARS-CoV Infection | PHASE4 | COMPLETED | 2020-06-13 | Sharp Grossmont Hospital, La M... More >>esa, California, 91942, United States|Sharp Chula Vista Medical Center, San Diego, California, 91911, United States|Sharp Memorial Hospital, San Diego, California, 92123, United States Less << |
NCT05012631 | Sickle Cell Disease|Diffuse My... More >>ocardial Fibrosis Less << | PHASE2 | RECRUITING | 2026-12-31 | Cincinnati Children's Hospital... More >> Medical Center, Cincinnati, Ohio, 45229, United States Less << |
NCT01479439 | Nephropathy|Sickle Cell Anemia | PHASE2 | COMPLETED | 2025-12-15 | University of Illinois at Chic... More >>ago, Chicago, Illinois, 60612, United States|University of Louisville, Louisville, Kentucky, 40201, United States|NHLBI, Bethesda, Maryland, 20892, United States|Akron Children's Hospital, Akron, Ohio, 44308, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|University of Cincinnati, Cincinnati, Ohio, 45229, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|University of Texas Southwestern, Dallas, Texas, 75390, United States|Texas Children's Hospital, Houston, Texas, 77030, United States Less << |
NCT03951142 | Glioblastoma|Brain Metastases | PHASE2 | ENROLLING_BY_INVITATION | 2024-12-31 | Oslo University Hospital, Oslo... More >>, 0372, Norway Less << |
NCT04335123 | COVID-19 | PHASE1 | COMPLETED | 2020-08-17 | University of Kansas Medical C... More >>enter, Kansas City, Kansas, 66160, United States Less << |
NCT05157464 | Arthrofibrosis | PHASE4 | WITHDRAWN | 2024-12-31 | NYU Langone Health, New York, ... More >>New York, 10016, United States Less << |
NCT00298714 | Chronic Hepatitis C|Liver Fibr... More >>osis Less << | PHASE4 | COMPLETED | 2025-01-06 | - |
NCT06333522 | Arthrofibrosis of Knee | PHASE4 | WITHDRAWN | 2026-01-01 | NYU Langone Health, New York, ... More >>New York, 10016, United States Less << |
NCT05243446 | Renal Transplant Failure|Cardi... More >>ovascular Complication Less << | UNKNOWN | 2023-12-31 | Medical University, Gdansk, 80... More >>-952, Poland Less << | |
NCT00001534 | Hypertrophic Cardiomyopathy|Le... More >>ft Ventricular Hypertrophy|Myocardial Ischemia Less << | COMPLETED | 2025-04-03 | National Heart, Lung and Blood... More >> Institute (NHLBI), Bethesda, Maryland, 20892, United States Less << | |
NCT06135493 | Peripheral Neuropathy Due to C... More >>hemotherapy Less << | PHASE2 | RECRUITING | 2025-03-30 | Breast Cancer Comprehensive Ce... More >>nter of the National Cancer Institute, Cairo University, Cairo, Egypt Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.36mL 0.47mL 0.24mL |
11.82mL 2.36mL 1.18mL |
23.65mL 4.73mL 2.36mL |
|
Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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