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CAS No. :	154447-36-6
Formula :	C₁₉H₁₇NO₃
M.W :	307.34
SMILES Code :	O=C1C=C(N2CCOCC2)OC3=C1C=CC=C3C4=CC=CC=C4
Synonyms :	SF 1101; NSC 697286
MDL No. :	MFCD00270881
InChI Key :	CZQHHVNHHHRRDU-UHFFFAOYSA-N
Pubchem ID :	3973

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

ADSCs	50 µM	24 h	To investigate the role of PI3K signaling on rGO/PCL induced neurotrophic phenotype changes and myelin protein secretion.	PMC9640298
H9C2 cells	25 μM	30 min	To explore the mechanisms of NGR1's protective effect on H9C2 cells.	PMC9287735
chondrocytes	20 μM	3 days	The study aims to investigate the effects of blood on chondrocyte viability and apoptosis.	PMC11076293
MLE-12 cells	50 μg/mL	24 h	LY294002 was used as a positive control to inhibit up-regulated expression of fibrosis-related genes.	PMC11515248
BMSCs	20 µM	0, 15, 30, 60, 120 min	LY294002 significantly inhibited the higher expression of osteogenic genes induced by Ginsenoside Rb1.	PMC8841501
CTLL-2 cells	50 μM	48 h	The purpose was to analyze the effect of LY294002 on the CTLL-2 cells in the presence of IL-7.	PMC10542607
Astrocytes	40 μM	immediately post-OGD/R	To inhibit PI3K signaling pathway and evaluate its effects on glycophagy.	PMC11215420
hWJ-MSCs	40 µM	2 h	Estimate the effects of the AKT inhibitor on the proliferation of FP2-cultured hWJ-MSCs.	PMC11331723
RAW 264.7	10 µM	24 h	To evaluate the effect of LY294002 on macrophage polarization.	PMC11162076
SKMEL28 melanoma cells	20 µM	2 h	The study involved the inhibition of AKT signaling to determine the effects on oxidative DNA damage repair; results showed reduced expression of OGG.	PMC11002308
various TNBC cell lines	2 μM	10 days	to investigate the effect of MAPK4 knockdown on cell growth and sensitivity to PI3K inhibitors	PMC8752662
Human fetal RPE cells	2 μM	4 days	To investigate the effect of glucose concentration on inflammatory responses, where inflammatory markers were evaluated.	PMC9561713
NHA/HRasV12/TRIM24 cells	0.01 to 100 μM	24, 48, and 72 h	Cell proliferation was evaluated and the half-maximal inhibitory concentration (IC50) values were determined from fitted concentration-response curves.	PMC11304257
RF24 cells	50 µM	6 h	The treatment resulted in reduced angiogenesis as inferred from subsequent experiments.	PMC10133315
HAEC and HSMEC	50 nM	30 min	To evaluate the effect of LY294002 on insulin uptake.	PMC10435471
U-251 and Ca9-22 cells	20 μm	2 h	To assess the impact of PI-3 kinase inhibition on cell behavior.	PMC9982589
hESCs	10 µM	24 h	To investigate the role of LY294002 in influencing differentiation to endoderm.	PMC9876972
Astrocytes	10 µM	1 h	AMPK inhibition reduces collective cell migration and invasion efficiency.	PMC9372137
Vascular Smooth Muscle Cells (VSMC)	50 μM	30 min	To inhibit the activation of Akt and study the effects on related signaling pathways.	PMC8980891
Human embryonic stem cells	5 μM	8 days	Induction of neuroectoderm differentiation.	PMC11109972
HUVECs	5 μg/mL	variable (6, 24, 48, and 72 h)	to observe the effects of the PI3K inhibitor as a negative control	PMC9972357
Primary chondrocytes	10 µM	24 h	LY294002 administration significantly reduced SNP-induced apoptosis activities and alleviated aberrant force-induced chondrocyte degeneration.	PMC9279410
RAW264.7 cells	25 µM	1 h	Inhibit PI3K signaling pathway and reduce M1 macrophage polarization	PMC11295337
BMDMs	25 µM	1 h	Inhibit PI3K signaling pathway and reduce M1 macrophage polarization	PMC11295337
neonatal rat cardiomyocytes (NRCMs)	10 μM	2 h	Inhibited PI3K α/AKT signaling, reversed FGF7-mediated promotion of Nrf2 nuclear translocation, and increased ROS levels and apoptotic cells	PMC9482143
human dental pulp stem cells	10 µM	7 days	LY294002 attenuated the responsiveness of 10−6 M insulin to IIS/PI3K/AKT/mTOR pathway axis, suppressing the promoting effect of insulin on cell proliferation, osteogenic differentiation and bone formation.	PMC11287875
PC-9R cells	25 μM		Inhibited the PI3K/AKT pathway and restored sensitivity to gefitinib in PC-9R cells	PMC8990424
BMDMs	0.5 μM	2 h	Inhibited PI3K/Akt/Nrf2 signaling pathway and increased NLRP3/Caspase-1/GSDMD protein expression	PMC10060206
A549 cells	10μM	1 h	Inhibited PI3K/AKT signaling pathway, alleviated TGF-β1-induced epithelial-mesenchymal transition (EMT)	PMC8959854
Huh7-SR cells	5 µM	1 h	Inhibited PI3K/Akt pathway, reduced Nrf2 nuclear translocation, and increased ferroptosis level	PMC8980859
HepG2-SR cells	5 µM	1 h	Inhibited PI3K/Akt pathway, reduced Nrf2 nuclear translocation, and increased ferroptosis level	PMC8980859
Mouse primary hepatocytes	10 μM	1.5 h	To evaluate the relationship between PI3K/AKT pathway and ferroptosis, LY294002 pretreatment exacerbated ferroptosis	PMC11495534

Mice	Experimental autoimmune hepatitis model	Intraperitoneal injection	30 mg/kg	Pretreatment 30 minutes before	Inhibit PI3K signaling pathway and reduce FGF4's regulatory effect on M1 macrophages	PMC11295337
C57BL/6 mice	Myocardial infarction model (LAD ligation)	Intraperitoneal injection	2.5 mg/kg	From LAD operation to 7 days post-operation	Inhibited PI3K α/AKT signaling, abolished FGF7-mediated regulation of Nrf2 and HXK2, and exacerbated myocardial oxidative stress and apoptosis	PMC9482143
BALB/c nude mice	PC-9R cell xenograft model	Intraperitoneal injection	2.5 mg/kg	Every three days for 12 days	LY294002 significantly reduced tumor volume and enhanced the anti-tumor effect of gefitinib	PMC8990424
C57BL/6 mice	Acute lung injury model	Injection	20 mg/kg	24 hours	Inhibited PI3K/Akt/Nrf2 signaling pathway and increased NLRP3/Caspase-1/GSDMD protein expression	PMC10060206
Mice	Bleomycin-induced pulmonary fibrosis model	Intraperitoneal injection	25 mg/kg	Every other day for 21 days	Inhibited PI3K/AKT signaling pathway, alleviated bleomycin-induced pulmonary fibrosis and EMT	PMC8959854
NOD mice	Diabetes model	Intraperitoneal injection	75 mg/kg	Daily for 3 days	Inhibition of PI3K signaling pathway to observe its effect on CD4+ T cell migration	PMC5101163
NOD-SCID mice	Subcutaneous tumor model	Intraperitoneal injection	25 mg/kg	Twice a week for 4 weeks	Inhibited PI3K/Akt pathway, slowed growth of FNDC5-overexpressing HCC cells, and increased ferroptosis level	PMC8980859
C57 mice	Liver warm ischemia/reperfusion model	Intraperitoneal injection	10 mg/kg	Single dose 36 h before liver ischemia followed by 6 h reperfusion	To assess the role of PI3K/AKT pathway in hepatic I/R injury, LY294002 pretreatment abolished the protective effect of rmGas6 and exacerbated ferroptosis	PMC11495534

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CAS No.: 154447-36-6

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CAS No.: 154447-36-6

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed