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Structure of Meloxicam
CAS No.: 71125-38-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 = 11.8 μM) over COX1 (IC50 = 143 μM) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity.
Synonyms: UH-AC 62XX
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Patel, Roshni P ; Taylor, Lynne S ; Polli, James E ;
Abstract: A hollow fiber membrane (HFM) was previously characterized as a potential permeation component of a dissolution/permeation system. Two objectives were to assess the impact of micellization on drug permeation across HFM and identify a preferred permeation model from three models: permeation from only free drug, permeation from both free drug and micelle-bound drug, and permeation with enhancement from micelle shuttling. HFM studies were conducted under unsaturated drug conditions, using griseofulvin and the more hydrophilic drug meloxicam, with and without surfactant [sodium lauryl sulfate, polysorbate 80, and polyoxyethylene (10) lauryl ether]. Griseofulvin was micelle incorporated to a greater extent than meloxicam, such that griseofulvin flux decreased to a greater extent than for meloxicam. The griseofulvin permeation model from only free drug was rejected, since griseofulvin flux required free drug to be about 5-20 fold higher in HFM flux studies than supported by solubility studies, depending on surfactant. Permeation from both free griseofulvin and micelle-bound griseofulvin successfully accommodated observed flux, where micelle permeability was about 5-fold lower than free drug permeability for HFM with 10KDa MWCO. Permeation with enhancement from micelle shuttling was not the preferred explanation, although the model accommodated flux data and provided aqueous boundary layer thicknesses similar to other setups.
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Keywords: surfactant ; micelle ; permeability ; solubility ; flux ; equilibrium coefficient ; free drug ; griseofulvin
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Wegner, Scott A ; Kim, Hahn ; Avalos, José L ;
Abstract: Lactate transport plays a crucial role in the metabolism, microenvironment, and survival of cancer cells. However, current drugs targeting either MCT1 or MCT4, which traditionally mediate lactate import or efflux respectively, show limited efficacy beyond in vitro models. This limitation partly arises from the existence of both isoforms in certain tumors, however existing high-affinity MCT1/4 inhibitors are years away from human testing. Therefore, we conducted an optogenetic drug screen in Saccharomyces cerevisiae on a subset of the FDA-approved drug library to identify existing scaffolds that could be repurposed as monocarboxylate transporter (MCT) inhibitors. Our findings show that several existing drug classes inhibit MCT1 activity, including non-steroidal estrogens, non-steroidal anti-inflammatory drugs (NSAIDs), and natural products (in total representing approximately 1% of the total library, 78 out of 6400), with a moderate affinity (IC50 1.8–21 μM). Given the well-tolerated nature of NSAIDs, and their known anticancer properties associated with COX inhibition, we chose to further investigate their MCT1 inhibition profile. The majority of NSAIDs in our screen cluster into a single large structural grouping. Moreover, this group is predominantly comprised of FDA-approved NSAIDs, with seven exhibiting moderate MCT1 inhibition. Since these molecules form a distinct structural cluster with known NSAID MCT4 inhibitors, such as diclofenac, ketoprofen, and indomethacin, we hypothesize that these newly identified inhibitors may also inhibit both transporters. Consequently, NSAIDs as a class, and piroxicam specifically (IC50 4.4 μM), demonstrate MCT1 inhibition at theoretically relevant human dosages, suggesting immediate potential for standalone MCT inhibition or combined anticancer therapy.
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Purchased from AmBeed: 61-68-7 ; 22071-15-4 ; 1448671-31-5 ; 169590-42-5 ; 71125-38-7 ; 29679-58-1 ; 42924-53-8 ; 162011-90-7 ; 500-38-9
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CAS No. : | 71125-38-7 |
Formula : | C14H13N3O4S2 |
M.W : | 351.40 |
SMILES Code : | O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3 |
Synonyms : |
UH-AC 62XX
|
MDL No. : | MFCD00868752 |
InChI Key : | ZRVUJXDFFKFLMG-UHFFFAOYSA-N |
Pubchem ID : | 54677470 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H301 |
Precautionary Statements: | P501-P270-P264-P301+P310+P330-P405 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
U937 cells | 500 µM | 6 h | Test the effect of Meloxicam on the DNA-sensing pathway in U937 cells, results showed that Meloxicam inhibited the DNA-sensing pathway | Cell Biosci. 2023 Apr 29;13(1):76. |
L929 cells | 500 µM | 6 h | Test the effect of Meloxicam on the DNA-sensing pathway in L929 cells, results showed that Meloxicam inhibited the DNA-sensing pathway | Cell Biosci. 2023 Apr 29;13(1):76. |
L929 cells | 1000 µM | 24 h | Test the cytotoxicity of Meloxicam on L929 cells, results showed that concentrations below 1000 µM are safe for the cells | Cell Biosci. 2023 Apr 29;13(1):76. |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | Trex1–/– mouse model | Intraperitoneal injection | 5 mg/kg | Once daily for 90 days | Test the effect of Meloxicam on the Trex1–/– mouse model, results showed that Meloxicam significantly increased the survival rate of the mice | Cell Biosci. 2023 Apr 29;13(1):76. |
Wistar rats | Osteoarthritis model | Intra-articular injection | 9.45 mg/kg | Single injection, observed for 144 hours | To evaluate the pharmacokinetics, tissue distribution, and pharmacodynamics of Meloxicam microspheres in vivo. The results showed that intra-articular injection of Meloxicam microspheres could prolong the drug action time and reduce side effects. | Drug Deliv. 2022 Dec;29(1):3317-3327 |
Mice | Alzheimer's disease model | Intragastric gavage | 5 mg/kg | Once every 48 hours for 12 days | To investigate the effects of Meloxicam on cognitive impairment in a mouse model of Alzheimer's disease, results showed that Meloxicam improved memory impairment in mice. | Neural Regen Res. 2021 Apr;16(4):783-789 |
Rats | Transient focal cerebral ischemia model | Intravenous injection | 1 mg/kg | 1 and 24 hours after reperfusion | To evaluate the neuroprotective effects of Meloxicam in a transient focal cerebral ischemia model. Results showed that Meloxicam maintained neuroprotective effects after 48 hours and 7 days of reperfusion, modulated glial scar reactivity, increased axonal sprouting, but decreased the formation of neuronal progenitor cells. | Neural Regen Res. 2023 Sep;18(9):1961-1967 |
Dogs | Ovariectomy model | Subcutaneous and oral | 0.2 mg/kg, 0.1 mg/kg | Once before surgery and every 24 hours after surgery until the end of the experiment | To evaluate the effect of Meloxicam on oxidative stress and serotonin levels during ovariectomy. Results showed a significant increase in oxidative stress and serotonin levels post-surgery, with a positive correlation between the two. | Vet Q. 2024 Dec;44(1):1-8 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02191358 | - | Completed | - | United States, California ... More >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 Less << | |
NCT01638962 | Osteoarthritis, Knee | Not Applicable | Completed | - | Denmark ... More >> University of Southern Denmark Odense, Region Syddanmark, Denmark, 5230 Less << |
NCT03549611 | Kidney Calculi ... More >> Pain, Postoperative Less << | Phase 4 | Not yet recruiting | June 30, 2019 | - |
NCT02456363 | Ankylosing Spondylitis | Phase 2 | Recruiting | December 2019 | Taiwan ... More >> Chung Shan Medical University Hospital Recruiting Taichung, Taiwan Contact: Cheng-Chung Wei, M.D., Ph.D. 24739595 ext 34718 wei3228@gmail.com Less << |
NCT03540030 | Opioid Use Sh... More >>oulder Osteoarthritis Avascular Necrosis Rotator Cuff Tear Arthritis;Inflammatory Less << | Phase 4 | Active, not recruiting | June 2019 | United States, North Carolina ... More >> OrthoCarolina Research Institute Charlotte, North Carolina, United States, 28207 Less << |
NCT00688545 | - | Terminated(See termination rea... More >>son in detailed description.) Less << | - | - | |
NCT03718039 | Analgesia | Phase 2 | Recruiting | January 2, 2019 | United States, Texas ... More >> Endeavor Clinical Trials, LLC Recruiting San Antonio, Texas, United States, 78229 Less << |
NCT00447759 | Osteoarthritis ... More >> Rheumatoid Arthritis Less << | Phase 4 | Completed | - | Denmark ... More >> University of Southern Denmark Odense, Denmark, 5000 Netherlands Julius Clinical Research Zeist, Netherlands, 3703 CD Zeist United Kingdom University of Aberdeen Aberdeen, United Kingdom, AB25 2ZN University of Birmingham Birmingham, United Kingdom, B15 2TT University of Dundee Dundee, United Kingdom, DD1 9SY University of Edinburgh Edinburgh, United Kingdom, EH4 2XU University of Glasgow Glasgow, United Kingdom, G11 6NT NHS Highlands Inverness, United Kingdom, IV2 3JH University of Nottingham Nottingham, United Kingdom, NG7 2UH University of Oxford Oxford, United Kingdom, OX1 2ET Less << |
NCT00688545 | - | Terminated(See termination rea... More >>son in detailed description.) Less << | - | - | |
NCT01782287 | Neoplasm Metastasis | Phase 2 Phase 3 | Enrolling by invitation | December 2020 | Russian Federation ... More >> ZAO "NeuroVita Clinic of Interventional and Restorative Neurology and Therapy" Moscow, Russian Federation, 115478 Less << |
NCT01782274 | Neoplasm Metastasis | Phase 2 Phase 3 | Enrolling by invitation | December 2020 | Russian Federation ... More >> ZAO "NeuroVita Clinic of Interventional and Restorative Neurology and Therapy" Moscow, Russian Federation, 115478 Less << |
NCT01759810 | Glioblastoma | Phase 2 Phase 3 | Enrolling by invitation | December 2020 | Russian Federation ... More >> ZAO "NeuroVita Clinic of Interventional and Restorative Neurology and Therapy" Moscow, Russian Federation, 115478 Less << |
NCT01979510 | Low Back Pain | Phase 3 | Withdrawn | May 2014 | - |
NCT01335542 | - | Completed | - | - | |
NCT02403687 | - | Completed | - | - | |
NCT01335542 | Readiness to Discharge | Phase 4 | Completed | - | United States, New York ... More >> Hospital for Special Surgery New York, New York, United States, 10021 Less << |
NCT02187575 | Healthy | Phase 1 | Completed | - | - |
NCT02180490 | Healthy | Phase 1 | Completed | - | - |
NCT01789216 | Pilon Fracture | Phase 3 | Active, not recruiting | December 2018 | United States, Florida ... More >> University of Miami Ryder Trauma Center Miami, Florida, United States St. Mary's Medical Center West Palm Beach, Florida, United States United States, Indiana Eskenazi Health Indianapolis, Indiana, United States United States, Iowa University of Iowa Hospitals & Clinics Iowa City, Iowa, United States United States, Louisiana Louisiana State University Health Sciences Center Shreveport, Louisiana, United States United States, Maryland Johns Hopkins University Baltimore, Maryland, United States University of Maryland, R Adams Cowley Shock Trauma Center Baltimore, Maryland, United States United States, Massachusetts Boston Medical Center Boston, Massachusetts, United States United States, Minnesota Hennepin County Medical Center Minneapolis, Minnesota, United States United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States United States, Ohio MetroHealth Medical Center Cleveland, Ohio, United States United States, Pennsylvania Penn State University M.S. Hershey Medical Center Hershey, Pennsylvania, United States University of Pittsburgh Pittsburgh, Pennsylvania, United States United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States United States, Texas University of Texas Southwestern Medical Center Dallas, Texas, United States UT Health: The University of Texas Health Science Center at Houston Medical School Houston, Texas, United States United States, Virginia Naval Medical Center Portsmouth Portsmouth, Virginia, United States Less << |
NCT00945763 | Dental Pain | Phase 2 | Completed | - | United States, Utah ... More >> Jean Brown Research Salt Lake City, Utah, United States, 84124 Less << |
NCT03364816 | - | Not yet recruiting | December 31, 2018 | - | |
NCT03092193 | Poor Metabolizer Due to Cytoch... More >>rome P450 CYP2C9 Variant Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant Less << | Phase 4 | Recruiting | December 2018 | Brazil ... More >> Bauru School of Dentistry/USP Recruiting Bauru, São Paulo, Brazil, 17012-901 Contact: Adriana M Calvo, PhD 551432358276 birinjela@yahoo.com.br Less << |
NCT00640029 | Lumbar Degenerative Disc Disea... More >>se Cervical Degenerative Disc Disease Kyphosis Less << | Not Applicable | Terminated(Insuffisent recruit... More >>ment) Less << | - | France ... More >> Service de Chirurgie CHU Hopital Antoine Béclère Clamart, France, 92140 Service de Neurochirurgie CHU Saint-Etienne Saint-etienne, France Less << |
NCT03717714 | Osteoarthritis of the Knee | Not Applicable | Completed | - | Vietnam ... More >> 198 Hospital Hanoi, Vietnam Less << |
NCT03586934 | Shoulder Pain ... More >> Opioid Use Less << | Phase 3 | Recruiting | September 1, 2020 | United States, Illinois ... More >> Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Kassie Blanchard, MA 312-432-2452 nicholson.research@rushortho.com Contact: Charles P Hannon, MD 203-247-9390 charles.p.hannon@gmail.com Less << |
NCT03473665 | Ankylosing Spondylitis ... More >> Axial Spondyloarthritis Less << | Phase 4 | Recruiting | May 1, 2019 | United States, New York ... More >> Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Christopher Depender 212-305-4114 cd2686@cumc.columbia.edu Less << |
NCT02924506 | Neck Pain Bac... More >>k Pain Less << | Not Applicable | Recruiting | February 19, 2020 | France ... More >> CHR d'ORLEANS Recruiting Orleans, France, 45067 Contact: Thierry DUFOUR, Ph 33 2 38 61 34 46 thierry.dufour@chr-orleans.fr Principal Investigator: Thierry DUFOUR, Ph Hôpital Bretonneau, CHU DE TOURS Recruiting Tours, France, 37044 Contact: Jean-Edouard LORET, Ph Principal Investigator: Jean-Edouard LORET, Ph Less << |
NCT02448199 | Osteoarthritis | Phase 3 | Unknown | July 2016 | - |
NCT03434275 | Pain, Postoperative | Phase 3 | Recruiting | December 2018 | United States, Alabama ... More >> Research Center Recruiting Florence, Alabama, United States, 35630 Research Center Recruiting Mobile, Alabama, United States, 36608 Research Center Recruiting Sheffield, Alabama, United States, 35660 United States, Arizona Research Center Recruiting Tempe, Arizona, United States, 85284 United States, Florida Research Center Recruiting Tamarac, Florida, United States, 33321 Research Center Recruiting Vero Beach, Florida, United States, 32960 Less << |
NCT00635349 | Osteoarthritis | Phase 4 | Completed | - | - |
NCT02184039 | - | Completed | - | - | |
NCT02540265 | Pain, Post-operative | Phase 2 | Completed | - | United States, Maryland ... More >> Chesapeake Research Group, LLC Pasadena, Maryland, United States Less << |
NCT00554528 | Clinical Radiculopathy ... More >> Myelopathy Due to a Cervical Disk Disease Less << | Phase 4 | Completed | - | France ... More >> Department of Neurosurgery, CHU de Nice Nice, France, 06000 Less << |
NCT02678286 | Pain, Post-operative | Phase 3 | Completed | - | United States, California ... More >> Lotus Clinical Research, LLC Pasadena, California, United States United States, Texas HD Research Bellaire, Texas, United States Research Concepts Bellaire, Texas, United States Endeavor Clinical Trials San Antonio, Texas, United States Less << |
NCT02675907 | Pain, Post-operative | Phase 3 | Completed | - | United States, California ... More >> Trovare Clinical Research Bakersfield, California, United States Lotus Clinical Research Pasadena, California, United States United States, Maryland Chesapeake Research Group Pasadena, Maryland, United States United States, Texas Endeavor Clinical Trials San Antonio, Texas, United States Less << |
NCT00635349 | - | Completed | - | - | |
NCT03323385 | Pain, Postoperative | Phase 3 | Recruiting | August 2018 | United States, Alabama ... More >> Research Center Recruiting Florence, Alabama, United States, 35630 Research Center Recruiting Mobile, Alabama, United States, 36605 United States, Florida Research Center Recruiting Miami, Florida, United States, 33136 Research Center Recruiting Tampa, Florida, United States, 33606 United States, Louisiana Research Center Recruiting Metairie, Louisiana, United States, 70006 United States, Mississippi Research Center Recruiting Jackson, Mississippi, United States, 39202 United States, Ohio Research Center Recruiting Cleveland, Ohio, United States, 44111 Research Center Recruiting Cleveland, Ohio, United States, 44195 Research Center Recruiting Columbus, Ohio, United States, 43210 United States, Pennsylvania Research Center Recruiting Philadelphia, Pennsylvania, United States, 19140 Less << |
NCT01799213 | Knee Osteoarthritis | Phase 2 | Active, not recruiting | December 31, 2018 | United States, Connecticut ... More >> VA Connecticut Healthcare System West Haven Campus, West Haven, CT West Haven, Connecticut, United States, 06516 United States, Florida North Florida/South Georgia Veterans Health System, Gainesville, FL Gainesville, Florida, United States, 32608 United States, Massachusetts VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA Boston, Massachusetts, United States, 02130 United States, Rhode Island Providence VA Medical Center, Providence, RI Providence, Rhode Island, United States, 02908 Less << |
NCT02720692 | Pain, Post-operative | Phase 3 | Completed | - | - |
NCT02678286 | - | Completed | - | - | |
NCT02675907 | - | Completed | - | - | |
NCT01147289 | Lumbar Sciatic Pain | Phase 3 | Completed | - | Brazil ... More >> CEDOES Vitoria, Espirito Santo, Brazil, 29055-450 Sociedade Beneficente São Camilo Campinas, São Paulo, Brazil, 05022-001 Instituto De Pesquisa Clínica De Campinas IPECC Campinas, São Paulo, Brazil, 13073-350 Instituto de Pesquisa Clínica e Medicina Avançada Ltda IMA São paulo, Brazil, 05437-010 Hospital Santa Marcelina São Paulo, Brazil, 08270-070 Faculdade de Medicina ABC São Paulo, Brazil, 0960-650 Less << |
NCT00389597 | Degenerative Disc Disease | Not Applicable | Completed | - | United States, Arizona ... More >> Texas Back Institute-West Phoenix, Arizona, United States, 85015 United States, California Southern California Institute of Neurological Surgery Escondido, California, United States, 92122 Massoudi & Jackson Neurosurgical Association Laguna Hills, California, United States, 92653 Memorial Orthopaedic Surgical Group Long Beach, California, United States, 90806 Eisenhower Medical Center Rancho Mirage, California, United States, 92270 University of California- Davis Medical Center Sacramento, California, United States, 95817 Spine Institute at St. John's Health Center Santa Monica, California, United States, 90404 Stanford University Stanford, California, United States, 94305 United States, Colorado Panorama Orthopedics and Spine Care Golden, Colorado, United States, 80401 United States, Florida Southeastern Clinical Research Orlando, Florida, United States, 32804 United States, Indiana Orthopaedics North East Fort Wayne, Indiana, United States, 46825 United States, Louisiana Spine Institute of Louisiana Shreveport, Louisiana, United States, 71101 United States, Maryland GBMC Healthcare Baltimore, Maryland, United States, 21204 United States, Michigan University Neurologic Systems Detroit, Michigan, United States, 48201 St. Mary's of Saginaw Field Neurosciences Institute Saginaw, Michigan, United States, 48604 United States, New York Simmons Orthopaedics and Spine Associates Buffalo, New York, United States, 14201 Orthopedic Spine Care of Long Island Melville, New York, United States, 11747 United States, Ohio The Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Oklahoma Oklahoma Spine & Brain Institute Tulsa, Oklahoma, United States, 74132 United States, Texas Austin Brain and Spine Austin, Texas, United States, 78701 Foundation Surgical Hospital Houston, Texas, United States, 77401 West Texas Spine Odessa, Texas, United States, 79761 Texas Back Institute Plano, Texas, United States, 75093 Texas Spine and Joint Hospital Tyler, Texas, United States, 75701 Less << |
NCT02183103 | Healthy | Phase 1 | Completed | - | - |
NCT02540265 | - | Completed | - | - | |
NCT00389597 | - | Completed | - | - | |
NCT00619177 | - | Completed | - | - | |
NCT00612885 | - | Completed | - | Korea, Republic of ... More >> Boehringer Ingelheim Investigational Site Busan, Korea, Republic of Boehringer Ingelheim Investigational Site Chungbuk, Korea, Republic of Boehringer Ingelheim Investigational Site Daegu, Korea, Republic of Boehringer Ingelheim Investigational Site Daejeon, Korea, Republic of Boehringer Ingelheim Investigational Site Gangwondo, Korea, Republic of Boehringer Ingelheim Investigational Site Gwangju, Korea, Republic of Boehringer Ingelheim Investigational Site Gyeongbuk, Korea, Republic of Boehringer Ingelheim Investigational Site Gyeonggido, Korea, Republic of Boehringer Ingelheim Investigational Site Gyeongnam, Korea, Republic of Boehringer Ingelheim Investigational Site Jeonnam, Korea, Republic of Boehringer Ingelheim Investigational Site Seoul, Korea, Republic of Less << | |
NCT03354117 | Contraception | Phase 1 | Recruiting | July 31, 2019 | United States, California ... More >> Stanford University Recruiting Stanford, California, United States, 94305 Contact: Erica Cahill, MD 650-721-1562 epcahill@stanford.edu Contact: Klaira Lerma, MPH 6507211562 klerma@stanford.edu Less << |
NCT02183051 | Pain | Phase 2 | Completed | - | - |
NCT00279747 | Arthritis, Juvenile Rheumatoid | Phase 3 | Completed | - | Austria ... More >> Landes-Kinderklinik Linz Linz, Austria, 4020 Univ.-Klinik für Kinder- und Jugendheilkunde Wien Wien, Austria, 1090 Gottfried Preyersches Kinderspital d. Stadt Wien Wien, Austria, 1100 Wien Belgium UZ Gent Gent, Belgium, 9000 U.Z. Gasthuisberg Leuven, Belgium, 3000 Boehringer Ingelheim Investigational Site Merksem, Belgium, 2170 France Boehringer Ingelheim Investigational Site Angers, France Boehringer Ingelheim Investigational Site Lille, France Boehringer Ingelheim Investigational Site Marseille, France Boehringer Ingelheim Investigational Site Paris, France Boehringer Ingelheim Investigational Site Strasbourg, France Boehringer Ingelheim Investigational Site Vandoeuvre les Nancy, France Germany Rheumaklinik Bad Bramstedt GmbH Bad Bramstedt, Germany, 24572 Neurologie Bremen, Germany, 28325 Universität Erlangen Erlangen, Germany, 91054 Martin-Luther-Universität Halle Halle/Saale, Germany, 06097 Boehringer Ingelheim Investigational Site Hamburg, Germany, 22081 Bayrische Julius-Maximilians-Universität Würzburg, Germany, 97080 Italy Ospedale Meyer Firenze, Italy, 50132 Istituto G. Gaslini Genova, Italy, 16147 Istituto Ortopedico Gaetano Pini Milano, Italy, 20122 II Università degli Studi di Napoli Napoli, Italy, 80129 Università Federico II Napoli, Italy, 80131 Clinica Pediatrica I Padova, Italy, 35128 IRCCS Policlinico San Matteo Pavia, Italy, 27100 Ospedale Pediatrico Bambin Gesù Roma, Italy, 00165 IRCCS Burlo Garofalo Trieste, Italy, 34137 Russian Federation Institute of Rheumatology of RAMN Moscow, Russian Federation, 115522 Medical Faculty of Russian People Friendship University Moscow, Russian Federation, 117049 Scientific Research Institute of Pediatric Hematology Moscow, Russian Federation, 117513 Medical Academy Setchenov Moscow, Russian Federation, 119435 United Kingdom Dept. of Child Health London, United Kingdom, WC1N 3JH Booth Hall Childrens Hospital Manchester, United Kingdom, M9 7AA Paediatric Department Wolverhampton, United Kingdom, WV10 0QP Less << |
NCT02183142 | Healthy | Phase 1 | Completed | - | - |
NCT00619177 | - | Completed | - | - | |
NCT00034853 | Arthritis, Juvenile Rheumatoid | Phase 3 | Completed | - | - |
NCT02060006 | Tuberculosis | Phase 3 | Unknown | - | South Africa ... More >> Stellenbosch University Tygerberg Hospital Recruiting Cape Town, Western Cape Province, South Africa, 7505 Contact: Jean B Nachega, MD, PhD +27219389933 JNACHEGA@SUN.AC.ZA Principal Investigator: Jean B Nachega, MD, PhD Less << |
NCT02298218 | Biliary Atresia, Kasai Portoen... More >>terostomy Status Less << | PHASE4 | COMPLETED | 2025-12-11 | - |
NCT02276352 | Healthy | Phase 1 | Completed | - | - |
NCT03173027 | Fangji Huangqi Pill ... More >> Knee Osteoarthritis Less << | Phase 2 Phase 3 | Recruiting | December 31, 2018 | China, Shanghai ... More >> Longhua Hospital, Shanghai University of TCM Recruiting Shanghai, Shanghai, China, 200032 Contact: Qianqian Liang, Doctor 86-021-64875390 liangqianqiantcm@126.com Contact: Qiong Wang 86-13671779096 13671779096@163.com Principal Investigator: Yongjun Wang, Doctor Less << |
NCT00042068 | Arthritis, Rheumatoid | PHASE3 | COMPLETED | 2025-07-03 | Suites 570 (research) & 600 (P... More >>I), Huntsville, Alabama, 35801, United States|Suite 200, Montgomery, Alabama, 36106, United States|Suite 140, Anchorage, Alaska, 99508, United States|#106, Glendale, Arizona, 85308, United States|Suite 601, Phoenix, Arizona, 85012, United States|Suite 201, Phoenix, Arizona, 85015, United States|Boehringer Ingelheim Investigational Site, Los Angeles, California, 90048, United States|Boehringer Ingelheim Investigational Site, Pasadena, California, 91105, United States|Suite 100, Rancho Cucamonga, California, 91730, United States|Boehringer Ingelheim Investigational Site, Rancho Mirage, California, 92270-4469, United States|Suite 208, San Diego, California, 92108, United States|Suite 202, San Diego, California, 92120, United States|Suite 301, San Leandro, California, 94578, United States|Suite A, Santa Maria, California, 93454, United States|Westlake Medical Research, Westlake Village, California, 91361, United States|Suite 200, Colorado Springs, Colorado, 80910, United States|Suites 205 & 206, Danbury, Connecticut, 06810, United States|Suite 300, Washington, District of Columbia, 20006, United States|Boehringer Ingelheim Investigational Site, Del Ray Beach, Florida, 33484, United States|Boehringer Ingelheim Investigational Site, Gainsville, Florida, 32607, United States|Boehringer Ingelheim Investigational Site, Jacksonville, Florida, 32204, United States|Boehringer Ingelheim Investigational Site, Largo, Florida, 33773, United States|Suite 202, Miami, Florida, 33173, United States|Boehringer Ingelheim Investigational Site, Ocala, Florida, 03474, United States|Renstar Medical Research, Ocala, Florida, 34471, United States|Boehringer Ingelheim Investigational Site, Orlando, Florida, 32804, United States|Suite 2, Orlando, Florida, 32806, United States|Suite 406, Safety Harbor, Florida, 34695, United States|Boehringer Ingelheim Investigational Site, Sarasota, Florida, 34239, United States|Boehringer Ingelheim Investigational Site, South Miami, Florida, 33143, United States|Suite 101, St. Petersburg, Florida, 33710, United States|Radiant Research, Stuart, Florida, 34996, United States|Suite 203, Tampa, Florida, 33614, United States|Boehringer Ingelheim Investigational Site, Zephyrhills, Florida, 33540, United States|Boehringer Ingelheim Investigational Site, Coeur d'Alene, Idaho, 83814-2644, United States|Suite 202, Idaho Falls, Idaho, 83404, United States|Boehringer Ingelheim Investigational Site, Lake Forest, Illinois, 60045, United States|Boehringer Ingelheim Investigational Site, Rockford, Illinois, 61103, United States|Boehringer Ingelheim Investigational Site, Springfield, Illinois, 62704, United States|Boehringer Ingelheim Investigational Site, Indianapolis, Indiana, 46202, United States|Attn: Kathy Stoddard, Director, Wichita, Kansas, 67207, United States|Suite 306, Wheaton, Maryland, 20902, United States|Truesdale Clinic, Fall River, Massachusetts, 02720, United States|Suite 202, Kalamazoo, Michigan, 49009, United States|Suite 101, St. Louis, Missouri, 63128, United States|Suite 240, St. Louis, Missouri, 63141, United States|Boehringer Ingelheim Investigational Site, Lincoln, Nebraska, 68506, United States|Boehringer Ingelheim Investigational Site, Reno, Nevada, 89502-1196, United States|PC, Jackson Commons D-2, Medford, New Jersey, 08055, United States|Suite 8, Mercerville, New Jersey, 08619, United States|Boehringer Ingelheim Investigational Site, New York, New York, 10021, United States|Suite 100, Charlotte, North Carolina, 28210, United States|Boehringer Ingelheim Investigational Site, Columbus, Ohio, 43214, United States|Boehringer Ingelheim Investigational Site, Tulsa, Oklahoma, 74135, United States|Boehringer Ingelheim Investigational Site, Camp Hill, Pennsylvania, 17011, United States|Altoona Center for Clinical Research, Duncansville, Pennsylvania, 16635, United States|Boehringer Ingelheim Investigational Site, Erie, Pennsylvania, 16508-1256, United States|Suite D, Mechanicsburg, Pennsylvania, 17055, United States|Suite 331-333, Johnston, Rhode Island, 02919, United States|Boehringer Ingelheim Investigational Site, Columbia, South Carolina, 29204, United States|Suite H, North Charleston, South Carolina, 29406, United States|Boehringer Ingelheim Investigational Site, Orangeburg, South Carolina, 29118, United States|Boehringer Ingelheim Investigational Site, Austin, Texas, 78705, United States|Boehringer Ingelheim Investigational Site, Dallas, Texas, 75225, United States|Radiant Research, Dallas, Texas, 75231, United States|Suite 200, Dallas, Texas, 75246-1632, United States|Suite 500, Lubbock, Texas, 79410, United States|Suites 207, San Antonio, Texas, 78217, United States|Suite 2A, Falls Church, Virginia, 22044, United States|Boehringer Ingelheim Investigational Site, Everett, Washington, 98201, United States|Suite D-3, Seattle, Washington, 98166-2967, United States|Boehringer Ingelheim Investigational Site, Yakima, Washington, 98902, United States|Boehringer Ingelheim Investigational Site, Buenos Aires, 1405, Argentina|Boehringer Ingelheim Investigational Site, Buenos Aires, 1427, Argentina|Boehringer Ingelheim Investigational Site, Buenos Aires, 1428, Argentina|Boehringer Ingelheim Investigational Site, Rosario, 2000, Argentina|Boehringer Ingelheim Investigational Site, Cotton Tree, Queensland, 4558, Australia|Emeritus Research, Malvern, Victoria, 3144, Australia|Department of Rheumatology, Perth, Western Australia, 6004, Australia|Clinique du Parc Léopold, Bruxelles, 1040, Belgium|Medisch Centrum van Huisartsen, Leuven, 3000, Belgium|Av Anhanguera 6479, Goiania GO, 74043-011, Brazil|Rua Ramiro Barcelos 2350, Porto Alegre RS, 90035-003, Brazil|Boehringer Ingelheim Investigational Site, S?o Paulo - SP, 04040-000, Brazil|Clínica de Doen?as Parasitárias e Infecciosas-Hospital Dia, S?o Paulo - SP, 04230-000, Brazil|230-6091, Richmond, British Columbia, V7C 5L9, Canada|Boehringer Ingelheim Investigational Site, Victoria, British Columbia, V8P 5P6, Canada|Boehringer Ingelheim Investigational Site, Corunna, Ontario, N0N 1G0, Canada|Boehringer Ingelheim Investigational Site, Fort Erie, Ontario, L2A 1Z3, Canada|Boehringer Ingelheim Investigational Site, Hamilton, Ontario, L8N 1Y2, Canada|Dr. Denis O'Donnell, Kingston, Ontario, K7L 2V6, Canada|Trillium Health Centre, Mississauga, Ontario, L5B 4A2, Canada|Boehringer Ingelheim Investigational Site, Ottawa, Ontario, K2P 1V3, Canada|Boehringer Ingelheim Investigational Site, Peterborough, Ontario, K9J 7H8, Canada|Boehringer Ingelheim Investigational Site, Sarnia, Ontario, N7T 4X3, Canada|Boehringer Ingelheim Investigational Site, Scarborough, Ontario, M1B 4Y9, Canada|104-532, St. Catharines, Ontario, L2N 4H4, Canada|Boehringer Ingelheim Investigational Site, Toronto, Ontario, M3B 2H9, Canada|Boehringer Ingelheim Investigational Site, Windsor, Ontario, N8W 5L7, Canada|Boehringer Ingelheim Investigational Site, Montreal, Quebec, H3G 1A4, Canada|Boehringer Ingelheim Investigational Site, Montreal, Quebec, H3Z, 2Z3, Canada|Boehringer Ingelheim Investigational Site, Pointe-Claire, Quebec, H9R 3J1, Canada|Boehringer Ingelheim Investigational Site, Marseille, 13008, France|Boehringer Ingelheim Investigational Site, Nice, 06000, France|Boehringer Ingelheim Investigational Site, Tours cedex 9, 37044, France|Boehringer Ingelheim Investigational Site, Tours, 37000, France|Boehringer Ingelheim Investigational Site, Aachen, 52064, Germany|Augusta-Klinik, Bad Kreuznach, 55543, Germany|Boehringer Ingelheim Investigational Site, Bad Segeberg, 23795, Germany|Rheumatologie und Physikalische Therapie, Berlin, 14059, Germany|Boehringer Ingelheim Investigational Site, Ellefeld, 08236, Germany|Elisabeth-Krankenhaus, Essen, 45356, Germany|Boehringer Ingelheim Investigational Site, Klotten, 56818, Germany|ClinPharm International GmbH & Co. KG, Leipzig, 04229, Germany|Boehringer Ingelheim Investigational Site, München, 81541, Germany|Boehringer Ingelheim Investigational Site, Nürnberg, 90402, Germany|Boehringer Ingelheim Investigational Site, Nürnberg, 90461, Germany|Boehringer Ingelheim Investigational Site, Steinh?ring, 85643, Germany|Boehringer Ingelheim Investigational Site, Tübingen, 72070, Germany|Klinik für Rheumatologie,, Wiesbaden, 65191, Germany|National Institute for Rheumatology and Physiotherapy, Budapest, 1027, Hungary|DOTE, Debrecen, 4031, Hungary|Aladár Petz County Hospital, Gy?r, 9024, Hungary|St. Andrew State Hospital, Hévíz, 8380, Hungary|St. Ferenc Hospital, Miskolc, 3501, Hungary|Hungarian Brothers of St. John of Good, Pecs, 7621, Hungary|Szegedi University, Szeged, 6720, Hungary|Ferenc Csolnoky County Hospital, Veszprem, 8201, Hungary|Pál Almási Balogh Hospital, ózd, 3601, Hungary|Università degli Studi, Genova, Italy|Ospedale Augusto Murri, Jesi, 60035, Italy|Università degli Studi di Napoli "Federico II", Napoli, 80131, Italy|Ospedale A. Galateo, SAN CESARIO (Lecce), 73016, Italy|896 Pyung Chon-Dong, Dongan-Gu, Gyeonggi-Do, 431-070, Korea, Republic of|San-5, Woncheon-Dong, Paldal-Gu, Gyeonggi-Do, 442-721, Korea, Republic of|85 Jeo-Dong 2Ga, Seoul, 100-032, Korea, Republic of|Seoul National University Hospital, Seoul, 110-744, Korea, Republic of|Boehringer Ingelheim Investigational Site, Seoul, 120-752, Korea, Republic of|Institute of Rheumatology of RAMN, Moscow, 115522, Russian Federation|City Clinical Hospital No. 1, Moscow, 117049, Russian Federation|Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan|Rheumatology-Allergy-Immunology, Kaohsiung, Taiwan|Chang Gung Memorial Hospital, Taipei, 105, Taiwan|Taipei Veterans General Hospital, Taipei, Taiwan|Dnyepropyetrovsk Medical Academy, Dnyepropetrovsk, 49044, Ukraine|Central City Hospital, Donetsk, 83098, Ukraine|State Medical University, Donetsk, 83114, Ukraine|Municipal Institute of Health Care, Kharkov, 61091, Ukraine|City Multitype Clinical Hospital No. 25, Kharkov, 61115, Ukraine|Central Clinical Hospital, Kiev, 01023, Ukraine|Institute of Cardiology, Kiev, 03151, Ukraine|Regional Hospital No. 1, Kiev, 04107, Ukraine|Institute of Gerontology, Kyiv, 04114, Ukraine Less << |
NCT02183038 | Pharyngitis | Phase 2 | Completed | - | - |
NCT02182739 | Arthritis, Rheumatoid | COMPLETED | - | - | |
NCT02182726 | - | Completed | - | - | |
NCT02183155 | Healthy | Phase 4 | Completed | - | - |
NCT00239382 | Arthritis, Rheumatoid | Phase 3 | Completed | - | China ... More >> People's Hospital, Beijing University Beijing, China, 100044 Beijing Xuan Wu Hospital Beijing, China, 100050 1st Affiliated, Anhui Medical University Hefei City, Anhui Province, China, 230022 Qilu Hospital, Shang Dong University Nan City, China, 250012 Shanghai Renji Hospital Shanghai, China, 200001 Shanghai Zhongshan Hospital Shanghai, China, 200032 Shanghai Guanghai Hospital Shanghai, China, 200052 Shanghai Changhai Hospital Shanghai, China, 200443 Less << |
NCT02183025 | Dysmenorrhea | Phase 2 | Completed | - | - |
NCT00152919 | Prostatic Neoplasms | PHASE3 | COMPLETED | 2025-05-09 | Princess Margaret Hospital, To... More >>ronto, Ontario, M5G 2M9, Canada Less << |
NCT00618163 | Inflammation | COMPLETED | 2025-04-05 | Novum Pharmaceutical Research ... More >>Services, Houston, Texas, 77042, United States Less << | |
NCT02229747 | Pharyngitis | Phase 4 | Completed | - | - |
NCT00601887 | Inflammation | COMPLETED | 2025-04-05 | Novum Pharmaceutical Research ... More >>Services, Houston, Texas, 77042, United States Less << | |
NCT03146000 | Postpartum | Phase 3 | Completed | - | Egypt ... More >> Assiut Faculty of Medicine Assiut, Egypt Less << |
NCT01587508 | Acute Lumbago | Phase 3 | Withdrawn(The comparator produ... More >>ct was withdrawn from the brazilian market not being possible to conduct the design regarding initially planned.) Less << | - | Brazil ... More >> Clínica de Ortopedia e Fraturas de Goiânia Goiania, GO, Brazil CIP Pesquisas Médicas Ltda Goiânia -, GO, Brazil Santa Casa de Misericórdia de Belo Horizonte Belo Horizonte, MG, Brazil Santa Casa de Juíz de Fora Juiz de Fora, MG, Brazil Hospital de Clínicas de Porto Alegre Porto Alegre, RS, Brazil Faculdade de Medicina ABC Santo Andre,, SP, Brazil Clinica de Ortopedia e Fisiatria Perdizes São Paulo, SP, Brazil Hospital Santa Marcelina São Paulo, SP, Brazil IMA Brasil São Paulo, SP, Brazil Santa Casa de Votuporanga Votuporanga, SP, Brazil Hospítal de Base São José Rio Preto, São Paulo, Brazil Less << |
NCT02183168 | Spondylitis, Ankylosing | Phase 3 | Completed | - | - |
NCT02180516 | - | Completed | - | - | |
NCT00649675 | Healthy | Phase 1 | Completed | - | United States, West Virginia ... More >> Kendle International Inc. Morgantown, West Virginia, United States, 26505 Less << |
NCT00649077 | Healthy | Phase 1 | Completed | - | United States, West Virginia ... More >> Kendle International Inc. Morgantown, West Virginia, United States, 26505 Less << |
NCT02181322 | Healthy | Phase 1 | Completed | - | - |
NCT02183129 | Osteoarthritis | Phase 4 | Completed | - | - |
NCT02184052 | Arthritis, Rheumatoid | COMPLETED | - | - | |
NCT01787188 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT02181309 | Healthy | Phase 1 | Completed | - | - |
NCT02187562 | Healthy | Phase 1 | Completed | - | - |
NCT02183090 | Healthy | Phase 1 | Completed | - | - |
NCT01787188 | - | Completed | - | - | |
NCT02255045 | Dysmenorrhea | Phase 2 Phase 3 | Unknown | September 2016 | Chile ... More >> Instituto Chileno de Medicina Reproductiva (ICMER) Recruiting Santiago, Chile, 8320165 Contact: Anita Retamales, Midwife +5626324644 aretamales@icmer.org Principal Investigator: Cristian Jesam, MD Less << |
NCT03077516 | - | Enrolling by invitation | December 2018 | United States, California ... More >> Orange County Neurosurgical Associates Laguna Hills, California, United States, 92653 Desert Orthopedic Center Rancho Mirage, California, United States, 92270 UC Davis Spine Center Sacramento, California, United States, 95816 The Spine Institute Santa Monica, California, United States, 90403 United States, Indiana Orthopedics Northeast Fort Wayne, Indiana, United States, 46825 United States, Louisiana Spine Institute of Louisiana Shreveport, Louisiana, United States, 71101 United States, Texas Texas Back Institute Plano, Texas, United States, 75093 Texas Spine and Joint Hospital Tyler, Texas, United States, 75701 Less << | |
NCT00840879 | - | Completed | - | - | |
NCT00840879 | Healthy | Phase 1 | Completed | - | Canada, Ontario ... More >> Biovail Contract Research Toronto, Ontario, Canada, M1L4S4 Less << |
NCT00840476 | Healthy | Phase 1 | Completed | - | Canada, Ontario ... More >> Biovail Contract Research Toronto, Ontario, Canada, M1L4S4 Less << |
NCT00840476 | - | Completed | - | - | |
NCT02183077 | Healthy | Phase 1 | Completed | - | - |
NCT02183064 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT02405793 | Osteoarthritis | Phase 2 | Withdrawn(Internal business de... More >>cision not to move forward with study) Less << | July 2015 | - |
NCT00731302 | Systemic Lupus Erythematosus | Phase 1 | Completed | - | United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Tennessee Vanderbilt University Medical School Nashville, Tennessee, United States, 37232 Less << |
NCT01346137 | Rupture; Graafian Follicle | PHASE2 | UNKNOWN | 2025-09-11 | Instituto Chileno de Medicina ... More >>Reproductiva (ICMER), Santiago, Chile Less << |
NCT02184065 | Arthritis, Rheumatoid | COMPLETED | - | - | |
NCT03684265 | Healthy | Phase 1 | Completed | - | Russian Federation ... More >> City Clinical Hospital named after V.P. Demikhova Department of Health of Moscow Moscow, Russian Federation, 109263 Less << |
NCT02003625 | Non-Hodgkin's Lymphoma ... More >> Hodgkin's Lymphoma Multiple Myeloma Hematopoietic Stem Cells Less << | Phase 2 | Recruiting | March 2021 | United States, Massachusetts ... More >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02215 Contact: Bimalangshu Dey, MD 617-724-1124 bdey@partners.org Principal Investigator: Bimalangshu Dey, MD Less << |
NCT01839643 | Contraception ... More >> Bleeding Pattern Less << | Phase 1 Phase 2 | Completed | - | Chile ... More >> Instituto Chileno de Medicina Reproductiva (ICMER) Santiago, Chile, 8320165 Less << |
NCT01750931 | - | Completed | - | - | |
NCT01430559 | Osteoarthritis of the Knee | Not Applicable | Completed | - | China, Anhui ... More >> Pfizer Investigational Site Hefei, Anhui, China, 230001 China, Guangdong Pfizer Investigational Site Guangzhou, Guangdong, China, 510630 Pfizer Investigational Site Shantou City, Guangdong, China, 515041 China, Heilongjiang Pfizer Investigational Site Harbin, Heilongjiang, China, 150001 China, Hubei Pfizer Investigational Site Wuhan, Hubei, China, 430022 China, Jiangsu Pfizer Investigational Site Nanjing, Jiangsu, China, 210029 China, Liaoning Pfizer Investigational Site Shenyang, Liaoning, China China, Shandong Pfizer Investigational Site Jinan, Shandong, China, 250012 Pfizer Investigational Site Liaocheng, Shandong, China, 252000 Pfizer Investigational Site Qingdao, Shandong, China, 266011 China, Shanxi Pfizer Investigational Site Xi'an, Shanxi, China, 710032 China, Sichuan Pfizer Investigational Site Chengdu, Sichuan, China, 610041 Pfizer Investigational Site Chengdu, Sichuan, China, 610044 Pfizer Investigational Site Chengdu, Sichuan, China, 610072 China Pfizer Investigational Site Beijing, China, 100029 Pfizer Investigational Site Beijing, China, 100032 Pfizer Investigational Site Beijing, China, 100044 Pfizer Investigational Site Beijing, China, 100053 Pfizer Investigational Site Beijing, China, 100730 Pfizer Investigational Site Shanghai, China, 200001 Pfizer Investigational Site Shanghai, China, 200003 Pfizer Investigational Site Shanghai, China, 200032 Pfizer Investigational Site Tianjin, China, 300052 Less << |
NCT02706054 | Low Back Pain | Phase 3 | Completed | - | Italy ... More >> Istituto ortopedico Rizzoli Bologna, Italy, 40136 Less << |
NCT02183116 | Osteoarthritis | PHASE4 | COMPLETED | - | - |
NCT01801735 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT01801735 | - | Completed | - | - | |
NCT01161134 | Healthy | PHASE1 | COMPLETED | 2025-11-04 | Allied Research International ... More >>Inc., Mississauga, Ontario, L4W 1N2, Canada Less << |
NCT01161147 | Healthy | PHASE1 | COMPLETED | 2025-12-04 | Allied Research International ... More >>Inc., Mississauga, Ontario, L4W 1N2, Canada Less << |
NCT02078102 | Multiple Myeloma ... More >> Non-Hodgkin's Lymphoma Less << | Phase 2 | Recruiting | January 1, 2020 | United States, Indiana ... More >> Indiana University Melvin and Bren Simon Cancer Center Recruiting Indianapolis, Indiana, United States, 46202 Contact: Carol Huntley, RN 317-274-3782 chuntley@iu.edu Contact: Sherif Farag, MBBS, PhD 317-274-0843 ssfarag@iupui.edu Principal Investigator: Sherif Farag, MBBS, PhD Less << |
NCT02183181 | Healthy | Phase 1 | Completed | - | - |
NCT01750931 | Arthritis, Rheumatoid | Not Applicable | Completed | - | - |
NCT00239395 | Osteoarthritis | Phase 3 | Completed | - | China ... More >> People's Hospital, Beijing University Beijing, China, 100044 Beijing Xuan Wu Hospital Beijing, China, 100050 1st Affiliated, Anhui Medical University Hefei City, Anhui Province, China, 230022 Qilu Hospital, Shang Dong University Nan City, China, 250012 Shanghai Renji Hospital Shanghai, China, 200001 Shanghai Zhongshan Hospital Shanghai, China, 200032 Shanghai Guanghai Hospital Shanghai, China, 200052 Shanghai Changhai Hospital Shanghai, China, 200443 Less << |
NCT04322175 | Healthy Volunteers | PHASE1 | UNKNOWN | 2020-07-01 | Institution of Drug Clinical T... More >>rials, Beijing, Beijing, 100730, China Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.85mL 0.57mL 0.28mL |
14.23mL 2.85mL 1.42mL |
28.46mL 5.69mL 2.85mL |