Structure of Metformin
CAS No.: 657-24-9
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Metformin (1,1-Dimethylbiguanide) activates AMPK by inhibiting mitochondrial respiratory chain in the liver, enhancing insulin sensitivity. It can be used in type 2 diabetes research and crosses the blood-brain barrier, inducing autophagy.
Synonyms: 1,1-Dimethylbiguanide
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Shinyoung Choi ;
Abstract: The groundbreaking Palladium/norbornene cooperative catalysis, also known as the Catellani reaction, was pioneered by Prof. Marta Catellani in 1997. This transformative reaction integrates the merits of traditional cross-coupling reactions and ortho-functionalization into a single process, offering a remarkably step-economical way to access complex polysubstituted aromatic compounds. Its versatility has proven invaluable to both organic chemists and material scientists alike. Within this dissertation, I explore my profound fascination with leveraging the Catellani reaction for methodology development in azaborine functionalization, and the synthesis of various materials such as dendrons and graphene nanoribbons. While engaging in the synthesis of graphene nanoribbons aimed for potential biomedical applications, my interest in graphene-based nanomaterials for such purposes grew stronger. Consequently, the final chapter of this dissertation offers a comprehensive review of graphene-based nanomaterials within the context of biomedical applications. Details
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CAS No. : | 657-24-9 |
Formula : | C4H11N5 |
M.W : | 129.16 |
SMILES Code : | NC(NC(N(C)C)=N)=N |
Synonyms : |
1,1-Dimethylbiguanide
|
MDL No. : | MFCD00242652 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
In Vitro:
Concentration | Treated Time | Description | References |
Primary Vascular Smooth Muscle Cells | 200 μM | 12 days | Metformin significantly reduced the number of SA-β-gal-positive cells in primary VSMCs and decreased p53, p21, and p16 protein levels. | PMC9637479 |
Vascular Smooth Muscle Cells (VSMCs) | 200 μM | 72 h | Metformin significantly reduced Ang II-induced senescence in VSMCs, decreased SA-β-gal activity, and reduced p53 and p21 protein levels. | PMC9637479 |
Human CD8 T cells | 2 mM | 24-72 h | Metformin reduced apoptosis and improved survival of human CD8 T cells under hypoxic conditions. | PMC10163559 |
OT-1 CD8 T cells | 2 mM | 24-72 h | Metformin improved the survival and function of OT-1 CD8 T cells under hypoxic conditions. | PMC10163559 |
TCRP1A CD8 T cells | 2 mM | 24-72 h | Metformin directly improved CD8 T-cell survival in hypoxia, reducing apoptosis and restoring cell proliferation. | PMC10163559 |
Human skeletal muscle cells | 0.1 and 2 mM | 12 h | Metformin dose-dependently increased the mRNA expression of myostatin. | PMC8818615 |
C2C12 myotubes | 0.01 - 2 mM | 36 h | Metformin increased the protein expression of myostatin in a dose- and time-dependent manner. | PMC8818615 |
C2C12 myotubes | 2 mM | 12 h | Metformin increased the mRNA and protein expression of myostatin, indicating that metformin may induce muscle atrophy. | PMC8818615 |
Astrocytes | 0.2 mM | 48 h | Metformin significantly inhibited MPP+-induced astrocyte senescence, reduced SASP factor secretion, and decreased the percentage of SA-β-gal positive cells. | PMC10986112 |
Astrocytes | 0.2 mM | 24 h | Metformin significantly inhibited α-Syn PFF-induced astrocyte senescence, reduced SASP factor secretion, and decreased the percentage of SA-β-gal positive cells. | PMC10986112 |
Hepatocytes | 10 μM | 96 h | To investigate the effect of metformin on hepatocytes, results showed that metformin treatment led to AMPK and CCO upregulation, and increased cell death | PMC9898507 |
BRL 3A cells | 10 μM | 48 h and 2 weeks | To investigate the effect of metformin on BRL 3A cells, results showed that metformin treatment led to AMPK overactivation, CCO upregulation, and increased cell death | PMC9898507 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
BALB/c nude mice | Subcutaneous xenograft tumor model | Oral | 250 mg/kg | Every 3 days | Evaluate the therapeutic effect of Metformin on prostate cancer | PMC10427640 |
Mice | C57BL/6 | Oral | 350 mg/kg | Once daily for 6 months | To investigate whether metformin can prevent and/or reverse ovarian fibrosis. Results showed that metformin treatment modulates the immune cells toward the emergence of a unique subpopulation of macrophages and prevents the establishment of age-associated ovarian fibrosis, likely by promoting ECM remodeling and the clearance of SASP-producing fibroblasts to maintain tissue homeostasis. | PMC10848964 |
Mice | Ang II-induced vascular senescence model | Intragastric administration | 150 mg/kg | Once daily for 28 days | Metformin significantly improved Ang II-induced vascular senescence, reduced arterial stiffness and vascular wall thickness, and decreased collagen accumulation. | PMC9637479 |
Mice | TiRP tumor model | Drinking water | 0.5 mg/mL | Daily, for 20 days | Metformin increased CD8 T-cell infiltration and survival in hypoxic tumor areas, enhancing tumor response to immunotherapy. | PMC10163559 |
Mice | C57BLKS/J-dbb and C57BL/6J mice | Intraperitoneal injection | 250 mg/kg | Three times a week for 4 weeks | Metformin-treated mice showed significantly increased mRNA expression of myostatin in GC muscles, indicating that metformin may impair muscle function via the AMPK-FoxO3a-HDAC6 axis. | PMC8818615 |
Mice | MPTP-induced Parkinson's disease model | Oral | 100 mg/kg | Once daily for 2 weeks | Metformin significantly delayed astrocyte senescence in the MPTP-induced Parkinson's disease model, reduced SASP factor secretion, and improved behavioral deficits. | PMC10986112 |
Rats | Sepsis-related liver injury model | Gavage | 100 mg/kg | Once, lasted for 24 hours | Metformin attenuated sepsis-related liver injury by modulating gut microbiota, improving liver inflammation and damage. | PMC8928825 |
Rats | ZDF rats and Lepr knockout rats | Oral | 50 mg/kg | Once daily for 6 months | To investigate the effect of metformin on ZDF rats and Lepr knockout rats, results showed that metformin led to liver damage and increased cell death in Lepr-defective rats | PMC9898507 |
C57BL6/J mice | Aged mouse model | Oral gavage | 100 mg/kg | Once daily for 10 weeks | To examine the effects of metformin treatment in late middle age on cognitive function in old age. The results showed that metformin treatment improved pattern separation, object location, and recognition memory function, reduced pathological microglial clustering, and enhanced autophagy in the hippocampus. | PMC7884047 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01685762 | Endometrial Hyperplasia|Endome... More >>trial Hyperplasia Without Atypia Less << | EARLY_PHASE1 | COMPLETED | 2015-12-01 | The University of North Caroli... More >>na at Chapel Hill, Chapel Hill, North Carolina, 27599, United States|Southern Pines Women's Health Center, Southern Pines, North Carolina, 28388, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19107, United States Less << |
NCT00319293 | Polycystic Ovary Syndrome | UNKNOWN | - | - | |
NCT02984722 | Polycystic Ovary Syndrome | UNKNOWN | - | Catholic university of Sacred ... More >>Heart, Rome, 00168, Italy Less << | |
NCT00463502 | Diabetes Mellitus, Type 2 | PHASE4 | COMPLETED | - | - |
NCT04925063 | Metastatic Prostate Cancer | PHASE2 | NOT_YET_RECRUITING | 2027-08-31 | Sun Yat-Sen University Cancer ... More >>Center, Guangzhou, Guangdong, 510060, China Less << |
NCT04926155 | Metastatic Prostate Cancer | PHASE2 | UNKNOWN | 2024-08-31 | Sun Yat-Sen University Cancer ... More >>Center, Guangzhou, Guangdong, 510060, China Less << |
NCT06325956 | Polycystic Ovary Syndrome|Metf... More >>ormin|Immune Function Less << | RECRUITING | 2026-07-01 | Department of Endocrinology, S... More >>hanghai Tenth People's Hospital, Shanghai, 200072, China Less << | |
NCT01266486 | Breast Cancer | PHASE2 | COMPLETED | 2025-05-14 | Mount Vernon Centre for Cancer... More >> Treatment, Rickmansworth Road, Northwood, Middlesex, HA6 2RN, United Kingdom|Dept Oncology, Churchill Hospital, Old Road, Headington, Oxford, Oxfordshire, OX3 7LJ, United Kingdom|Surgery and Molecular Oncology Ninewells Hospital, Dundee, Scotland, DD1 9SY, United Kingdom Less << |
NCT05418452 | Horizontal Ridge Deficiency | PHASE3 | UNKNOWN | 2023-06-15 | AlAzhar universty, Cairo, 0444... More >>4, Egypt Less << |
NCT01442870 | Cancer | PHASE1 | COMPLETED | 2025-11-14 | Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less << |
NCT03398356 | PreDiabetes|Impaired Fasting G... More >>lucose (IFG)|Impaired Glucose Tolerance (IGT) Less << | PHASE4 | COMPLETED | 2019-04-30 | NZOZ Nowy Dwór, Wroclaw, Lower... More >> Silesia, 54-438, Poland Less << |
NCT06326840 | Metabolic Disturbance|Hyperpro... More >>lactinemia|Schizophrenia Less << | COMPLETED | 2011-06-10 | Taipei Medical University-Wan ... More >>Fang Hospital, Taipei, 116, Taiwan Less << | |
NCT06772857 | Insulin Sensitivity/Resistance | EARLY_PHASE1 | ACTIVE_NOT_RECRUITING | 2025-01-30 | Cairo University, Cairo, Egypt |
NCT06519786 | Fanconi Anemia | PHASE3 | RECRUITING | 2025-03-25 | University of Alexandria, Alex... More >>andria, Egypt|Ain Shams University, Cairo, 11566, Egypt Less << |
NCT00670800 | Polycystic Ovary Syndrome | COMPLETED | 2025-08-09 | University of Michigan, Michig... More >>an Clinical Research Unit, Ann Arbor, Michigan, 48109, United States Less << | |
NCT02684578 | Age-Related Macular Degenerati... More >>on|Macular Degeneration, Age-Related|Dry Macular Degeneration|Geographic Atrophy Less << | PHASE2 | COMPLETED | 2025-10-22 | University of California, Davi... More >>s, Davis, California, 95616, United States|Palo Alto Veteran Affairs Medical Center, Palo Alto, California, 94304, United States|Retinal Consultants Medical Group, Sacramento, California, 95819, United States|San Francisco Veteran Affairs Medical Center, San Francisco, California, 94121, United States|University of California San Francisco, San Francisco, California, 94143, United States|California Retina Consultants, Santa Maria, California, 93454, United States|North Bay Vitreoretinal Consultants, Santa Rosa, California, 95403, United States|Retina Health Center, Fort Myers, Florida, 33907, United States|Northwestern University, Chicago, Illinois, 60611, United States|University of Illinois at Chicago, Chicago, Illinois, 60612, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Austin Retina Associates, Austin, Texas, 78705, United States Less << |
NCT01911247 | Endometrial Cancer | EARLY_PHASE1 | COMPLETED | 2025-02-13 | Lineberger Comprehensive Cance... More >>r Center, Chapel Hill, North Carolina, 27599, United States Less << |
NCT02895750 | Renal Insufficiency, Chronic | PHASE2 | COMPLETED | 2022-10-10 | CHU Amiens Picardie, Amiens, 8... More >>0054, France Less << |
NCT02710448 | Renal Disorder Associated With... More >> Type II Diabetes Mellitus Less << | PHASE2 | COMPLETED | 2025-10-15 | Service d'Endocrinologie, Mala... More >>dies Métaboliques et Nutrition, Amiens, 80054, France Less << |
NCT00930579 | Breast Cancer | PHASE2 | COMPLETED | 2017-01-09 | Columbia University Irving Med... More >>ical Center, New York, New York, 10032, United States Less << |
NCT00390273 | Hyperlactatemia | PHASE1|PHASE2 | COMPLETED | 2025-10-07 | Centre Hospitalier Universitai... More >>re de Grenoble, Grenoble cedex 9, 38043, France Less << |
NCT06429007 | Hypoxic-Ischemic Encephalopath... More >>y|HIE|Neurodevelopment|Infant Development Less << | PHASE2 | NOT_YET_RECRUITING | 2028-03-01 | - |
NCT00501787 | Polycystic Ovary Syndrome | PHASE4 | WITHDRAWN | - | Pugliese Hospital, Catanzaro, ... More >>Catanzaro, CZ, 88100, Italy Less << |
NCT01037660 | Cardiovascular Disease | EARLY_PHASE1 | COMPLETED | 2016-12-01 | Boston Medical Center, Boston,... More >> Massachusetts, 02118, United States Less << |
NCT01341886 | Malignant Neoplasm of Thyroid ... More >>Stage I|Malignant Neoplasm of Thyroid Stage II Less << | COMPLETED | 2025-04-11 | Mashad University of Medical S... More >>ciences, Mashad, Khorasan Razavi, Iran, Islamic Republic of Less << | |
NCT01750567 | Relapsed Chronic Lymphocytic L... More >>eukemia Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-12-24 | University of Michigan Compreh... More >>ensive Cancer Center, Ann Arbor, Michigan, 48109, United States Less << |
NCT03118128 | Acute Lymphoblastic Leukemia | COMPLETED | 2017-04-30 | - | |
NCT01366391 | Polycystic Ovary Syndrome | PHASE4 | UNKNOWN | 2025-10-11 | Biocinese, Toledo, Parana, 859... More >>03-590, Brazil Less << |
NCT06080802 | Heart Failure With Preserved E... More >>jection Fraction|Diabete Type 2 Less << | PHASE2|PHASE3 | NOT_YET_RECRUITING | 2024-12-01 | clinical research uint- El-she... More >>ikh zayed specialized hospital SMC- Egyptian Ministry of health, Cairo, Egypt Less << |
NCT05932251 | Gestational Diabetes|Gestation... More >>al Diabetes Mellitus Less << | RECRUITING | 2025-12-31 | Zuyderland Medisch Centrum, He... More >>erlen, 6419PC, Netherlands Less << | |
NCT02500628 | Fibromyalgia|Mitochondrial Dis... More >>eases|Movement Disorders|Diabetes Mellitus, Type 2 Less << | PHASE2 | COMPLETED | 2025-02-16 | Woodinville Psychiatric Associ... More >>ates, Woodinville, Washington, 98072, United States Less << |
NCT05929495 | Glioblastoma, IDH-wildtype|Met... More >>formin|Malignancies Less << | PHASE2 | NOT_YET_RECRUITING | 2026-01-01 | Fondazione IRCCS Ca' Granda Os... More >>pedale Maggiore Policlinico di Milano, Milan, Italy Less << |
NCT04762966 | Metformin Associated Lactic Ac... More >>idosis Less << | UNKNOWN | 2021-09-01 | University Hospital of Nancy, ... More >>Vandoeuvre-les-nancy, 54000, France Less << | |
NCT04332393 | Pregnancy Preterm|Glycemic Con... More >>trol|Corticosteroids Induced Hyperglycemia Less << | PHASE4 | ACTIVE_NOT_RECRUITING | 2025-12-25 | Baruch Padeh Medical center, P... More >>oriya, Tiberias, North, 15208, Israel|Emek medical center, Afula, Israel|Galilee medical center, Nahariya, Israel|Ziv medical center, Safed, Israel Less << |
NCT05326984 | Acute Lymphoblastic Leukemia | UNKNOWN | 2025-12-23 | Hospital General de México, Me... More >>xico City, 06720, Mexico Less << | |
NCT03486626 | Polycystic Ovary Syndrome|Anov... More >>ulatory Less << | PHASE4 | UNKNOWN | 2025-10-18 | Ain Shams University Maternity... More >> Hospital, Cairo, 1156, Egypt Less << |
NCT05280496 | Diabetes, Gestational|PreDiabe... More >>tes|Diabetes Mellitus, Type 2 Less << | PHASE3 | ACTIVE_NOT_RECRUITING | 2025-01-25 | Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less << |
NCT05740345 | New Approaches in INOCA | COMPLETED | 2021-01-15 | - | |
NCT01566799 | Locally Advanced Malignant Neo... More >>plasm Less << | PHASE2 | UNKNOWN | 2025-04-14 | Instituto Nacional Cancerologi... More >>, Mexico, Distrito Federal, 14080, Mexico Less << |
NCT03980990 | Acute Coronary Syndrome|Unstab... More >>le Angina|Diabetes Mellitus|Metformin Adverse Reaction Less << | PHASE4 | UNKNOWN | 2020-06-17 | Royal University Hospital, Sas... More >>katoon, Saskatchewan, S7N0W8, Canada Less << |
NCT01910246 | Insulin Resistance | PHASE4 | WITHDRAWN | 2025-10-16 | UCSF, Radiology and Biomedical... More >> Imaging, San Francisco, California, 94143, United States Less << |
NCT03053544 | Rectal Neoplasm Carcinoma in S... More >>itu Adenocarcinoma Less << | PHASE2 | COMPLETED | 2019-06-26 | Odette Cancer Centre, Sunnybro... More >>ok Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada Less << |
NCT05305898 | Acute Coronary Syndrome | PHASE3 | RECRUITING | 2025-12-25 | Wielospecjalistyczny Szpital W... More >>ojewódzki w Gorzowie Wielkopolskim, Gorzów Wielkopolski, Lubuskie, 66-400, Poland|Wojskowy Instytut Medyczny, Warszawa, Mazowieckie, 04-141, Poland|Oddzia? Kardiologii Szpitala ?w. Rafa?a, Kraków, Ma?opolskie, 30-693, Poland|Kluczborskie Centrum Kardiologii, Kluczbork, Opolskie, 46-200, Poland|Centrum Kardiologii Scanmed w Bielsku Podlaskim, Bielsk Podlaski, Podlaskie, 17-100, Poland|Centrum Kardiologii Scanmed w E?ku, E?k, Warmińsko-Mazurskie, 19-300, Poland|Centrum Kardiologii Scanmed w I?awie, I?awa, Warmińsko-Mazurskie, 14-202, Poland|Centrum Kardiologii Scanmed w Szczecinku, Szczecinek, Zachodniopomorskie, 78-400, Poland|Centrum Kardiologii Scanmed w Kutnie, Kutno, ?ódzkie, 99-320, Poland|Centrum Kardiologii Scanmed w Tomaszowie Mazowieckim, Tomaszów Mazowiecki, ?ódzkie, 97-200, Poland|Cz?stochowskie Centrum Kardiologii, Cz?stochowa, ?l?ske, 42-200, Poland|Chorzowskie Centrum Kardiologii, Chorzów, ?l?skie, 41-500, Poland|Raciborskie Centrum Medyczne, Racibórz, ?l?skie, 47-400, Poland|Sosnowieckie Centrum Kardiologii, Sosnowiec, ?l?skie, 41-219, Poland Less << |
NCT03570632 | Diabetes Mellitus, Type 1|Preg... More >>nancy in Diabetes Less << | PHASE4 | ACTIVE_NOT_RECRUITING | 2025-12-31 | Magee Womens Hospital of UPMC,... More >> Pittsburgh, Pennsylvania, 15213, United States Less << |
NCT01579812 | Ovarian, Fallopian Tube, and P... More >>rimary Peritoneal Cancer Less << | PHASE2 | COMPLETED | 2025-07-17 | University of Michigan, Ann Ar... More >>bor, Michigan, 48109, United States Less << |
NCT01486043 | Acute Lymphoblastic Leukemia|H... More >>yperglycemia|Insulin Resistance|Diabetes Mellitus Less << | TERMINATED | 2025-05-13 | Children's Hospital Los Angele... More >>s, Los Angeles, California, 90027, United States Less << | |
NCT01677923 | Obesity | PHASE3 | COMPLETED | 2025-12-15 | Rasa Verkauskiene, Kaunas, Eiv... More >>eniu str. 2, LT50009, Lithuania Less << |
NCT06120881 | Type 2 Diabetes | EARLY_PHASE1 | RECRUITING | 2025-12-31 | UCSF Benioff Children's Hospit... More >>al Oakland, Pediatric Diabetes Clinic, Oakland, California, 94609, United States|UCSF Benioff Children's Hospital San Francisco, Madison Clinic for Pediatric Diabetes, San Francisco, California, 94158, United States Less << |
NCT01400191 | Pharmacogenetics of Metformin | PHASE4 | COMPLETED | 2025-12-12 | Clinical pharmacology, Institu... More >>te og public health, University of Southern Denmark, Odense, 5000, Denmark Less << |
NCT04766008 | Diabetes Mellitus|Coronary Art... More >>ery Disease|Lactic Acidosis With Diabetes Mellitus|Contrast-induced Nephropathy|Metformin Associated Lactic Acidosis Less << | PHASE4 | UNKNOWN | 2022-04-30 | Humanitas Research Hospital, R... More >>ozzano, Milan, 20089, Italy Less << |
NCT03590262 | Type 1 Diabetes Mellitus|Metfo... More >>rmin Less << | PHASE4 | UNKNOWN | 2019-09-30 | Shenzhen People's Hospital, Sh... More >>enzhen, Guangdong, 518020, China Less << |
NCT01243385 | Prostate Cancer | PHASE2 | COMPLETED | 2019-08-09 | Kantonsspital Aarau, Aarau, CH... More >>-5001, Switzerland|Universitaetsspital-Basel, Basel, CH-4031, Switzerland|Inselspital Bern, Bern, CH-3010, Switzerland|Kantonsspital Graubuenden, Chur, CH-7000, Switzerland|Kantonsspital Luzern, Luzerne, CH-6000, Switzerland|Kantonsspital - St. Gallen, St. Gallen, CH-9007, Switzerland|Kantonsspital Winterthur, Winterthur, CH-8401, Switzerland|Onkozentrum, Zurich, 8038, Switzerland|UniversitaetsSpital Zuerich, Zurich, CH-8091, Switzerland Less << |
NCT00187681 | Other Conditions That May Be A... More >> Focus of Clinical Attention Less << | PHASE4 | COMPLETED | 2025-03-08 | San Francisco General Hospital... More >>, San Francsico, California, 94143, United States Less << |
NCT01842620 | Diabetes Mellitus, Type 2 | PHASE4 | COMPLETED | 2013-05-04 | - |
NCT04947020 | Rectal Cancer|Metformin|Overal... More >>l Survival|Lymph Node Metastases|Disease-free Survival Less << | ACTIVE_NOT_RECRUITING | 2024-12-31 | 1st Department of General Surg... More >>ery, Krakow, Malopolska, 31-501, Poland Less << | |
NCT01228240 | Diabetes Mellitus, Type 2 AND ... More >>Metformin Less << | PHASE4 | COMPLETED | 2025-09-09 | - |
NCT06296836 | Diabetes Mellitus, Type 2 | PHASE4 | NOT_YET_RECRUITING | 2026-06-30 | University of Illinois at Chic... More >>ago, Chicago, Illinois, 60612, United States Less << |
NCT02780024 | Glioblastoma Multiforme | PHASE2 | ACTIVE_NOT_RECRUITING | 2026-02-28 | Montreal Neurological Institut... More >>e - McGill University Health Centre, Montréal, Quebec, H3A 2B4, Canada Less << |
NCT01521624 | Type 2 Diabetes Mellitus | COMPLETED | 2025-09-11 | Tehran University of Medical S... More >>ciences, Tehran, 13145-784, Iran, Islamic Republic of Less << | |
NCT00391261 | Schizophrenia|Schizoaffective ... More >>Disorder|Schizophreniform Disorder|Bipolar Disorder|Autism Spectrum Disorders Less << | PHASE4 | COMPLETED | 2025-10-07 | Cambridge Health Alliance, Med... More >>ford, Massachusetts, 02155, United States Less << |
NCT02848950 | Infertility Female | PHASE2 | UNKNOWN | 2025-07-17 | - |
NCT05708053 | Elective Percutaneous Coronary... More >> Intervention|Ischemic Reperfusion Injury Less << | PHASE3 | ACTIVE_NOT_RECRUITING | 2025-12-24 | Faculty of Pharmacy, Cairo Uni... More >>versity, Cairo, Egypt|Kasr El Aini Hospital, Cairo, Egypt|Kasr El-Aini Hospital, Cairo, Egypt Less << |
NCT02026869 | PCOS | EARLY_PHASE1 | UNKNOWN | 2025-02-14 | Women's Health Hospital, Assiu... More >>t, 71516, Egypt Less << |
NCT00247117 | Liver Diseases | UNKNOWN | 2025-08-05 | Institute of Endocrinology, Ka... More >>plan Medical Center, Rehovot, 76100, Israel Less << | |
NCT01869621 | Type 2 Diabetes | PHASE1 | COMPLETED | 2025-10-14 | Clinical Pharmacology, Odense ... More >>C, 5000, Denmark Less << |
NCT02848508 | Renal Insufficiency, Chronic | PHASE2 | WITHDRAWN | 2017-06-07 | CHU Amiens, Amiens, 80054, Fra... More >>nce Less << |
NCT02083692 | Head and Neck Squamous Cell Ca... More >>ncer Less << | EARLY_PHASE1 | COMPLETED | 2017-04-06 | Thomas Jefferson University, P... More >>hiladelphia, Pennsylvania, 19107, United States Less << |
NCT05553704 | Inflammatory Bowel Diseases | PHASE2 | RECRUITING | 2025-12-20 | Faculty of Medicine, Mansoura ... More >>University, Mansoura, 35511, Egypt Less << |
NCT01926769 | Previously Treated Advanced Co... More >>lorectal Cancer Less << | PHASE2 | TERMINATED | 2025-12-14 | Gachon University Gil Medical ... More >>Center, Incheon, Korea, Republic of Less << |
NCT01077479 | Metabolic Syndrome|Hypercholes... More >>terolemia Less << | PHASE2 | COMPLETED | 2025-06-13 | Westmead Hospital, Sydney, New... More >> South Wales, 2145, Australia Less << |
NCT03722290 | Fragile X Syndrome | PHASE2 | COMPLETED | 2020-11-01 | Université de Sherbrooke, Sher... More >>brooke, Quebec, J1H 5H3, Canada Less << |
NCT01352026 | Pulmonary Arterial Hypertensio... More >>n Less << | PHASE2 | WITHDRAWN | - | CHU de Nantes, Nantes, 44093, ... More >>France|CHU de Bordeaux, Pessac, 33604, France Less << |
NCT00325910 | Diabetes Mellitus, Type 2|Hear... More >>t Failure, Congestive Less << | PHASE3 | TERMINATED | 2025-05-07 | Misericordia Hospital, Edmonto... More >>n, Alberta, T5R 4H5, Canada|University of Alberta Hospital, Edmonton, Alberta, T6G 2B7, Canada Less << |
NCT04792749 | Endometrial Cancer Stage I | PHASE3 | RECRUITING | 2024-03-31 | Samsung Medical Center, Seoul,... More >> 06351, Korea, Republic of Less << |
NCT02086526 | Polycystic Ovary Syndrome | PHASE1 | COMPLETED | 2016-11-20 | Mayo Clinic in Rochester, Roch... More >>ester, Minnesota, 55905, United States Less << |
NCT06405971 | Dissecting Aneurysm of Cerebra... More >>l Artery Less << | RECRUITING | 2025-06-01 | Beijing Tiantan Hospital, Beij... More >>ing, Beijing, 100010, China Less << | |
NCT06015594 | Polycystic Ovary Syndrome | COMPLETED | 2022-05-01 | - | |
NCT00279240 | Diabetes | PHASE1 | COMPLETED | 2025-12-04 | Diabetes Research Centre & MV ... More >>Hospital for Diabetes, Chennai, Tamilnadu, 600013, India Less << |
NCT04377451 | Dengue|Viral Infection|Metform... More >>in|Anti-inflammatory Agents|Obesity|Overweight Less << | PHASE1|PHASE2 | COMPLETED | 2023-08-01 | Hospital for Tropical Diseases... More >>, Ho Chi Minh City, Vietnam Less << |
NCT01677897 | Metastatic Prostate Cancer | PHASE2 | COMPLETED | 2025-06-18 | Kantonsspital Graubünden, Chur... More >>, Graubünden, 7000, Switzerland Less << |
NCT01043965 | Type 2 Diabetes | PHASE1|PHASE2 | COMPLETED | 2025-08-09 | - |
NCT06479434 | Polycystic Ovary Syndrome|Insu... More >>lin Resistance Less << | RECRUITING | 2025-12-30 | DBBS, Karachi, Sind, 74800, Pa... More >>kistan Less << | |
NCT06728982 | Rectal Cancer Patients | PHASE1|PHASE2 | RECRUITING | 2025-11-25 | Minia Oncology Center, Minya, ... More >>61512, Egypt|Minia University Hospital, Minya, 61512, Egypt Less << |
NCT06766201 | Apical Periodontitis | PHASE4 | RECRUITING | 2025-01-31 | Ambika Tekta, Rohtak, Haryana,... More >> 124001, India Less << |
NCT01084486 | Nonalcoholic Fatty Liver Disea... More >>se Less << | PHASE1|PHASE2 | COMPLETED | - | Wolfson Medical Center, Holon,... More >> 58100, Israel Less << |
NCT04523363 | Prediabetes; Complicating Preg... More >>nancy Less << | PHASE4 | NOT_YET_RECRUITING | 2026-06-30 | University of Massachusetts Me... More >>morial Medical Center, Worcester, Massachusetts, 01605, United States Less << |
NCT02498522 | Polycystic Ovary Syndrome | EARLY_PHASE1 | COMPLETED | 2025-03-16 | Faculty of Medicine, Ain Shams... More >> University, Cairo, Al Qahirah, Egypt Less << |
NCT05574387 | Inflammatory Bowel Diseases | PHASE2 | RECRUITING | 2025-04-27 | Faculty of Medicine, Mansoura ... More >>University, Mansoura, 7650001, Egypt Less << |
NCT02279758 | Well-differentiated Neuroendoc... More >>rine Tumors Less << | PHASE2 | UNKNOWN | - | Instituto do Cancer do Estado ... More >>de S?o Paulo, Sao Paulo, SP, 01246-000, Brazil Less << |
NCT06199544 | Comparative Study | PHASE1 | RECRUITING | 2024-12-01 | Shifa ul mulk memorial hospita... More >>l, Karachi, Sindh, Pakistan Less << |
NCT01215032 | Prostate Cancer | PHASE2 | TERMINATED | 2025-01-15 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less << |
NCT02376166 | Prostate Cancer | COMPLETED | 2025-12-16 | Icahn School of Medicine at Mo... More >>unt Sinai, New York, New York, 10029, United States Less << | |
NCT06096454 | Hypothyroidism|Insulin Resista... More >>nce Less << | PHASE4 | NOT_YET_RECRUITING | 2024-10-30 | - |
NCT01237522 | Metformin|Organic Cation Trans... More >>porter 2|Polymorphism,Single Nucleotide Less << | PHASE4 | COMPLETED | 2025-12-10 | Institute of Public Health, Cl... More >>inical Pharmacology, University of Southern Denmark, Odense, 5000, Denmark Less << |
NCT01594697 | Polycystic Ovary Syndrome | COMPLETED | - | Catholic University of Sacred ... More >>Heart, Rome, 00168, Italy Less << | |
NCT04489147 | Infertility | COMPLETED | 2020-11-27 | Faculty of medicine, Cairo, Eg... More >>ypt Less << | |
NCT05988684 | PsA (Psoriatic Arthritis) | PHASE4 | RECRUITING | 2025-10-25 | The Chinese University of Hong... More >> Kong, Hong Kong, Hong Kong Less << |
NCT00317928 | Polycystic Ovary Syndrome | UNKNOWN | 2025-09-04 | - | |
NCT00588172 | Type 2 Diabetes | PHASE4 | WITHDRAWN | 2025-06-11 | - |
NCT01440127 | Colon Cancer | PHASE1 | TERMINATED | 2025-10-12 | Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less << |
NCT01718340 | Abortion, Habitual | PHASE4 | WITHDRAWN | 2025-06-14 | Women's Health Hospital, Assiu... More >>t, Egypt Less << |
NCT02460354 | Diabetes Insipidus | PHASE1 | TERMINATED | 2025-06-17 | Childen's Healthcare of Atlant... More >>a, Atlanta, Georgia, 30322, United States|Emory University Hospital - Atlanta Clinical and Translational Science Institute (ACTSI), Atlanta, Georgia, 30322, United States|Emory University Hospital, Atlanta, Georgia, 30322, United States Less << |
NCT02931253 | Atrial Fibrillation | PHASE2 | TERMINATED | 2018-07-10 | The Guthrie Clinic, Sayre, Pen... More >>nsylvania, 18840, United States Less << |
NCT02712619 | Healthy | PHASE1 | COMPLETED | - | - |
NCT02568488 | Polycystic Ovarian Syndrome | PHASE4 | COMPLETED | 2025-09-15 | - |
NCT04741945 | Preleukemia|Myelodysplastic Ne... More >>oplasm|Cytopenia|Preleukemic Anemia Less << | PHASE2 | RECRUITING | 2025-02-26 | Rigshospitalet, Copenhagen, Co... More >>penhagen N, 2200, Denmark Less << |
NCT02659306 | HIV Infection | PHASE1 | COMPLETED | 2025-02-20 | Chronic Viral Illness Service,... More >> McGill University Health Centre, Montreal, Quebec, H4A 3J1, Canada Less << |
NCT03510390 | Head and Neck Cancer|Oral Cavi... More >>ty Squamous Cell Carcinoma Less << | COMPLETED | 2021-11-15 | Inselspital, Bern University H... More >>ospital, Bern, 3010, Switzerland Less << | |
NCT01681680 | Healthy | PHASE1 | COMPLETED | 2025-10-13 | - |
NCT00134303 | Obesity | PHASE4 | COMPLETED | 2006-03-31 | University Hospital Ghent, Ghe... More >>nt, 9000, Belgium Less << |
NCT04089813 | Postoperative Chronic Pain | UNKNOWN | 2020-12-31 | The Affiliated Hospital of Xuz... More >>hou Medical University, Xuzhou, Jiangsu, China Less << | |
NCT03379909 | Superficial Bladder Cancer|Bla... More >>dder Cancer Less << | PHASE2 | RECRUITING | 2029-10-01 | RadboudUMC, Nijmegen, Gelderla... More >>nd, Netherlands|Sint Franciscus Gasthuis, Rotterdam, Zuid-Holland, Netherlands|Academic Medical Center, Amsterdam, 1105 AZ, Netherlands Less << |
NCT01205672 | Endometrial Cancer | EARLY_PHASE1 | COMPLETED | 2017-05-28 | Lyndon B. Johnson General Hosp... More >>ital, Houston, Texas, 77026, United States|University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States Less << |
NCT02972723 | Chronic Hepatitis C Infection | PHASE4 | COMPLETED | 2025-12-11 | Secondary care Hepatitis clini... More >>c at Nottingham University Hospital, Nottingham, NG7 2UH, United Kingdom Less << |
NCT03086733 | Non Small Cell Lung Cancer|Lun... More >>g Cancer Less << | PHASE2 | COMPLETED | 2025-08-20 | Toronto General Hospital, Toro... More >>nto, Ontario, M5G 2C4, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less << |
NCT05847244 | Diastolic Dysfunction|Obesity | PHASE2 | RECRUITING | 2024-12-01 | Cairo University Hospitala, Ca... More >>iro, Egypt|Cairo University Hospitals, Cairo, Egypt Less << |
NCT01573949 | Diabetes|Heart Failure | COMPLETED | 2025-12-12 | Ahmanson-UCLA Cardiomyopathy C... More >>enter, Los Angeles, California, 90095, United States Less << | |
NCT04151459 | Polycystic Ovary Syndrome|Seve... More >>re Obesity|Laparoscopic Sleeve Gastrectomy Less << | UNKNOWN | 2022-01-15 | Renji Hospital Affiliated to S... More >>hanghai Jiaotong University School of Medicine, Shanghai, 200127, China Less << | |
NCT06266598 | Childhood Obesity|Insulin Resi... More >>stance Less << | PHASE4 | COMPLETED | 2021-10-27 | Erciyes University, Kayseri?, ... More >>Melikgazi, 38030, Turkey Less << |
NCT04566718 | PCOS | COMPLETED | 2020-02-01 | University Medical Center Ljub... More >>ljana, Ljubljana, 1000, Slovenia Less << | |
NCT04930471 | Autistic Disorder | UNKNOWN | 2025-12-23 | Lindenhofgruppe, Berne, 3012, ... More >>Switzerland Less << | |
NCT00897884 | Breast Cancer | COMPLETED | 2025-07-11 | Mount Sinai Hospital, Toronto,... More >> Ontario, M5G 1X5, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less << | |
NCT00845936 | Drug Induced Weight Gain | PHASE4 | UNKNOWN | 2025-05-10 | Beer-Yaacov MHC, Beer Yaacov, ... More >>70350, Israel Less << |
NCT04220021 | C9orf72 Amyotrophic Lateral Sc... More >>lerosis (ALS)|Frontotemporal Dementia Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-06-30 | UF Health at the University of... More >> Florida, Gainesville, Florida, 32610, United States Less << |
NCT01422746 | Obesity|Hyperandrogenemia|Poly... More >>cystic Ovary Syndrome Less << | EARLY_PHASE1 | RECRUITING | 2025-12-24 | University of Virginia Center ... More >>for Research in Reproduction, Charlottesville, Virginia, 22908, United States Less << |
NCT03477162 | Thoracic Neoplasm | EARLY_PHASE1 | TERMINATED | 2021-11-30 | Dartmouth Hitchcock Medical Ce... More >>nter, Lebanon, New Hampshire, 03756, United States Less << |
NCT05292573 | Female | PHASE3 | RECRUITING | 2026-01-29 | Chang Gung Memorial Hospital, ... More >>Linkou Branch, Taoyuan, 333, Taiwan Less << |
NCT01981525 | Li-Fraumeni Syndrome | PHASE1 | COMPLETED | 2020-12-11 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT03718715 | Type 2 Diabetes Mellitus | UNKNOWN | 2025-03-22 | Region V?sterbotten, Ume?, Swe... More >>den Less << | |
NCT01873859 | Diabetes Mellitus|Lactic Acido... More >>sis Less << | COMPLETED | 2025-02-14 | Cardiovascular research center... More >>, Modarres hospital., Tehran, Iran, Islamic Republic of Less << | |
NCT03629639 | Psoriasis Vulgaris With Metabo... More >>lic Disorders Less << | PHASE4 | UNKNOWN | 2020-12-01 | - |
NCT02815397 | Diffuse Large B-Cell Lymphoma | PHASE2 | TERMINATED | 2025-07-16 | Rush University Medical Center... More >>, Chicago, Illinois, 60612, United States Less << |
NCT00501904 | Polycystic Ovary Syndrome | PHASE4 | UNKNOWN | 2025-12-16 | Pugliese Hospital, Catanzaro, ... More >>Catanzaro, CZ, Italy, 88100, Italy Less << |
NCT00063232 | Hepatitis | PHASE2 | COMPLETED | 2025-03-08 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT02402348 | Cancer of Head and Neck | EARLY_PHASE1 | TERMINATED | 2025-08-16 | West Virginia University Hospi... More >>tals - Mary Babb Randolph Cancer Center, Morgantown, West Virginia, 26506, United States Less << |
NCT01122316 | Heart Failure|Diabetes | COMPLETED | 2025-01-12 | Ahmanson-UCLA Cardiomyopathy C... More >>enter, Los Angeles, California, 90095-7368, United States Less << | |
NCT01349387 | Type 2 Diabetes | COMPLETED | 2025-01-12 | Centre Hospitalier Sud Francil... More >>ien, Corbeil Essonnes, 91106, France Less << | |
NCT02546050 | Healthy | PHASE1 | COMPLETED | 2025-02-16 | The Novo Nordisk Foundation Ce... More >>nter of Basic Metabolic Research, Section for Metabolic Genetics, University of Copenhagen, Copenhagen, Copenhagen ?, 2100, Denmark Less << |
NCT02949700 | Head and Neck Squamous Cell Ca... More >>rcinoma Less << | PHASE1|PHASE2 | COMPLETED | 2022-07-07 | Baylor College of Medicine, Ho... More >>uston, Texas, 77030, United States|Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, 77030, United States|Harris Health System - Smith Clinic, Houston, Texas, 77054, United States Less << |
NCT03538704 | Endometrial Cancer|Fertility | UNKNOWN | 2020-12-31 | Peking University People's Hos... More >>pital, Beijing, Beijing, 100044, China Less << | |
NCT05463627 | Polycystic Ovary Syndrome|Metf... More >>ormin Less << | UNKNOWN | 2023-01-01 | Renji Hospital Department of E... More >>ndocrinology and Metabolism, Shanghai, Shanghai, China Less << | |
NCT03490019 | Bardet-Biedl Syndrome|Visual I... More >>mpairment Less << | PHASE2 | WITHDRAWN | 2025-08-20 | - |
NCT01334684 | Type 2 Diabetes | UNKNOWN | 2025-09-13 | Casa Sollievo Della Sofferenza... More >> IRCCS, San Giovanni Rotondo, Foggia, 71013, Italy Less << | |
NCT02042495 | Endometrial Cancer | PHASE2 | WITHDRAWN | - | Jewish General Hospital, Montr... More >>eal, Quebec, H3T1E2, Canada Less << |
NCT01877564 | Adenocarcinoma of the Endometr... More >>ium Less << | PHASE2 | COMPLETED | 2017-07-10 | University of Arkansas for Med... More >>ical Sciences, Little Rock, Arkansas, 72205, United States Less << |
NCT05414409 | Type 1 Diabetes|Obesity | PHASE2 | RECRUITING | 2026-08-01 | Indiana University School of M... More >>edicine, Indianapolis, Indiana, 46202, United States Less << |
NCT01089205 | Type 2 Diabetes | PHASE1 | COMPLETED | - | - |
NCT05939921 | Type2diabetes | COMPLETED | 2023-06-30 | Anoop misra, New Delhi, Delhi,... More >> 110048, India Less << | |
NCT01089166 | Type 2 Diabetes | PHASE1 | COMPLETED | - | Torrent Research Centre, Bhat,... More >> Gujarat, 382 428, India Less << |
NCT02437656 | Rectal Cancer | PHASE2 | COMPLETED | 2025-03-17 | Centre Marie Curie, Arras, 620... More >>00, France|Centre Pierre Curie, Beuvry, 62880, France|Centre Léonard de Vinci - SARL du pont Saint Vaast, Douai, 59500, France|Institut André Dutreix, Dunkerque, 59240, France|Centre Hospitalier, Lens, 62300, France|Clinique du Bois - Centre Bourgogne, Lille, 59000, France|Centre Oscar Lambret, Lille, 59020, France|Centre Galilée - H?pital Privé La Louvière, Lille, 59045, France|Centre Gray, Maubeuge, 59600, France|Centre Joliot-Curie, St Martin-Boulogne, 62200, France|Clinique des Dentellières, Valenciennes, 59300, France Less << |
NCT02783053 | Obesity | COMPLETED | 2025-06-16 | Academic Medical Center, Amste... More >>rdam, 1105AZ, Netherlands Less << | |
NCT04615351 | Gestational Diabetes | PHASE3 | UNKNOWN | 2022-06-30 | Women & Infants Hospital, Prov... More >>idence, Rhode Island, 02905, United States Less << |
NCT04855513 | Preeclampsia|Preeclampsia Seve... More >>re|High Risk Pregnancy|Eclampsia Less << | UNKNOWN | 2023-12-30 | Women Wellness and Research Ce... More >>nter, Doha, 3050, Qatar Less << | |
NCT03200015 | Diffuse Large B Cell Lymphoma | PHASE2 | COMPLETED | 2019-01-27 | Hospital Universitario Dr. Jos... More >>é Eleuterio González, Monterrey, Nuevo Leon, 64610, Mexico Less << |
NCT01876992 | Diabetes|Pre-diabetes|Obesity | TERMINATED | 2025-06-15 | Johns Hopkins University, Balt... More >>imore, Maryland, 21287, United States Less << | |
NCT00881725 | Prostate Cancer | PHASE2 | TERMINATED | 2025-06-12 | University Health Network, Tor... More >>onto, Ontario, M5G2M9, Canada Less << |
NCT00187720 | Other Conditions That May Be A... More >> Focus of Clinical Attention Less << | PHASE4 | COMPLETED | 2025-04-08 | San Francisco General Hospital... More >>, San Francisco, California, 94143, United States Less << |
NCT05554679 | Metformin for Obese Pregnant W... More >>omen Less << | PHASE4 | TERMINATED | 2023-07-11 | Assiut university, Asyut, 1111... More >>7, Egypt Less << |
NCT02125305 | Healthy Elderly | PHASE1 | COMPLETED | - | Seoul National University Bund... More >>ang Hospital, Seoul, Korea, Republic of Less << |
NCT04841668 | Type 2 Diabetes Mellitus | RECRUITING | 2026-02-28 | Institut d'Investigació Biomèd... More >>ica de Girona (IDIBGI), Girona, 17007, Spain Less << | |
NCT01177709 | Schizophrenia|Obesity | TERMINATED | 2025-04-11 | Manhatan Psychiatric Center, N... More >>ew York, New York, 10035, United States Less << | |
NCT02035787 | Complex Atypical Hyperplasia|E... More >>ndometrial Cancer Less << | PHASE2 | COMPLETED | 2024-04-12 | Lineberger Comprehensive Cance... More >>r Center, Chapel Hill, North Carolina, 27599, United States|TriHealth, Cincinnati, Ohio, 45220, United States Less << |
NCT06125873 | Diabetes Mellitus Type 2 | PHASE2 | ENROLLING_BY_INVITATION | 2024-08-01 | Islamabad Medical and Dental C... More >>ollege, Islamabad, Federal, 44000, Pakistan Less << |
NCT03710343 | Cerebral Palsy | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-03-31 | Holland Bloorview Kids Rehabil... More >>itation Hospital, Toronto, Ontario, M4G1R8, Canada|The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Less << |
NCT03155087 | T2DM (Type 2 Diabetes Mellitus... More >>) Less << | COMPLETED | 2025-12-15 | - | |
NCT05979038 | Sepsis | PHASE3 | RECRUITING | 2024-07-10 | Al Demerdash University Hospit... More >>al, Cairo, Egypt Less << |
NCT01231074 | Obesity|Weight Gain|Psychotrop... More >>ic Induced Weight Gain Less << | PHASE1 | COMPLETED | 2025-05-13 | Nationwide Children's Hospital... More >>, Columbus, Ohio, 43205, United States Less << |
NCT05182970 | PreDiabetes|Acute Myocardial I... More >>nfarction|Non ST Elevation Myocardial Infarction|ST Elevation Myocardial Infarction Less << | PHASE3 | RECRUITING | 2025-05-26 | Medicinkliniken, Ljungby Hospi... More >>tal, Ljungby, 341 35, Sweden Less << |
NCT01681693 | Healthy|Type 2 Diabetes Mellit... More >>us Less << | PHASE1 | COMPLETED | 2025-07-13 | San Francisco General Hospital... More >>, San Francisco, California, 94110, United States Less << |
NCT02984475 | Beta Thalassemia Major Anemia | PHASE4 | UNKNOWN | 2025-04-19 | Abo El Reesh Hospital, Cairo.,... More >> Egypt|El Demerdash (Ain Shams Teaching Hospital)., Cairo., Egypt Less << |
NCT01274130 | Healthy Adult | COMPLETED | 2025-09-11 | Severance Hospital, Seoul, 120... More >>-752, Korea, Republic of Less << | |
NCT05041673 | Fatty Liver, Nonalcoholic|Diab... More >>etes Mellitus, Type 2 Less << | UNKNOWN | 2022-09-30 | Alexandria University., Alexan... More >>dria, 21131, Egypt Less << | |
NCT06687876 | Oesophageal Adenocarcinoma|Tum... More >>or Microenvironment Less << | PHASE2 | NOT_YET_RECRUITING | 2025-12-30 | Amsterdam UMC, Amsterdam, Neth... More >>erlands Less << |
NCT04145687 | Lupus Nephritis | PHASE4 | UNKNOWN | 2025-06-22 | Fangfang Sun, MD, Shanghai, Sh... More >>anghai, China Less << |
NCT03137186 | Prostate Cancer | PHASE2 | UNKNOWN | 2025-01-20 | Mansoura university, Mansourah... More >>, 35516, Egypt Less << |
NCT01089192 | Type 2 Diabetes | PHASE1 | COMPLETED | - | Torrent Research Centre, Bhat,... More >> Gujarat, 382 428, India Less << |
NCT01089179 | Type 2 Diabetes | PHASE1 | COMPLETED | - | Torrent Research Centre, Bhat,... More >> Gujarat, 382 428, India Less << |
NCT05053841 | Metformin|Breast Cancer | PHASE2 | COMPLETED | 2025-06-15 | - |
NCT05921942 | Colorectal Cancer | PHASE3 | COMPLETED | 2022-12-30 | Ain Shams University, Cairo, 1... More >>1314, Egypt Less << |
NCT04500678 | HIV/AIDS | PHASE2|PHASE3 | UNKNOWN | 2022-12-31 | John A. Burns School of Medici... More >>ne, University of Hawaii - Manoa, Honolulu, Hawaii, 96813, United States Less << |
NCT03086005 | Polycystic Ovary Syndrome | PHASE3 | COMPLETED | 2015-07-23 | Asan Medical Center, Seoul, So... More >>ngpa-gu, 05505, Korea, Republic of Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
7.74mL 1.55mL 0.77mL |
38.71mL 7.74mL 3.87mL |
77.42mL 15.48mL 7.74mL |
|
Dissolving Methods |
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
|