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Product Details of Methyl 3-amino-2-pyrazinecarboxylate

CAS No. :16298-03-6
Formula : C6H7N3O2
M.W : 153.14
SMILES Code : C1=CN=C(C(=N1)C(OC)=O)N
MDL No. :MFCD00010097
InChI Key :INCSQLZZXBPATR-UHFFFAOYSA-N
Pubchem ID :72669

Safety of Methyl 3-amino-2-pyrazinecarboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Methyl 3-amino-2-pyrazinecarboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 16298-03-6 ]
  • Downstream synthetic route of [ 16298-03-6 ]

[ 16298-03-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 16298-03-6 ]
  • [ 173290-17-0 ]
YieldReaction ConditionsOperation in experiment
44% With diiodomethane; isopentyl nitrite In diiodomethane at 85 - 100℃; for 15 h; Reference Example 15
3-Iodopyrazine-2-carboxylic acid methyl ester (Reference compound No.15-1)
Isoamyl nitrite (5.2 mL, 39 mmol) was added to a suspension of 3-aminopyrazine-2-carboxylic acid methyl ester (1.9 g, 12 mmol) in diiodomethane (20 mL) at 85°C, then the mixture was stirred at 100°C for 15 hours.
The reaction mixture was allowed to stand and purified by silica gel column chromatography to give 1.4 g of the title reference compound as a pale yellow solid. (Yield 44percent)
1H-NMR(500MHz,CDCl3)
δ 4.04(s,3H),8.47(d,J = 2.1 Hz,1H),8.56(d,J = 2.1 Hz,1H)
References: [1] Patent: EP1602647, 2005, A1, . Location in patent: Page/Page column 58.
[2] Patent: WO2018/118670, 2018, A1, . Location in patent: Page/Page column 180; 181.
  • 2
  • [ 16298-03-6 ]
  • [ 1232410-49-9 ]
References: [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330.
 

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