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Chemical Structure| 29475-64-7 Chemical Structure| 29475-64-7
Chemical Structure| 29475-64-7

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Product Details of N-D-Me-Ala-OH

CAS No. :29475-64-7
Formula : C4H9NO2
M.W : 103.12
SMILES Code : C[C@@H](NC)C(O)=O
MDL No. :MFCD00063135
InChI Key :GDFAOVXKHJXLEI-GSVOUGTGSA-N
Pubchem ID :92973

Safety of N-D-Me-Ala-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of N-D-Me-Ala-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29475-64-7 ]

[ 29475-64-7 ] Synthesis Path-Downstream   1~3

  • 1
  • cyclombandakamine A<SUB>1</SUB> [ No CAS ]
  • [ 56-41-7 ]
  • [ 338-69-2 ]
  • [ 3775-72-2 ]
  • [ 3775-73-3 ]
  • [ 3913-67-5 ]
  • [ 29475-64-7 ]
  • (S)-3-(N-methylamino)butanoic acid [ No CAS ]
  • (R)-N-methyl-3-aminobutyric acid [ No CAS ]
  • 2
  • cyclombandakamine A<SUB>2</SUB> [ No CAS ]
  • [ 56-41-7 ]
  • [ 338-69-2 ]
  • [ 3775-72-2 ]
  • [ 3775-73-3 ]
  • [ 3913-67-5 ]
  • [ 29475-64-7 ]
  • (S)-3-(N-methylamino)butanoic acid [ No CAS ]
  • (R)-N-methyl-3-aminobutyric acid [ No CAS ]
  • 3
  • [ 29475-64-7 ]
  • [ 24424-99-5 ]
  • [ 13734-31-1 ]
YieldReaction ConditionsOperation in experiment
In a clean 1000ml four-necked flask was added 23.5g of sodium hydroxide and 100g of water, stirred to dissolve, cooled to below 10 , 150ml of methanol was added, cooled to 0-5 , was added to the residue obtained above, stirred 10min, at 0-5 C was added dropwise 56g BOC anhydride and 100ml of methanol solution was added dropwise at the end of the incubation at 5-30 overnight, the temperature was completed, the methanol was concentrated under reduced pressure, concentrated to about 200ml, add water 350ml, 150ml of petroleum ether was added to extract The aqueous layer was cooled to 0 C to 5 C. The mixture was adjusted to pH 2-3 with concentrated hydrochloric acid, extracted with 250 ml of methylene chloride and the aqueous layer was extracted with 200 ml of dichloromethane. The organic layers were combined and the organic layer was washed with 10%Hydrochloric acid once, the organic layer was dried over anhydrous magnesium sulfate and activated carbon was decolorized, suction filtered and concentrated to dryness. Add 50ml of petroleum ether and stir and cool to crystallize. Suction filtration, rinsed with petroleum ether drying, were dry, HPLC purity 98.6%, ee value of 99.2%.
 

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