Structure of Nifedipine
CAS No.: 21829-25-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Nifedipine is a calcium channel blocker with high affinity for L-type calcium channels, with an IC50 value of 10 nM. Nifedipine has antihypertensive and antianginal effects and can be used in cardiovascular disease research.
Synonyms: BAY-a-1040; BAY 1040
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Fofie, Christian Kuete ; Granja-Vazquez, Rafael ; Truong, Vincent ; Walsh, Patrick ; Price, Theodore ; Biswas, Swati , et al.
Abstract: Chronic pain is a global health issue, yet effective treatments remain limited due to poor preclinical-to-human translation. To address this, we developed a high-content screening (HCS) platform using hiPSC-derived nociceptors to identify analgesics targeting the peripheral nervous system. These cells, cultured on multi-well microelectrode arrays, achieved nearly 100% active electrodes by week 2, maintaining stable activity for at least 2 weeks. After 28 days, we assessed drug effects on neuronal activity, achieving strong assay performance (robust Z′ > 0.5). Pharmacological tests confirmed responses to key analgesic targets, including ion channels (Nav, Cav, Kv, and TRPV1), neurotransmitter receptors (AMPAR and GABA-R), and kinase inhibitors (tyrosine and JAK1/2). Transcriptomic analysis validated target expression, though levels differed from primary human DRG cells. The platform was used to screen over 700 natural compounds, demonstrating its potential for analgesic discovery. This HCS platform facilitates the rapid discovery of uncharacterized analgesics, reducing preclinical-to-human translation failure.
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CAS No. : | 21829-25-4 |
Formula : | C17H18N2O6 |
M.W : | 346.33 |
SMILES Code : | O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC |
Synonyms : |
BAY-a-1040; BAY 1040
|
MDL No. : | MFCD00057326 |
InChI Key : | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
Pubchem ID : | 4485 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H351-H361 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
Rat aortic smooth muscle cells | 25 and 100 nM | 30 min | To investigate the effect of Nifedipine on Ang II-induced NADPH oxidase activity, results showed that Nifedipine significantly attenuated Ang II-induced NADPH oxidase activity. | PMC4637219 |
Mouse liver S9 fraction | 50 μM | 40 min | To test the activity of mouse hepatic CYP3A11, the results showed that the generation of oxidized nifedipine in control mice was significantly higher than in treated mice | PMC8727778 |
Gastric Smooth Muscle Cells | 10 μM | Used to test the occurrence of L-type calcium current (ICa,L). | PMC7767160 | |
CAFs | 2.5 μM | 24 h | To assess the effect of Nifedipine on the activated state of CAFs, results showed that Nifedipine reduced CAF motility and ECM remodeling ability, and decreased MMP-2 release. | PMC11165820 |
DU145 cells | 2.5 μM | 24 h | To evaluate the effect of Nifedipine-treated CAFs on the growth of DU145 cells, results showed that Nifedipine significantly inhibited the growth of DU145 cells. | PMC11165820 |
LNCaP cells | 14.69 µM | 72 h | Nifedipine showed dose-dependent antiproliferative effects in LNCaP cells with an IC50 value of 14.69 µM. | PMC8762999 |
DU145 cells | 26.66 µM | 72 h | Nifedipine showed dose-dependent antiproliferative effects in DU145 cells with an IC50 value of 26.66 µM. | PMC8762999 |
MGC-803 cells | 20.73 µM | 72 h | Nifedipine showed toxicity in the MGC-803 cell line with an IC50 value of 20.73 µM. | PMC8762999 |
hSSC-derived cells | 5 μM | 3 weeks | To determine the Ca2+ influx in hSSC-derived cells, results showed that nifedipine significantly reduced the Ca2+ influx. | PMC6598262 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | Cacna1d KO mice | Apical administration | 10 μM | Single dose | To investigate the effect of Nifedipine on ileal calcium absorption in Cacna1d KO mice, results showed that Nifedipine significantly inhibited ileal calcium absorption in WT mice but not in Cacna1d KO mice. | PMC6889763 |
Mice | Awake and freely moving mouse model | Intraperitoneal injection | 1 mg/kg | Single administration, observed for 6 hours | To investigate the modulation of JWH-018-induced cardiovascular and respiratory responses by Nifedipine. Results showed that Nifedipine did not significantly reverse the JWH-018-induced bradycardia but slightly reduced the JWH-018-induced tachyarrhythmic events during the last two hours of the experiment. Additionally, Nifedipine restored the JWH-018-induced reduction in breath rate and SpO2 immediately after administration. | PMC10142259 |
hph-1 mice | Ang II-induced abdominal aortic aneurysm model | Oral | 5 and 20 mg/kg | Once daily for 2 weeks | To investigate the effect of Nifedipine on AAA formation, results showed that Nifedipine significantly reduced the incidence of AAA and improved eNOS coupling and NO bioavailability. | PMC4637219 |
Mice | Chronic colitis model | Oral | 20 mg/kg | Once daily for 14 weeks | To study the effects of long-term exposure to RTS and/or DSS on the liver and intestines of mice, the results showed that RTS exposure caused intestinal injury, and DSS exacerbated RTS-induced liver injury | PMC8727778 |
SCID mice | Prostate cancer xenograft model | Intratumoral injection | 250 μl | 5 consecutive days for 2 weeks | To evaluate the effect of Nifedipine-treated CAFs on the growth of prostate cancer xenografts, results showed that Nifedipine significantly inhibited tumor growth. | PMC11165820 |
Male athymic nude mice | Prostate cancer xenograft model | Intraperitoneal injection | 50 mg/kg | Once daily for 18 days | Nifedipine significantly inhibited the growth of prostate tumors without causing apparent changes. | PMC8762999 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00000102 | Congenital Adrenal Hyperplasia | Phase 1 Phase 2 | Completed | - | United States, South Carolina ... More >> Medical University of South Carolina Charleston, South Carolina, United States Less << |
NCT01010048 | Urinary Calculus | Phase 4 | Unknown | December 2010 | China, Chongqing ... More >> The First Affiliated Hospital, ChongQing medical University Recruiting ChongQing, Chongqing, China, 400016 Contact: Yunfeng He, Doctor 86-23-89011121 Contact: Xiaohou Wu, Doctor 86-23-89011122 Less << |
NCT00280462 | Ocular Physiology ... More >> Regional Blood Flow Less << | Not Applicable | Completed | - | Austria ... More >> Department of Clinical Pharmacology Vienna, Austria, 1090 Less << |
NCT01912677 | Hypertension in Pregnancy ... More >> Preeclampsia Less << | Phase 4 | Completed | - | India ... More >> Daga Women's Hospital Nagpur, Maharashtra, India, 440003 Government Medical College Nagpur, Maharashtra, India, 440003 Less << |
NCT02933593 | Hypertension | Not Applicable | Withdrawn(PI withdrew the prot... More >>ocol) Less << | - | - |
NCT00722215 | Chronic Kidney Disease ... More >> Proteinuria Less << | Phase 1 | Completed | - | United Kingdom ... More >> Clinical Research Centre, Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Less << |
NCT00817037 | Chronic Kidney Disease ... More >> Proteinuria Blood Pressure Less << | Phase 2 | Unknown | - | United Kingdom ... More >> Clinical Research Centre, Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Less << |
NCT02337881 | Labor Preterm Requiring Hospit... More >>alization Less << | Phase 1 | Unknown | October 2016 | Egypt ... More >> Menoufia University Recruiting Shebin Elkom, Egypt Principal Investigator: tarek sayed Saudi Arabia Alhayah national hospital Recruiting Abha, Saudi Arabia Principal Investigator: mohamed maher Less << |
NCT00641784 | Labor, Premature | Phase 3 | Terminated | March 2012 | United States, California ... More >> Memorial Care Center for Women/Long Beach Memorial Medical Center Long Beach, California, United States, 92806 Less << |
NCT01363336 | - | Completed | - | Japan ... More >> Many Locations, Japan Less << | |
NCT01351428 | Pre-Eclampsia ... More >> Pregnancy Hypertension Less << | Not Applicable | Completed | - | Canada, Ontario ... More >> Mount Sinai Hospital Toronto, Ontario, Canada, M5G1X5 Less << |
NCT03695107 | - | Recruiting | September 10, 2020 | China, Hunan ... More >> The Third Xiangya Hospital of Central South University , , China, Recruiting Changsha, Hunan, China, 410013 Contact: Yang Guoping , professor, doctor 0086 0731 88618326 ygp9880@126.com Less << | |
NCT02885558 | Endothelium, Vascular | Not Applicable | Recruiting | December 2018 | Denmark ... More >> Centre for Phsical Activity Research Not yet recruiting Copenhagen, Denmark, 2100 Contact: Stefan P Mortensen, DMSc smortensen@health.sdu.dk Cardiovascular and Renal Research Recruiting Odense, Denmark, 5000 Contact: Stefan P Mortensen, DMSc smortensen@health.sdu.dk Less << |
NCT01518855 | Hypertension | Phase 4 | Completed | - | Japan ... More >> Sapporo, Hokkaido, Japan, 060-0003 Setagaya-ku, Tokyo, Japan, 158-0097 Shinjuku-ku, Tokyo, Japan, 163-6003 Hiroshima, Japan, 733-0011 Less << |
NCT00728858 | - | Completed | - | - | |
NCT00519870 | Pulmonary Hypertension | Phase 3 | Completed | - | - |
NCT01215708 | Renal Calculi | Phase 3 | Unknown | December 2010 | Brazil ... More >> Clinics Hospital of University of Sao Paulo Sao Paulo, Brazil, 05403900 Less << |
NCT01830530 | Hypertension ... More >>High Altitude Less << | Phase 4 | Completed | - | Peru ... More >> Universidad Peruana Cayetano Heredia Lima, Peru Less << |
NCT02725736 | Labor Preterm Multiple | Phase 3 | Unknown | March 2018 | - |
NCT01348880 | Erectile Dysfunction | Phase 1 | Completed | - | United States, Florida ... More >> Miami, Florida, United States, 33014 United States, Tennessee Knoxville, Tennessee, United States, 37920 Less << |
NCT03136666 | Clinical Pharmacology | Phase 1 | Completed | - | Germany ... More >> Wuppertal, Nordrhein-Westfalen, Germany, 42096 Less << |
NCT00391339 | Tocolysis | Phase 2 Phase 3 | Unknown | - | Switzerland ... More >> Department of Obstetrics, University of Zuerich Not yet recruiting Zuerich, Switzerland, 8091 Principal Investigator: Roland Zimmermann, Prof. Dr. med. Principal Investigator: Ursula von Mandach, Prof. Dr. pharm. Less << |
NCT00713011 | Diabetic Nephropathies ... More >> Hypertension Less << | Phase 3 | Withdrawn(Study was stopped by... More >> sponsor prior to first patient assignment to groups due to operational reasons.) Less << | March 2009 | - |
NCT00620724 | Placenta Previa | Phase 2 | Completed | - | France ... More >> University Hospital Rouen Rouen, France, 76031 Less << |
NCT03506724 | Hypertension in Pregnancy ... More >> Preeclampsia Less << | Phase 4 | Recruiting | January 2019 | United States, New York ... More >> Maimonides Hospital Recruiting Brooklyn, New York, United States, 11219 Contact: Poroshat Shekarloo, MD pshekarloo@maimonidesmed.org Mount Sinai West Recruiting New York, New York, United States, 10019 Contact: Dyese Taylor, MD 212-523-7579 dyese.taylor@mountsinai.org Principal Investigator: Dyese Taylor, MD Less << |
NCT03654378 | - | Recruiting | December 2022 | United States, Illinois ... More >> Northwestern University Asher Center for the Study and Treatment of Depressive Disorders Recruiting Chicago, Illinois, United States, 60611 Contact: Minaz K Cattan, M.D. 312-695-7190 minaz.kolia@northwestern.edu Contact: Gabrielle A Mesches, M.S. 312-695-6684 gabrielle.mesches@northwestern.edu Principal Investigator: Katherine L Wisner, M.D., M.S. Less << | |
NCT01429545 | Preterm Labour | Phase 2 | Completed | - | United Arab Emirates ... More >> Department of obstetrics and Gynecology, Tawam Hospital Al Ain, Abudhabi, United Arab Emirates, 15258 Tawam Hospital Al Ain, Abudhabi, United Arab Emirates, 15258 Less << |
NCT01796522 | Preterm Delivery. | Phase 3 | Withdrawn(have been published ... More >>new studies that it showed the ineffectiveness of the treatments proposed in this study.) Less << | May 2013 | Spain ... More >> Hospital Universitari y Politécnic La Fe Valencia, Spain, 46026 Less << |
NCT00750113 | Hypertension | Phase 4 | Completed | - | Italy ... More >> Pozzilli, Isernia, Italy, 86077 Monza, Monza-Brianza, Italy, 20052 Somma Lombardo, Varese, Italy, 21013 Ancona, Italy, 60126 Bologna, Italy, 40138 Brescia, Italy, 25123 Broni, Italy, 27043 Catania, Italy, 95126 Cinisello Balsamo, Italy, 20092 Ferrara, Italy, 44100 L'Aquila, Italy, 67100 Milano, Italy, 20143 Napoli, Italy, 80136 Napoli, Italy, 80141 Novara, Italy, 28100 Padova, Italy, 35128 Palermo, Italy, 90127 Pavia, Italy, 27100 Perugia, Italy, 06129 Pisa, Italy, 56126 Reggio Emilia, Italy, 42100 Roma, Italy, 00152 Roma, Italy, 00157 Roma, Italy, 00161 Sassari, Italy, 07100 Siena, Italy, 53100 Siracusa, Italy, 96100 Treviso, Italy, 31100 Trieste, Italy, 34149 Varese, Italy, 21100 Venezia, Italy, 30122 Spain Ferrol, A Coruña, Spain, 15405 Gijón, Asturias, Spain, 33394 Badalona, Barcelona, Spain, 08916 Jerez de la Frontera, Cádiz, Spain, 11407 Las Palmas de Gran Canaria, Las Palmas, Spain, 35020 Beniganim, Valencia, Spain, 46830 Badajoz, Spain, 06080 Ciudad Real, Spain, 13005 Madrid, Spain, 28040 Madrid, Spain, 28041 Málaga, Spain, 29010 Valencia, Spain, 46006 Less << |
NCT01118286 | - | Completed | - | Bahrain ... More >> Many Locations, Bahrain Egypt Many Locations, Egypt Jordan Many Locations, Jordan Lebanon Many Locations, Lebanon Morocco Many Locations, Morocco Oman Many Locations, Oman Pakistan Many Locations, Pakistan Qatar Many Locations, Qatar Russian Federation Many Locations, Russian Federation Saudi Arabia Many Locations, Saudi Arabia United Arab Emirates Many Locations, United Arab Emirates Less << | |
NCT01030081 | Hypertension | Phase 4 | Completed | - | China ... More >> Shanghai Institite of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai, China, 200025 Less << |
NCT00173667 | Hypertension | Phase 4 | Unknown | - | Taiwan ... More >> Cardiovascular Division, Department of Internal Medicine, National Taiwan University Hospital Not yet recruiting Taipei, Taiwan Contact: Gen-Gae Chen, MD 886-2-23123456 Less << |
NCT01355367 | Hypertension | Phase 3 | Completed | - | Japan ... More >> Hirosaki, Aomori, Japan, 036-8082 Kamagaya, Chiba, Japan, 273-0100 Asahikawa, Hokkaido, Japan, 070-0061 Asahikawa, Hokkaido, Japan, 078-8214 Sapporo, Hokkaido, Japan, 003-0026 Sapporo, Hokkaido, Japan, 003-0825 Sapporo, Hokkaido, Japan, 004-0004 Sapporo, Hokkaido, Japan, 007-0841 Sapporo, Hokkaido, Japan, 062-0053 Sapporo, Hokkaido, Japan, 063-0841 Sapporo, Hokkaido, Japan, 064-0803 Sapporo, Hokkaido, Japan, 064-0807 Kawasaki, Kanagawa, Japan, 210-0852 Daito, Osaka, Japan, 574-0074 Kishiwada, Osaka, Japan, 596-8522 Yao, Osaka, Japan, 581-0011 Tokorozawa, Saitama, Japan, 359-1141 Hachioji, Tokyo, Japan, 192-0046 Meguro, Tokyo, Japan, 152-0031 Minato, Tokyo, Japan, 105-7390 Minato, Tokyo, Japan, 108-0075 Shizuoka, Japan, 421-0193 Less << |
NCT02912910 | - | Withdrawn(PI withdrew protocol... More >>) Less << | - | - | |
NCT00672113 | Hypertension | Phase 4 | Completed | - | United Kingdom ... More >> Cambridge, Cambridgeshire, United Kingdom, CB2 2XY Less << |
NCT01985594 | Preterm Labor | Phase 2 | Unknown | October 2014 | Malaysia ... More >> Obstetric and Gynaecology Department, National University of Malaysia Medical Centre Recruiting Cheras, Kuala Lumpur, Malaysia, 56000 Contact: national university of malaysia medical centre 60391455950 Sub-Investigator: nor zila hassan malek Principal Investigator: nor azlin mohamed ismail Less << |
NCT03449277 | Postpartum Preeclampsia | Phase 4 | Recruiting | March 1, 2019 | Egypt ... More >> Hossam Ahmed Abd Ellah Recruiting Assiut, Egypt Contact: Hossam Ahmed Abd Ellah, MBBCH 0201119939775 drhaaada@gmail.com Less << |
NCT00244530 | Kidney Failure, Chronic ... More >> Coronary Artery Disease Less << | Phase 4 | Completed | - | Norway ... More >> Rikshospitalet University Hospital Oslo, Norway, 0027 Less << |
NCT00993109 | Hypertension | Phase 4 | Completed | - | China, Guangdong ... More >> Guangzhou, Guangdong, China, 510080 China, Hebei Shijiazhuang, Hebei, China, 050051 China, Hunan Changsha, Hunan, China, 410008 Changsha, Hunan, China, 410013 China, Jiangsu Nanjing, Jiangsu, China, 210008 Nanjing, Jiangsu, China, 210029 China, Liaoning Shenyang, Liaoning, China, 110001 China Beijing, China, 100029 Beijing, China, 100037 Shanghai, China, 200025 Korea, Republic of Donggu,, Gwangju Gwang''yeogsi, Korea, Republic of, 501757 Bucheon-si,, Gyeonggido, Korea, Republic of Yangsan-si, Gyeongnam, Korea, Republic of Jongno-gu, Korea, Republic of Jung-gu, Korea, Republic of Seoul, Korea, Republic of, 110-744 Seoul, Korea, Republic of, 120-752 Less << |
NCT02047019 | Hypertension | Phase 3 | Withdrawn(GPDC decided to term... More >>inate the study) Less << | December 8, 2019 | Italy ... More >> Fondazione Università G.D'Annunzio Chieti, Abruzzo, Italy, 66100 A.O.U. di Bologna Policlinico S.Orsola Malpighi Bologna, Emilia-Romagna, Italy, 40138 AAS 3 Friuli Alto Medio Collin Udine, Friuli-Venezia Giulia, Italy, 33038 Fondazione Salvatore Maugeri Pavia, Lombardia, Italy, 27100 IRCCS Ist Neurologico Mediterraneo Isernia, Molise, Italy, 86077 A.O.U. di Sassari Sassari, Sardegna, Italy, 07100 A.O.U. Pisana Pisa, Toscana, Italy, 56126 AULSS 07 Pieve Soligo Treviso, Veneto, Italy, 31029 Less << |
NCT02513927 | Hypertension | Phase 2 Phase 3 | Unknown | October 2018 | Hungary ... More >> Twenty-four-hour ambulatory BP monitoring Recruiting Budapest, Hungary Contact: Jingyan Piao, MM 86-451-85555333 411483521@qq.com Contact: Yujiao Pan, MM 86-451-85555671 panyujiao@163.com Less << |
NCT01071122 | Hypertension | Phase 4 | Completed | - | Korea, Republic of ... More >> Goyang-si, Gyeonggido, Korea, Republic of, 411-706 Goyang, Gyeonggido, Korea, Republic of, 410-773 Chungchungbuk-do, Korea, Korea, Republic of, 361-711 Seoul, Korea, Korea, Republic of, 135-720 Seoul, Seoul Teugbyeolsi, Korea, Republic of, 152-703 Busan, Korea, Republic of Gwangju, Korea, Republic of, 501-757 Joong-gu, Korea, Republic of, 100-380 Kungki-do, Korea, Republic of, 463-707 Seoul, Korea, Republic of, 110-744 Seoul, Korea, Republic of, 120-752 Seoul, Korea, Republic of, 135-710 Seoul, Korea, Republic of, 136-705 Seoul, Korea, Republic of, 137-701 Suwan, Korea, Republic of, 443-721 Less << |
NCT03542552 | Placenta Previa | Phase 3 | Not yet recruiting | January 2020 | - |
NCT01287260 | Hypertension | Phase 3 | Completed | - | Japan ... More >> Hirosaki, Aomori, Japan, 036-8082 Kamagaya, Chiba, Japan, 273-0100 Asahikawa, Hokkaido, Japan, 070-0061 Asahikawa, Hokkaido, Japan, 078-8214 Sapporo, Hokkaido, Japan, 003-0026 Sapporo, Hokkaido, Japan, 003-0825 Sapporo, Hokkaido, Japan, 004-0004 Sapporo, Hokkaido, Japan, 007-0841 Sapporo, Hokkaido, Japan, 062-0053 Sapporo, Hokkaido, Japan, 063-0841 Sapporo, Hokkaido, Japan, 064-0803 Sapporo, Hokkaido, Japan, 064-0807 Kawasaki, Kanagawa, Japan, 210-0852 Daito, Osaka, Japan, 574-0074 Kishiwada, Osaka, Japan, 596-8522 Yao, Osaka, Japan, 581-0011 Tokorozawa, Saitama, Japan, 359-1141 Hachioji, Tokyo, Japan, 192-0046 Meguro, Tokyo, Japan, 152-0031 Minato, Tokyo, Japan, 105-7390 Minato, Tokyo, Japan, 108-0075 Shizuoka, Japan, 421-0193 Less << |
NCT00816205 | Anal Resting Pressure | Phase 1 Phase 2 | Completed | - | Israel ... More >> Dept of Gastroeneterology, Asaf Harofe Medical Center Zrifin, Israel Less << |
NCT00768560 | Hypertension | Phase 2 | Completed | - | Japan ... More >> Sendai, Miyagi, Japan, 982-0032 Suita, Osaka, Japan, 565-0853 Koshigaya, Saitama, Japan, 343-0827 Less << |
NCT01294215 | Hypertension | Phase 3 | Completed | - | Japan ... More >> Ebina, Kanagawa, Japan, 243-0401 Sagamihara, Kanagawa, Japan, 252-0311 Kawaguchi, Saitama, Japan, 332-0012 Shinjuku, Tokyo, Japan, 169-0072 Less << |
NCT00599898 | Labor, Premature | Phase 4 | Completed | - | Israel ... More >> HaEmek Medical Center Afula, Israel, 18100 Less << |
NCT01314859 | Threatened Preterm Labor | Phase 3 | Withdrawn | July 2013 | - |
NCT02563405 | Hypertension | Phase 2 Phase 3 | Unknown | October 2018 | China, Heilongjiang ... More >> uric acid test and 24-hour ambulatory BP monitoring Recruiting Harbin, Heilongjiang, China, 150001 Contact: Yujiao Pan, MM 86-451-85555671 panyujiao@163.com Less << |
NCT01303783 | Hypertension, Essential | Phase 2 | Completed | - | - |
NCT00185900 | - | Completed | - | - | |
NCT02357615 | Essential Hypertension | Phase 4 | Unknown | September 2015 | China ... More >> Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School Recruiting Shanghai, China Contact: Pingjin Gao Less << |
NCT00712738 | Thalassemia I... More >>ron Overload Hemochromatosis Less << | Phase 1 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00185900 | Obstetric Labor, Premature | Not Applicable | Completed | - | United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less << |
NCT03245307 | Cytochrome P450 Interaction | Phase 1 | Recruiting | September 30, 2018 | China, Liaoning ... More >> Chinese Medical University First Hospital Recruiting Shenyang, Liaoning, China Contact: Yunpeng Liu 86024-83282802 cmu_trial@163.com Less << |
NCT00768560 | - | Completed | - | - | |
NCT00486824 | - | Completed | - | - | |
NCT00486824 | Obstetric Labor, Premature | Phase 1 Phase 2 | Completed | - | United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less << |
NCT01586286 | Levator Ani Syndrome | Not Applicable | Withdrawn(No patients were rec... More >>ruited over a 12 month period) Less << | May 2014 | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less << |
NCT01788358 | - | Completed | - | - | |
NCT00306462 | Premature Birth ... More >> Premature Labor Less << | Not Applicable | Terminated(No enrollment in pa... More >>st year, lack of interest) Less << | - | United States, Ohio ... More >> University Hospital Cincinnati, Ohio, United States, 45219 Less << |
NCT00496184 | Vulvar Diseases ... More >> Vulvar Pain Vestibulitis Vestibulodynia Vulvodynia Less << | Phase 3 | Completed | - | Israel ... More >> Colposcopy Clinic, Obstetrics and Gynecology Department, Western galilee Hospital Nahariya, Israel Department of Obstetrics and Gynecology Nahariya, Israel Less << |
NCT01346657 | Healthy Volunteers | Phase 4 | Completed | - | Taiwan ... More >> Taipei Medical University - WanFang Hospital Taipei, Taiwan Less << |
NCT01157481 | Diastolic Heart Failure | Not Applicable | Unknown | December 2016 | Japan ... More >> Hokkaido Univestity Hospital Sapporo, Japan, 060-8638 Less << |
NCT02583633 | Managing Preterm Labor | Phase 4 | Completed | - | - |
NCT02499822 | Hypertension ... More >>High Blood Pressure Variability Less << | Phase 4 | Recruiting | December 2018 | China ... More >> Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine Recruiting Shanghai, China Contact: Jiguang Wang, MD jiguangwang@aim.com Greece Hypertension Center, Third University Department of Medicine, Sotiria Hospital Not yet recruiting Athens, Greece Contact: George S Stergiou, MD gstergi@med.uoa.gr Italy Istituto Auxologico Italiano Recruiting Milan, Italy Contact: Gianfranco Parati, MD 390261911 ext 2890 gianfranco.parati@unimib.it Less << |
NCT00185952 | Obstetric Labor, Premature ... More >> Venous Thrombosis Less << | Not Applicable | Completed | - | United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less << |
NCT01788358 | Hypertension | Phase 3 | Completed | - | - |
NCT01435161 | Atrial Fibrillation | Phase 4 | Completed | - | China, Chongqing ... More >> 2ndChongqingMU Chongqing, Chongqing, China, 400010 Less << |
NCT00137501 | Labor, Premature | Phase 3 | Terminated(The trial was termi... More >>nated because of difficulties in recruitement.) Less << | - | Lebanon ... More >> American University of Beirut Medical Center Beirut, Lebanon Less << |
NCT01167153 | Hypertension | Phase 4 | Completed | - | China ... More >> Novartis Pharmaceuticals Beijing, China Less << |
NCT02031861 | Essential Hypertension | Phase 4 | Completed | - | China, Shanghai ... More >> Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School Shanghai, Shanghai, China, 200025 Less << |
NCT02426177 | Postnatal Hypertension | Phase 3 | Unknown | December 2016 | - |
NCT00525486 | Preterm Labor | Not Applicable | Terminated | - | - |
NCT03027674 | Raynaud Phenomenon Due to Trau... More >>ma Raynaud Disease System; Sclerosis Lupus Erythematosus, Systemic Dermatomyositis Ultrasound Therapy; Complications Less << | Early Phase 1 | Completed | - | Chile ... More >> Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Santiago, RM, Chile, 7820436 Less << |
NCT01167153 | - | Completed | - | - | |
NCT00865891 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less << |
NCT01227603 | Hypertension, Essential | Phase 1 | Completed | - | Germany ... More >> Köln, Nordrhein-Westfalen, Germany, 51063 Less << |
NCT00864617 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... More >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Less << |
NCT02168309 | Severe Postpartum Hypertension | Not Applicable | Completed | - | United States, California ... More >> Cedars Sinai Medical Center Los Angeles, California, United States, 90048 Less << |
NCT03194633 | - | Recruiting | May 31, 2019 | China ... More >> Many Locations Recruiting Multiple Locations, China Less << | |
NCT02168309 | - | Completed | - | - | |
NCT01360034 | Obstetric Labor, Premature | Phase 3 | Unknown | June 2016 | Panama ... More >> Saint Thomas Hospital Panama, Panama Less << |
NCT02641821 | Hypertension | Phase 4 | Unknown | December 2016 | China ... More >> Division of Cardiology, Peking University First Hospital Recruiting Beijing, China, 100034 Contact: Yang Yu 8610-83575262 jiyou_2000@163.com Principal Investigator: Yong Huo, MD Less << |
NCT00972907 | Chronic Anal Fissure | Phase 1 Phase 2 | Completed | - | Israel ... More >> Sapir Medical Center Kfar Saba, Israel Macabi HMO Tel Aviv, Israel Less << |
NCT02527109 | Chronic Anal Fissure | Phase 2 Phase 3 | Completed | - | Bulgaria ... More >> UMHAT "Sveti Georgi", Internal Consulting Department Plovdiv, Bulgaria "Multiprofile Hospital for Active Treatment - Doverie" AD, Clinic of Gastroenterology Sofia, Bulgaria, 1632 II MHAT, Internal Clinic, Department of Gastroenterology Sofia, Bulgaria MC Health BG EOOD Sofia, Bulgaria Multiprofile Hospital for Active Treatment Lulin Sofia, Bulgaria MC "New rehabilitation centre'' EOOD Stara Zagora, Bulgaria "Multiprofile Regional Hospital for Active Treatment - Dr. St. Cherkezov" AD Department of Gastroenterology Veliko Tarnovo, Bulgaria, 5002 Moldova, Republic of IMSP Spitalul Clinic Municipal Nr 1 Chisinau, Moldova, Republic of IMSP Spitalul Clinic Municipal Nr 3 "Sfanta Treime" Chisinau, Moldova, Republic of IMSP Spitalul Clinic Republican Chisinau, Moldova, Republic of Poland Med-Gastr Centrum Medyczne Lodz, Poland, 91-034 Ambulatorium Medyczne Medical Hair & Esthetic Lublin, Poland, 20-844 Centrum Innowacyjnych Terapii Sp. z o.o. Oddział w Piasecznie Piaseczno, Poland, 05-500 NZOZ Specjalistyczne Centrum Medyczne Flebo Wolomin, Poland, 05-200 Romania Pelican Impex SRL Oradea, Jud. Bihor, Romania, 410469 IRGH Cluj Napoca, Jud. Cluj, Romania, 400162 Tvm Med Serv Srl Cluj Napoca, Jud. Cluj, Romania Institutul Regional de Gastroenterologie si Hepatologie "Prof. Dr. Octavian Fodor" Cluj-Napoca, Jud. Cluj, Romania, 400162 SC Schnelbach Medical Care SRL Ploiesti, Jud. Prahova, Romania Spit. Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta Constanta, Judet Constanta, Romania Dacmed SRL Ploiesti, Judetul Prahova, Romania Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL Brasov, Romania, 500283 Institutul Clinic Fundeni Bucharest, Romania, 022328 Centrul Medical Sfanta Vineri SRL Bucharest, Romania Less << |
NCT00884442 | Bioavailability, Therapeutical... More >> Indication Not Studied Less << | Phase 1 | Completed | - | Germany ... More >> SocraTec R&D Probandenstation Erfurt, Thüringen, Germany, 99084 Less << |
NCT03040752 | Preterm Birth | Phase 4 | Completed | - | Egypt ... More >> Kasr Alainy medical school Cairo, Egypt, 12151 Less << |
NCT02413515 | Hypertension | Phase 4 | Completed | - | China, Fujian ... More >> Fuzhou, Fujian, China, 350001 China, Hebei Tangshan, Hebei, China, 063000 China, Hubei Wudan, Hubei, China, 430022 China, Hunan Changsha, Hunan, China, 410008 China, Jiangsu Nanjing, Jiangsu, China, 210008 China, Shanxi Xi'an, Shanxi, China, 710061 China, Zhejiang Hangzhou, Zhejiang, China, 310006 China Beijing, China, 100028 Beijing, China, 100037 Beijing, China Shandong, China Shanghai, China, 200025 Tangshang, China Tianjin, China, 300052 Less << |
NCT02071589 | Bioequivalence | Phase 1 | Completed | - | Spain ... More >> CIM Sant Pau Barcelona, Spain, 08025 Less << |
NCT01350609 | Hypertension, Essential | Phase 1 | Completed | - | Germany ... More >> Berlin, Germany, 13353 Less << |
NCT01021501 | Hypertension on Chronic Mainte... More >>nance Hemodialysis Less << | Phase 4 | Unknown | April 2011 | China, Guangdong ... More >> Department of Nephrology, Guangzhou First Municipal People's Hospital Not yet recruiting Guangzhou, Guangdong, China, 510180 Contact: Riguang LIU, PhD 802081048157 ext 8157 houqs@yahoo.cn Contact: Lin Chen 802081048157 Principal Investigator: Junzhou Fu, MASTER Sub-Investigator: Ming Liang, PhD Less << |
NCT02438371 | Preterm Labor | Phase 4 | Recruiting | March 2020 | United States, Texas ... More >> Memorial Hermann Hospital Texas Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Jerrie S Refuerzo, M.D. 713-500-6416 Jerrie.S.Refuerzo@uth.tmc.edu Contact: Maria Hutchinson, M.S 713-500-5850 Maria.S.Keefer@uth.tmc.edu Principal Investigator: Jerrie S Refuerzo, M.D. Less << |
NCT03325348 | Severe Pre-Eclampsia, Antepart... More >>um Less << | Phase 2 Phase 3 | Recruiting | January 15, 2018 | Pakistan ... More >> Services Institute of Medical Sciences Recruiting Lahore, Punjab, Pakistan Contact: TAYYIBA WASIM, FCPS +923008400197 tayyibawasim@yahoo.com Contact: Natasha Usman, FCPS natashausman5@hotmail.com Less << |
NCT02023047 | Anal Fissure | Phase 1 Phase 2 | Terminated(Met primary endpoin... More >>t) Less << | - | Israel ... More >> Macabi outpatient clinic Beer Sheba, Negev, Israel Macabi outpatient clinic Rehovot, Israel Macabi HMO outpatient clinic Tel Aviv, Israel Asaf Harofe Hospital Zrifin, Israel Less << |
NCT03100838 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... More >> BioPharma Services Inc. Columbia, Missouri, United States, 65201 Less << |
NCT03129945 | Obstetric Labor, Premature | Not Applicable | Active, not recruiting | September 2019 | United States, California ... More >> University of California, Los Angeles Los Angeles, California, United States, 90095 University of California, Irvine Orange, California, United States, 92868 University of California, Davis Sacramento, California, United States, 95817 University of California, San Diego San Diego, California, United States, 92103 University of California, San Francisco San Francisco, California, United States, 94143 Less << |
NCT02072291 | Embryo Implantation | Phase 2 | Recruiting | June 2018 | Israel ... More >> Hadassah Medical Organization Recruiting Jerusalem, Israel Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il Contact: Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il Principal Investigator: Assaf Ben-Meir, MD Less << |
NCT02132533 | Preterm Labor | Phase 3 | Recruiting | May 2018 | United States, Texas ... More >> Parkland Memorial Hospital Recruiting Dallas, Texas, United States, 75390 Principal Investigator: Josiah S Hawkins, MD Sub-Investigator: Brian M Casey, MD Sub-Investigator: Kenneth J Leveno, MD Less << |
NCT02068404 | Preterm Labor | Phase 4 | Unknown | January 2016 | Switzerland ... More >> Centre Hospitalier Universitaire Vaudois Recruiting Lausanne, Vaud, Switzerland, 1011 Contact: Alice Panchaud, PhD 0213144276 ext +41 Alice.Panchaud@chuv.ch Principal Investigator: Alice Panchaud, PhD Sub-Investigator: David Baud, MD PhD MER Sub-Investigator: Chantal Csajka, Prof PhD Sub-Investigator: Chin B Eap, Prof PhD Sub-Investigator: Karine Lepigeon Sub-Investigator: Etienne Weisskopf, PharmD Less << |
NCT02902354 | Tocolysis With Nifedipine | Not Applicable | Withdrawn | - | - |
NCT03595982 | Hypertension in Pregnancy ... More >> Hypertension in Postpartum Less << | Phase 4 | Recruiting | February 11, 2019 | United States, New York ... More >> Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Principal Investigator: Melissa Chu Lam, MD Less << |
NCT02940548 | Hypertension | Phase 4 | Unknown | December 2018 | China ... More >> Peking University People's Hospital Recruiting Beijing, China, 100044 Contact: Jing Liu, M.D. 861088325457 heartcenter@163.com Principal Investigator: Jing Liu, M.D. Less << |
NCT02090920 | - | Active, not recruiting | May 2018 | United States, Indiana ... More >> Eskenazi Health Indianapolis, Indiana, United States, 46202 IU Health Methodist Indianapolis, Indiana, United States, 46202 Less << | |
NCT03710395 | Drug Transporter | Phase 4 | Active, not recruiting | October 1, 2019 | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.89mL 0.58mL 0.29mL |
14.44mL 2.89mL 1.44mL |
28.87mL 5.77mL 2.89mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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