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Chemical Structure| 23256-30-6 Chemical Structure| 23256-30-6

Structure of Nifurtimox
CAS No.: 23256-30-6

Chemical Structure| 23256-30-6

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Nifurtimox, an antiprotozoal agent, which is used to treat diseases caused by trypanosomes including Chagas disease and sleeping sickness, has been used in the therapy of neuroblastoma.

Synonyms: BAY-2502; BAY-A-2502; Lampit.

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Product Citations

Product Citations

Carla B. Hartman ; Phelelisiwe S. Dube ; Lesetja J. Legoabe ; Natascha Van Pelt ; An Matheeussen ; Guy Caljon , et al.

Abstract: Several quinoline derivatives incorporating arylnitro and aminochalcone moieties were synthesized and evaluated in vitro against a broad panel of trypanosomatid protozoan parasites responsible for sleeping sickness (Trypanosoma brucei rhodesiense), nagana (Trypanosoma brucei brucei), Chagas disease (Trypanosoma cruzi), and leishmaniasis (Leishmania infantum). Several of the compounds demonstrated significant antiprotozoal activity. Specifically, compounds 2c, 2d, and 4i displayed submicromolar activity against T. b. rhodesiense with half-maximal effective concentration (EC50) values of 0.68, 0.8, and 0.19 µM, respectively, and with a high selectivity relative to human lung fibroblasts and mouse primary macrophages (∼100-fold). Compounds 2d and 4i also showed considerable activity against T. b. brucei with EC50 values of 1.4 and 0.4 µM, respectively.

Keywords: anti‐infectives ; arylnitro ; chalcones ; protozoal ; quinoline

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Product Details of Nifurtimox

CAS No. :23256-30-6
Formula : C10H13N3O5S
M.W : 287.29
SMILES Code : O=[N+](C1=CC=C(/C=N/N2C(C)CS(CC2)(=O)=O)O1)[O-]
Synonyms :
BAY-2502; BAY-A-2502; Lampit.
MDL No. :MFCD00869254
InChI Key :ARFHIAQFJWUCFH-IZZDOVSWSA-N
Pubchem ID :6842999

Safety of Nifurtimox

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H373
Precautionary Statements:P260-P314-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00486564 Neuroblastoma PHASE1 COMPLETED 2025-06-09 St. Louis University/Cardinal ... More >>Glennon Childrens Medical Center, St. Louis, Missouri, 63104, United States|University of Vermont/Vermont Children's Hospital, Burlington, Vermont, 05401, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.48mL

0.70mL

0.35mL

17.40mL

3.48mL

1.74mL

34.81mL

6.96mL

3.48mL

 

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