652-34-6|2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid| Ambeed

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Quality Control of [ 652-34-6 ] Purity: 98% SDS Specification

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Product Details of [ 652-34-6 ]

CAS No. :	652-34-6
Formula :	C₇H₂F₄O₃
M.W :	210.08
SMILES Code :	O=C(O)C1=C(F)C(F)=C(O)C(F)=C1F
MDL No. :	MFCD00129952
InChI Key :	FTLHGQOBAPTEHE-UHFFFAOYSA-N
Pubchem ID :	98835

Safety of [ 652-34-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 652-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 652-34-6 ]

[ 652-34-6 ] Synthesis Path-Downstream 1~41

1
[ 124-38-9 ]
[ 769-39-1 ]
[ 652-34-6 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.
[2]Tetrahedron Letters,2010,vol. 51,p. 5930 - 5932.
[3]Journal of Organic Chemistry,1966,vol. 31,p. 746 - 749.

2
[ 2002-99-5 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society,1962,p. 1801 - 1805.

3
[ 602-94-8 ]
[ 652-18-6 ]
[ 652-34-6 ]

References: [1]Journal of Physical Chemistry A,2000,vol. 104,p. 352 - 361.

5
[ 100-39-0 ]
[ 652-34-6 ]
[ 197903-54-1 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.
[2]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1709 - 1713.

6
[ 64-17-5 ]
[ 652-34-6 ]
[ 123270-98-4 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

7
[ 115-20-8 ]
[ 652-34-6 ]
[ 562070-99-9 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

8
[ 652-34-6 ]
aminomethylated polystyrene [ No CAS ]
(polystyrene resin)-NH-C(O)-p-C₆F₆-OH [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 2009 - 2014.

9
2-[(2-pyridin-2-ylquinoline-4-carbonyl)amino]ethylammonium chloride [ No CAS ]
[ 652-34-6 ]
2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(2,3,5,6-tetrafluoro-4-hydroxy-benzoylamino)-ethyl]-amide [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 8729 - 8738.

10
[ 652-34-6 ]
[ 210228-13-0 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.
[2]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1709 - 1713.

11
[ 652-34-6 ]
[ 562071-00-5 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

12
[ 652-34-6 ]
[ 562071-03-8 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

13
[ 652-34-6 ]
[ 562071-02-7 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

14
[ 652-34-6 ]
[ 562071-01-6 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

15
[ 652-34-6 ]
C₂₇H₅F₁₃O₈ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

16
[ 652-34-6 ]
C₄₁H₁₇F₁₃O₈ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

17
[ 652-34-6 ]
C₄₁H₁₃F₁₃O₁₀ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

18
[ 652-34-6 ]
[ 197903-58-5 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

19
[ 652-34-6 ]
[ 197903-55-2 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

20
[ 652-34-6 ]
[ 197903-60-9 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

21
[ 652-34-6 ]
Ethyl 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

22
[ 652-34-6 ]
Benzyl 2,4,6-tris(benzyloxy)-3,5-difluorobenzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

23
[ 652-34-6 ]
Sodium 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

24
[ 434-64-0 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society,1962,p. 1801 - 1805.

25
[ 652-34-6 ]
C₈H₃F₅NOPol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		51.2 g of polystyrene-aminomethyl resin (loading 1.36 mmol/g, 69.6 mmol; from Argonaut Technologies, USA) are suspended in 700 ml of DMF. 41.6 g (107.8 mmol) of HOBt and 24.1 g (114.8 mmol) of 4-hydroxy-2,3,5,6-tetrafluoro-benzoic acid are added. After 15 min, 16.9 ml (107.8 mmol) of N,N'-diisopropylcarbodiimide are added to the reaction mixture while stirring gently, and it is then stirred overnight. It is filtered, and the remaining resin is washed with DMF. The resulting resin is resuspended in 450 ml of DMF, mixed with 8.26 ml (83.5 mmol) of piperidine and shaken. After 2 h, filtration is repeated and the remaining resin is added to a solution of 120 ml of 1 M hydrochloric acid in 500 ml of DMF and shaken for a further 2 h. Renewed filtration is followed by washing with 500 ml each of DMF, THF and DCM. Drying in vacuo at 50 C. results in 77.2 g of the polymer-bound title compound.

References: [1]Patent: US2007/37844,2007,A1 .Location in patent: Page/Page column 8.

26
[ 19161-30-9 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society C: Organic,.
Journal of the Chemical Society [Section] C: Organic,1968,p. 1569 - 1575.
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

27
[ 553-26-4 ]
[ 5970-45-6 ]
[ 652-34-6 ]
[Zn₂(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]

References: [1]Inorganic Chemistry,2010,vol. 49,p. 4594 - 4598.

28
[ 553-26-4 ]
cobalt(II) chloride hexahydrate [ No CAS ]
[ 652-34-6 ]
[Co₂(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]

References: [1]Inorganic Chemistry,2010,vol. 49,p. 4594 - 4598.

29
[ 475289-85-1 ]
[ 652-34-6 ]
[ 1257325-77-1 ]

References: [1]Tetrahedron Letters,2010,vol. 51,p. 5930 - 5932.

30
[ 67-56-1 ]
[ 652-34-6 ]
[ 58286-07-0 ]

Yield	Reaction Conditions	Operation in experiment
90%	With sulfuric acid; for 16h;Reflux;	To a solution of <strong>[652-34-6]2,3,5,6-tetrafluoro-4-hydroxybenzoic acid</strong> hydrate (5.2 g, 22.8 mmol) in methanol (400 ml) concentrated sulphuric acid (98%, 2 ml)was added. The solutionwas heated to reflux for 16 h. TLC was used to monitor the reaction. After the complete conversion, methanol was removed, and then water (100 ml) was added to the residual. Dichloromethane was used to extract the product from aqueous solution. The extract was dried over anhydrous magnesium sulphate, and the solvent was removed under reduced pressure to give white solid methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (5.01 g, yield 90%). 1H NMR, CD3OD: 4.92(br s,1H, OH), 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO),148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F) To a solution of methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (1.02 g, 4.55 mmol) in anhydrous THF (10 ml) was added a solution of thallium ethoxide (1.19 g, 4.78 mmol, 1.05 eq) in anhydrous THF (5 ml). The white solid was formed and the suspension was stirred for further 3 h. The white solid was collected, washed with anhydrous THF, dried under reduced pressure, to give product Tl-6 (1.82 g, yield 90%). 1H NMR, CD3OD: 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO), 148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F).

References: [1]Journal of Organometallic Chemistry,2011,vol. 696,p. 1591 - 1599.

31
[ 827-15-6 ]
[ 652-34-6 ]

32
[ 344-07-0 ]
[ 652-34-6 ]

33
[ 773-82-0 ]
[ 652-34-6 ]

34
[ 344-04-7 ]
[ 652-34-6 ]

35
[ 20925-85-3 ]
[ 652-34-6 ]

References: [1]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[3]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[4]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[5]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[6]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

36
[ 27318-28-1 ]
[ 652-34-6 ]

References: [1]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

37
[ 653-37-2 ]
[ 652-34-6 ]

38
N-mono-trityl 1,6-diaminohexane acetic acid salt [ No CAS ]
[ 652-34-6 ]
2,3,5,6-tetrafluoro-4-hydroxy-N-(6-(tritylamino)hexyl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%		Mono-trityl 1,6-diaminohexane acetic acid salt (9a) (117.2 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (15% -> 30% ethyl acetate in hexane) to yield 90 mg (0.16 mmol, 58% isolated yield).
58%		Mono-trityl 1,6-diaminohexane acetic acid salt (9a) (117.2 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (15% -> 30% ethyl acetate in hexane) to yield 90 mg (0.16 mmol, 58% isolated yield).

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2014/145257,2014,A2 .Location in patent: Paragraph 0146.
[3]Patent: WO2018/119476,2018,A1 .Location in patent: Paragraph 0134; 0137.

39
N-mono-trityl 1,6-diaminohexane acetic acid salt [ No CAS ]
[ 652-34-6 ]
C₄₂H₅₃F₄N₅O₈*C₂HF₃O₂ [ No CAS ]

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2018/119476,2018,A1 .

40
N-mono-trityl ethylenediamine acetic acid salt [ No CAS ]
[ 652-34-6 ]
2,3,5,6-tetrafluoro-4-hydroxy-N-(2-(tritylamino)ethyl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%		Mono-trityl ethylenediamine acetic acid salt (9b) (100 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (20% -> 35% ethyl acetate in hexane) to yield 90 mg (0.18 mmol, 65% isolated yield). 1H NMR (400 MHz, DMSO) δ = 8.77 (t, J=6.0, 1H), 7.39 (d, J=7.8, 6H), 7.27 (t, J=7.7, 6H), 7.17 (t, J=7.2, 3H), 3.40 - 3.35 (m, 2H), 2.86 - 2.77 (m, 1H), 2.14 - 2.04 (m, 2H).
65%		Mono-trityl ethylenediamme acetic acid salt (9b) (100 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and (0224) concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (20% -> 35% ethyl acetate in hexane) to yield 90 mg (0.18 mmol, 65% isolated yield). lH NMR (400 MHz, DMSO) δ = 8.77 (t, 7=6.0, 1H), 7.39 (d, 7=7.8, 6H), 7.27 (t, 7=7.7, 6H), 7.17 (t, 7=7.2, 3H), 3.40 - 3.35 (m, 2H), 2.86 - 2.77 (m, 1H), 2.14 - 2.04 (m, 2H).

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2014/145257,2014,A2 .Location in patent: Paragraph 0147.
[3]Patent: WO2018/119476,2018,A1 .Location in patent: Paragraph 0134; 0138.

41
[ 652-34-6 ]
dibenzyl [2,3,5,6-tetrafluoro-4-(hydroxymethyl)phenyl] phosphate [ No CAS ]

References: [1]ChemBioChem,2014,vol. 15,p. 961 - 976.

Historical Records

Technical Information

• Acidity of Phenols • Alkyl Halide Occurrence • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Electrophilic Substitution of the Phenol Aromatic Ring • Etherification Reaction of Phenolic Hydroxyl Group • Fischer Indole Synthesis • Grignard Reaction • Halogenation of Phenols • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Oxidation of Phenols • Passerini Reaction • Paternò-Büchi Reaction • Pechmann Coumarin Synthesis • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reformatsky Reaction • Reimer-Tiemann Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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Precautionary Statements-General
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 652-34-6

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