Home Cart Sign in  
Chemical Structure| 302-79-4 Chemical Structure| 302-79-4

Structure of Retinoic acid
CAS No.: 302-79-4

Chemical Structure| 302-79-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Retinoic acid (Vitamin A acid) acts as an RAR nuclear receptor agonist and is used as an adjunct in cell therapy.

Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Retinoic acid

CAS No. :302-79-4
Formula : C20H28O2
M.W : 300.44
SMILES Code : CC1(C(=C(CCC1)C)C=CC(=CC=CC(=CC(O)=O)C)C)C
Synonyms :
Vitamin A acid; all-trans-Retinoic acid; ATRA
MDL No. :MFCD00001551

Safety of Retinoic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H360-H410
Precautionary Statements:P201-P202-P264-P270-P273-P280-P301+P312+P330-P302+P352-P308+P313-P332+P313-P391-P405-P501
Class:9
UN#:3077
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HepG2 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
Human fetal lung capillary endothelial precursor cells 0.01, 0.1, 1 µM 24 hours To evaluate the effect of RA on endothelial cell proliferation, results showed RA increased cell proliferation in a concentration-dependent manner. Am J Respir Cell Mol Biol. 2005 Dec;33(6):622-8.
THP-1 cells 10 µM 24 hours To evaluate the inhibitory effect of Palovarotene on HSV-1 replication, results showed RA inhibited HSV-1 replication in a dose-dependent manner. iScience. 2024 Jun 4;27(7):110144
Hep3B 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
HLF 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
HLE 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
HuH6 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
PLC/PRF/5 5 µM and 10 µM 48 hours Enhanced the cytotoxicity of sorafenib Cancer Sci. 2015 May;106(5):567-75
neurons 2 μM 1 week to induce neuronal differentiation Nat Biotechnol. 2011 Aug 10;29(9):824-8.
GABAergic neurons 1 μM 7 days to induce GABAergic neuron differentiation Nat Biotechnol. 2011 Aug 10;29(9):824-8.
mouse iPSCs 10 M Differentiation of mouse iPSCs into neurospheres Bioeng Transl Med. 2022 Sep 10;8(5):e10406.
femoral head chondrocytes 10 μM 3 days To investigate the effect of retinoic acid on aggrecan degradation in chondrocytes, results showed reduced aggrecan degradation products in Ndst1+/− samples upon RA treatment. Osteoarthritis Cartilage. 2020 Jul;28(7):977-987.
Neuro-2a (N2A) cells 2 μM 5 days Induced differentiation of Hb9GFP mouse stem cells into motor neurons Nat Commun. 2017 Jul 5;8:16063.
iPSC-derived motoneurons 1 µM 4-10 days Used to induce differentiation of iPSCs into motoneurons, results showed that retinoic acid at 1 µM successfully induced motoneuron differentiation. Nat Commun. 2015 Jan 12;6:5999.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Balb/c mice Pristane-induced lupus model Oral 1 mg/kg Daily administration from 3 weeks to 3 months of age (tRA pre-treatment) or from 3 to 9 months of age (tRA post-treatment) Investigate the role of tRA at different stages of lupus, finding that tRA pre-treatment exacerbates glomerulonephritis while post-treatment has immunosuppressive effects Front Immunol. 2020 Mar 20;11:408
Mouse Embryonic stem cells Culture medium 5 µM 7 days Induced differentiation of embryonic stem cells Sci Adv. 2021 Oct 29;7(44):eabk2775
Mice Osteoporosis model Gavage 70 mg/kg Once daily for 2 weeks Establish an osteoporosis model, results indicated the model was successfully established Polymers (Basel). 2018 Feb 14;10(2):185
Mice Osteoporosis model Gavage 70 mg/kg Once daily for 2 weeks To induce an osteoporosis model in mice by administering retinoic acid, the results showed that serum calcium and ALP levels in the model group were significantly increased, indicating the successful establishment of the osteoporosis model. Polymers (Basel). 2018 Feb 14;10(2):185
ICR mice UVB-induced skin damage model Oral and topical application 2 mg/kg Once daily for one week Retinoic acid as the positive control improved UVB-induced skin damage but did not significantly reduce oxidative stress and inflammation, and caused liver damage. Int J Mol Sci. 2022 Sep 16;23(18):10833

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05281965 Autism|Treatment Adherence|Ret... More >>inoic Acid|Dup15Q Syndrome Less << EARLY_PHASE1 UNKNOWN 2024-06-01 Zhejiang University, Hangzhou,... More >> Zhejiang, 310000, China|Miao pu, Hangzhou, 310009, China Less <<
NCT04417348 Melasma COMPLETED 2019-12-15 Dermatology Department. Hospit... More >>al Central "Dr. Ignacio Morones Prieto", San Luis Potosí, 78290, Mexico Less <<
NCT03999684 Adenoid Cystic Carcinoma PHASE2 COMPLETED 2020-04-15 Massachusetts General Hospital... More >> Cancer Center, Boston, Massachusetts, 02114, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less <<
NCT01349556 Medication Reaction WITHDRAWN 2025-03-14 -
NCT02249767 Acne PHASE3 COMPLETED 2025-06-14 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.64mL

3.33mL

1.66mL

33.28mL

6.66mL

3.33mL

References

 

Historical Records

Categories