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Chemical Structure| 478-43-3 Chemical Structure| 478-43-3

Structure of Rhein
CAS No.: 478-43-3

Chemical Structure| 478-43-3

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Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling.

Synonyms: Rheic Acid; Rhubarb yellow; Rheinic Acid

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Product Citations

Product Citations

Twitty, Alyssa ; Barnes, Hamlin ; Levy, Noa ; Mizrahi, Yaniv ; Geva, Yosef ; Phillip, Yael , et al.

Abstract: The natural anthraquinone rhein has been identified as a novel herbicide with a potentially new mode of action using a generative AI system for functional molecules discovery. Its herbicidal activity was light-dependent and resulted in rapid burndown symptoms on leaves of treated plants. Rhein interferes with photosynthesis by acting as an electron diverter at the level of photosystem I (PSI). The redox potential of rhein suggests that it accepts electrons between P700 and NADP+ of PSI. This is consistent with the redox potential of rhein that enables it to accept electrons from flavoproteins. Ferredoxin-NAPD+ reductase is a flavoprotein with a redox potential near that of rhein. Thus, it is currently hypothesized that rhein acts as an electron acceptor at or near the PSI Ferredoxin-NAPD+ reductase to form a radical and generate reactive oxygen species that drive the light-dependent herbicidal effect which is observed in treated plants from greenhouse trials.

Keywords: AI ; Artificial intelligence ; Generative AI ; Mode of action ; Photosystem I ; Anthraquinone ; Natural product ; Light-dependent ; Electron acceptor ; ROS ; Flavoprotein

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Product Details of Rhein

CAS No. :478-43-3
Formula : C15H8O6
M.W : 284.22
SMILES Code : O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)O
Synonyms :
Rheic Acid; Rhubarb yellow; Rheinic Acid
MDL No. :MFCD00009618
InChI Key :FCDLCPWAQCPTKC-UHFFFAOYSA-N
Pubchem ID :10168

Safety of Rhein

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL

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