Roxithromycin (RU-28965) | Bacterial Inhibitor

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	80214-83-1
Formula :	C₄₁H₇₆N₂O₁₅
M.W :	837.05
SMILES Code :	C[C@H]([C@H]([C@](O)(C[C@H](/C1=N\OCOCCOC)C)C)O[C@@](O[C@H](C)C[C@@H]2N(C)C)([H])[C@@H]2O)[C@]([C@H](C(O[C@@H]([C@@](O)([C@H](O)[C@H]1C)C)CC)=O)C)([H])O[C@@](O[C@@H](C)[C@@H]3O)([H])C[C@@]3(C)OC
Synonyms :	RU-28965; RU 965; Rulide
MDL No. :	MFCD00214389

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

MRC-5 cells	10, 20, 40, 80 μM	24 h	Evaluate the effect of roxithromycin on TGF-β-induced fibroblast activation, results showed that roxithromycin dose-dependently inhibited the expression of fibronectin, collagen I and α-SMA	PMC8633281
A549 cells	40, 80 μM	24 h	Evaluate the effect of roxithromycin on BLM-induced cell cycle arrest, results showed that roxithromycin significantly suppressed the expression of p53, p21, and p16	PMC8633281
WI-38 cells	20, 40, 60, 80, 100 μM	60–72 h	Evaluate the killing effect of roxithromycin on senescent cells, results showed that roxithromycin selectively killed senescent cells	PMC8633281
Rat airway smooth muscle cells	100 μg/ml	48 h	To investigate the inhibitory effect of roxithromycin on TGF-β1-induced ASMCs proliferation and its mechanism, results showed that roxithromycin significantly inhibited ASMCs proliferation and up-regulated caveolin-1 expression	PMC4256937
Streptococcus pneumoniae NMU112	0.5 to 5 μg/ml	12 h	To evaluate the effect of roxithromycin on the production of pneumococcal virulence factors (PLY and PspA). Results showed that roxithromycin did not suppress the production of PLY and PspA at sub-MIC levels.	PMC1855574
Human monocyte-derived macrophages	10 μg/ml	7 days	Evaluate the intracellular bactericidal activity of roxithromycin against three clinical isolates of M. avium (MO-1, N-92159, and N-93043). Results showed that roxithromycin was bactericidal for strains MO-1 and N-92159 and bacteriostatic for strain N-93043. Compared with clarithromycin, the intracellular activities of roxithromycin were not significantly different after 7 days of treatment	PMC162646
Freshly isolated rat hepatocytes	5 mg/L	5, 10, 20, 30, 60, and 120 min	To study the uptake kinetics of roxithromycin and erythromycin base, results showed that the uptake of roxithromycin was about 1.8 to 2.5 times that of erythromycin base.	PMC175915

C57BL/6 male mice	Bleomycin-induced pulmonary fibrosis model	Oral gavage	40, 80, 160 mg/kg	Once daily for 3 weeks	Evaluate the effect of roxithromycin on bleomycin-induced pulmonary fibrosis, results showed that roxithromycin attenuated lung injury, inflammation, and fibrosis	PMC8633281
Beige mice	Disseminated Mycobacterium avium complex infection model	Gavage	200 mg/kg	Once daily for 28 days	Roxithromycin alone significantly reduced the bacterial load of Mycobacterium avium complex in the blood, liver, and spleen of beige mice and decreased mortality. The combination of roxithromycin with ethambutol showed enhanced antibacterial effects in splenic tissues compared to roxithromycin alone.	PMC163255
CBA/J mice	Pneumonia model	Oral gavage	1.25 to 10 mg/kg	Twice daily for 3 days	To evaluate the effect of roxithromycin on host resistance against macrolide-resistant S. pneumoniae infection. Results showed that roxithromycin (≥5 mg/kg/day) increased the median survival time and delayed bacteremia without suppressing the production of PLY and PspA in infected lungs.	PMC1855574
C57BL/6 mice	M. avium MO-1 infection model	Oral gavage	200 mg/kg	6 days per week for 16 weeks	Evaluate the efficacy of roxithromycin against M. avium MO-1 infection in C57BL/6 mice. Results showed that both roxithromycin and clarithromycin significantly reduced bacterial loads in spleens and lungs. Clarithromycin was more effective than roxithromycin in lungs, while their activities were comparable in spleens. No resistant mutants were selected during the 16-week treatment period	PMC162646

{[proInfo.proName]}

CAS No.: 80214-83-1

{[proInfo.proName]}

CAS No.: 80214-83-1

Alternative Products

Product Details of Roxithromycin

Safety of Roxithromycin

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

NCT02735707	Community-Acquired Pneumonia	Phase 4	Recruiting	June 2022	-
NCT03571230	Helicobacter Pylori Infection ... More >> Antimicrobial Susceptibility Testing Less <<	Phase 4	Not yet recruiting	January 30, 2020	China, Shandong ... More >> Xiuli Zuo Not yet recruiting Jinan, Shandong, China Contact: Xiuli Zuo, PhD,MD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Jing Liu, MD Sub-Investigator: Chaoran Ji, MD Less <<
NCT02819570	Premature Rupture of Membrane	Phase 4	Unknown	December 2017	Israel ... More >> Galil Medical Center Recruiting Nahariyya, Israel Contact: Maya Wolf, MD 972-507887800 homesickid@yahoo.com Less <<
NCT02469298	Virus Diseases	Phase 2	Completed	-	-
NCT00285493	Low Back Pain	Phase 1	Withdrawn(Withdrawn study halt... More >>ed prematurely, prior to enrollment of first participant) Less <<	-	-
NCT03148444	Infection, Bacterial ... More >> Pacemaker Complication Less <<	Phase 4	Not yet recruiting	June 1, 2020	-
NCT02469298	-		Completed	-	-
NCT01843946	-		Completed	-	Korea, Republic of ... More >> The Catholic University of Korea, St. Vincent's Hospital Suwon, Korea, Republic of, 442-723 Less <<
NCT03414918	Hyperaldosteronism	Not Applicable	Not yet recruiting	January 2020	Italy ... More >> Department of Medicine - DIMED, University of Padova, Italy Not yet recruiting Padova, Italy Principal Investigator: Gian Paolo Rossi, MD Less <<
NCT00621387	Reactive Arthritis	Not Applicable	Completed	-	Finland ... More >> Division of Rheumatology, Department of Medicine Helsinki, Finland, 00029 Peijas Hospital Vantaa, Finland, 01400 Less <<
NCT00197379	Alopecia	Not Applicable	Unknown	January 2007	Japan ... More >> Department of Dermatology, Hamamatsu University School of Medicine Hamamatsu, Japan, 431-3192 Less <<
NCT03565484	Helicobacter Pylori Infection	Phase 4	Not yet recruiting	April 30, 2020	China, Shandong ... More >> Qilu hosipital Not yet recruiting Jinan, Shandong, China, 257000 Contact: Xiuli Zuo, MD,PhD 15588818685 ext 053188369277 zuoxiuli@sina.com Sub-Investigator: Chaoran Ji, MD Sub-Investigator: Jing Liu, MD Less <<
NCT00439062	Rheumatoid Arthritis	PHASE4	COMPLETED	2025-06-06	Nazilli State Hospital, Nazill... More >>i, Aydin, 09800, Turkey Less <<

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed