Home Cart Sign in  
Chemical Structure| 81-07-2 Chemical Structure| 81-07-2
Chemical Structure| 81-07-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Saccharin is an artificial sweetener with effectively no food energy, which has been used for the administration of Hypertension and Hyperglycemia and in various of biochemical tests.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Saccharin

CAS No. :81-07-2
Formula : C7H5NO3S
M.W : 183.18
SMILES Code : O=C(C1=CC=CC=C12)NS2(=O)=O
MDL No. :MFCD00005866
InChI Key :CVHZOJJKTDOEJC-UHFFFAOYSA-N
Pubchem ID :5143

Safety of Saccharin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of Saccharin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81-07-2 ]

[ 81-07-2 ] Synthesis Path-Downstream   1~15

  • 4
  • furan-2,3,5(4H)-trione pyridine (1:1) [ No CAS ]
  • [ 81-07-2 ]
  • KOH-solution [ No CAS ]
  • [ 632-24-6 ]
  • 5
  • [ 27148-03-4 ]
  • [ 7732-18-5 ]
  • [ 81-07-2 ]
  • 6
  • [ 27148-03-4 ]
  • alkaline solution [ No CAS ]
  • [ 81-07-2 ]
  • 7
  • [ 7664-93-9 ]
  • [ 632-24-6 ]
  • [ 7446-11-9 ]
  • [ 81-07-2 ]
  • 8
  • [ 632-24-6 ]
  • [ 10025-87-3 ]
  • [ 81-07-2 ]
  • 9
  • [ 632-24-6 ]
  • aqueous alkaline solution [ No CAS ]
  • [ 81-07-2 ]
  • 10
  • [ 14437-03-7 ]
  • [ 81-07-2 ]
  • [ 28946-24-9 ]
  • 11
  • [ 2456-81-7 ]
  • [ 81-07-2 ]
  • 4-(1-pyrrolidinyl)pyridinium saccharinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% In tetrahydrofuran; at 60℃; General procedure: The 100mL round bottomed flask was charged with pyridine derivatives (or pyridine) (4.09mmol) and equimolar of saccharin (4.09mmol, 500mg) followed by the addition of 20mL THF as solvent. Then the reaction mixture was set to react in THF, at ca. 60°C for overnight. After the reaction, the solvent was removed by vacuum. The crude product was then obtained. Recrystallization proceeded with dissolution of crude product in methanol to form a saturated solution, to which a hexane overlayer (ca. 10cm high) was added. Solvent diffusion over a period of a week at room temperature afforded white crystals of the desired salt.
  • 12
  • [ 4532-25-6 ]
  • [ 81-07-2 ]
  • 2-(7-chloroimidazo[1,2-a]pyridin-3-yl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide [ No CAS ]
  • 13
  • [ 2456-81-7 ]
  • [ 81-07-2 ]
  • 4‐(1‐pyrrolidinyl)pyridinium saccharinate [ No CAS ]
  • 14
  • [ 3375-31-3 ]
  • [ 81-07-2 ]
  • [ 607-01-2 ]
  • [ 1192-62-7 ]
YieldReaction ConditionsOperation in experiment
66% General procedure: Complexes 4, 6, 8 and 10-12 were prepared by the following method. SacH (0.5mmol, 91.6mg) in water (5mL) was added to a solution of Pd(OAc)2 (0.25mmol, 56.1mg) in MeCN (10mL) and the solution was stirred for 30min at rt. Then, the corresponding phosphine (0.5mmol) in MeOH (10mL) was added to this solution and the resulting solutions were refluxed over a day. Complexes 2, 5 and 9 were synthesized using the same procedure, but the SacH/phosphine ratio was 2:1. In the case of 9, DMSO (10mL) was added to the reaction medium to dissolve the solid particles. The powders of these complexes were obtained after removal of the solvents using a rotary evaporator.
  • 15
  • [ 138964-51-9 ]
  • [ 81-07-2 ]
  • C16H9BrN2O4S [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% In propan-1-ol; water; at 125℃; for 8.0h; Put into 1000kg propanol water and stir in the reactor, add 183kg (1000mol) of saccharin successively, and then added 238.9kg (1000mol) of <strong>[138964-51-9]2-hydroxy-6-bromobenzopyridin-4-one</strong>, heated to 125C under pressure, and reacted under reflux for 8 hours, cool down and reduce pressure, steam to remove 600kg of reclaimed propanol, cool to 5C, and filter after standing for 12 hours to obtain yellow-brown product 4 379.6kg, yield 94%,
 

Historical Records

Categories