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Chemical Structure| 10338-51-9 Chemical Structure| 10338-51-9

Structure of Salidroside
CAS No.: 10338-51-9

Chemical Structure| 10338-51-9

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Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. By activating mTOR signaling, Salidroside alleviates cachexia symptoms in a mouse model of tumor cachexia and protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

Synonyms: Rhodioloside

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Product Citations

Product Citations

Guo, Wen ; Huang, Rong ; Bian, Jiaojiao ; Liao, Qing ; You, Jun ; Yong, Xi , et al.

Abstract: Background: Hipoxia-inducible factor 1 alpha (Hif-1α) is a significant risk factor for atherosclerotic cardiovascular disease. Salidroside (SAL) has demonstrated anti-oxidative and anti-cardiovascular disease effects. Currently, there are no relevant studies investigating the interaction between SAL and Hif-1α in the progression of atherosclerosis. Methods: Hif-1α was either knocked down or upregulated in Ana-1 macrophages-derived foam cells, and atherosclerosis ApoE−/− mice were treated with or without SAL. A Protein-protein network involving Hif-1α and pyroptosis-related genes was identified through bioinformatic analysis and validated in human vascular tissues. The Oil Red O and DiI staining were used to detect the intracellular ox-LDL accumulation. The HE and Oil Red O staining were employed to evaluate atherosclerotic plaque in vivo. The levels of relevant molecules were quantified using WB, qRT-PCR, ELISA, and immunohistochemistry. The target proteins of SAL were identified through Molecular docking and Cell Thermal Shift Assay (CESTA). Results: Both Hif-1α knockdown and SAL treatment markedly reduced lipid accumulation in macrophages-derived foam cells. Hif-1α was closely associated with Caspase1, Gsdmd, NRLP3, and IL-1β, and co-located in CD86+ macrophages-derived foam cells within atherosclerotic plaque. SAL inhibited Hif-1α-induced Caspase-1-dependent pyroptosis and lipid accumulation by directly bonding to Hif-1α. In vivo, SAL treatment decreased atherosclerotic plaque and improved plasma lipid profiles. Furthermore, SAL reduced M1 macrophages infiltration and the levels of Hif-1α, C-Caspase1, Gsdmd-N, NRLP3, IL-18, and IL-1β in atherosclerotic plaque. Conclusion: SAL alleviated the lipid accumulation in macrophages and atherosclerotic plaques by inhibiting pyroptosis pathway via directly binding to Hif-1α, which may be a promising therapeutic strategy for AS treatment.

Keywords: Salidroside ; Hif-1α ; Pyroptosis ; Macrophages-derived foam cells ; Atherosclerosis

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Product Details of Salidroside

CAS No. :10338-51-9
Formula : C14H20O7
M.W : 300.30
SMILES Code : O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCCC2=CC=C(O)C=C2
Synonyms :
Rhodioloside
MDL No. :MFCD00210553

Safety of Salidroside

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Related Pathways of Salidroside

PI3K-AKT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.67mL

33.30mL

6.66mL

3.33mL

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