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Chemical Structure| 5616-81-9 Chemical Structure| 5616-81-9
Chemical Structure| 5616-81-9

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Product Details of tert-Butyl 2-(methylamino)acetate

CAS No. :5616-81-9
Formula : C7H15NO2
M.W : 145.20
SMILES Code : O=C(OC(C)(C)C)CNC
MDL No. :MFCD05864597

Safety of tert-Butyl 2-(methylamino)acetate

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P210-P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of tert-Butyl 2-(methylamino)acetate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5616-81-9 ]

[ 5616-81-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15855-06-8 ]
  • [ 5616-81-9 ]
  • [ 1370448-71-7 ]
YieldReaction ConditionsOperation in experiment
A slurry of <strong>[15855-06-8]2-chloro-6-methoxyisonicotinic acid</strong> (100 mg, 0.53 mmol), sacrcosine tert- butyl ester (1 16 mg, (0.64 mmol), chloro(di-2-norborylphosphino)(2- dimethylaminomethylferrocen-1 yl)palladium (II) (9.8 mg, 0.02 mmol) and sodium tert- butoxide (128 mg, 1 .3 mmol) in p-dioxane (3 ml_) were stirred at 1 10C for 18 hr. The reaction mixture was cooled and the solvent removed in vacuo. The residue was diluted with water, pH adjusted to 4 with 1 N aqueous hydrochloric acid and extrated with ethyl acetate (3 x 10 ml_). The combined organic layer was dried over magnesium sulfate, filtered, concentrated in vacuo and the residue flashchromatographed (0-10% methanol/dichloromethane) to afford the title compound (60 mg) as a yellow solid, m/z = 297.5 (M+1 ).
 

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