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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
TRIS base is an established basimetric standard and buffer used in biochemistry and molecular biology.
Synonyms: Tris; Tris(hydroxymethyl)aminomethane; NSC 6365
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 77-86-1 |
Formula : | C4H11NO3 |
M.W : | 121.14 |
SMILES Code : | OCC(CO)(N)CO |
Synonyms : |
Tris; Tris(hydroxymethyl)aminomethane; NSC 6365
|
MDL No. : | MFCD00004679 |
InChI Key : | LENZDBCJOHFCAS-UHFFFAOYSA-N |
Pubchem ID : | 6503 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319 |
Precautionary Statements: | P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
EXAMPLE 13 The Tetrakismaleamic Acid 28a This has the structure 28a shown in Scheme II where R3 and R4 are, respectively, STR20 To a magnetically stirred solution of 21 (5.535 g, 0.0075 mole in DMAC (35.0 ml), granular maleic anhydride (1.5375 g, 0.01569 mole) was added. A dark yellow solution obtained just after addition changes to a light yellow color. To this solution, powdered benzophenonetetracarboxylic dianhydride (1.2083 g. 0.00375 mole) was added and stirring continued at ambient temperature for 8-10 hrs. The solution was then poured over crushed ice. The light-yellow solid obtained was filtered, washed with water, and dried to yield tetrakismaleamic acid 28a. By using the appropriate molar proportions of maleic anhydride the maleamic acid 28b was prepared using a similar method. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; for 0.0333333h;Heating; | To a solution of the free acid form of the product of Example 5 prepared above (0.252 g, 0.569 mmol) in DMF (5 mL) was added aq. tris(hydroxymethyl)aminomethane (0.569 mL, 0.569 mmol, 1 M). The reaction was heated with a heat gun for 2 min and concentrated affording the title compound. HPLC/MS: 444.22 (M+1); Rt=2.99 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | In ethanol; at 47℃;Industry scale; | <strong>[156897-06-2]Licofelone</strong> (2.25 kg) was slurried in ethanol (59.2 I). The slurry was heated to 47C until dissolution. Tromethamol (0.79 kg) was introduced maintaining the temperature at 47C and the resulting slurry was stirred at 47C for 1 h. Diisopropylether (14.8 I) was added in 15 min maintaining the temperature at 47C. The suspension was cooled in 3 h to 27C, stirred at this temperature for about 1 h, further cooled to -13C in 1 h and stirred at this temperature for 2 h. The product was centrifuged and the cake was washed with cold diisopropylether (7.1 I). The wet cake was dried at approx. 800C for 15 h.Yield: 2.73 kg (= 92%), chemical purity (HPLC): >99.9% (water content: 0.1 %)X-ray diffraction diagram and IR-spectrum of the tromethamine salt are shown in Figures 3 and 4, respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; water; at 25 - 35℃; | 39.5 g of <strong>[91832-40-5]cefdinir</strong> (0.1 mol) and 18.7 g tris(hydroxymethyl)aminomethane (0.15 mol) is stirred in a mixture of 100 mL ethanol and 50 mL deionized water at a temperature of 25-35 C. The reaction mixture is then cooled to the room temperature and the formed precipitate is separated and recrystallized. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92.5% | The oil of 150 g of prostaglandin F2alpha (formula 6) was mixed with 5 L of acetonitrile and heated to dissolve. The temperature was controlled at 43 to 47 C and stirred for 15 min.And then filtered hot to obtain the filtrate, and then washed with acetonitrile, the total volume of acetonitrile to 21L, combined filtrate, and stir for 5min or so,In the course of stirring, to the filtrate by adding tromethamine solution, tromethamine solution by 49.2g of butyral trioxide and 90ml of water, and heated to 53 ~ 57 holding temperature for 5min, after the addition of crystallization Precipitation, add to continue after mixing 18 ~ 24h,And then natural cooling to room temperature, filtration, washing with acetonitrile crystallization 3 times, each 100ml, placed in a dry phosphorus pentahydrate drying vacuum to constant weight, generally need more than 5h, get tromethamine prostaglandin F2alpha ( 7) of about 180 g in 89% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In tetrahydrofuran; ethanol; at 0℃; for 1.5h; | A solution of 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino] benzoic acid (10 mmol) was dissolved in THF/EtOH (1:1) (250 mL), and the resulting solution was cooled to 0 C. in an ice bath. Once the solution cooled, the 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIZMA, Sigma-Aldrich, St. Louis, Mo.) (10 mmol) was added, and the mixture was stirred for 90 minutes at 0 C. Upon completion, the solvent was removed with care taken to keep the mixture at or below room temperature. The resulting residue was triturated with pentanes, and was placed under high vacuum at 0 C. for 2 hours and then backfilled with argon. The resulting white solid (quantitative yield) was stored in the freezer (-20 C.) until ready to use. |