CAS No. :	69205-79-4
Formula :	C₇H₅N₅O
M.W :	175.15
SMILES Code :	N#CC1=CNC(N=C(N)N2)=C1C2=O
MDL No. :	MFCD13178502
InChI Key :	FMKSMYDYKXQYRV-UHFFFAOYSA-N
Pubchem ID :	135446206

Safety of 2-Amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P280-P305+P351+P338-P310

Application In Synthesis of 2-Amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 69205-79-4 ]

[ 69205-79-4 ] Synthesis Path-Downstream 1~54

1
[ 74511-37-8 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

2
[ 100643-27-4 ]
[ 53106-70-0 ]
[ 69205-79-4 ]

Yield	Reaction Conditions	Operation in experiment
10.11 g	With sodium acetate; In water; at 100℃;Inert atmosphere;	Methyl formate (18.0 mL, 17.48 g, 291.4 mmol) in toluene (8 mL) was added at 0 C to a stirred suspension ofNaOMe (14.30 g, 264.9 mmol) in toluene (200 mL). This was followed by dropwise addition of chloroacetonitrile (16.8 mL, 20.00 g, 264.9 mmol) in toluene (60 mL) over 1 h. The reaction mixture was stirred for 3 h followed by addition of H2O (150 mL). The organic layer was separated and the aqueous layer was acidified to pH 5 using 6 M HCl and subsequently extracted with EtOAc (3 × 100 mL). The organic layers were combined and dried over MgSO4 and concentrated in vacuo (40 C, 70 mbar). The dark residue was suspended in H2O (60 mL) and added to a solution of NaOAc (16.39 g, 199.8 mmol) and 2,6-diaminopyrimidin-4(3H)-one(12.00 g, 95.2 mmol) in H2O (200 mL) (previously stirred at 100 C until complete dissolution). The reaction was refluxed for 16 h. After cooling to room temperature the suspension was filtered and washed with H2O (2 ×20 mL), acetone (2 × 10 mL) and Et2O (2 × 40 mL) to yield 1 (10.11 g, 60%) as a light tan solid.

References: [1]Journal of the American Chemical Society,2015,vol. 137,p. 9015 - 9021.
[2]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.
[3]Synthetic Communications,1996,vol. 26,p. 3317 - 3322.
[4]Journal of Enzyme Inhibition and Medicinal Chemistry,2013,vol. 28,p. 1080 - 1087.
[5]Archiv der Pharmazie,2008,vol. 341,p. 113 - 120.
[6]Beilstein Journal of Organic Chemistry,2014,vol. 10,p. 1333 - 1338.
[7]Tetrahedron,2018,vol. 74,p. 5709 - 5714.

3
[ 100643-27-4 ]
[ 53106-70-0 ]
[ 69205-79-4 ]
2-Amino-6-hydroxy-4-oxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Synthetic Communications,1996,vol. 26,p. 3317 - 3322.

4
[ 69205-79-4 ]
[ 124738-80-3 ]

References: [1]Synthetic Communications,1996,vol. 26,p. 3317 - 3322.
[2]Angewandte Chemie - International Edition,2015,vol. 54,p. 10627 - 10629.
Angew. Chem.,2015,vol. 127,p. 10773 - 10775,3.

5
[ 95-82-9 ]
[ 69205-79-4 ]
2-amino-5-[(2,5-dichloro-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

6
[ 13726-52-8 ]
[ 69205-79-4 ]
2-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

7
[ 554-00-7 ]
[ 69205-79-4 ]
2-amino-5-[(2,4-dichloro-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

8
[ 69205-79-4 ]
[ 108-42-9 ]
2-amino-5-[(3-chloro-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

9
[ 69205-79-4 ]
[ 626-43-7 ]
2-amino-5-[(3,5-dichloro-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

10
[ 69205-79-4 ]
[ 10272-07-8 ]
2-amino-5-[(3,5-dimethoxy-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

11
[ 69205-79-4 ]
[ 2735-04-8 ]
2-amino-5-[(2,4-dimethoxy-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

12
[ 69205-79-4 ]
[ 24313-88-0 ]
2-amino-5-[(3,4,5-trimethoxy-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

13
[ 69205-79-4 ]
[ 102-56-7 ]
2-amino-5-[(2,5-dimethoxy-phenylamino)-methyl]-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

14
[ 6974-32-9 ]
[ 69205-79-4 ]
2-amino-7-(2',3',5'-tri-O-benzoyl-D-ribofuranosyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

15
[ 67-56-1 ]
[ 5617-70-9 ]
[ 69205-79-4 ]
[ 674310-63-5 ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

16
[ 108-24-7 ]
[ 69205-79-4 ]
7-acetyl-2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

17
[ 108-24-7 ]
[ 69205-79-4 ]
N-(7-acetyl-5-cyano-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)acetamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2017,vol. 60,p. 7043 - 7066.
[2]Tetrahedron,2018,vol. 74,p. 5709 - 5714.
[3]Tetrahedron,2004,vol. 60,p. 943 - 959.

18
[ 69205-79-4 ]
[ 124738-81-4 ]

References: [1]Advanced Synthesis and Catalysis,2012,vol. 354,p. 2191 - 2198.
[2]Tetrahedron,2004,vol. 60,p. 943 - 959.
[3]Journal of Medicinal Chemistry,2017,vol. 60,p. 7043 - 7066.

19
[ 69205-79-4 ]
[ 106-95-6 ]
7-allyl-2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

20
[ 69205-79-4 ]
[ 106-54-7 ]
2-amino-4-[(4-chlorophenyl)sulfanyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

21
[ 100643-27-4 ]
[ 107-31-3 ]
[ 107-14-2 ]
[ 69205-79-4 ]

References: [1]Helvetica Chimica Acta,2005,vol. 88,p. 2610 - 2616.
[2]Journal of Medicinal Chemistry,2017,vol. 60,p. 7043 - 7066.

22
[ 69205-79-4 ]
[ 69251-45-2 ]

References: [1]Journal of Enzyme Inhibition and Medicinal Chemistry,2013,vol. 28,p. 1080 - 1087.
[2]Helvetica Chimica Acta,2005,vol. 88,p. 2610 - 2616.
[3]Journal of Biological Chemistry,2012,vol. 287,p. 30560 - 30570.
[4]Advanced Synthesis and Catalysis,2012,vol. 354,p. 2191 - 2198.
[5]Advanced Synthesis and Catalysis,2012,vol. 354,p. 2191 - 2198.
[6]Chemistry - A European Journal,2013,vol. 19,p. 7007 - 7012.
[7]Journal of the American Chemical Society,2015,vol. 137,p. 9015 - 9021.
[8]Journal of Biological Chemistry,2018,vol. 293,p. 3720 - 3733.

23
[ 76513-69-4 ]
[ 69205-79-4 ]
[ 908845-60-3 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

24
[ 53106-70-0 ]
[ 56-06-4 ]
[ 69205-79-4 ]

Yield	Reaction Conditions	Operation in experiment
40%		Preparation 4: 2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidine- 5-carbonitrile 2,4-Diamino-6-hydroxypyrimidine (3.00 g, 24 mmol) was added to a solution of sodium acetate (6.4g, 76 mmol) in millipore water (90 mL) and stirred at 50 C for 1 hour. While still at 50 C a solution of crude chloro(formyl)acetonitrile (3.00 g,32 mmol) in mQ water (44 mL) was added dropwise with a dropping funnel, during which time the reaction turned beigeand heating continued for 18 h at 50 C, after which time the reaction was heated to 100 C for 3 h. The reaction mixture was allowed to cool to room temperature and the solid removed by filtration. The solid was suspended in EtOH and SM aqueous KOH solution was added until the soliddissolved. Charcoal was added to the solution and the mixture stirred for 30 minutes before removal of the solid by filtration. The pH of the filtrate was adjusted to pH=6 with concentrated aqueous HCI solution during which time a precipitate formed and was collected by filtration. In order to remove the final traces of water from the solid it was dissolved in a mixture of toluene/methanol 1/1 and thenconcentrated at reduced pressure. The resultant solid was dried over P205 to afford the desired compound (1.68 g, 9.6 mmol, 40% yield) as beige solid. Procedure based on Brooks 2012.OH (400 MHz, DMSO-d6) 0 11.98 (br s, 1H) 10.74 (br s, 1H), 7.59 (s, 1H), 6.43 (s, 2H).Oc(100 MHz, DMSO-d6) 0 158.0, 154.3, 152.1, 128.2, 116.4, 99.2, 86.0. HRMS (m/z ESI): C7H5N50 EM-H]- Found 174.0415 Requires: 174.0416.
1.68 g	With sodium acetate; In water; at 50 - 100℃; for 22h;	2,4-Diamino-6-hydroxypyrimidine (3.00 g, 24 mmol) was added to a solution of sodium acetate (6.4g, 76 mmol) in millipore water (90 ml.) and stirred at 50 C for 1 hour. While still at 50 C a solution of crude chloro(formyl)acetonitrile (3.00 g, 32 mmol) in mQ water (44 ml.) was added dropwise with a dropping funnel, during which time the reaction turned beige and heating continued for 18 h at 50 C, after which time the reaction was heated to 100 C for 3 h. The reaction mixture was allowed to cool to room temperature and the solid removed by filtration. The solid was suspended in EtOH and 5M aqueous KOH solution was added until the solid dissolved. Charcoal was added to the solution and the mixture stirred for 30 minutes before removal of the solid by filtration. The pH of the filtrate was adjusted to pH=6 with concentrated aqueous HCI solution during which time a precipitate formed and was collected by filtration. In order to remove the final traces of water from the solid it was dissolved in a mixture of toluene/methanol 1/1 and then concentrated at reduced pressure. The resultant solid was dried over P2O5 to afford the desired compound (1.68 g, 9.6 mmol, 40% yield) as beige solid. Procedure based on Brooks 2012. deltaEta (400 MHz, DMSO-tfe) delta 11.98 (br s, 1H) 10.74 (br s, 1H), 7.59 (s, 1H), 6.43 (s, 2H). deltaalpha (100 MHz, DMSO-tfe) delta 158.0, 154.3, 152.1, 128.2, 116.4, 99.2, 86.0. HRMS (m/z ESI ) : C7H5N5O [M-H]" Found 174.0415 Requires: 174.0416.

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.
[2]Advanced Synthesis and Catalysis,2012,vol. 354,p. 2191 - 2198.
[3]Patent: WO2016/50806,2016,A1 .Location in patent: Page/Page column 22; 23.
[4]Patent: WO2016/50804,2016,A1 .Location in patent: Page/Page column 20.
[5]Chemistry and biodiversity,2019,vol. 16.

25
[ 69205-79-4 ]
[ 908845-55-6 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

26
[ 69205-79-4 ]
2-amino-3-methyl-4-oxo-7-(2-trimethylsilanyl-ethoxymethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

27
[ 69205-79-4 ]
[ 908845-62-5 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

28
[ 69205-79-4 ]
dapiramicin B [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

29
[ 69205-79-4 ]
[ 908845-63-6 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

30
[ 69205-79-4 ]
[ 908845-64-7 ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

31
[ 69205-79-4 ]
C₇₅H₉₁N₅O₁₈Si [ No CAS ]

References: [1]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.
[2]Tetrahedron Letters,2006,vol. 47,p. 5747 - 5750.

32
[ 69205-79-4 ]
[ 872968-96-2 ]

References: [1]Helvetica Chimica Acta,2005,vol. 88,p. 2610 - 2616.

33
[ 69205-79-4 ]
7-(aminomethyl)-7-deazaguanine trifluoroacetic acid salt [ No CAS ]

References: [1]Helvetica Chimica Acta,2005,vol. 88,p. 2610 - 2616.

34
[ 69205-79-4 ]
[ 674310-64-6 ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

35
[ 69205-79-4 ]
2-amino-6-bromo-7-[4-hydroxy-3-(hydroxymethyl)butyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 943 - 959.

36
[ 69205-79-4 ]
2-amino-5-[(2,5-dimethoxy-phenyl)-methyl-amino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

37
[ 69205-79-4 ]
2-amino-5-[(3,5-dimethoxy-phenyl)-methyl-amino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

38
[ 69205-79-4 ]
2-amino-5-[methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

39
[ 69205-79-4 ]
2-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1993 - 2003.

40
[ 62805-58-7 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

41
[ 74511-36-7 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

42
[ 62805-57-6 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

43
[ 74511-33-4 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

44
[ 74511-34-5 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

45
[ 74511-35-6 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

46
[ 74511-32-3 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

47
[ 74511-29-8 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

48
[ 74511-30-1 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

49
[ 74511-31-2 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

50
[ 64609-31-0 ]
[ 69205-79-4 ]

References: [1]Chemistry Letters,1980,p. 559 - 562.

51
[ 107-31-3 ]
[ 56-06-4 ]
[ 107-14-2 ]
[ 69205-79-4 ]

References: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 3821 - 3825.

52
[ 3282-30-2 ]
[ 69205-79-4 ]
5-cyano-3,4-dihydro-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine-4-one [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 3821 - 3825.

53
[ 76-83-5 ]
[ 69205-79-4 ]
[ 1019853-64-5 ]

Yield	Reaction Conditions	Operation in experiment
53%	With pyridine; at 90℃; for 48h;Inert atmosphere;	In a dry round bottomed flask under an atmosphere of argon, trityl chloride (1.20 g, 4.28 mmol) was added to a solution of <strong>[69205-79-4]2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile</strong> (0.50 g, 2.85 mmol) in dry pyridine (29 mL). The mixture reaction was heated at 90 C for 48 h. The reaction mixture was concentrated under reduced pressure then absorbed on silica gel and purified by flash chromatography on silica gel eluting with dichloromethane/MeOH with a gradient starting at 2% of MeOH and rising to lO%. The desired compound wasobtained as a brown solid (0.63 g, 1.5 mmol, 53% yield).Procedure based on Olgen 2008.OH (400 MHz, DMSO-d6) oe 11.80 (br s, 1H); 10.64 (br s, 1H), 7.56 (s, 1H), 7.41(s, 1H), 7.29-7.28 (m, 12H), 7.23-7.17 (m, 3H), 5.73 (s, 1H).HRMS (m/z ESI): C26H18N50 [M-H] Found 416.1514 Requires: 416.1511.
53%	With pyridine; at 90℃; for 48h;Inert atmosphere;	In a dry round bottomed flask under an atmosphere of argon, trityl chloride (1.20 g, 4.28 mmol) was added to a solution of 2-amino-4,7-dihydro-4-oxo-3A/- pyrrolo[2,3-d]pyrimidine-5-carbonitrile (0.50 g, 2.85 mmol) in dry pyridine (29 ml_). The mixture reaction was heated at 90 C for 48 h. The reaction mixture was concentrated under reduced pressure then absorbed on silica gel and purified by flash chromatography on silica gel eluting with dichloromethane/MeOH with a gradient starting at 2% of MeOH and rising to 10%. The desired compound was obtained as a brown solid (0.63 g, 1.5 mmol, 53% yield). Procedure based on Olgen 2008. deltaEta (400 MHz, DMSO-de) delta 11.80 (br s, 1H); 10.64 (br s, 1H), 7.56 (s, 1H), 7.41(s, 1H), 7.29-7.28 (m, 12H), 7.23-7.17 (m, 3H), 5.73 (s, 1H). HRMS (m/z ESI+) : C26Hi8N50 [M-H]+ Found 416.1514 Requires: 416.1511.

References: [1]Archiv der Pharmazie,2008,vol. 341,p. 113 - 120.
[2]Tetrahedron Letters,2010,vol. 51,p. 4163 - 4165.
[3]Patent: WO2016/50806,2016,A1 .Location in patent: Page/Page column 23.
[4]Patent: WO2016/50804,2016,A1 .Location in patent: Page/Page column 21.

54
[ 69205-79-4 ]
[ 1160569-66-3 ]

References: [1]Organic and Biomolecular Chemistry,2009,vol. 7,p. 1829 - 1842.
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 6479 - 6494.

Historical Records

Technical Information

• Acyl Group Substitution • Blaise Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Aldehydes and Ketones • Preparation of Amines • Reactions of Amines • Ritter Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Thorpe-Ziegler Reaction • Ugi Reaction

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P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 69205-79-4

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CAS No.: 69205-79-4

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