Home Cart Sign in  
Chemical Structure| 2162-31-4 Chemical Structure| 2162-31-4
Chemical Structure| 2162-31-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

THP-PEG1-alcohol is a PEG derivative containing a THP (tetrahydropyranyl) group and a hydroxyl group. It is used in protecting group chemistry and as a building block in organic synthesis.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of THP-PEG1-alcohol

CAS No. :2162-31-4
Formula : C7H14O3
M.W : 146.18
SMILES Code : OCCOC1CCCCO1
MDL No. :MFCD00185588
InChI Key :XDBZJXRPEKFIFR-UHFFFAOYSA-N
Pubchem ID :4166833

Safety of THP-PEG1-alcohol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of THP-PEG1-alcohol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2162-31-4 ]

[ 2162-31-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 2162-31-4 ]
  • [ 52867-42-2 ]
  • methyl-5-[2-(tetrahydropyran-2-yloxy)ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
26.6 g With di-isopropyl azodicarboxylate; triphenylphosphine; at 0 - 80℃; for 48h;Reflux; Step 2: 2-Methyl-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-2H-pyrazole-3-carboxylic acid ethyl ester (3_ 1_3) [00353] Diisopropyl azodicarboxylate (DIAD, 41.6 mL, 205.8 mmol) was added to a solution of 3_41_2 (10.7 g, 68.6 mmol), 2-(tetrahydro-pyran-2-yloxy)- ethanol (17 mL, 102.9 mmol) and triphenylphosphine (53.9 g, 205.8 mmol) at 0C, and the mixture was stirred at room temperature for 16 hours. The reaction mixture was heated at 80C for 16 hours, more 2-(tetrahydro-pyran-2-yloxy)-ethanol (3.75 mL), triphenylphosphine (5.3 g) and diisopropyl azodicarboxylate (3 mL) were added, and the reaction mixture was refluxed for 16 hours, concentrated and treated with diethyl ether and hexanes (2:3, 500 mL) to give a precipitate, which was removed by filtration. The filtrate was concentrated and the residue obtained was purified by column chromatography to give compound 3_41_3 (26.6 g, >100 % yield, contaminated with diisopropyl azodicarboxylate) as a yellow oil. [00354] NMR (400 MHz, CDC13): delta = 1.45-1.90 (m, 6H), 3.52 (d, ]=UA Hz, 1H), 3.79-3.92 (m, 5H), 3.95-4.10 (m, 5H), 4.31 (t, J=4.9 Hz, 2H), 4.69 (t, J=3.5 Hz, 1H), 6.21 (s, 1H).
  • 2
  • [ 2162-31-4 ]
  • [ 1597-32-6 ]
  • 6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
25.9% 2-((tetrahydro-2H-pyran-2-yl)oxy)ethanol (1.5 g, 10.26 mmol) in N-Methyl-2-pyrrolidone ( MP) (4 mL) was added to a suspension of NaH (0.616 g, 25.7 mmol) at 0 C and the reaction mixture was stirred for 30 min at 28 C. <strong>[1597-32-6]6-fluoropyridin-2-amine</strong> (1.150 g, 10.26 mmol) was added to the reaction mixture at 0C, and the reaction mixture was stirred at 120 C for 16 hr. The reaction mixture was quenched with cold water and extracted with dichloromethane(2 x 60 mL). The organic layer was washed with water (30 mL) and saturated brine solution(20 mL), dried over anhydrous Na2SC>4, filtered and concentrated. Crude was purified by flash chromatography on neutral alumina. Crude was diluted with DCM and absorbed with neutral alumina and eluted with 20-25-% EtOAc in pet ether fractions were collected and concentrated to get 6-(2-((tetrahydro-2H-pyran-2- yl)oxy)ethoxy)pyridin-2-amine (700 mg, 2.66 mmol, 25.9 % yield), LCMS (m/z): 239.0 [M+H]+.
  • 3
  • [ 2162-31-4 ]
  • [ 33332-28-4 ]
  • 6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrazin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% NaH (60%) (0.556 g, 23.16 mmol) was added to a stirred solution of 2-((tetrahydro-2H- pyran-2-yl)oxy)ethanol (3.39 g, 23.16 mmol) in 1,4-Dioxane (100 mL) at 0 C then stirred at RT for 30 min and 6-chloropyrazin-2-amine (3 g, 23.16 mmol) was added at 0 C then it was kept at 80 C for 16 h. The reaction mixture was cooled to RT, and was quenched with ice cold water (50 mL) then partitioned between ice cold water (20 mLX2) and ethyl acetate (20 mL x 2). Organic layers were separated and was dried over anhydrous Na2S04, filtered and filtrate was evaporated to get crude compound, then it was purified by column chromatography (using 100-200 silica gel, column eluted at 60% ethyl acetate in hexane) to afford the 6-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrazin-2-amine (5 g, 20.06 mmol, 87 % yield) as gum oil, LCMS (m/z): 240.13 [M+H]+.
 

Historical Records

Technical Information

Categories