Structure of Vemurafenib
CAS No.: 918504-65-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Vemurafenib (PLX4032) is a first-in-class, selective, and potent inhibitor of B-RAF kinase, with IC50s of 31 nM for RAFV600E and 48 nM for c-RAF-1. Vemurafenib induces cell autophagy.
Synonyms: PLX4032; RG7204; RO5185426
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Foda, Bardees ; Baker, Annika ; Joachimiak, Lukasz ; Mazur, Marzena ; Neubig, Richard Rick ;
Abstract: Aim: Overcoming therapy resistance is critical for effective melanoma control. Upregulation of Rho/MRTF signaling in human and mouse melanomas causes resistance to targeted therapies. Inhibition of this pathway by MRTFi, CCG-257081 resensitized resistant melanomas to BRAF and MEK inhibitors. It also prevented the development of resistance to vemurafenib (Vem). Here, we investigate the role of apoptosis and the protein pirin in CCG-257081-mediated suppression of drug resistance. Methods: Using naïve and resistant mouse YUMMER melanoma cells, we studied the effect of the BRAF inhibitor Vem with or without CCG-257081 on real-time growth and apoptosis (activation of caspase, Propidium iodide (PI) staining, and PARP cleavage). The effects of CCG-257081 on proliferation (Ki67) and caspase-3 activation were assessed in resistant YUMMER_R tumors in vivo. Finally, two CCG-257081 enantiomers were tested for pirin binding, inhibition of the Rho/MRTF-mediated activation of ACTA2 gene expression in fibroblasts, and the prevention of Vem resistance development by YUMMER_P cells. Results: Vem reduced growth of parental but not resistant cells, while CCG-257081 inhibited both. The combination was more effective than Vem alone. CCG-257081, but not Vem, induced activation of caspase-3 and -7 in resistant cells and increased PARP cleavage and PI staining. CCG-257081 reduced proliferation and activated caspase-3 in YUMMER_R melanoma tumors. Both CCG-257081 enantiomers robustly suppressed development of Vem-resistant colonies with the S isomer being more potent (1 µM IC50). Conclusion: CCG-257081 appears to target pre-resistant cells and Vem-induced resistant cells through enhanced apoptosis. Inhibition of pirin or the Rho/MRTF pathway can be employed to prevent melanoma resistance.
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Foda, Bardees M. ; Neubig, Richard R. ;
Abstract: Cutaneous melanoma is the deadliest skin cancer. Most have Ras-MAPK pathway (BRAFV600E or NRAS) mutations and highly effective targeted therapies exist; however, they and immune therapies are limited by resistance, in part driven by small GTPase (Rho and Rac) activation. To facilitate preclin. studies of combination therapies to provide durable responses, we describe the first mouse melanoma lines resistant to BRAF inhibitors. Treatment of mouse lines, YUMM1.7 and YUMMER, with vemurafenib (Vem), the BRAFV600E-selective inhibitor, resulted in high-level resistance (IC50 shifts 20-30-fold). Resistant cells showed enhanced activation of Rho and the downstream transcriptional coactivator, myocardin-related transcription factor (MRTF). Resistant cells exhibited increased stress fibers, nuclear translocation of MRTF-A, and an increased MRTF-A gene signature. Pharmacol. inhibition of the Rho/MRTF pathway using CCG-257081 reduced viability of resistant lines and enhanced sensitivity to Vem. Remarkably, co-treatment of parental lines with Vem and CCG-257081 eliminated resistant colony development. Resistant cells grew more slowly in vitro, but they developed highly aggressive tumors with a shortened survival of tumor-bearing mice. Increased expression of immune checkpoint inhibitor proteins (ICIs) in resistant lines may contribute to aggressive in vivo behavior. Here, we introduce the first drug-resistant mouse melanoma models for assessing combinations of targeted and immune therapies.
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Keywords: melanoma ; resistance ; immune checkpoint ; BRAF ; RhoGTPase
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CAS No. : | 918504-65-1 |
Formula : | C23H18ClF2N3O3S |
M.W : | 489.92 |
SMILES Code : | CCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CC=C(Cl)C=C4)C=C32)=O)=C1F)=O |
Synonyms : |
PLX4032; RG7204; RO5185426
|
MDL No. : | MFCD18074504 |
InChI Key : | GPXBXXGIAQBQNI-UHFFFAOYSA-N |
Pubchem ID : | 42611257 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
SK-Mel-19R | 2 μM | 2 months | To select vemurafenib-resistant melanoma cell lines and analyze the activation of the RhoA signaling pathway. | PMC7024013 |
UACC62R | 2 μM | 2 months | To select vemurafenib-resistant melanoma cell lines and analyze the activation of the RhoA signaling pathway. | PMC7024013 |
K-1 | 10 μM | 24 h | To evaluate the antitumor effect of Vemurafenib on K-1 cells, results showed that E3330 could enhance the antitumor effect of vemurafenib. | PMC8825860 |
BCPAP | 10 μM | 24 h | To evaluate the antitumor effect of Vemurafenib on BCPAP cells, results showed that E3330 could enhance the antitumor effect of vemurafenib. | PMC8825860 |
HT29 cells | 10 µM | 12 h | To evaluate the inhibitory effect of Vemurafenib on TSZ-induced necroptotic cell death, results showed that Vemurafenib significantly inhibited necroptotic cell death. | PMC10449909 |
MDF cells | 10 µM | 6 h | To evaluate the inhibitory effect of Vemurafenib on TSZ-induced necroptotic cell death, results showed that Vemurafenib significantly inhibited necroptotic cell death. | PMC10449909 |
L929 cells | 10 µM | 24 h | To evaluate the inhibitory effect of Vemurafenib on TNFα-induced necroptotic cell death, results showed that Vemurafenib significantly inhibited necroptotic cell death. | PMC10449909 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | Xenogeneic subcutaneous tumor model | Oral | 20 mg/kg | Once daily for 21 days | To evaluate the inhibitory effect of combined treatment with Vemurafenib and E3330 on xenogeneic subcutaneous tumors, results showed that the combined treatment significantly inhibited tumor growth and progression. | PMC8825860 |
C57BL/6 mice | LPS/z-VAD-induced macrophage necroptosis model | Intraperitoneal injection | 5 mg/kg | 15 mins pretreatment | To evaluate the inhibitory effect of Vemurafenib on LPS/z-VAD-induced macrophage necroptosis, results showed that Vemurafenib significantly inhibited macrophage necroptosis and reduced the secretion of proinflammatory cytokines. | PMC10449909 |
Mice | Melanoma model | Intraperitoneal injection | 1 mg/kg | Daily for one week | PLX4032 inhibits melanoma metastasis by suppressing integrin signaling through PGC1α and ID2 | PMC5161587 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02052193 | Metastatic Melanoma (Carrying ... More >>BRAF V600 Mutation) Less << | Phase 2 | Terminated(Second cohort not o... More >>pened because Simon-Two_Step model failed) Less << | December 2017 | Germany ... More >> Department of Dermatology Tuebingen, BW, Germany, 72076 Less << |
NCT01603212 | Melanoma | Phase 1 Phase 2 | Completed | - | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT03139513 | - | Active, not recruiting | December 31, 2018 | France ... More >> Centre Hospitalier d'Albi Albi Cedex 9, France, 81013 Hopital Prive D Antony; Dermatologie Antony, France, 92166 Chic Cote Basque Bayonne; Medecine II Bayonne, France, 64109 CHU Besançon - Hôpital Jean Minjoz Besançon Cedex, France, 25030 Hopital Avicenne; Dermatologie Bobigny, France, 93009 CH Fleyriat Bourg en Bresse, France, 01000 CH Metropole de Savoie CHAMBERY Cedex, France, 73011 Chu Estaing; Dermatologie Clermont Ferrand, France, 63003 Hopital Louis Pasteur; Sce Dermatologie Colmar, France, 68024 Centre Georges Francois Leclerc Dijon, France, 21000 Chu Site Du Bocage;Dermatologie Dijon, France, 21079 Centre Hospitalier Le Mans; Dermatologie Le Mans, France, 72037 Hopital Claude Huriez; Sce Dermatologie Lille, France, 59037 CHU de Limoges - Hôpital Dupuytren Limoges, France, 87042 Hopital Timone Adultes; Dermatologie Marseille, France, 13385 Hopital Jacques Monod; Dermatologie Montivilliers, France, 76290 Hopital Saint Eloi; CHU de Montpellier; Svc de Dermatologie Montpellier, France, 34295 CH de Mulhouse Hôpital Emile Muller Mulhouse, France, 68070 Hopital l Archet 2; Ginestriere, Service de; Dermatologie Nice cedex 3, France, 06200 Hopital Cochin; Dermatologie Paris, France, 75006 Groupe Hospitalier Bichat Claude Bernard Paris, France, 75018 CENTRE HOSPITALIER ANNECY-GENEVOIS; Dematologie Pringy, France Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer Rennes, France, 35000 CHU Rouen - CH C. Nicolle - Clinique dermatologique Rouen, France, 76031 CHU de Saint-Etienne - Hopital Nord Saint Etienne, France, 42055 CHI de Poissy St Germain Saint Germain, France, 07810 Hopital Broussais St Malo Cedex, France, 35403 Pole de Cancerologie Prive Strasbourgeois Strasbourg, France, 67000 Hopital Bel Air Thionville Cedex, France, 57126 Hia Sainte Anne; Medecine Interne Oncologie Toulon, France, 83041 CHU de Toulouse - Hôpital Larrey Toulouse, France, 31059 Centre Hospitalier Valence Valence, France, 26953 Institut Gustave Roussy; Dermatologie Villejuif, France, 94805 Less << | |
NCT03543969 | Melanoma (Skin) ... More >> Skin Cancer Skin Melanoma Skin Carcinoma Less << | Early Phase 1 | Recruiting | September 2021 | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Recruiting Tampa, Florida, United States, 33612 Contact: Leticia Tetteh 813-745-4617 leticia.tetteh@moffitt.org Principal Investigator: Zeynep Eroglu, M.D. Less << |
NCT03101254 | Melanoma | Phase 1 Phase 2 | Recruiting | October 30, 2023 | United States, Massachusetts ... More >> Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Elizabeth Buchcinder, MD 617-632-5055 Principal Investigator: Elizabeth Buchbinder, MD Less << |
NCT01659151 | Metastatic Melanoma | Phase 2 | Active, not recruiting | December 2019 | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Less << |
NCT01974258 | Neoplasms | Phase 1 | Withdrawn | July 2014 | United States, California ... More >> Los Angeles, California, United States, 90025 United States, Florida Sarasota, Florida, United States, 34232 United States, Michigan Detroit, Michigan, United States, 48201 United States, Ohio Canton, Ohio, United States, 44718 United States, Oklahoma Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Nashville, Tennessee, United States, 37203 Less << |
NCT00405587 | Malignant Melanoma|Colorectal ... More >>Carcinoma Less << | PHASE1 | COMPLETED | 2025-02-16 | University of California Los A... More >>ngeles, Los Angeles, California, 90095, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Vanderbilt Ingram Cancer Center, Nashville, Tennessee, 37232, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia|Royal Melbourne Hospital, Parkville, Victoria, Australia Less << |
NCT02902029 | Malignant Melanoma | Phase 2 | Recruiting | December 2021 | France ... More >> Hôpital Ambroise-Paré Recruiting Boulogne-Billancourt, France, 92104 Contact: Philippe Saiag, Prof. philippe.saiag@apr.aphp.fr Hospital Claude Huriez Not yet recruiting Lille, France, 59000 Contact: Laurent Mortier, Prof. laurent.mortier@chru-lille.fr Hôpital de la Timone Recruiting Marseille, France, 13885 Contact: Jean J Grob, Prof. jean-jacques.grob@ap-hm.fr CHU de Nantes Not yet recruiting Nantes, France, 44093 Contact: Brigitte Dreno, Prof. brigitte.dreno@wanadoo.fr Centre Hospitalier Lyon Sud Not yet recruiting Pierre-Bénite, France, 69310 Contact: Stéphane Dalle, Dr. stephane.dalle@chu-lyon.fr Germany SLK-Kliniken Heilbronn GmbH Recruiting Heilbronn, Baden-Wuerttemberg, Germany, 74078 Contact: Uwe Martens, Prof. Dr. uwe.martens@slk-kliniken.de Principal Investigator: Uwe Martens, Prof. Dr. Sub-Investigator: Jamil Akkad University Hospital Mannheim, Clinic for Dermatology Recruiting Mannheim, Baden-Wuerttemberg, Germany, 68167 Contact: Jochen Utikal, Prof. Dr. jochen.utikal@umm.de Principal Investigator: Jochen Utikal, Prof. Dr. Sub-Investigator: Maria Rita Gaiser, PD Dr. med. National Centre for Tumour Diseases (NCT) Recruiting Heidelberg, BW, Germany, 69120 Contact: Jessica Hassel, Dr. med. jessica.hassel@med.uni-heidelberg.de Principal Investigator: Jessica Hassel, Dr. med. Sub-Investigator: Martin Hartmann, Dr. med University Hospital Essen, Department of Dermatology, Skin Cancer Center Recruiting Essen, North Rhine-Westphalia, Germany, 45122 Contact: Dirk Schadendorf, Prof. Dr. dirk.schadendorf@uk-essen.de Principal Investigator: Dirk Schadendorf, Prof. Dr. Sub-Investigator: Elisabeth Livingstone, Dr. Sub-Investigator: Lisa Zimmer, Dr. HELIOS Klinikum Erfurt Recruiting Erfurt, Thuringia, Germany, 99089 Contact: Rudolf Herbst, Prof. Dr. rudolf.herbst@helios-kliniken.de Principal Investigator: Rudolf Herbst, Prof. Dr. Sub-Investigator: Ivonne Kellner, Dr. med. Charité-Universitätsmedizin Berlin Recruiting Berlin, Germany, 10117 Contact: Felix Kiecker, Dr. med. felix.kiecker@charite.de Principal Investigator: Felix Kiecker, Dr. med. Sub-Investigator: Claas Ulrich, Dr. med. Elbe Kliniken Stade - Buxtehude Not yet recruiting Buxtehude, Germany, 21614 Contact: Peter Mohr, Dr. med. Peter.Mohr@elbekliniken.de Principal Investigator: Peter Mohr, Dr. med. Universitätsklinik Dresden Recruiting Dresden, Germany, 01307 Contact: Friedegund Meier, Prof. Dr. friedegund.meier@uniklinikum-dresden.de Principal Investigator: Friedegund Meier, Prof. Dr. Sub-Investigator: Marlene Garzarolli Medizinische Hochschule Hannover Recruiting Hannover, Germany, 30625 Contact: Ralf Gutzmer, Prof. Dr. gutzmer.ralf@mh-hannover.de Principal Investigator: Ralf Gutzmer, Prof. Dr. Sub-Investigator: Imke Satzger, Pd Dr. Universitätsklinikum des Saarlandes Not yet recruiting Homburg/Saar, Germany, 66421 Contact: Claudia Pföhler, Prof. Dr. Claudia.Pfoehler@uniklinikum-saarland.de Principal Investigator: Claudia Pföhler, Prof. Dr. Sub-Investigator: Thomas Vogt, Prof. Dr. Universitäts-Hautklinik Kiel Recruiting Kiel, Germany, 24105 Contact: Katharina Kähler, Dr. med. kckaehler@yahoo.de Principal Investigator: Katharina Kähler, Dr. med. Sub-Investigator: Axel Hauschild, Prof. Dr. Universitätsklinikum Köln Not yet recruiting Köln, Germany, 50937 Contact: Cornelia Mauch, Prof. Dr. cornelia.mauch@uk-koeln.de Principal Investigator: Cornelia Mauch, Prof. Dr. Universitätsklinikum Leipzig Recruiting Leipzig, Germany, 04103 Contact: Jan Christoph Simon, Prof. Dr. jan.simon@medizin.uni-leipzig.de Principal Investigator: Jan Christoph Simon, Prof. Dr. Sub-Investigator: Mirjana Ziemer, Dr. med. Gesellschaft für Klinische Forschung Ludwigshafen mbH Recruiting Ludwigshafen, Germany, 67063 Contact: Edgar Dippel, Prof. Dr. dippele@klilu.de Principal Investigator: Edgar Dippel, Prof. Dr. Sub-Investigator: Evelyn Dabrowski, Dr. med. Universitätsklinikum Schleswig-Holstein Recruiting Lübeck, Germany, 23538 Contact: Patrick AM Terheyden, PD Dr. med. patrick.terheyden@uksh.de Principal Investigator: Patrick AM Terheyden, PD Dr. med. Sub-Investigator: Diamant Thaci, Prof. Universitätsklinikum Mainz Recruiting Mainz, Germany, 55131 Contact: Carmen Loquai, Prof. Dr. carmen.loquai@unimedizin-mainz.de Principal Investigator: Carmen Loquai, Prof. Dr. Sub-Investigator: Stephan Grabbe, Prof. Dr. Sub-Investigator: Heidrun Karin Mitzel-Rink, Dr. Johannes Wesling Klinikum Minden Recruiting Minden, Germany, 32429 Contact: Rudolf Stadler, Prof. Dr. rudolf.stadler@muehlenkreiskliniken.de Principal Investigator: Rudolf Stadler, Prof. Dr. Sub-Investigator: Jörg Böttjer, Dr. Klinikum der Universität München Recruiting München, Germany, 80337 Contact: Carola Berking, Prof. Dr. Carola.Berking@med.uni-muenchen.de Principal Investigator: Carola Berking, Prof. Dr. Sub-Investigator: Julia Katharina Tietze, Dr. med. Universitätsklinikum Tübingen Recruiting Tübingen, Germany, 72076 Contact: Claus Garbe, Prof. Dr. claus.garbe@med.uni-tuebingen.de Principal Investigator: Claus Garbe, Prof. Dr. Sub-Investigator: Thomas Kurt Eigentler, PD Dr. med. Sub-Investigator: Benjamin Matthias Weide, Dr. med. Uniklinikum Würzburg Recruiting Würzburg, Germany, 97080 Contact: Anja Heike Gesierich, MD Gesierich_A@ukw.de Principal Investigator: Anja Heike Gesierich, MD Sub-Investigator: Marion Wobser, Dr. Greece "LAIKO" General Hospital of Athens Recruiting Athens, Greece, 11527 Contact: Helen Gogas, Prof. hgogas@hol.gr Serbia Military Medical Academy Recruiting Belgrad, Serbia, 11000 Contact: Lidija Kandolf-Sekulovic, Prof. lkandolfsekulovic@gmail.com Less << |
NCT00405587 | Malignant Melanoma|Colorectal ... More >>Carcinoma Less << | PHASE1 | COMPLETED | 2025-02-16 | University of California Los A... More >>ngeles, Los Angeles, California, 90095, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Vanderbilt Ingram Cancer Center, Nashville, Tennessee, 37232, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia|Royal Melbourne Hospital, Parkville, Victoria, Australia Less << |
NCT02077114 | Malignant Melanoma With Metast... More >>asis Less << | Phase 1 | Completed | - | Denmark ... More >> Department of Oncology, Herlev Hospital Herlev, Denmark, 2730 Less << |
NCT01897116 | Melanoma | Phase 1 | Completed | - | United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
NCT02089724 | - | Recruiting | April 2019 | United States, New York ... More >> Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Eli L. Diamond, MD, PhD diamonel@mskcc.org Principal Investigator: Eli L. Diamond, MD, PhD Sub-Investigator: Omar Abdel-Wahab, MD France AP-HP, Groupe Hospitalier Pitié-Salpêtrière Recruiting Paris, France, 75013 Contact: Julien Haroche, MD, PhD +33 1 42 17 80 37 julien.haroche@psl.aphp.fr Contact: Fleur Cohen Aubart, MD, PhD +33 1 42 17 82 42 fleur.cohen@psl.aphp.fr Principal Investigator: Julien Haroche, MD, PhD Sub-Investigator: Fleur Cohen Aubart, MD, PhD Sub-Investigator: Zahir Amoura, MD, MSc Less << | |
NCT03224767 | BRAF V600E Mutation Present ... More >> Papillary Craniopharyngioma Less << | Phase 2 | Recruiting | August 2026 | - |
NCT03013491 | Solid Tumor L... More >>ymphoma Less << | Phase 1 Phase 2 | Recruiting | December 2021 | - |
NCT01656642 | Malignant Melanoma | Phase 1 | Active, not recruiting | November 28, 2018 | United States, California ... More >> UCLA Los Angeles, California, United States, 90024 The Angeles Clinic and Research Institute - W LA Office Los Angeles, California, United States, 90025 United States, Colorado University of Colorado Health Science Center; Biomedical Research Bldg. Room 511 Aurora, Colorado, United States, 80045 United States, Florida Florida Cancer Specialists - Sarasota Sarasota, Florida, United States, 34232 Florida Cancer Specialists West Palm Beach, Florida, United States, 33401 United States, Massachusetts Massachusetts General Hospital. Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Med Ctr Boston, Massachusetts, United States, 02215 Dana Farber Can Ins Boston, Massachusetts, United States, 02215 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT03108209 | Phototoxicity | Not Applicable | Recruiting | October 2017 | France ... More >> CHU Nantes Recruiting Nantes, France Contact: Aurélie BOISROBERT Contact 02.40.08.31.22 Less << |
NCT03514901 | Melanoma Metastatic ... More >> BRAF V600 Mutation Less << | Phase 2 | Not yet recruiting | April 3, 2021 | Italy ... More >> Istituto dei Tumori "Giovanni Paolo II" Not yet recruiting Bari, BA, Italy, 70124 Contact: Michele Guida, Dr. ASST Papa Giovanni XXIII Not yet recruiting Bergamo, BG, Italy, 24127 Contact: Mario Mandalà, Dr. Policlinico Sant'Orsola Malpighi Not yet recruiting Bologna, BO, Italy, 40138 Contact: Barbara Melotti, Dr. IRCCS IRST Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Not yet recruiting Meldola, FC, Italy, 47014 Contact: Massimo Guidoboni, Dr. Ospedale Policlinico San Martino Active, not recruiting Genova, GE, Italy, 16132 P.O. di Taormina - Azienda Sanitaria Provinciale di Messina Not yet recruiting Taormina, ME, Italy, 98039 Contact: Francesco Ferraù, Dr. Fondazione IRCCS Istituto Nazionale dei Tumori Not yet recruiting Milano, MI, Italy, 20133 Contact: Michele Del Vecchio, Dr. Istituto Oncologico Veneto - IRCCS Not yet recruiting Padova, PD, Italy, 35128 Contact: Vanna Chiarion Sileni, Dr. Ospedale S. Chiara - A.O.U. Pisana Not yet recruiting Pisa, PI, Italy, 56125 Contact: Alfredo Falcone, Prof. A.O.U.S. Policlinico "Le Scotte" Not yet recruiting Siena, SI, Italy, 53100 Contact: Anna Maria Di Giacomo, Dr. P.O. San Lazzaro - A.O.U. Città della Salute e della Scienza di Torino - Molinette Not yet recruiting Torino, TO, Italy, 10126 Contact: Maria Teresa Fierro, Prof. Istituti Fisioterapici Ospitalieri - IFO - Istituto "Regina Elena" Not yet recruiting Roma, Italy, 00144 Contact: Virginia Ferraresi, Dr. IDI Istituto Dermopatico Immacolata Not yet recruiting Roma, Italy, 00167 Contact: Alessandro Scoppola, Dr. Less << |
NCT01585415 | Metastatic Cancer ... More >> Melanoma Less << | Phase 1 | Terminated | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01597908 | - | Active, not recruiting | - | - | |
NCT01841463 | Advanced or Inoperable Maligna... More >>nt Melanoma With BRAF Mutation Less << | Phase 1 | Suspended(Sponsor decision not... More >> related to patient safety) Less << | March 2016 | United States, California ... More >> UCSF Medical Center at Mount Zion South San Francisco, California, United States, 94115 United States, Colorado University of Colorado Anschutz Medical Campus Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown-Lombardi Comprehensive Cancer Ctr Washington, District of Columbia, United States, 20057 United States, Texas The University of Texas, MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00949702 | Malignant Melanoma | Phase 2 | Completed | - | United States, California ... More >> UCLA - School of Medicine; Division of Hematology/Oncology Los Angeles, California, United States, 90095-6984 United States, Colorado University of Colorado Denver, Colorado, United States, 80262 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Massachusetts Massachusetts General Hospital;Hematology/ Oncology Boston, Massachusetts, United States, 02114 Dana Farber Cancer Inst. ; Dept. of Medical Oncology Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, New York New York University Medical Center New York, New York, United States, 10036 United States, Pennsylvania Hospital of the Uni of Pennsylvania; Section of Hematology/Oncology Philadelphia, Pennsylvania, United States, 19104-4283 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee Vanderbilt-Ingram Cancer Ctr Nashville, Tennessee, United States, 37232 United States, Texas Texas Oncology-Baylor Sammons Cancer Center Dallas, Texas, United States, 75246 University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Australia, New South Wales Calvary Mater Newcastle; Melanoma Clinic Newcastle, New South Wales, Australia, 2298 Westmead Hospital; Medical Oncology and Pallative Care Westmead, New South Wales, Australia, 2145 Australia, Victoria Peter Maccallum Cancer Institute; Medical Oncology Melbourne, Victoria, Australia, 3000 Less << |
NCT01597908 | Melanoma | Phase 3 | Active, not recruiting | March 18, 2019 | - |
NCT00949702 | - | Completed | - | - | |
NCT02908672 | Melanoma | Phase 3 | Active, not recruiting | July 29, 2023 | - |
NCT01512251 | - | Completed | - | - | |
NCT01378975 | Malignant Melanoma | PHASE2 | COMPLETED | 2025-07-15 | Los Angeles, California, 90025... More >>, United States|Aurora, Colorado, 80045, United States|Tampa, Florida, 33612-9497, United States|Boston, Massachusetts, 02114, United States|Boston, Massachusetts, 02215, United States|Detroit, Michigan, 48201, United States|Rochester, Minnesota, 55905, United States|Saint Louis, Missouri, 63110, United States|Charlotte, North Carolina, 28204-2839, United States|Dallas, Texas, 75246, United States|Seattle, Washington, 98195, United States|Wentworthville, New South Wales, 2145, Australia|Melbourne, Victoria, 3002, Australia|Toronto, Ontario, M4N 3M5, Canada|Bordeaux, 33075, France|Nice, 06202, France|Paris, 75006, France|Paris, 75475, France|Essen, 45122, Germany|Frankfurt, 60596, Germany|Kiel, 24105, Germany|Mannheim, 68167, Germany|Münster, 48157, Germany|Tübingen, 72076, Germany|Tel-Hashomer, 52621, Israel|Milano, Lombardia, 20133, Italy|Siena, Toscana, 53100, Italy|Amsterdam, 1066 CX, Netherlands|Groningen, 9713 GZ, Netherlands|Pamplona, Navarra, 31008, Spain|Barcelona, 08036, Spain|Madrid, 28046, Spain|Northwood, HA6 2RN, United Kingdom Less << |
NCT02164916 | Colorectal Cancer | Phase 2 | Active, not recruiting | January 2020 | - |
NCT01849666 | Malignant Melanoma, Neoplasms | Phase 1 | Completed | - | Belgium ... More >> Brussels, Belgium, 1000 Edegem, Belgium, 2650 Gent, Belgium, 9000 Wilrijk, Belgium, 2610 Finland Helsinki, Finland, 00180 Germany Heidelberg, Germany, 69120 Mainz, Germany, 55101 Netherlands Amsterdam, Netherlands, 1066 CX Maastricht, Netherlands, 6229HX Utrecht, Netherlands, 3584 CX Spain Pamplona, Navarra, Spain, 31008 Barcelona, Spain, 08908 Madrid, Spain, 280146 Madrid, Spain, 28031 Madrid, Spain, 28040 Madrid, Spain, 28041 Madrid, Spain, 28050 Less << |
NCT03727763 | Colorectal Cancer | Phase 2 | Recruiting | December 31, 2020 | China, Shanghai ... More >> Shanghai Changzheng Hospital Recruiting Shanghai, Shanghai, China, 200433 Contact: Zhan Wang, Prof. +8613916229609 profoundamir@139.com Less << |
NCT01378975 | Malignant Melanoma | PHASE2 | COMPLETED | 2025-07-15 | Los Angeles, California, 90025... More >>, United States|Aurora, Colorado, 80045, United States|Tampa, Florida, 33612-9497, United States|Boston, Massachusetts, 02114, United States|Boston, Massachusetts, 02215, United States|Detroit, Michigan, 48201, United States|Rochester, Minnesota, 55905, United States|Saint Louis, Missouri, 63110, United States|Charlotte, North Carolina, 28204-2839, United States|Dallas, Texas, 75246, United States|Seattle, Washington, 98195, United States|Wentworthville, New South Wales, 2145, Australia|Melbourne, Victoria, 3002, Australia|Toronto, Ontario, M4N 3M5, Canada|Bordeaux, 33075, France|Nice, 06202, France|Paris, 75006, France|Paris, 75475, France|Essen, 45122, Germany|Frankfurt, 60596, Germany|Kiel, 24105, Germany|Mannheim, 68167, Germany|Münster, 48157, Germany|Tübingen, 72076, Germany|Tel-Hashomer, 52621, Israel|Milano, Lombardia, 20133, Italy|Siena, Toscana, 53100, Italy|Amsterdam, 1066 CX, Netherlands|Groningen, 9713 GZ, Netherlands|Pamplona, Navarra, 31008, Spain|Barcelona, 08036, Spain|Madrid, 28046, Spain|Northwood, HA6 2RN, United Kingdom Less << |
NCT01765556 | Malignant Melanoma, Neoplasms | Phase 1 | Withdrawn | October 2013 | - |
NCT01843738 | BRAFV600 Mutation ... More >> Stage IV Melanoma Less << | Phase 1 | Withdrawn(Competing Trials) | August 2022 | United States, Utah ... More >> Huntsman Cancer Institute Salt Lake City, Utah, United States, 84112 Less << |
NCT02414750 | Metastatic Melanoma | Phase 2 | Recruiting | December 2018 | Netherlands ... More >> The Netherlands Cancer Institute Recruiting Amsterdam, Netherlands, 1066CX Contact: Bernies Van der Hiel, MD +31205126129 b.vd.hiel@nki.nl Principal Investigator: John B.A.G. Haanen, Prof. VU medical center Recruiting Amsterdam, Netherlands Contact: Fons J.M. Van den Eertwegh, MD PhD +31204444336 vandeneertwegh@vumc.nl Principal Investigator: Fons J.M. Van den Eertwegh, MD PhD Medisch Spectrum Twente Not yet recruiting Enschede, Netherlands Contact: D. Piersma, MD PhD d.piersma@mst.nl Principal Investigator: D. Piersma, MD PhD University Medical Center Groningen Recruiting Groningen, Netherlands Contact: G. A.P. Hospers, Prof. g.a.p.hospers@umcg.nl Principal Investigator: G. A.P. Hospers, Prof. Leiden University Medical Center Recruiting Leiden, Netherlands Contact: H. W. Kapiteijn, MD PhD h.w.kapiteijn@lumc.nl Principal Investigator: H. W. Kapiteijn, MD PhD Maastricht University Medical Center Recruiting Maastricht, Netherlands Contact: M. J.B. Aarts, MD mjb.essers.aarts@mumc.nl Principal Investigator: M. J.B. Aarts, MD University Medical Center St Radboud Recruiting Nijmegen, Netherlands Contact: R. H.T. Koornstra, MD r.koornstra@onco.umcn.nl Principal Investigator: R. H.T. Koornstra, MD Erasmus Medical Center Recruiting Rotterdam, Netherlands Contact: W. H.J. Kruit, MD PhD w.kruit@erasmusmc.nl Principal Investigator: W. H.J. Kruit, MD PhD University Medical Center Utrecht Recruiting Utrecht, Netherlands Contact: F. Y.F.L. de Vos, MD PhD f.devos@umcutrecht.nl Principal Investigator: F. Y.F.L. de Vos, MD PhD Isala Klinieken Recruiting Zwolle, Netherlands Contact: J. W.B. de Groot, MD PhD j.w.b.de.groot@isala.nl Principal Investigator: J. W.B. de Groot, MD PhD Less << |
NCT01271803 | Malignant Melanoma | Phase 1 | Completed | - | United States, California ... More >> UCLA Department of Medicine Los Angeles, California, United States, 90024 University of California at San Francisco San Francisco, California, United States, 94115 The Angeles Clinic and Research Institute, Santa Monica Office Santa Monica, California, United States, 90025 United States, Colorado University of Colorado; Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Indiana Indiana University - Department of Medicine, Division of Gastroenterology/Hepatology Indianapolis, Indiana, United States, 46202 United States, Michigan Karmanos Cancer Inst. ; Hudson Webber; Cancer Research Building Detroit, Michigan, United States, 48201 United States, New York New York University Medical Center New York, New York, United States, 10036 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Australia, Victoria Peter Maccallum Cancer Institute; Medical Oncology Melbourne, Victoria, Australia, 3000 Less << |
NCT02164916 | - | Active, not recruiting | - | - | |
NCT01909453 | Melanoma | Phase 3 | Active, not recruiting | March 31, 2019 | - |
NCT01512251 | BRAF Mutant Metastatic Melanom... More >>a Less << | Phase 1 Phase 2 | Completed | - | United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94115 Less << |
NCT02583516 | Melanoma | Phase 2 | Active, not recruiting | September 2019 | Spain ... More >> Hospital Universitario Donostia Donostia - San Sebastián, Guipuzcoa, Spain Hospital General Universitario Santa Lucía Cartagena, Murcia, Spain Hospital Clínic de Barcelona Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital Universitario Vall d'Hebron Barcelona, Spain Hospital Insular de Gran Canaria Las Palmas de Gran Canaria, Spain Hospital Universitario Lucus Augusti Lugo, Spain Hospital Universitario 12 de Octubre Madrid, Spain Hospital Universitario La Paz Madrid, Spain Hospital Regional Universitario de Málaga Málaga, Spain Hospital Clínico Universitario de Salamanca Salamanca, Spain Hospital Universitario Virgen Macarena Sevilla, Spain Hospital Universitario de Canarias Tenerife, Spain Hospital General Universitario de Valencia Valencia, Spain Hospital Universitario Doctor Peset Valencia, Spain Hospital Universitario y Politécnico La Fe Valencia, Spain Hospital Álvaro Cunqueiro (Complejo Hospitalario Universitario de Vigo) Vigo, Spain Hospital Universitario Miguel Servet Zaragoza, Spain Less << |
NCT02608034 | Metastatic Melanoma, BRAF V600... More >> Mutation Positive Less << | Phase 1 | Active, not recruiting | January 8, 2019 | United States, Kansas ... More >> University of Kansas Cancer Center and Medical Pavilion Westwood, Kansas, United States, 66205 United States, Texas Mary Crowley Medical Research Center Dallas, Texas, United States, 75230 Israel Rambam Health Care Campus; Oncology Haifa, Israel, 3109601 Hadassah Ein Karem Hospital; Oncology Dept Jerusalem, Israel, 9112001 Tel Aviv Sourasky Medical Center Tel Aviv, Israel, 64239 Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 03080 Samsung Medical Center; Gastroenterology Seoul, Korea, Republic of, 135-710 Asan Medical Center; Division of Oncology Seoul, Korea, Republic of, 138-736 Severance Hospital - Yonsei Uni ; Obstetrics & Gynaecology Dept. Seoul, Korea, Republic of Russian Federation Republican Clinical Oncologic Dispensary of Republic Of Tatarstan Kazan, Russian Federation, 420029 FSBSI "N. N. Blokhin Russian Cancer Research Center" Moscow, Russian Federation, 115478 St. Petersburg Oncology Hospital St Petersburg, Russian Federation, 198255 Less << |
NCT01531361 | Advanced Malignant Neoplasm ... More >> BRAF Gene Mutation Metastatic Malignant Neoplasm Recurrent Malignant Neoplasm Refractory Malignant Neoplasm Less << | Phase 1 | Active, not recruiting | February 28, 2020 | United States, Texas ... More >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT01006980 | Malignant Melanoma | Phase 3 | Completed | - | - |
NCT01844674 | Malignant Melanoma, Neoplasms | Phase 1 | Completed | - | United States, California ... More >> Diablo Valley Oncology and Hematology Pleasant Hill, California, United States, 94523 United States, Michigan Karmanos Cancer Center Detroit, Michigan, United States, 48201 United States, North Carolina Duke University Health Systems Durham, North Carolina, United States, 27710 Brazil Instituto Nacional do Cancer - INCA Rio de Janeiro, RJ, Brazil, 20560-120 Hospital de Caridade de Ijui; Oncologia Ijui, RS, Brazil, 98700-000 CITO - Centro Integrado de Terapia Onco-Hematológica - Hospital da Cidade de Passo Fundo Passo Fundo, RS, Brazil, 99010-260 Hospital Sao Lucas - PUCRS Porto Alegre, RS, Brazil, 90610-000 Canada, Quebec CSSS champlain - Charles-Le Moyne Greenfield Park, Quebec, Canada, J4V 2H1 Cyprus Bank of Cyprus Oncology Center Nicosia, Cyprus, 2006 Korea, Republic of Severance Hospital, Yonsei University Health System Seoul, Korea, Republic of, 03722 Samsung Medical Center Seoul, Korea, Republic of, 06351 Asan Medical Center. Seoul, Korea, Republic of, 138-736 Less << |
NCT01673737 | Neoplasm Malignant | Phase 1 | Completed | - | United States, Massachusetts ... More >> Investigational Site Number 840001 Boston, Massachusetts, United States, 02114 Investigational Site Number 840101 Boston, Massachusetts, United States, 02115 United States, Texas Investigational Site Number 840002 Houston, Texas, United States, 77054 Canada Investigational Site Number 124001 Toronto, Canada, M5G 2M9 Less << |
NCT02354690 | Metastatic Melanoma | Phase 1 Phase 2 | Active, not recruiting | August 2020 | Denmark ... More >> Center for Cancer Immune Therapy, Dept. of Haematology/Oncology Copenhagen, Herlev, Denmark, 2730 Less << |
NCT01271803 | - | Completed | - | - | |
NCT01006980 | - | Completed | - | - | |
NCT01898585 | Malignant Melanoma | Phase 4 | Active, not recruiting | December 10, 2019 | South Africa ... More >> National Hospital; Oncotherapy Dept Bloemfontein, South Africa, 9301 Groote Schuur Hospital ( Uni of Capetown ); Oncology Dept Cape Town, South Africa, 7506 Cape Town Oncology Trials Cape Town, South Africa, 7570 Cancercare Cape Town, South Africa, 7700 Cancercare George, South Africa, 6529 Mary Potter Oncology Centre Groenkloof, South Africa, 0181 Medical Oncology Centre of Rosebank; Oncology Johannesburg, South Africa, 2196 University of Pretoria; Department of Medical Oncology Pretoria, South Africa, 0002 Sandton Oncology Medical Group Sandton, South Africa, 2196 Less << |
NCT01787500 | Advanced Cancers | Phase 1 | Active, not recruiting | February 2019 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT01689519 | Malignant Melanoma | Phase 3 | Active, not recruiting | December 28, 2019 | - |
NCT02068079 | Melanoma | Phase 1 | Withdrawn(Study is being revis... More >>ed) Less << | - | United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27710 Less << |
NCT01400451 | Melanoma | Phase 1 | Terminated(More than 2 of 6 pa... More >>tients treated experienced dose limiting toxicities.) Less << | - | United States, California ... More >> University Of California Los Angeles Los Angeles, California, United States, 90095 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Dana Farber Cancer Inst Boston, Massachusetts, United States, 02215 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT01683188 | Metastatic Melanoma | Phase 4 | Terminated(A shift in the mela... More >>noma treatment landscape adversely affected accrual & to early closure.) Less << | - | - |
NCT01689519 | - | Active, not recruiting | - | - | |
NCT01765569 | Malignant Melanoma, Neoplasms | Phase 1 | Completed | - | Belarus ... More >> Minsk District, Belarus, 223040 Minsk, Belarus, BU-220013 Vitebsk, Belarus, BU-210603 Israel Haifa, Israel, 31096 Tel Aviv, Israel, 6423906 Tel Hashomer, Israel, 52661 Korea, Republic of Daegu, Korea, Republic of, 702-911 Seoul, Korea, Republic of, 110-774 Seoul, Korea, Republic of, 135-710 Russian Federation Kazan, Russian Federation, 420029 Moscow, Russian Federation, 115478 St. Petersburg, Russian Federation, 197758 South Africa Johannesburg, South Africa, 2193 Less << |
NCT02968303 | Melanoma, Malignant, of Soft P... More >>arts Less << | Phase 2 | Recruiting | October 2023 | Netherlands ... More >> The Netherlands Cancer Institute Not yet recruiting Amsterdam, Netherlands, 1066 CX Contact: Christian U Blank, Prof MD PhD +31205129111 c.blank@nki.nl Principal Investigator: Christian U Blank, Prof MD PhD Radboudumc Recruiting Nijmegen, Netherlands, 6525GA Contact: Rutger HT Koornstra, MD +31243610354 Rutger.Koornstra@radboudumc.nl Contact: Peter van Essen, MSc +31243655388 studies.onco@radboudumc.nl Principal Investigator: Rutger HT Koornstra, MD Isala Not yet recruiting Zwolle, Netherlands, 8025 AB Contact: Johannes WB de Groot, MD PhD +31384245000 j.w.b.de.groot@isala.nl Principal Investigator: Johannes WB de Groot, MD PhD Less << |
NCT01524978 | Multiple Myeloma, Neoplasms | Phase 2 | Completed | - | - |
NCT01524978 | - | Completed | - | - | |
NCT01400451 | - | Terminated(More than 2 of 6 pa... More >>tients treated experienced dose limiting toxicities.) Less << | - | - | |
NCT01765569 | - | Completed | - | - | |
NCT01673854 | Melanoma | Phase 2 | Completed | - | United States, California ... More >> Beverly Hills Cancer Center Beverly Hills, California, United States, 90211 United States, Florida Baptist Cancer Institute Jacksonville, Florida, United States, 32207 Orlando Health, Inc Orlando, Florida, United States, 32806 United States, Georgia Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, New Mexico University Of New Mexico Cancer Center Albuquerque, New Mexico, United States, 87106 United States, New York Mount Sinai School Of Medicine New York, New York, United States, 10029 United States, North Carolina Levine Cancer Institute Charlotte, North Carolina, United States, 28204 Duke University Hospital Durham, North Carolina, United States, 27710 Dumc Durham, North Carolina, United States, 27710 United States, Ohio University Hospitals Of Cleveland Cleveland, Ohio, United States, 44106 University Hospitals Cleveland, Ohio, United States, 44106 Less << |
NCT01673854 | - | Completed | - | - | |
NCT01876641 | Metastatic Melanoma ... More >> Melanoma BRAF-mutated Metastatic Melanoma V600EBRAF-mutated Metastatic Melanoma Less << | Phase 1 | Terminated(Loss of funding) | - | United States, Iowa ... More >> University of Iowa Hospitals & Clinics Iowa City, Iowa, United States, 52242 Less << |
NCT01826448 | V600-mutated BRAF Unresectable... More >> Melanoma V600-mutated BRAF Metastatic Melanoma Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor Less << | Phase 1 | Terminated | - | United States, California ... More >> UCLA Los Angeles, California, United States, 90024 United States, Colorado University of Colorado, Denver Aurora, Colorado, United States, 80012 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 France Institute Gustave Roussy Paris, France Germany University Hospital Essen Essen, Germany Less << |
NCT03625141 | Metastatic Melanoma | Phase 2 | Not yet recruiting | March 29, 2023 | France ... More >> CHRU de Lille - Hopital Claude Huriez Not yet recruiting Lille, France, 59037 CH Saint Eloi Not yet recruiting Montpellier, France, 34295 Nantes hospital, Hôtél_Dieu, Oncodermatology Not yet recruiting Nantes, France, 44093 Institut Claudius Regaud; Departement Oncologie Medicale Not yet recruiting Toulouse, France, 31059 Institut Gustave Roussy; Dermatologie Not yet recruiting Villejuif, France, 94805 Hungary Semmelweis Egyetem; Bor-, Nemikortani es Boronkologiai Klinika Not yet recruiting Budapest, Hungary, 1085 Orszagos Onkologiai Intezet; Borgyogyaszati Osztaly Not yet recruiting Budapest, Hungary, 1122 Pecsi Tudomanyegyetem AOK; Borgyogyaszati Klinika Not yet recruiting Pecs, Hungary, 7632 Less << |
NCT01657591 | Melanoma | Phase 1 | Active, not recruiting | June 2019 | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Less << |
NCT01835184 | Recurrent Melanoma ... More >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Terminated | - | United States, Georgia ... More >> Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Virginia Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT02145143 | Thyroid Carcinoma | Not Applicable | Active, not recruiting | May 2019 | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT01495988 | - | Terminated(Slow accrual; toxic... More >>ity; change in priorities) Less << | - | - | |
NCT01474551 | - | Terminated(Lack of accrual) | - | - | |
NCT01474551 | Melanoma | Phase 2 | Terminated(Lack of accrual) | - | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT01495988 | Melanoma Meta... More >>static Melanoma Less << | Phase 2 | Terminated(Slow accrual; toxic... More >>ity; change in priorities) Less << | - | United States, California ... More >> The Angeles Clinic Los Angeles, California, United States, 90025 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, District of Columbia Georgetown Lombardi Comprehensive Cancer Center Washington, D.C., District of Columbia, United States, 20007 Washington Cancer Institute at MedStar Washington Hospital Center Washington, D.C., District of Columbia, United States, 20010 United States, Maryland Harry and Jeannette Weinberg Cancer Institute at Franklin Square Baltimore, Maryland, United States, 21237 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center (BIDMC) Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York NYU Clinical Cancer Center New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 United States, Ohio OSU Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Washington University of Washington Medical Center Seattle, Washington, United States, 98109 Less << |
NCT01638676 | Melanoma | Phase 1 Phase 2 | Recruiting | June 2019 | United States, Kentucky ... More >> James Graham Brown Cancer Center-University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Jason A Chesney, MD PhD 502-562-3429 jason.chesney@louisville.edu Contact: Sarah Lush, RN 502-540-1537 s.lush@louisville.edu Less << |
NCT02721459 | Melanoma Skin... More >> Cancer Less << | Phase 1 | Active, not recruiting | December 2021 | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Less << |
NCT02145910 | Recurrent Melanoma ... More >> Stage IV Melanoma Tumors Metastatic to Brain Less << | Phase 1 | Withdrawn(Study was never open... More >>ed to accrual. There is no clinical benefit to patients.) Less << | - | - |
NCT03224208 | Melanoma Mela... More >>noma (Skin) Melanoma Stage Less << | Phase 2 | Not yet recruiting | March 2020 | - |
NCT03430947 | Malignant Melanoma Stage IV ... More >> BRAF V600 Mutation Brain Metastases Less << | Phase 2 | Recruiting | August 31, 2021 | Germany ... More >> Technische Universität Dresden Recruiting Dresden, Germany, 01307 Contact: Friedegund Meier, MD +49 351 458 ext 2497 friedegund.meier@uniklinikum-dresden.de Contact: Esther Troost, MD +49 351 458 ext 2394 esther.troost@uniklinikum-dresden.de Principal Investigator: Friedegund Meier, MD Principal Investigator: Esther Troost, MD, PhD Ruprecht-Karls-University of Heidelberg, Faculty of Medicine Not yet recruiting Heidelberg, Germany, 69120 Contact: Jessica Hassel, MD Eberhard Karls University of Tübingen, University Medical Center Not yet recruiting Tuebingen, Germany, 72076 Contact: Thomas Eigentler, MD Less << |
NCT01851824 | Malignant Melanoma, Neoplasms | Phase 1 | Completed | - | Australia, New South Wales ... More >> Wodonga, New South Wales, Australia, 3690 Germany Buxtehude, Germany, 21614 Essen, Germany, 45122 Mannheim, Germany, 68167 Greece Crete, Greece, 71110 Thessaloniki, Greece, 56429 Hungary Budapest, Hungary, 1122 Netherlands Amsterdam, Netherlands, 1066 CX Maastricht, Netherlands, 6229HX Utrecht, Netherlands, 3584 CX New Zealand Auckland, New Zealand, 1142 Christchurch, New Zealand, 8011 Portugal Lisboa, Portugal, 1099-023 Porto, Portugal, 4200-072 Serbia Belgrade, Serbia, 11000 Spain Barcelona, Spain, 08036 Barcelona, Spain, 08908 Madrid, Spain, 28031 Madrid, Spain, 28040 Madrid, Spain, 28050 Less << |
NCT01286753 | Neoplasms | PHASE2 | COMPLETED | 2025-05-15 | Torrance, California, 90502, U... More >>nited States|New Haven, Connecticut, 06510, United States|Chicago, Illinois, 60637, United States|Baltimore, Maryland, 21231, United States|Boston, Massachusetts, 02114, United States|Boston, Massachusetts, 02215, United States|New York, New York, 10017, United States|Philadelphia, Pennsylvania, 19104, United States|Houston, Texas, 77030, United States|Lyon, 69008, France|Paris, 75651, France|Villejuif, 94805, France|Milano, Lombardia, 20133, Italy|Pisa, Toscana, 56124, Italy|Groningen, 9700 RB, Netherlands|Leiden, 2300 RC, Netherlands Less << |
NCT03585686 | Langerhans Cell Histiocytosis | Phase 2 | Recruiting | December 2020 | Russian Federation ... More >> Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Recruiting Moscow, Russian Federation, 117997 Contact: Zhanna Shekhovtsova, MD 4956647078 ext 7538 zhanna.shekhovtsova@fccho-moscow.ru Contact: Eugene Pashanov, PhD +79262205578 e.pashanov@gmail.com Sub-Investigator: Dmitry Evseev, MD Principal Investigator: Michael Maschan, PhD Less << |
NCT01286753 | Neoplasms | PHASE2 | COMPLETED | 2025-05-15 | Torrance, California, 90502, U... More >>nited States|New Haven, Connecticut, 06510, United States|Chicago, Illinois, 60637, United States|Baltimore, Maryland, 21231, United States|Boston, Massachusetts, 02114, United States|Boston, Massachusetts, 02215, United States|New York, New York, 10017, United States|Philadelphia, Pennsylvania, 19104, United States|Houston, Texas, 77030, United States|Lyon, 69008, France|Paris, 75651, France|Villejuif, 94805, France|Milano, Lombardia, 20133, Italy|Pisa, Toscana, 56124, Italy|Groningen, 9700 RB, Netherlands|Leiden, 2300 RC, Netherlands Less << |
NCT03220035 | Advanced Malignant Solid Neopl... More >>asm Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma BRAF NP_004324.2:p.V600X Ependymoma Ewing Sarcoma Hepatoblastoma Histiocytosis Langerhans Cell Histiocytosis Malignant Germ Cell Tumor Malignant Glioma Osteosarcoma Peripheral Primitive Neuroectodermal Tumor Recurrent Childhood Central Nervous System Neoplasm Recurrent Childhood Non-Hodgkin Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Neuroblastoma Refractory Central Nervous System Neoplasm Refractory Malignant Solid Neoplasm Refractory Neuroblastoma Refractory Non-Hodgkin Lymphoma Rhabdoid Tumor Rhabdomyosarcoma Soft Tissue Sarcoma Wilms Tumor Less << | Phase 2 | Recruiting | December 31, 2023 | - |
NCT01667419 | Melanoma | Phase 3 | Active, not recruiting | October 14, 2020 | - |
NCT02303951 | Malignant Melanoma | Phase 2 | Recruiting | April 2020 | France ... More >> Department of Dermatology & Skin Cancer University Hospital La Timone, Aix-Marseille University Recruiting Marseille, France, 13385 Contact: Jean-Jacque Grob, MD Department of Dermatology, University Hospital of Nantes Recruiting Nantes, France, 44093 Contact: Brigitte Dreno, MD Hopital Saint-Louis Hopitaux Universitaires Saint-Louis Laboisiere Fernand-Widal Recruiting Paris, France, 75010 Contact: Celeste Lebbé, MD Germany Department of Dermatology, Elbe Hospital Recruiting Buxtehude, Germany, 21614 Contact: Peter Mohr, MD Peter.Mohr@elbekliniken.de Department of Dermatology, University Hospital Recruiting Kiel, Germany, 24105 Contact: Katharina C Kähler, MD kkaehler@dermatology.uni-kiel.de Department of Dermatology, University Hospital Recruiting Mainz, Germany, 55101 Contact: Carmen Loquai, MD carmen.loquai@unimedizin-mainz.de Contact: Stephan Grabbe, MD hautklinik@unimedizin-mainz.de University hospital Tübingen Recruiting Tübingen, Germany, 72076 Contact: Thomas Eigentler, Dr. +49 7071 298 ext 5748 thomas.eigentler@med.uni-tuebingen.de Contact: Claus Garbe, Prof. +49 7071 298 ext 7110 claus.garbe@med.uni-tuebingen.de Principal Investigator: Claus Garbe, Prof. Less << |
NCT02818023 | Melanoma | Phase 1 | Recruiting | October 2019 | United States, Pennsylvania ... More >> UPMC Cancer Center Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Yana M. Najjar, MD 412-623-2294 najjaryg@upmc.edu Contact: Amy Rose, RN, BSN 412-647-8587 kennaj@upmc.edu Less << |
NCT01611675 | Melanoma | Phase 1 | Terminated(Adverse Events) | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT01636622 | Advanced Cancers | Phase 1 | Active, not recruiting | July 2019 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT03410875 | Hairy Cell Leukemia ... More >> Leukemia Leukemia, Hairy Cell Less << | Phase 2 | Recruiting | January 2020 | United States, Connecticut ... More >> Yale University Not yet recruiting New Haven, Connecticut, United States, 06511 Contact: Gottfried von Keudell, MD/PhD 203-737-5312 United States, Massachusetts Dana Farber Cancer Institute Not yet recruiting Boston, Massachusetts, United States, 02115 Contact: Eric Winer, MD 617-632-6876 United States, New York Memorial Sloan - Kettering Cancer Center Recruiting New York, New York, United States, 10021 Contact: Jae Park, MD 212-639-4048 parkj6@mskcc.org Less << |
NCT01943422 | Melanoma | Phase 1 | Completed | - | United States, Pennsylvania ... More >> Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Less << |
NCT01519323 | Malignant Melanoma | Phase 1 | Terminated(Study was terminate... More >>d due to low enrollment.) Less << | - | - |
NCT01791309 | Metastatic Colorectal Cancer | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT01519323 | - | Terminated(Study was terminate... More >>d due to low enrollment.) Less << | - | - | |
NCT01959633 | Melanoma | Phase 1 Phase 2 | Recruiting | December 2017 | Italy ... More >> Fondazione G.Pascale Recruiting Napoli, Italy, 80131 Principal Investigator: Paolo A Ascierto Less << |
NCT01667419 | - | Active, not recruiting | - | - | |
NCT02050321 | - | Terminated(Pharmaceutical comp... More >>any pulled support for the trial.) Less << | - | - | |
NCT01596140 | Advanced Cancer ... More >> Solid Tumor Less << | Phase 1 | Active, not recruiting | December 2020 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT01616199 | Advanced BRAF-mutant Cancers | Phase 1 Phase 2 | Terminated(slow accrual) | - | United States, Florida ... More >> H. Lee Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, New York New York University New York, New York, United States, 10016 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 Less << |
NCT02050321 | Malignant Melanoma | Phase 2 | Terminated(Pharmaceutical comp... More >>any pulled support for the trial.) Less << | - | United States, Arizona ... More >> University of Arizona Cancer Center Tucson, Arizona, United States, 85724 Less << |
NCT01307397 | Malignant Melanoma | PHASE3 | COMPLETED | 2016-02-24 | University "Mother Theresa" Ho... More >>spital Center; Oncology Department, Tirana, 1000, Albania|Hospital Britanico; Oncologia, Buenos Aires, C1280AEB, Argentina|Fundación CIDEA, Buenos Aires, C1425DTG, Argentina|Inst. Alexander Fleming; Oncologia, Buenos Aires, C1426ANZ, Argentina|Melanoma Institute Australia, North Sydney, New South Wales, 2060, Australia|Newcastle Mater Misericordiae Hospital; Oncology, Waratah, New South Wales, 2298, Australia|Westmead Hospital, Westmead, New South Wales, 2145, Australia|Border Medical Oncology, Wodonga, New South Wales, 3690, Australia|Greenslopes Private Hospital; Gallipoli Research Centre, Greenslopes, Queensland, 4120, Australia|The Townsville Hospital; Townsville Cancer Centre, Townsville, Queensland, 4812, Australia|Princess Alexandra Hospital Woolloongabba; Clinical Hematology and Medical Oncology, Woolloongabba, Queensland, 4102, Australia|Royal Adelaide Hospital; Oncology, Adelaide, South Australia, 5000, Australia|Geelong Hospital; Geelong Cardiology Practice, Geelong, Victoria, 3220, Australia|Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, 3000, Australia|Alfred Hospital, Melbourne, Victoria, 3004, Australia|Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia|Landeskrankenhaus Feldkirch; Abteilung für Innere Medizin, Feldkirch, 6807, Austria|LKH Graz; Abteilung für allgemeine Dermatologie, Graz, 8036, Austria|LKH Innsbruck; Universit?tsklinik für Dermatologie, Innsbruck, 6020, Austria|Krankenhaus der Elisabethinen Linz; Abteilung für Dermatologie, Linz, 4020, Austria|Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg, 5020, Austria|LKH Salzburg; Universit?tsklinik für Dermatologie, Salzburg, 5020, Austria|Landesklinikum St. P?lten, St. P?lten, 3100, Austria|Medizinische Universit?t Wien; Univ.Klinik für Dermatologie, Wien, 1090, Austria|UZ Brussel, Brussel, 1090, Belgium|Cliniques Universitaires St-Luc, Bruxelles, 1200, Belgium|Sint Augustinus Wilrijk, Wilrijk, 2610, Belgium|University Clinical Center of the Republic of Srpska, Banja Luka, 78000, Bosnia and Herzegovina|Clinic of Oncology, University Clinical Center Sarajevo, Sarajevo, 71000, Bosnia and Herzegovina|Instituto Nacional de Cancer - INCa; Pesquisa Clinica, Rio de Janeiro, RJ, 20230-130, Brazil|Hospital das Clinicas - UFRGS, Porto Alegre, RS, 90035-003, Brazil|Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, 01246-000, Brazil|Hospital A. C. Camargo; Oncologia, Sao Paulo, SP, 01509-010, Brazil|Hospital Sao Jose, S?o Paulo, SP, CEP 01321-001, Brazil|District Oncology Dispensary; Department for Oncology and Dermatology, Plovdiv, 4000, Bulgaria|National Specialized Hospital for Active Oncology Treatment; Dermatology Clinic, Sofia, 1756, Bulgaria|Cross Cancer Institute ; Dept of Medical Oncology, Edmonton, Alberta, T6G 1Z2, Canada|Lion'S Gate Hospital, North Vancouver, British Columbia, V7L 2L7, Canada|British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver, British Columbia, V5Z 4E6, Canada|St. Boniface General Hospital; Medicine, Winnipeg, Manitoba, R2H 2A6, Canada|QEII HSC; Oncology, Halifax, Nova Scotia, B3H 2Y9, Canada|Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton, Ontario, L8V 5C2, Canada|London Regional Cancer Centre, London, Ontario, N6A 4L6, Canada|The Ottawa Hospital; Division of Infectious Diseases, Ottawa, Ontario, K1H 8L6, Canada|Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada|University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto, Ontario, M5G 2M9, Canada|McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal, Quebec, H3T 1E2, Canada|Chuq - Hopital Hotel Dieu de Quebec; Oncology, Quebec City, Quebec, G1R 2J6, Canada|Centro Javeriano de Oncología, Bogota, Colombia|Fundacion Santa Fe de Bogotá, Bogota, Colombia|Clínica Imbanaco; Oncology, Cali, Colombia|Hospital Pablo Tobon Uribe, Medellin-Antioquia, Colombia|Clinical Hospital Sisters of Mercy, Zagreb, 10000, Croatia|Masaryk?v onkologicky ústav; Klinika komplexní onkologické pé?e, Brno, 656 53, Czechia|University Hospital; Oncology and Radiotherapy, Hradec Kralove, 500 05, Czechia|Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc, 779 00, Czechia|Faculty Hospital; Dialysis Unit, Ostrava, 708 52, Czechia|1 Lekarska Fakulta Uni Karlovy; 3 Interni Klinika, Labor. Pro Endokrinologii A Metabolismus, Praha, 128 00, Czechia|Faculty Hospital Kralovske Vinohrady; Oncology, Praha, Czechia|Aarhus Universitetshospital; Kr?ftafdelingen, Aarhus C, 8000, Denmark|Herlev Hospital; Onkologisk afdeling, Herlev, 2730, Denmark|Odense Universitetshospital, Onkologisk Afdeling R, Odense, 5000, Denmark|Hospital Regional Vicente Corral Moscoso, Servicio de Oncología, Cuenca, Ecuador|Hospital Abel Gilbert Ponton; Oncology, Guayaquil, EC090104, Ecuador|Hospital Solca Portoviejo; Oncologia, Portoviejo, EC130104, Ecuador|East Tallinn Central Hospital; Clinic of Internal Medicine, Tallinn, 11312, Estonia|North Estonia Medical Centre Foundation; Oncology Center, Tallinn, 13419, Estonia|Tartu University Hospital; Clinic of Hematology and Oncology, Tartu, 50406, Estonia|Helsinki University Central Hospital; Dept of Oncology, Helsinki, 00029, Finland|Tampere University Hospital; Dept of Oncology, Tampere, 33520, Finland|Turku Uni Central Hospital; Oncology Clinics, Turku, 20520, Finland|Uniklinik RWTH Aachen; Klinik für Dermatologie und Allergologie - Hautklinik, Aachen, 52074, Germany|Klinikum Augsburg Süd; Klinik für Dermatologie und Allergologie, Augsburg, 86179, Germany|CAMPUS BENJAMIN FRANKLIN CharitéCentrum 14 Med.Klinik f.H?matologie u.Onkologie, Berlin, 12200, Germany|St. Josef-Hospital Klinik f. Dermatologie u. Allergologie, Bochum, 44791, Germany|Elbekliniken Buxtehude; Klinik für Dermatologie, Buxtehude, 21614, Germany|DRK-Krankenhaus; Hautklinik, Chemnitz, 09117, Germany|Universit?tsklinikum "Carl Gustav Carus"; Medizinische Klinik und Poliklinik I, Dresden, 01307, Germany|Universit?tsklinikum Düsseldorf; Hautklinik, Düsseldorf, 40225, Germany|HELIOS Klinikum Erfurt, Klinik für Hautkrankheiten und Allergologie, Erfurt, 99089, Germany|Universit?tsklinikum Erlangen; Hautklinik, Erlangen, 91054, Germany|Universit?tsklinikum Essen, Essen, 45122, Germany|Klinik Johann Wolfgang von Goethe Uni; Klinik fuer Allgemein- und Viszeralchirurgie, Frankfurt, 60596, Germany|Uniklinikum Freiburg Dermatol, Freiburg, 79104, Germany|SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera, 07548, Germany|Universit?tsmedizin G?ttingen Georg-August-Universit?t Zentrum Dermatologie, G?ttingen, 37075, Germany|Universit?tsklinikum Hamburg-Eppendorf Zentrum f.Innere Medizin Klinik f.Dermatologie, Hamburg, 20246, Germany|Medizinische Hochschule; Hautklinik Linden, Hannover, 30449, Germany|Uni-Hautklinik, Heidelberg, 69115, Germany|Klinikum am Gesundbrunnen; Tumorzentrum, Heilbronn, 74078, Germany|Universit?tsklinikum Jena; Klinik für Hautkrankheiten, Jena, 07743, Germany|Klinikum Kassel; Hautklinik, Kassel, 34125, Germany|UNI-Klinikum Campus Kiel Klinik f.Dermatologie Tagesklinik f.Dermatologie, Kiel, 24105, Germany|Klinik der Uni zu K?ln; Klinik & Poliklinik fuer Dermatologie & Venerologie, K?ln, 50937, Germany|Universit?tsklinikum Leipzig Klinik f.Dermatologie Venerologie u.Allergologie, Leipzig, 04103, Germany|Klinikum d.Stadt Ludwigshafen Hautklinik, Ludwigshafen, 67063, Germany|Universit?tsklinikum Schleswig-Holstein; Campus Lübeck, Lübeck, 23538, Germany|Universit?tsklinikum Magdeburg; Hautklinik; Klinik für Dermatologie und Venerologie, Magdeburg, 39120, Germany|Johannes Gutenberg Unis-Klinik; Dept For Dermatology, Mainz, 55131, Germany|Klinikum Mannheim Klinik fuer Dermatologie, Venerologie und Allergologie, Mannheim, 68167, Germany|Universit?tsklinikum Marburg Klinik f. Dermatologie, Marburg, 35043, Germany|Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik, Minden, 32429, Germany|Klinikum der LMU München; Klinik und Poliklinik für Dermatologie und Allergologie, München, 80337, Germany|Staedtisches Krankenhaus Muenchen-Schwabing, Haematologie & Onkolgie, München, 80804, Germany|Universit?tsklinikum Münster, Münster, 48149, Germany|Fachklinik Hornheide; Internistische Onkologie, Münster, 48157, Germany|Klinikum Nürnberg Nord; Hautklinik; Klinik für Dermatologie, Nürnberg, 90419, Germany|Klinikum Dorothea Ch.Erxleben; Klinik für Dermatologie und Allergologie, Quedlinburg, 06484, Germany|KLINIKUM VEST GmbH Knappschaftskrankenhaus Abt.Haut- Allergie- Venen- und Umwelterkrankungen, Recklinghausen, 45657, Germany|Universit?tsklinikum Regensburg; Klinik und Poliklinik für Dermatologie, Regensburg, 93053, Germany|Universitaets-Hautklinik Tuebingen, Tübingen, 72076, Germany|Wilhelm Fresenius Klinik; Klinik f. Dermatologie u. Allergologie, Wiesbaden, 65191, Germany|HELIOS Klinikum Barmen Zentrum Dermatologie Allergologie und Umweltmedizin, Wuppertal, 42283, Germany|Universit?tsklinikum Würzburg; Klinik und Poliklinik für Dermatologie Venerologie u. Allergologie, Würzburg, 97080, Germany|Laiko General Hospital; 1St Pathological Clinic, Athens, 115 27, Greece|Hospital Hygeia; 1St Oncology Dept., Athens, 15123, Greece|Univ General Hosp Heraklion; Medical Oncology, Heraklion, 711 10, Greece|Metropolitan Hospital; Dept. of Oncology, Piraeus, 185 47, Greece|Semmelweis Egyetem; Bor-, Nemikortani es Boronkologiai Klinika, Budapest, 1085, Hungary|Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly, Budapest, 1122, Hungary|Debreceni Egyetem OEC; Borgyogyaszati Klinika, Debrecen, 4012, Hungary|Pecsi Tudomanyegyetem AOK; Borgyogyaszati Klinika, Pecs, 7632, Hungary|Szegedi Tud.Egyetem Szent-Gyorgyi Albert Klin.Kozp., Szeged, 6720, Hungary|Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology, New Delhi, Delhi, 110085, India|Tata Memorial Hospital; Dept of Medical Oncology, Mumbai, Maharashtra, 400012, India|Curie Manavata Cancer Centre, Nashik, Maharashtra, 422004, India|Basavatarakam Indo-American Cancer Hospital & Research Institute, Hyderabad, 500034, India|Chhatrapati Shahuji Maharaj Medical University; Department of Oncology, Lucknow, 226003, India|Regional Cancer Centre; Dept of Oncology, Trivandrum, 695 011, India|Christian Med Clg & Hspt, Vellore, 632004, India|Cork Uni Hospital; Oncology Dept, Cork, Ireland|St Vincent'S Uni Hospital; Medical Oncology, Dublin, 4, Ireland|Mater Misericordiae Uni Hospital; Oncology, Dublin, 7, Ireland|Mater Private Hospital, Dublin, 7, Ireland|St James' Hospital; Cancer Clinical Trials Office, Dublin, Ireland|Galway Uni Hospital; Oncology Dept, Galway, Ireland|University Hospital Limerick - Oncology, Limerick, Ireland|Waterford Regional Hospital; Department Of Medical Oncology, Waterford, Ireland|Soroka Medical Center; Oncology Dept, Beer Sheva, 8410101, Israel|Ranbam Health Care Campus; Oncology - Hafia, Hafia, 3109601, Israel|Hadassah Ein Karem Hospital; Oncology Dept, Jerusalem, 91120-01, Israel|Chaim Sheba Medical Center; Oncology Dept, Ramat Gan, 5262100, Israel|Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania, 80131, Italy|IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola, Emilia-Romagna, 47014, Italy|A.O. Universitaria Policlinico Di Modena; Oncologia, Modena, Emilia-Romagna, 41100, Italy|AO Santa Maria Nuova; U.O. Day Hospital di Oncologi, Reggio Emilia, Emilia-Romagna, 42100, Italy|A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia, Udine, Friuli-Venezia Giulia, 33100, Italy|Istituto Dermopatico dell'Immacolata (IDI)-IRCCS; IV Divisione Oncologica e Dermatologia Oncologica, Roma, Lazio, 00167, Italy|IFO - Istituto Regina Elena; Oncologia Medica, Roma, Lazio, 00168, Italy|IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A, Genova, Liguria, 16132, Italy|Asst Papa Giovanni XXIII; Oncologia Medica, Bergamo, Lombardia, 24128, Italy|Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina, Brescia, Lombardia, 25123, Italy|Irccs Ospedale San Raffaele;Oncologia Medica, Milano, Lombardia, 20132, Italy|Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milano, Lombardia, 20133, Italy|Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milano, Lombardia, 20141, Italy|Policlinico Le Molinette; Clinica Dermatologica, Torino, Piemonte, 10126, Italy|Istituto Tumori Giovanni Paolo II IRCSS; Ospedale Oncologico Bari, Bari, Puglia, 70126, Italy|Policlinico P. Giaccone; Istituto Di Oncologia, Clinica Medica 1, Palermo, Sicilia, 90127, Italy|Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1, Firenze, Toscana, 50139, Italy|Azienda Ospedaliera S. Chiara; Dip di Onc,Trapianti e delle Nuove Tecnologie in Medicina, Pisa, Toscana, 50126, Italy|A.O.U. Senese Policlinico Santa Maria Alle Scotte, Siena, Toscana, 53100, Italy|Azienda Ospedaliera S. Maria - Terni; Oncologia, Terni, Umbria, 05100, Italy|IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda, Padova, Veneto, 35128, Italy|Samsung Medical Center, Seoul, 06351, Korea, Republic of|Seoul St Mary's Hospital, Seoul, 06591, Korea, Republic of|Seoul National University Hosp; Dept Internal Med Hem Onc, Seoul, 110-744, Korea, Republic of|Yonsei University Severance Hospital; Medical Oncology, Seoul, 120-752, Korea, Republic of|Asan Medical Center., Seoul, 138-736, Korea, Republic of|Daugavpils Regional Hospital, Daugavpils, 5417, Latvia|Rigas Austrumu Kliniska Universitates slimnica, Latvijas Onkologijas centrs, Riga, LV 1079, Latvia|Klaipeda University Hospital, Klaipeda, 92288, Lithuania|Vilnius University Hospital Santariskiu Clinic, Hematology, Oncology and Tranfusion Medicine Center, Vilnius, 08661, Lithuania|University Clinic for Radiotherapy and Oncology Skopje; Department of skin malignancies, Skopje, 1000, Macedonia, The Former Yugoslav Republic of|Fundación Rodolfo Padilla Padilla, A.C.; Oncology, Leon, 37000, Mexico|Inst. Nacional de Cancerologia; Investigacion Clinica, Mexico City, 14000, Mexico|Hospital General de México; Unidad de Oncologia, Mexico DF, 06726, Mexico|Antoni Van Leeuwenhoek Ziekenhuis; Inwendige Geneeskunde, Amsterdam, 1066 CX, Netherlands|VU MEDISCH CENTRUM; Dept. of Medical Oncology, Amsterdam, 1081 HV, Netherlands|Tergooiziekenhuizen, Blaricum, 1261 AN, Netherlands|Amphia Ziekenhuis, Breda, 4818 CK, Netherlands|Academ Ziekenhuis Groningen; Medical Oncology, Groningen, 9713 GZ, Netherlands|Academisch Ziekenhuis Leiden; Clinical Oncology, Leiden, 2333 ZA, Netherlands|Academish Ziekenhuis Maastricht (Azm); Inwendige Geneeskunde, Maastricht, 6229 HX, Netherlands|UMC St Radboud; Interne Oncologie; Medical Oncology Department, Nijmegen, 6500 HB, Netherlands|Erasmus MC, Rotterdam, 3000 CA, Netherlands|Universitair Medisch Centrum Utrecht; Inwendige Geneeskunde Afd., Utrecht, 3584 CX, Netherlands|Haukeland Universitetshospital; Onkologisk Avd., Bergen, 5021, Norway|The Norvegian Radium Hospital Montebello; Dept of Oncology, Oslo, 0379, Norway|Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology, Arequipa, 04001, Peru|Instituto Nacional de Enfermedades Neoplasicas, Lima, 34, Peru|Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow, 31-531, Poland|ZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii;Wojska Polskiego 37, Olsztyn, 10-228, Poland|NZOZ Med.-Polonia sp. z o.o., Poznań, 60-693, Poland|Centrum Onkologii- Instytut; im. M.Sk?odowskiej-Curie, Warszawa, 02-781, Poland|IPO de Lisboa; Servico de Oncologia Medica, Lisboa, 1099-023, Portugal|IPO do Porto; Servico de Oncologia Medica, Porto, 4200-072, Portugal|Institut of Oncology Al. Trestioreanu Bucharest; Oncology, Bucuresti, 022328, Romania|Medisprof SRL, Cluj-Napoca, 400058, Romania|S.C. Life Search S.R.L; Medical Oncology Clinic, Timisoara, 300167, Romania|FSBI "Scientific Research Institute of Oncology named after N.N.Petrov" Ministry of Health of RF, St Petersburg, Leningrad, 197758, Russian Federation|Regional Clinical Oncology Dispensary, Krasnodar, 350040, Russian Federation|Russian Cancer Research Center, Moscow, 115478, Russian Federation|Moscow city oncology hospital #62 of Moscow Healthcare Department, Moscow, 143423, Russian Federation|St. Petersburg Oncology & Gynecology; City Clinical Oncology Dispensary, Saint-Petersburg, 197022, Russian Federation|Stavropol Clinical Oncology Dispansary, Stavropol, ND, Russian Federation|Bashkirian Republican Clinical Oncology Dispensary, UFA, 450054, Russian Federation|Institute for Oncology and Radiology of Serbia; Medical Oncology, Belgrade, 11000, Serbia|Clinical Center Bezanijska Kosa; Oncology, Belgrade, 11080, Serbia|Onkologicky ustav sv. Alzbety; Oddelenie ambulantnej chemoterapie, Bratislava, 812 50, Slovakia|Narodny Onkologicky Ustav; Oddelenie klinickej onkologie E, Bratislava, 833 10, Slovakia|POKO Poprad; Department of Oncology, Poprad, 058 01, Slovakia|Institute of Oncology Ljubljana, Ljubljana, 1000, Slovenia|Universitas Annex, University of the Free State; Clinical Oncology, Bloemfontein, 9300, South Africa|Cape Town Oncology Trials, Cape Town, 7570, South Africa|Cancercare, Cape Town, 7700, South Africa|Medical Oncology Centre of Rosebank; Oncology, Johannesburg, 2196, South Africa|Steve Biko Academic Hospital; Oncology, Pretoria, 0002, South Africa|Sandton Oncology Centre, Sandton, 2196, South Africa|Hospital Univ. Central de Asturias; Servicio de Oncologia, Oviedo, Asturias, 33011, Spain|Hospital Universitario Marques de Valdecilla; Servicio de Oncologia, Santander, Cantabria, 39008, Spain|Hospital Universitario Son Espases, Palma De Mallorca, Islas Baleares, 07014, Spain|Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia, Las Palmas de Gran Canaria, Las Palmas, 35016, Spain|Hospital Universitario de Santa Lucía; Servicio de Oncología Médica, Cartagena (Murcia), Murcia, 30202, Spain|Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona, Navarra, 31008, Spain|Hospital Xeral Cíes; Servicio de Oncologia, Vigo, Pontevedra, 36312, Spain|Hospital Universitario de Canarias (HUC), La Laguna (Tenerife), Tenerife, 38320, Spain|Hospital de Cruces; Servicio de Oncologia, Barakaldo, Vizcaya, 48903, Spain|Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona, 08035, Spain|Hospital Clínic i Provincial; Servicio de Hematología y Oncología, Barcelona, 08036, Spain|Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Barcelona, 08916, Spain|Hospital Reina Sofia, Cordoba, 14004, Spain|Hospital Universitario Virgen de las Nieves; Servicio de Oncologia, Granada, 18014, Spain|Complejo Hospitalario Universitario A Coru?a (CHUAC, Materno Infantil), Oncología, La Coru?a, 15006, Spain|Complejo Asistencial Universitario de Leon; Servicio de Oncologia, Leon, 24071, Spain|Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, 28034, Spain|Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, 28041, Spain|Hospital Universitario La Paz; Servicio de Oncologia, Madrid, 28046, Spain|Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Malaga, 29010, Spain|Hospital Regional Universitario Carlos Haya; Servicio de Oncologia, Malaga, 29010, Spain|Hospital Clinico Universitario de Salamanca; Servicio de Oncologia, Salamanca, 37007, Spain|Hospital Universitario Virgen Macarena; Servicio de Oncologia, Sevilla, 41009, Spain|Hospital General Universitario de Valencia; Servicio de oncologia, Valencia, 41014, Spain|Instituto Valenciano Oncologia; Oncologia Medica, Valencia, 46009, Spain|Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza, 50009, Spain|Sahlgrenska Universitetssjukhuset; Onkology, Gothenburg, SE-41 343, Sweden|Sk?nes Onkologiska Klinik, Universitetssjukhuset, Lund, 22185, Sweden|Karolinska Universitetssjukhuset, Solna, Stockholm, 171 76, Sweden|Norrlands universitetssjukhus; Onkologkliniken, Ume?, Sweden|Akademiska sjukhuset, Onkologkliniken, Uppsala, 75185, Sweden|Universitaetsspital Basel; Onkologie, Basel, 4031, Switzerland|Inselspital Bern; Medizinische Onkologie, Bern, 3010, Switzerland|Kantonsspital Graubünden;Onkologie und H?matologie, Chur, 7000, Switzerland|CHUV; Departement d'Oncologie, Lausanne, 1011, Switzerland|Kantonsspital St. Gallen; Onkologie/H?matologie, St. Gallen, 9007, Switzerland|Universit?tsspital Zürich; Dermatologische Klinik, Zürich, 8091, Switzerland|Adana Baskent University Hospital; Medical Oncology, Adana, 01120, Turkey|Cukurova Uni Faculty of Medicine; Medical Oncology, Adana, 01330, Turkey|Ankara Uni , Ibn-I Sina Hospital; Oncology Dept, Ankara, 06230, Turkey|Gazi Uni Medical Faculty Hospital; Oncology Dept, Ankara, 06500, Turkey|Akdeniz University School of Medicine; General Surgery, Antalya, 07000, Turkey|Ege University Medical Faculty; Medical Oncology Department, Bornova, ?ZM?R, 35100, Turkey|Gaziantep University Medical Faculty, Medical Oncology Department, Gaziantep, 27310, Turkey|Kartal Training and Research Hospital;Medical Oncology Department, Istanbul, 34000, Turkey|Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul, 34300, Turkey|American Hospital, Medical Oncology Department, Istanbul, 34365, Turkey|Dokuz Eylul Uni ; Medical Oncology, Izmir, 35340, Turkey|Hacettepe Uni Medical Faculty Hospital; Oncology Dept, S?hhiye, ANKARA, 06100, Turkey|Addenbrookes Nhs Trust; Oncology Clinical Trials Unit, Cambridge, CB2 0QQ, United Kingdom|Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, United Kingdom|Royal Surrey County Hospital; St. Lukes Cancer Centre, Guildford, GU2 7XX, United Kingdom|St James University Hospital, Leeds, LS9 7TF, United Kingdom|Royal Marsden Hospital, London, SW3 6JJ, United Kingdom|Christie Hospital; Breast Cancer Research Office, Manchester, M20 4QL, United Kingdom|Northern Centre for Cancer Care Freeman Hospital; Sir Bobby Robson Cancer Trials Research Centre, Newcastle upon Tyne, NE7 7DN, United Kingdom|Mount Vernon Hospital; Centre For Cancer Treatment, Northwood, HA6 2RN, United Kingdom|Nottingham University Hospitals City Campus, Nottingham, NG5 1PB, United Kingdom|Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford, OX3 7LJ, United Kingdom|Southampton General Hospital; Medical Oncology, Southampton, SO16 6YD, United Kingdom|Singleton Hospital; Oncology, Swansea, SA2 8QA, United Kingdom Less << |
NCT01709292 | Thyroid Cancer | Phase 2 | Active, not recruiting | November 2019 | United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT02230306 | Active Melanoma Brain Metastas... More >>es Less << | Phase 2 | Terminated(closed due to slow ... More >>accrual) Less << | - | United States, Connecticut ... More >> Harriet Kluger New Haven, Connecticut, United States, 06510 United States, Iowa Mohammed Milhem, MD Iowa City, Iowa, United States, 52242 United States, New York Anna Pavlick, MD New York, New York, United States, 10016 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania Ravi Amaravadi, MD Philadelphia, Pennsylvania, United States, 19104 UPMC Hillman Cancer Center Pittsburgh, Pennsylvania, United States, 15232 Less << |
NCT01307397 | Malignant Melanoma | PHASE3 | COMPLETED | 2016-02-24 | University "Mother Theresa" Ho... More >>spital Center; Oncology Department, Tirana, 1000, Albania|Hospital Britanico; Oncologia, Buenos Aires, C1280AEB, Argentina|Fundación CIDEA, Buenos Aires, C1425DTG, Argentina|Inst. Alexander Fleming; Oncologia, Buenos Aires, C1426ANZ, Argentina|Melanoma Institute Australia, North Sydney, New South Wales, 2060, Australia|Newcastle Mater Misericordiae Hospital; Oncology, Waratah, New South Wales, 2298, Australia|Westmead Hospital, Westmead, New South Wales, 2145, Australia|Border Medical Oncology, Wodonga, New South Wales, 3690, Australia|Greenslopes Private Hospital; Gallipoli Research Centre, Greenslopes, Queensland, 4120, Australia|The Townsville Hospital; Townsville Cancer Centre, Townsville, Queensland, 4812, Australia|Princess Alexandra Hospital Woolloongabba; Clinical Hematology and Medical Oncology, Woolloongabba, Queensland, 4102, Australia|Royal Adelaide Hospital; Oncology, Adelaide, South Australia, 5000, Australia|Geelong Hospital; Geelong Cardiology Practice, Geelong, Victoria, 3220, Australia|Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, 3000, Australia|Alfred Hospital, Melbourne, Victoria, 3004, Australia|Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia|Landeskrankenhaus Feldkirch; Abteilung für Innere Medizin, Feldkirch, 6807, Austria|LKH Graz; Abteilung für allgemeine Dermatologie, Graz, 8036, Austria|LKH Innsbruck; Universit?tsklinik für Dermatologie, Innsbruck, 6020, Austria|Krankenhaus der Elisabethinen Linz; Abteilung für Dermatologie, Linz, 4020, Austria|Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt., Salzburg, 5020, Austria|LKH Salzburg; Universit?tsklinik für Dermatologie, Salzburg, 5020, Austria|Landesklinikum St. P?lten, St. P?lten, 3100, Austria|Medizinische Universit?t Wien; Univ.Klinik für Dermatologie, Wien, 1090, Austria|UZ Brussel, Brussel, 1090, Belgium|Cliniques Universitaires St-Luc, Bruxelles, 1200, Belgium|Sint Augustinus Wilrijk, Wilrijk, 2610, Belgium|University Clinical Center of the Republic of Srpska, Banja Luka, 78000, Bosnia and Herzegovina|Clinic of Oncology, University Clinical Center Sarajevo, Sarajevo, 71000, Bosnia and Herzegovina|Instituto Nacional de Cancer - INCa; Pesquisa Clinica, Rio de Janeiro, RJ, 20230-130, Brazil|Hospital das Clinicas - UFRGS, Porto Alegre, RS, 90035-003, Brazil|Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, SP, 01246-000, Brazil|Hospital A. C. Camargo; Oncologia, Sao Paulo, SP, 01509-010, Brazil|Hospital Sao Jose, S?o Paulo, SP, CEP 01321-001, Brazil|District Oncology Dispensary; Department for Oncology and Dermatology, Plovdiv, 4000, Bulgaria|National Specialized Hospital for Active Oncology Treatment; Dermatology Clinic, Sofia, 1756, Bulgaria|Cross Cancer Institute ; Dept of Medical Oncology, Edmonton, Alberta, T6G 1Z2, Canada|Lion'S Gate Hospital, North Vancouver, British Columbia, V7L 2L7, Canada|British Columbia Cancer Agency (Bcca) - Vancouver Cancer Centre, Vancouver, British Columbia, V5Z 4E6, Canada|St. Boniface General Hospital; Medicine, Winnipeg, Manitoba, R2H 2A6, Canada|QEII HSC; Oncology, Halifax, Nova Scotia, B3H 2Y9, Canada|Hamilton Health Sciences - Juravinski Cancer Centre, Hamilton, Ontario, L8V 5C2, Canada|London Regional Cancer Centre, London, Ontario, N6A 4L6, Canada|The Ottawa Hospital; Division of Infectious Diseases, Ottawa, Ontario, K1H 8L6, Canada|Sunnybrook Health Sciences Centre, Toronto, Ontario, M4N 3M5, Canada|University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto, Ontario, M5G 2M9, Canada|McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal, Quebec, H3T 1E2, Canada|Chuq - Hopital Hotel Dieu de Quebec; Oncology, Quebec City, Quebec, G1R 2J6, Canada|Centro Javeriano de Oncología, Bogota, Colombia|Fundacion Santa Fe de Bogotá, Bogota, Colombia|Clínica Imbanaco; Oncology, Cali, Colombia|Hospital Pablo Tobon Uribe, Medellin-Antioquia, Colombia|Clinical Hospital Sisters of Mercy, Zagreb, 10000, Croatia|Masaryk?v onkologicky ústav; Klinika komplexní onkologické pé?e, Brno, 656 53, Czechia|University Hospital; Oncology and Radiotherapy, Hradec Kralove, 500 05, Czechia|Fakultni nemocnice Olomouc; Onkologicka klinika, Olomouc, 779 00, Czechia|Faculty Hospital; Dialysis Unit, Ostrava, 708 52, Czechia|1 Lekarska Fakulta Uni Karlovy; 3 Interni Klinika, Labor. Pro Endokrinologii A Metabolismus, Praha, 128 00, Czechia|Faculty Hospital Kralovske Vinohrady; Oncology, Praha, Czechia|Aarhus Universitetshospital; Kr?ftafdelingen, Aarhus C, 8000, Denmark|Herlev Hospital; Onkologisk afdeling, Herlev, 2730, Denmark|Odense Universitetshospital, Onkologisk Afdeling R, Odense, 5000, Denmark|Hospital Regional Vicente Corral Moscoso, Servicio de Oncología, Cuenca, Ecuador|Hospital Abel Gilbert Ponton; Oncology, Guayaquil, EC090104, Ecuador|Hospital Solca Portoviejo; Oncologia, Portoviejo, EC130104, Ecuador|East Tallinn Central Hospital; Clinic of Internal Medicine, Tallinn, 11312, Estonia|North Estonia Medical Centre Foundation; Oncology Center, Tallinn, 13419, Estonia|Tartu University Hospital; Clinic of Hematology and Oncology, Tartu, 50406, Estonia|Helsinki University Central Hospital; Dept of Oncology, Helsinki, 00029, Finland|Tampere University Hospital; Dept of Oncology, Tampere, 33520, Finland|Turku Uni Central Hospital; Oncology Clinics, Turku, 20520, Finland|Uniklinik RWTH Aachen; Klinik für Dermatologie und Allergologie - Hautklinik, Aachen, 52074, Germany|Klinikum Augsburg Süd; Klinik für Dermatologie und Allergologie, Augsburg, 86179, Germany|CAMPUS BENJAMIN FRANKLIN CharitéCentrum 14 Med.Klinik f.H?matologie u.Onkologie, Berlin, 12200, Germany|St. Josef-Hospital Klinik f. Dermatologie u. Allergologie, Bochum, 44791, Germany|Elbekliniken Buxtehude; Klinik für Dermatologie, Buxtehude, 21614, Germany|DRK-Krankenhaus; Hautklinik, Chemnitz, 09117, Germany|Universit?tsklinikum "Carl Gustav Carus"; Medizinische Klinik und Poliklinik I, Dresden, 01307, Germany|Universit?tsklinikum Düsseldorf; Hautklinik, Düsseldorf, 40225, Germany|HELIOS Klinikum Erfurt, Klinik für Hautkrankheiten und Allergologie, Erfurt, 99089, Germany|Universit?tsklinikum Erlangen; Hautklinik, Erlangen, 91054, Germany|Universit?tsklinikum Essen, Essen, 45122, Germany|Klinik Johann Wolfgang von Goethe Uni; Klinik fuer Allgemein- und Viszeralchirurgie, Frankfurt, 60596, Germany|Uniklinikum Freiburg Dermatol, Freiburg, 79104, Germany|SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie, Gera, 07548, Germany|Universit?tsmedizin G?ttingen Georg-August-Universit?t Zentrum Dermatologie, G?ttingen, 37075, Germany|Universit?tsklinikum Hamburg-Eppendorf Zentrum f.Innere Medizin Klinik f.Dermatologie, Hamburg, 20246, Germany|Medizinische Hochschule; Hautklinik Linden, Hannover, 30449, Germany|Uni-Hautklinik, Heidelberg, 69115, Germany|Klinikum am Gesundbrunnen; Tumorzentrum, Heilbronn, 74078, Germany|Universit?tsklinikum Jena; Klinik für Hautkrankheiten, Jena, 07743, Germany|Klinikum Kassel; Hautklinik, Kassel, 34125, Germany|UNI-Klinikum Campus Kiel Klinik f.Dermatologie Tagesklinik f.Dermatologie, Kiel, 24105, Germany|Klinik der Uni zu K?ln; Klinik & Poliklinik fuer Dermatologie & Venerologie, K?ln, 50937, Germany|Universit?tsklinikum Leipzig Klinik f.Dermatologie Venerologie u.Allergologie, Leipzig, 04103, Germany|Klinikum d.Stadt Ludwigshafen Hautklinik, Ludwigshafen, 67063, Germany|Universit?tsklinikum Schleswig-Holstein; Campus Lübeck, Lübeck, 23538, Germany|Universit?tsklinikum Magdeburg; Hautklinik; Klinik für Dermatologie und Venerologie, Magdeburg, 39120, Germany|Johannes Gutenberg Unis-Klinik; Dept For Dermatology, Mainz, 55131, Germany|Klinikum Mannheim Klinik fuer Dermatologie, Venerologie und Allergologie, Mannheim, 68167, Germany|Universit?tsklinikum Marburg Klinik f. Dermatologie, Marburg, 35043, Germany|Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik, Minden, 32429, Germany|Klinikum der LMU München; Klinik und Poliklinik für Dermatologie und Allergologie, München, 80337, Germany|Staedtisches Krankenhaus Muenchen-Schwabing, Haematologie & Onkolgie, München, 80804, Germany|Universit?tsklinikum Münster, Münster, 48149, Germany|Fachklinik Hornheide; Internistische Onkologie, Münster, 48157, Germany|Klinikum Nürnberg Nord; Hautklinik; Klinik für Dermatologie, Nürnberg, 90419, Germany|Klinikum Dorothea Ch.Erxleben; Klinik für Dermatologie und Allergologie, Quedlinburg, 06484, Germany|KLINIKUM VEST GmbH Knappschaftskrankenhaus Abt.Haut- Allergie- Venen- und Umwelterkrankungen, Recklinghausen, 45657, Germany|Universit?tsklinikum Regensburg; Klinik und Poliklinik für Dermatologie, Regensburg, 93053, Germany|Universitaets-Hautklinik Tuebingen, Tübingen, 72076, Germany|Wilhelm Fresenius Klinik; Klinik f. Dermatologie u. Allergologie, Wiesbaden, 65191, Germany|HELIOS Klinikum Barmen Zentrum Dermatologie Allergologie und Umweltmedizin, Wuppertal, 42283, Germany|Universit?tsklinikum Würzburg; Klinik und Poliklinik für Dermatologie Venerologie u. Allergologie, Würzburg, 97080, Germany|Laiko General Hospital; 1St Pathological Clinic, Athens, 115 27, Greece|Hospital Hygeia; 1St Oncology Dept., Athens, 15123, Greece|Univ General Hosp Heraklion; Medical Oncology, Heraklion, 711 10, Greece|Metropolitan Hospital; Dept. of Oncology, Piraeus, 185 47, Greece|Semmelweis Egyetem; Bor-, Nemikortani es Boronkologiai Klinika, Budapest, 1085, Hungary|Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly, Budapest, 1122, Hungary|Debreceni Egyetem OEC; Borgyogyaszati Klinika, Debrecen, 4012, Hungary|Pecsi Tudomanyegyetem AOK; Borgyogyaszati Klinika, Pecs, 7632, Hungary|Szegedi Tud.Egyetem Szent-Gyorgyi Albert Klin.Kozp., Szeged, 6720, Hungary|Rajiv Gandhi Cancer Inst.&Research Center; Medical Oncology, New Delhi, Delhi, 110085, India|Tata Memorial Hospital; Dept of Medical Oncology, Mumbai, Maharashtra, 400012, India|Curie Manavata Cancer Centre, Nashik, Maharashtra, 422004, India|Basavatarakam Indo-American Cancer Hospital & Research Institute, Hyderabad, 500034, India|Chhatrapati Shahuji Maharaj Medical University; Department of Oncology, Lucknow, 226003, India|Regional Cancer Centre; Dept of Oncology, Trivandrum, 695 011, India|Christian Med Clg & Hspt, Vellore, 632004, India|Cork Uni Hospital; Oncology Dept, Cork, Ireland|St Vincent'S Uni Hospital; Medical Oncology, Dublin, 4, Ireland|Mater Misericordiae Uni Hospital; Oncology, Dublin, 7, Ireland|Mater Private Hospital, Dublin, 7, Ireland|St James' Hospital; Cancer Clinical Trials Office, Dublin, Ireland|Galway Uni Hospital; Oncology Dept, Galway, Ireland|University Hospital Limerick - Oncology, Limerick, Ireland|Waterford Regional Hospital; Department Of Medical Oncology, Waterford, Ireland|Soroka Medical Center; Oncology Dept, Beer Sheva, 8410101, Israel|Ranbam Health Care Campus; Oncology - Hafia, Hafia, 3109601, Israel|Hadassah Ein Karem Hospital; Oncology Dept, Jerusalem, 91120-01, Israel|Chaim Sheba Medical Center; Oncology Dept, Ramat Gan, 5262100, Israel|Istituto Nazionale Tumori Fondazione G. Pascale, Napoli, Campania, 80131, Italy|IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola, Emilia-Romagna, 47014, Italy|A.O. Universitaria Policlinico Di Modena; Oncologia, Modena, Emilia-Romagna, 41100, Italy|AO Santa Maria Nuova; U.O. Day Hospital di Oncologi, Reggio Emilia, Emilia-Romagna, 42100, Italy|A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia, Udine, Friuli-Venezia Giulia, 33100, Italy|Istituto Dermopatico dell'Immacolata (IDI)-IRCCS; IV Divisione Oncologica e Dermatologia Oncologica, Roma, Lazio, 00167, Italy|IFO - Istituto Regina Elena; Oncologia Medica, Roma, Lazio, 00168, Italy|IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A, Genova, Liguria, 16132, Italy|Asst Papa Giovanni XXIII; Oncologia Medica, Bergamo, Lombardia, 24128, Italy|Az. Osp. Spedali Civili; Divisione Di Oncologia - Iii Medicina, Brescia, Lombardia, 25123, Italy|Irccs Ospedale San Raffaele;Oncologia Medica, Milano, Lombardia, 20132, Italy|Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2, Milano, Lombardia, 20133, Italy|Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milano, Lombardia, 20141, Italy|Policlinico Le Molinette; Clinica Dermatologica, Torino, Piemonte, 10126, Italy|Istituto Tumori Giovanni Paolo II IRCSS; Ospedale Oncologico Bari, Bari, Puglia, 70126, Italy|Policlinico P. Giaccone; Istituto Di Oncologia, Clinica Medica 1, Palermo, Sicilia, 90127, Italy|Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1, Firenze, Toscana, 50139, Italy|Azienda Ospedaliera S. Chiara; Dip di Onc,Trapianti e delle Nuove Tecnologie in Medicina, Pisa, Toscana, 50126, Italy|A.O.U. Senese Policlinico Santa Maria Alle Scotte, Siena, Toscana, 53100, Italy|Azienda Ospedaliera S. Maria - Terni; Oncologia, Terni, Umbria, 05100, Italy|IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda, Padova, Veneto, 35128, Italy|Samsung Medical Center, Seoul, 06351, Korea, Republic of|Seoul St Mary's Hospital, Seoul, 06591, Korea, Republic of|Seoul National University Hosp; Dept Internal Med Hem Onc, Seoul, 110-744, Korea, Republic of|Yonsei University Severance Hospital; Medical Oncology, Seoul, 120-752, Korea, Republic of|Asan Medical Center., Seoul, 138-736, Korea, Republic of|Daugavpils Regional Hospital, Daugavpils, 5417, Latvia|Rigas Austrumu Kliniska Universitates slimnica, Latvijas Onkologijas centrs, Riga, LV 1079, Latvia|Klaipeda University Hospital, Klaipeda, 92288, Lithuania|Vilnius University Hospital Santariskiu Clinic, Hematology, Oncology and Tranfusion Medicine Center, Vilnius, 08661, Lithuania|University Clinic for Radiotherapy and Oncology Skopje; Department of skin malignancies, Skopje, 1000, Macedonia, The Former Yugoslav Republic of|Fundación Rodolfo Padilla Padilla, A.C.; Oncology, Leon, 37000, Mexico|Inst. Nacional de Cancerologia; Investigacion Clinica, Mexico City, 14000, Mexico|Hospital General de México; Unidad de Oncologia, Mexico DF, 06726, Mexico|Antoni Van Leeuwenhoek Ziekenhuis; Inwendige Geneeskunde, Amsterdam, 1066 CX, Netherlands|VU MEDISCH CENTRUM; Dept. of Medical Oncology, Amsterdam, 1081 HV, Netherlands|Tergooiziekenhuizen, Blaricum, 1261 AN, Netherlands|Amphia Ziekenhuis, Breda, 4818 CK, Netherlands|Academ Ziekenhuis Groningen; Medical Oncology, Groningen, 9713 GZ, Netherlands|Academisch Ziekenhuis Leiden; Clinical Oncology, Leiden, 2333 ZA, Netherlands|Academish Ziekenhuis Maastricht (Azm); Inwendige Geneeskunde, Maastricht, 6229 HX, Netherlands|UMC St Radboud; Interne Oncologie; Medical Oncology Department, Nijmegen, 6500 HB, Netherlands|Erasmus MC, Rotterdam, 3000 CA, Netherlands|Universitair Medisch Centrum Utrecht; Inwendige Geneeskunde Afd., Utrecht, 3584 CX, Netherlands|Haukeland Universitetshospital; Onkologisk Avd., Bergen, 5021, Norway|The Norvegian Radium Hospital Montebello; Dept of Oncology, Oslo, 0379, Norway|Hospital Nacional Carlos Alberto Seguin Escobedo-Essalud; Oncology & Haemathology, Arequipa, 04001, Peru|Instituto Nacional de Enfermedades Neoplasicas, Lima, 34, Peru|Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii, Krakow, 31-531, Poland|ZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii;Wojska Polskiego 37, Olsztyn, 10-228, Poland|NZOZ Med.-Polonia sp. z o.o., Poznań, 60-693, Poland|Centrum Onkologii- Instytut; im. M.Sk?odowskiej-Curie, Warszawa, 02-781, Poland|IPO de Lisboa; Servico de Oncologia Medica, Lisboa, 1099-023, Portugal|IPO do Porto; Servico de Oncologia Medica, Porto, 4200-072, Portugal|Institut of Oncology Al. Trestioreanu Bucharest; Oncology, Bucuresti, 022328, Romania|Medisprof SRL, Cluj-Napoca, 400058, Romania|S.C. Life Search S.R.L; Medical Oncology Clinic, Timisoara, 300167, Romania|FSBI "Scientific Research Institute of Oncology named after N.N.Petrov" Ministry of Health of RF, St Petersburg, Leningrad, 197758, Russian Federation|Regional Clinical Oncology Dispensary, Krasnodar, 350040, Russian Federation|Russian Cancer Research Center, Moscow, 115478, Russian Federation|Moscow city oncology hospital #62 of Moscow Healthcare Department, Moscow, 143423, Russian Federation|St. Petersburg Oncology & Gynecology; City Clinical Oncology Dispensary, Saint-Petersburg, 197022, Russian Federation|Stavropol Clinical Oncology Dispansary, Stavropol, ND, Russian Federation|Bashkirian Republican Clinical Oncology Dispensary, UFA, 450054, Russian Federation|Institute for Oncology and Radiology of Serbia; Medical Oncology, Belgrade, 11000, Serbia|Clinical Center Bezanijska Kosa; Oncology, Belgrade, 11080, Serbia|Onkologicky ustav sv. Alzbety; Oddelenie ambulantnej chemoterapie, Bratislava, 812 50, Slovakia|Narodny Onkologicky Ustav; Oddelenie klinickej onkologie E, Bratislava, 833 10, Slovakia|POKO Poprad; Department of Oncology, Poprad, 058 01, Slovakia|Institute of Oncology Ljubljana, Ljubljana, 1000, Slovenia|Universitas Annex, University of the Free State; Clinical Oncology, Bloemfontein, 9300, South Africa|Cape Town Oncology Trials, Cape Town, 7570, South Africa|Cancercare, Cape Town, 7700, South Africa|Medical Oncology Centre of Rosebank; Oncology, Johannesburg, 2196, South Africa|Steve Biko Academic Hospital; Oncology, Pretoria, 0002, South Africa|Sandton Oncology Centre, Sandton, 2196, South Africa|Hospital Univ. Central de Asturias; Servicio de Oncologia, Oviedo, Asturias, 33011, Spain|Hospital Universitario Marques de Valdecilla; Servicio de Oncologia, Santander, Cantabria, 39008, Spain|Hospital Universitario Son Espases, Palma De Mallorca, Islas Baleares, 07014, Spain|Hospital Universitario Materno Infantil de Gran Canaria; Servicio de Oncologia, Las Palmas de Gran Canaria, Las Palmas, 35016, Spain|Hospital Universitario de Santa Lucía; Servicio de Oncología Médica, Cartagena (Murcia), Murcia, 30202, Spain|Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona, Navarra, 31008, Spain|Hospital Xeral Cíes; Servicio de Oncologia, Vigo, Pontevedra, 36312, Spain|Hospital Universitario de Canarias (HUC), La Laguna (Tenerife), Tenerife, 38320, Spain|Hospital de Cruces; Servicio de Oncologia, Barakaldo, Vizcaya, 48903, Spain|Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona, 08035, Spain|Hospital Clínic i Provincial; Servicio de Hematología y Oncología, Barcelona, 08036, Spain|Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Barcelona, 08916, Spain|Hospital Reina Sofia, Cordoba, 14004, Spain|Hospital Universitario Virgen de las Nieves; Servicio de Oncologia, Granada, 18014, Spain|Complejo Hospitalario Universitario A Coru?a (CHUAC, Materno Infantil), Oncología, La Coru?a, 15006, Spain|Complejo Asistencial Universitario de Leon; Servicio de Oncologia, Leon, 24071, Spain|Hospital Ramon y Cajal; Servicio de Oncologia, Madrid, 28034, Spain|Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid, 28041, Spain|Hospital Universitario La Paz; Servicio de Oncologia, Madrid, 28046, Spain|Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Malaga, 29010, Spain|Hospital Regional Universitario Carlos Haya; Servicio de Oncologia, Malaga, 29010, Spain|Hospital Clinico Universitario de Salamanca; Servicio de Oncologia, Salamanca, 37007, Spain|Hospital Universitario Virgen Macarena; Servicio de Oncologia, Sevilla, 41009, Spain|Hospital General Universitario de Valencia; Servicio de oncologia, Valencia, 41014, Spain|Instituto Valenciano Oncologia; Oncologia Medica, Valencia, 46009, Spain|Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza, 50009, Spain|Sahlgrenska Universitetssjukhuset; Onkology, Gothenburg, SE-41 343, Sweden|Sk?nes Onkologiska Klinik, Universitetssjukhuset, Lund, 22185, Sweden|Karolinska Universitetssjukhuset, Solna, Stockholm, 171 76, Sweden|Norrlands universitetssjukhus; Onkologkliniken, Ume?, Sweden|Akademiska sjukhuset, Onkologkliniken, Uppsala, 75185, Sweden|Universitaetsspital Basel; Onkologie, Basel, 4031, Switzerland|Inselspital Bern; Medizinische Onkologie, Bern, 3010, Switzerland|Kantonsspital Graubünden;Onkologie und H?matologie, Chur, 7000, Switzerland|CHUV; Departement d'Oncologie, Lausanne, 1011, Switzerland|Kantonsspital St. Gallen; Onkologie/H?matologie, St. Gallen, 9007, Switzerland|Universit?tsspital Zürich; Dermatologische Klinik, Zürich, 8091, Switzerland|Adana Baskent University Hospital; Medical Oncology, Adana, 01120, Turkey|Cukurova Uni Faculty of Medicine; Medical Oncology, Adana, 01330, Turkey|Ankara Uni , Ibn-I Sina Hospital; Oncology Dept, Ankara, 06230, Turkey|Gazi Uni Medical Faculty Hospital; Oncology Dept, Ankara, 06500, Turkey|Akdeniz University School of Medicine; General Surgery, Antalya, 07000, Turkey|Ege University Medical Faculty; Medical Oncology Department, Bornova, ?ZM?R, 35100, Turkey|Gaziantep University Medical Faculty, Medical Oncology Department, Gaziantep, 27310, Turkey|Kartal Training and Research Hospital;Medical Oncology Department, Istanbul, 34000, Turkey|Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology, Istanbul, 34300, Turkey|American Hospital, Medical Oncology Department, Istanbul, 34365, Turkey|Dokuz Eylul Uni ; Medical Oncology, Izmir, 35340, Turkey|Hacettepe Uni Medical Faculty Hospital; Oncology Dept, S?hhiye, ANKARA, 06100, Turkey|Addenbrookes Nhs Trust; Oncology Clinical Trials Unit, Cambridge, CB2 0QQ, United Kingdom|Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, United Kingdom|Royal Surrey County Hospital; St. Lukes Cancer Centre, Guildford, GU2 7XX, United Kingdom|St James University Hospital, Leeds, LS9 7TF, United Kingdom|Royal Marsden Hospital, London, SW3 6JJ, United Kingdom|Christie Hospital; Breast Cancer Research Office, Manchester, M20 4QL, United Kingdom|Northern Centre for Cancer Care Freeman Hospital; Sir Bobby Robson Cancer Trials Research Centre, Newcastle upon Tyne, NE7 7DN, United Kingdom|Mount Vernon Hospital; Centre For Cancer Treatment, Northwood, HA6 2RN, United Kingdom|Nottingham University Hospitals City Campus, Nottingham, NG5 1PB, United Kingdom|Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford, OX3 7LJ, United Kingdom|Southampton General Hospital; Medical Oncology, Southampton, SO16 6YD, United Kingdom|Singleton Hospital; Oncology, Swansea, SA2 8QA, United Kingdom Less << |
NCT01586195 | Malignant Melanoma | PHASE2 | TERMINATED | 2015-04-30 | Arizona Cancer Center, Tucson,... More >> Arizona, 85724, United States|UCSD Moores Cancer Center, La Jolla, California, 92093, United States|UCLA School of Medicine; Hematology/Oncology, Los Angeles, California, 90095, United States|The Angeles Clinic and Research Institute, Santa Monica Office, Santa Monica, California, 90025, United States|University of Colorado; Anschutz Cancer Pavilion, Aurora, Colorado, 80045, United States|Moffitt Cancer Center, Tampa, Florida, 33612, United States|Emory University; Winship Cancer Institute, Atlanta, Georgia, 30308, United States|Oncology Specialists, S.C., Park Ridge, Illinois, 60068, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Atlantic Health System, Morristown, New Jersey, 07960, United States|Columbia University Medical Center, New York, New York, 10032, United States|Mid Ohio Onc Hematology Inc, Columbus, Ohio, 43219, United States|UPCI Cancer Institute; Cancer Pavillion, Pittsburgh, Pennsylvania, 15232, United States|Vanderbilt Univ Medical Ctr, Nashville, Tennessee, 37232, United States|Texas Oncology-Baylor Sammons Cancer Center, Dallas, Texas, 75246, United States Less << |
NCT01586195 | Malignant Melanoma | PHASE2 | TERMINATED | 2015-04-30 | Arizona Cancer Center, Tucson,... More >> Arizona, 85724, United States|UCSD Moores Cancer Center, La Jolla, California, 92093, United States|UCLA School of Medicine; Hematology/Oncology, Los Angeles, California, 90095, United States|The Angeles Clinic and Research Institute, Santa Monica Office, Santa Monica, California, 90025, United States|University of Colorado; Anschutz Cancer Pavilion, Aurora, Colorado, 80045, United States|Moffitt Cancer Center, Tampa, Florida, 33612, United States|Emory University; Winship Cancer Institute, Atlanta, Georgia, 30308, United States|Oncology Specialists, S.C., Park Ridge, Illinois, 60068, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Atlantic Health System, Morristown, New Jersey, 07960, United States|Columbia University Medical Center, New York, New York, 10032, United States|Mid Ohio Onc Hematology Inc, Columbus, Ohio, 43219, United States|UPCI Cancer Institute; Cancer Pavillion, Pittsburgh, Pennsylvania, 15232, United States|Vanderbilt Univ Medical Ctr, Nashville, Tennessee, 37232, United States|Texas Oncology-Baylor Sammons Cancer Center, Dallas, Texas, 75246, United States Less << |
NCT01942993 | Melanoma | PHASE2 | TERMINATED | 2025-11-15 | Icahn School of Medicine at Mo... More >>unt Sinai, New York, New York, 11103, United States Less << |
NCT02230306 | - | Terminated(closed due to slow ... More >>accrual) Less << | - | - | |
NCT01767623 | Neoplasms | PHASE1 | COMPLETED | 2017-04-20 | California Cancer Associates f... More >>or Research & Excellence, Inc., Encinitas, California, 92008, United States|Peninsula and South Eastern Haematology and Oncology Grou, Frankston, Victoria, 3199, Australia|District General Hospital of Athens Laiko; 1st Internal Medicine Clinic, Athens, 11527, Greece|Rambam Health Care Campus, Haifa, 31096, Israel|Tel Aviv Sourasky Medical Center, Tel Aviv, 64239, Israel|SBIH " Clinical Oncological Dispensary # 1"; Chemotherapy department #1 and #2, Krasnodar, 350040, Russian Federation|Ege University Medicine Develoment and Pharmacokinetics Research Center; Pulmonary Diseases, Izmir, 35040, Turkey|Velindre Cancer Centre, Cardiff, CF14 2TL, United Kingdom Less << |
NCT01910181 | Malignant Melanoma | PHASE1 | COMPLETED | 2018-04-20 | Beijing Cancer Hospital, Beiji... More >>ng, 100142, China|Sun Yet-sen University Cancer Center, Guangzhou, 510060, China Less << |
NCT01910181 | Malignant Melanoma | PHASE1 | COMPLETED | 2018-04-20 | Beijing Cancer Hospital, Beiji... More >>ng, 100142, China|Sun Yet-sen University Cancer Center, Guangzhou, 510060, China Less << |
NCT01813214 | Melanoma | Phase 2 | Terminated(Recruitment difficu... More >>lties.) Less << | - | United States, District of Col... More >>umbia Georgetown Lombardi Comprehsnive Cancer Center Washington, District of Columbia, United States, 20007 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Texas University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Virginia University of Virginia Health System Charlottesville, Virginia, United States, 22903 Less << |
NCT01765543 | Malignant Melanoma, Neoplasms | Phase 1 | Completed | - | United States, Arkansas ... More >> Rogers, Arkansas, United States, 72758 United States, California Pleasant Hill, California, United States, 94523 United States, Ohio Middletown, Ohio, United States, 45042 United States, Texas Dallas, Texas, United States, 75246 Brazil Porto Alegre, RS, Brazil, 90020-090 Porto Alegre, RS, Brazil, 90035-003 Porto Alegre, RS, Brazil, 90840-440 Croatia Varazdin, Croatia, 42000 Zagreb, Croatia, 10000 Egypt Alexandria, Egypt, 21131 Cairo, Egypt, 11796 Dakahlia, Egypt, 324 Tanta, Egypt South Africa Cape Town, South Africa, 7570 Port Elizabeth, South Africa, 6045 Less << |
NCT01813214 | - | Terminated(Recruitment difficu... More >>lties.) Less << | - | - | |
NCT01781026 | Melanoma | PHASE2 | COMPLETED | 2025-06-14 | Smilow Cancer Hospital at Yale... More >> New Haven, New Haven, Connecticut, 06510, United States Less << |
NCT01983124 | Malignant Melanoma Stage IV | Phase 2 | Completed | - | Italy ... More >> Paola Queirolo Genova, Italy, 16132 Istituto Nazionale per lo Studio e la Cura dei Tumori "G.Pascale" Napoli, Italy, 80131 Less << |
NCT02427893 | Melanoma | Phase 3 | Withdrawn(no patients were enr... More >>olled) Less << | - | United States, Maryland ... More >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 Less << |
NCT01781026 | Melanoma | PHASE2 | COMPLETED | 2025-06-14 | Smilow Cancer Hospital at Yale... More >> New Haven, New Haven, Connecticut, 06510, United States Less << |
NCT01739764 | Neoplasms | PHASE4 | COMPLETED | 2020-02-17 | Highlands Oncology Group, Roge... More >>rs, Arkansas, 72758, United States|UCLA Department of Medicine, Los Angeles, California, 90024, United States|Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, 90502, United States|University of Chicago Medical Center; Medicine, Section of Pulmonary, Chicago, Illinois, 60637, United States|Siouxland Regional Cancer Center d/b/a June E. Nylen Cancer Center, Sioux City, Iowa, 51108, United States|Massachusetts General Hospital Cancer Center, Boston, Massachusetts, 02114, United States|New York University Medical Center PRIME, New York, New York, 10016, United States|Evelyn H. Lauder Center, New York, New York, 10065, United States|University of Pennsylvania Health System, Philadelphia, Pennsylvania, 19104, United States|Mary Crowley Medical Research Center; Oncology, Dallas, Texas, 75246, United States|M D Anderson Physician Network, Webster, Texas, 77598, United States|University of Washington Seattle Cancer Care Alliance, Seattle, Washington, 98195, United States|N.N. Alexandrov National Cancer Centre of Belarus, Minsk District, 223040, Belarus|Institut Jules Bordet, Brussels, 1000, Belgium|University Clinical Center of the Republic of Srpska, Banja Luka, 78000, Bosnia and Herzegovina|University Clinic Centre Sarajevo, Sarajevo, 71000, Bosnia and Herzegovina|Hospital das Clinicas - UFRGS, Porto Alegre, RS, Brazil|McGill University; Sir Mortimer B Davis Jewish General Hospital; Oncology, Montreal, Quebec, H3T 1E2, Canada|Clinical Hospital Center Sestre Milosrdnice, Zagreb, 10000, Croatia|Clinical Hospital Centre Zagreb, Zagreb, 10000, Croatia|Bank of Cyprus Oncology Center, Nicosia, 2006, Cyprus|Medical Research Institute, Alexandria, 21131, Egypt|National Cancer Institute, Cairo, 11796, Egypt|Mansoura University Hospital, Dakahlia, 324, Egypt|Gharbia Cancer Society, Tanta, Egypt|Centre Léon Bérard, Lyon, 69373, France|Institut Gustave Roussy, Villejuif, 94805, France|Universit?tsklinikum Heidelberg, Heidelberg, 69120, Germany|Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz; Apotheke, Mainz, 55131, Germany|Universit?tsklinikum Wurzburg, Würzburg, 97080, Germany|University General Hospital of Heraklion, Crete, 711 10, Greece|Semmelweis Egyetem, Budapest, 1083, Hungary|Orszagos Onkologiai Intezet, Budapest, 1122, Hungary|Magyar Honvedseg Egeszsegugyi Kozpont; Fázis I-es Klinikai Farmakológiai Vizsgálóhely, Budapest, H-1077, Hungary|Debreceni Egyetem Klinikai K?zpont; B?rgyógyászati Klinika, Debrecen, 4012, Hungary|Pecsi Tudomanyegyetem, Pecs, 7624, Hungary|Rambam Health Care Campus, Haifa, 3109600, Israel|Hadassah University Hospital - Ein Kerem, Jerusalem, 9112001, Israel|Chaim Sheba Medical Center; Allergy and Clinical Immunology Unit, Ramat Gan, 5266202, Israel|Tel-Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel|Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda), Milano, Lombardia, Italy|Azienda Ospedaliero Universitaria Pisana, Pisa, Toscana, 56100, Italy|Kyungpook National University Chilgok Hospital, Daegu, 41404, Korea, Republic of|Samsung Medical Center, Seoul, (0)6351, Korea, Republic of|Seoul National University Hospital, Seoul, 03080, Korea, Republic of|Severance Hospital, Yonsei University Health System, Seoul, 03722, Korea, Republic of|Asan Medical Center, Seoul, 05505, Korea, Republic of|Maastricht University Medical Center, Maastricht, 6229 HX, Netherlands|Auckland City Hospital, Auckland, 1023, New Zealand|Christchurch Clinical Studies Trust, Christchurch, 8011, New Zealand|IPO de Lisboa; Servico de Oncologia Medica, Lisboa, 1099-023, Portugal|IPO do Porto; Servico de Oncologia Medica, Porto, 4200-072, Portugal|Medisprof SRL, Cluj-Napoca, 400058, Romania|FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin"; Chemotherapy Departement, Moskva, Moskovskaja Oblast, 115478, Russian Federation|Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic, Kazan, 420029, Russian Federation|SBIH " Clinical Oncological Dispensary # 1"; Chemotherapy department #1 and #2, Krasnodar, 350040, Russian Federation|Moscow city oncology hospital #62 of Moscow Healthcare Department, Moscow, 143423, Russian Federation|St. Petersburg SHI "City Clinical Oncology Dispensary", Saint-Petersburg, 197022, Russian Federation|SBIH Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan, Ufa, 450054, Russian Federation|Institute for Oncology and Radiology of Serbia; Medical Oncology, Belgrade, 11000, Serbia|Clinical Center Bezanijska Kosa, Belgrade, 11070, Serbia|Cape Town Oncology Trials, Cape Town, 7570, South Africa|Wits Donald Gordon Clinical Trial Centre; Medical Oncology, Parktown, Johannesburg, 2193, South Africa|Cancercare Langenhoven Drive Oncology Centre, Port Elizabeth, 6045, South Africa|Hospital Universitario Marques de Valdecilla; Servicio de Oncologia, Santander, Cantabria, 39008, Spain|Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, 07010, Spain|Complejo Hospitalario Universitario A Coru?a, A Coru?a, LA Coru?a, 15006, Spain|Hospital Regional Universitario de Malaga; Oncologia, Málaga, Malaga, 29010, Spain|Hospital General Universitario Santa Lucia, Cartagena (Murcia), Murcia, 30202, Spain|Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain|Hospital Clinic i Provincial de Barcelona, Barcelona, 08036, Spain|Hospital Universitario La Paz, Madrid, 280146, Spain|Hospital Universitario Ramón y Cajal, Madrid, 28034, Spain|Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|START Madrid. Centro Integral Oncologico Clara Campal; CIOCC, Madrid, 28050, Spain|Hospital Universitario de Salamanca, Salamanca, 37007, Spain|Hospital Universitario Virgen Macarena, Sevilla, 41009, Spain|Instituto Valenciano Oncologia; Oncologia Medica, Valencia, 46009, Spain|Hospital General Universitario de Valencia, Valencia, 46014, Spain|Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, United Kingdom|Churchill Hospital, Oxford, OX3 7LJ, United Kingdom|Royal Marsden Hospital, Surrey, SM2 5PT, United Kingdom Less << |
NCT02036086 | Melanoma | Phase 2 | Recruiting | October 2022 | Canada, Ontario ... More >> The Ottawa Hospital - General Campus Recruiting Ottawa, Ontario, Canada, K1H 8L6 Contact: Carolyn Nessim, MD, MSc 613-737-8899 ext 71085 cnessim@toh.on.ca Principal Investigator: Carolyn Nessim, MD, MSc Sunnybrook Health Sciences Centre Recruiting Toronto, Ontario, Canada, M4N 3M5 Contact: Teresa Petrella, MD, BSc, MSc 416 480 5248 teresa.petrella@sunnybrook.ca Principal Investigator: Teresa Petrella, MD, BSc, MSc Canada, Quebec Royal Victoria Hospital Recruiting Montreal, Quebec, Canada, H3A 1A1 Contact: Catalin Mihalcioiu, MD 514 934 1934 ext 35800 catalin.mihalcioiu@muhc.mcgill.ca Principal Investigator: Catalin Mihalcioiu, MD Less << |
NCT01765543 | - | Completed | - | - | |
NCT02537600 | Malignant Melanoma | Phase 2 | Recruiting | June 2020 | France ... More >> CHU de Bordeaux Not yet recruiting Bordeaux, France, 33000 Principal Investigator: Caroline DUTRIAUX CHU Ambroise Paré Recruiting Boulogne, France, 92104 Principal Investigator: Philippe SAIAG, Professor CHU Brest - Hôpital Morvan Recruiting Brest, France Principal Investigator: Delphine LEGOUPIL CHU Caen - Hôpital Clémenceau Recruiting Caen, France, 14033 Principal Investigator: Michel DE PONTVILLE, MD Hôpital Henri Mondor Recruiting Creteil, France, 94010 Principal Investigator: Ouidad ZEHOU CHU de Dijon Not yet recruiting Dijon, France Principal Investigator: Sophie DALAC-RAT CHU Albert Michallon Recruiting Grenoble, France, 38014 Principal Investigator: Marie-Thérèse LECCIA Centre Hospitalier du Mans Recruiting Le Mans, France, 72037 Principal Investigator: Nathalie BENETON CHRU Lille Recruiting Lille, France, 59037 Principal Investigator: Laurent MORTIER, Professor Centre Hospitalier Lyon Sud Not yet recruiting Lyon, France, 69495 Principal Investigator: Stéphane DALLE Centre Hospitalier Annecy Genevois Not yet recruiting Metz-Tessy, France, 74370 Principal Investigator: Julie DE QUATREBARBES CHU de Nantes Not yet recruiting Nantes, France, 44093 Principal Investigator: Brigitte DRENO Groupe Hospitalier l'Archet Recruiting Nice, France, 06202 Principal Investigator: Jean-Philippe LACOUR, Professor CHR Orléans Not yet recruiting Orléans, France, 45032 Principal Investigator: Guido BENS, MD Hôîtal St louis Recruiting Paris, France, 75010 Principal Investigator: Céleste LEBBE, Professor Hôpital Cochin Recruiting Paris, France, 75014 Principal Investigator: Nora KRAMKIMEL Hôpital Bichat Not yet recruiting Paris, France, 75018 Principal Investigator: Eve MAUBEC, MD Centre Eugène Marquis Recruiting Rennes, France, 35042 Principal Investigator: Thierry Lesimple, MD Hôpital Charles Nicolle - CHU Rouen Not yet recruiting Rouen, France, 76031 Principal Investigator: Anne-Bénédicte DUVAL-MODESTE Institut Claude Regaud Not yet recruiting Toulouse, France Principal Investigator: Nicolas MEYER CHU Tours Recruiting Tours, France, 37044 Principal Investigator: Laurent MACHET, Professor Institut Gustave Roussy Not yet recruiting Villejuif, France, 94805 Principal Investigator: Caroline ROBERT Less << |
NCT01711632 | Hairy Cell Leukemia | PHASE2 | COMPLETED | 2024-08-16 | Scripps Clinic, La Jolla, Cali... More >>fornia, 92037, United States|Northwestern University, Evanston, Illinois, 60208, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Ohio State University, Columbus, Ohio, 43210, United States Less << |
NCT02456701 | Thyroid Cancer | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT03005639 | Stage IIIB-C Melanoma | Phase 2 | Withdrawn(Sponsor has decided ... More >>to close study.) Less << | - | United States, Virginia ... More >> Inova Schar Cancer Institute Fairfax, Virginia, United States, 22031 Less << |
NCT01748149 | Pediatric Recurrent/Refractory... More >> BRAFV600E-mutant Gliomas Less << | EARLY_PHASE1 | ACTIVE_NOT_RECRUITING | 2025-12-31 | Children's Hospital Los Angele... More >>s, Los Angeles, California, 90027, United States|Mattel Children's Hospital UCLA, Los Angeles, California, 90095, United States|Children's Hospital and Research Center at Oakland, Oakland, California, 94609-1809, United States|Rady Children's Hospital - San Diego, San Diego, California, 92123, United States|UCSF Medical Center-Mount Zion, San Francisco, California, 94115, United States|UCSF Medical Center-Parnassus, San Francisco, California, 94143, United States|Children's National Medical Center, Washington, District of Columbia, 20010, United States|University of Florida Health Science Center - Gainesville, Gainesville, Florida, 32610, United States|Lurie Children's Hospital-Chicago, Chicago, Illinois, 60611, United States|Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, 21287, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|University of Minnesota/Masonic Children's Hospital, Minneapolis, Minnesota, 55454, United States|Saint Louis Children's Hospital, Saint Louis, Missouri, 63110, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|St. Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States|Texas Children's Hospital, Houston, Texas, 77030, United States|Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, 84112, United States|Seattle Children's Hospital, Seattle, Washington, 98105, United States|Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Less << |
NCT02441465 | Malignant Melanoma, Cancer | Phase 1 | Completed | - | Hungary ... More >> Magyar Honvedseg Egeszsegugyi Kozpont Budapest, Hungary, H-1134 Less << |
NCT02304809 | Solid Tumors|Hematologic Cance... More >>rs|Metastatic Cancers Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2027-10-13 | Tredaniel, Paris, 75014, Franc... More >>e Less << |
NCT01248936 | Malignant Melanoma | PHASE2 | COMPLETED | 2025-10-11 | Tucson, Arizona, 85724-5078, U... More >>nited States|Los Angeles, California, 90095, United States|San Francisco, California, 94115, United States|San Francisco, California, 94117, United States|Santa Monica, California, 90025, United States|Aurora, Colorado, 80045, United States|New Haven, Connecticut, 06520-8063, United States|Palm Harbor, Florida, 34684, United States|Tampa, Florida, 33612-9497, United States|Atlanta, Georgia, 30322, United States|Park Ridge, Illinois, 60068, United States|Boston, Massachusetts, 02114, United States|Boston, Massachusetts, 02215, United States|Detroit, Michigan, 48201, United States|St. Louis, Missouri, 63110, United States|New York, New York, 10016, United States|New York, New York, 10029, United States|New York, New York, 10032, United States|New York, New York, 10065, United States|Cincinnati, Ohio, 45242, United States|Oklahoma City, Oklahoma, 73104, United States|Portland, Oregon, 97225, United States|Philadelphia, Pennsylvania, 19104, United States|Columbia, South Carolina, 29210, United States|Nashville, Tennessee, 37203, United States|Dallas, Texas, 75246, United States|Richmond, Virginia, 23230, United States|Seattle, Washington, 98195, United States Less << |
NCT01164891 | Malignant Melanoma | PHASE1 | COMPLETED | 2025-12-12 | Zürich, 8091, Switzerland |
NCT01253564 | Malignant Melanoma | PHASE2 | COMPLETED | 2012-03-14 | CHUV; Departement d'Oncologie,... More >> Lausanne, 1011, Switzerland|Universit?tsspital Zürich; Dermatologische Klinik, Zürich, 8091, Switzerland Less << |
NCT04943198 | Histiocytosis | PHASE2 | RECRUITING | 2026-03-30 | Mother and Child Institute, Wa... More >>rsaw, Mazovian, 01-211, Poland Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.04mL 0.41mL 0.20mL |
10.21mL 2.04mL 1.02mL |
20.41mL 4.08mL 2.04mL |