Products Cited in Publications Worldwide Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis

Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis

Nyarko, Mavis Sersah; Danquah, Cynthia Amaning; Antwi, Aaron Opoku

DOI:

Abstract

Allergic rhinitis (AR) is a growing global health concern. Despite being non-fatal, it has a detrimental effect on people′s quality of life and poses a significant economic burden. In this study, we aimed to evaluate the anti-allergic effects of against ovalbumin-induced murine model of allergic rhinitis. was administered to rats orally after sensitization to ovalbumin. Results of the study suggested that causes a significant reduction in nose rubs and sneeze as compared to the vehicle-treated disease control group. The treated group showed a dose-dependent significant reduction in serum TNF-α, IL-4, and IL-6 levels as well as levels in the nasal mucosa. Addnl., it decreased neutrophil and eosinophil numbers in blood of AR rats′. In the nasal tissues of the vehicle-treated rats that were subjected to an OVA challenge, the histol. of the nasal mucosa of AR rats revealed aberrant histol. changes. A variety of histol. abnormalities, including vascular congestion in the nasal mucosa, substantial inflammatory cell infiltration, and obvious alveolar wall edema were present. In the rats treated with , these characteristics were reversed. Collectively, the findings suggests that could be used to enhance current AR treatment approaches.

Keywords

Allergic rhinitis ; Aurantio-obtusin

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Aurantio-obtusin

A22104267979-25-398%

Aurantio-obtusin

280.0/250mg

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