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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 51-45-6 Chemical Structure| 51-45-6

Structure of Histamine
CAS No.: 51-45-6

Chemical Structure| 51-45-6

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Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

Synonyms: Ergamine; NSC 33792

4.5 *For Research Use Only !

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Product Citations

Product Citations

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing ; Gordon, Akiva ; Jiang, Allen ; Varley, Andrew , et al.

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

Alternative Products

Product Details of Histamine

CAS No. :51-45-6
Formula : C5H9N3
M.W : 111.14
SMILES Code : NCCC1=CNC=N1
Synonyms :
Ergamine; NSC 33792
MDL No. :MFCD00005210

Safety of Histamine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H317-H319-H334-H335
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338-P342+P311
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Histamine

GPCR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
human airway smooth muscle cells 10 μM ~127 seconds delay before shortening Study histamine-induced cell contraction and shortening ACS Nano. 2021 Jul 27;15(7):11585-11596
HEK293T cells 2.5 μM 30 minutes Identified CG1358 (HisT) as a histamine-specific transporter, whose transport activity is Na+-dependent but Cl−-independent, and highly specific to histamine Sci Adv. 2022 Oct 28;8(43):eabq1780
CINs (cholinergic interneurons) 10 μM To assess the effects of histamine on CIN excitability, results showed histamine significantly increased spontaneous firing frequency of CINs Biol Psychiatry. 2023 Jun 1;93(11):1041-1052
PV-INs (parvalbumin-expressing fast-spiking interneurons) 10 μM To assess the effects of histamine on PV-IN excitability and resting membrane potential, results showed no significant effect of histamine on PV-IN excitability or resting membrane potential Biol Psychiatry. 2023 Jun 1;93(11):1041-1052
human induced pluripotent stem cells (hiPSCs) 10 μM 3-5 days promoted cardiac progenitor cell generation and cardiomyocyte differentiation Stem Cell Res Ther. 2020 Mar 4;11(1):27
HeLa cells 30 μM 1 min The IC50 value of the inhibition of histamine (30 μM, 1 min)-induced Ca2+ rise was 951 nM for cetirizine/DBD-pz, which is equivalent to the IC50 value of cetirizine (867 nM) Br J Pharmacol. 2012 Jan;165(1):167-82.

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Bio Calculators
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9.00mL

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0.90mL

44.99mL

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89.97mL

17.99mL

9.00mL

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