Products Cited in Publications Worldwide Metallaphotoredox-Catalyzed C-S Cross-Coupling between Heteroaryl Bromides and α-Thioacetic Acids to Access Biaryl Thioethers

Metallaphotoredox-Catalyzed C-S Cross-Coupling between Heteroaryl Bromides and α-Thioacetic Acids to Access Biaryl Thioethers

Christian, Alec H.

DOI: PMID:

Abstract

Metallaphotoredox-catalyzed C-S cross-coupling between heteroaryl bromides RBr (R = quinolin-3-yl, pyrimidin-5-yl, pyridin-2-yl, 2-methyl-imidazo[1,2-a]pyridin-5-yl, etc.) and α-thioacetic acids R1SC(R2R3)CO2H (R1 = 4-methoxyphenyl, pyridin-4-yl, benzo[d]oxazol-2-yl, etc.; R2 = H, Me, Ph; R3 = H, Me) to form biaryl thioethers RSR1 is described. This transformation allows for cross-coupling between building blocks containing reactive functional groups, nitrogen heterocycles, and pharmaceutically relevant scaffolds. Mechanistic experiments indicate a unique means by which this C-S cross-coupling occurs.

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