Products Cited in Publications Worldwide Non-Invasive Ultrasonic Debridement of Implant Biofilms Via Hydrogen-Sulfide Releasing Peptide Nanoemulsions

Non-Invasive Ultrasonic Debridement of Implant Biofilms Via Hydrogen-Sulfide Releasing Peptide Nanoemulsions

Singh, Harminder; Biswas, Diptomit; Medina, Scott

DOI:

Abstract

Implant contamination by bacterial biofilms remains a significant healthcare burden, often necessitating revision surgeries due to biofilm-enabled antibiotic resistance. Physical debridement, in combination with chemical antiseptics, is a simple and effective therapeutic strategy, but requires highly invasive surgical procedures and risks secondary infection events. Herein, we report a non-invasive, nanoparticle-enabled ultrasonic debridement strategy that exerts synergistic physical and chemical antiseptic effects to rapidly and efficiently clear implant-associated biofilms in situ. This approach is realized through the development of hydrogen sulfide- releasing peptide nanoemulsions that preferentially target bacterial biofilms and can be vaporized via diagnostic ultrasound to spatiotemporally clear methicillin-resistant Staphylococcus aureus (MRSA) infections. Biophysical studies elucidate the mechanistic basis for the platform’s antibiofilm activity, and in vitro and ex vivo experiments confirm efficacy in the context of MRSA-infected titanium implants. By exploiting the portable, low cost and safe nature of low intensity diagnostic ultrasound, this non-invasive approach avoids the collateral tissue damage associated with current surgical and high intensity acoustic ablative modalities.

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