Products Cited in Publications Worldwide Acrylate Monolith Precursor Having Carboxy Surface and Its Functionalization With Polar, Non-Polar, and Chiral Ligands for Capillary Electrochromatographic Separation

Acrylate Monolith Precursor Having Carboxy Surface and Its Functionalization With Polar, Non-Polar, and Chiral Ligands for Capillary Electrochromatographic Separation

Neequaye, Theophilus

Abstract

The main aim of this dissertation is to develop novel stationary phases for the chromatographic separation of a wide range of polar and nonpolar analytes by employing the capillary electrochromatography (CEC) technique. It focused on advancing the concept of post-polymerization functionalization in stationary phase preparation by using a poly(CEA-co-EDMA) precursor monolithic column to which many kinds of ligands were chemically attached. Four various types of monolithic stationary phases, including those with surface functionalized n-octadecylamine and anthracene-2-amine generating nonpolar linear C18 and aromatic surfaces, respectively, were fabricated from the above-named single precursor monolithic column and analyzed in the RP-CEC separation mode. A chiral ligand, (S)-(-)-1-(2-naphthyl)ethylamine, in a similar approach, was chemically attached to the carboxy monolith and evaluated for its dual chromatographic functionalities for enantioseparation and RP-CEC. On the other hand, tris(hydroxymethyl) aminomethane hydrochloride was grafted onto the same base monolith to obtain a polar stationary phase and analyzed using CEC under hydrophilic interaction liquid chromatography (HILIC) mode. The research findings presented in this dissertation have proved the flexibility of the carboxy monolithic column as a precursor or parent monolith to produce a variety of stationary phases. Various types of ligands were immobilized on the precursor surface using a simple and well-known amide bond formation process by using an organic soluble carbodiimide such as DCC and water-soluble carbodiimide, namely EDAC, which demonstrated that a desirable stationary phase may be customized from the carboxy monolith as needed.

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Pentylbenzene

A339680538-68-195%

Pentylbenzene

215.0/500g

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