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Chemical Structure| 538-68-1 Chemical Structure| 538-68-1

Structure of Pentylbenzene
CAS No.: 538-68-1

Chemical Structure| 538-68-1

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Neequaye, Theophilus ; El Rassi, Ziad ;

Abstract: In this research report, the post polymerization functionalization (PPF) of a carboxyethyl acrylate (CEA)-co-ethylene glycol dimethacrylate (EDMA) [(poly-CEA-co-EDMA)] precursor monolith with 2-aminoanthracene was carried out in the presence of an organic solvent soluble carbodiimide, namely N,N'-dicyclohexylcarbodiimide (DCC), yielding the so-called anthracenyl-poly-CEA-co-EDMA monolith. This novel monolith proved to be an excellent monolithic stationary for reversed-phase capillary electrochromatog. (RP-CEC) with hydrophobic and π-π interactions of a wide range of nonpolar solutes including those bearing aryl functional groups in their structures such as polycyclic aromatic hydrocarbons (PAHs), toluene derivatives and aniline derivatives as well as solutes carrying in their structures electron withdrawing substituents such as dinitrophenyl-amino acids (DNP-AAs) and di-DNP-AAs. The retention behaviors of the just mentioned solutes obtained on the anthracenyl-poly-CEA-co-EDMA monolithic column were compared to those obtained on octadecyl-poly-CEA-co-EDMA monolithic column prepared from the same carboxy-precursor monolith. The results demonstrated the superiority of anthracenyl column over the octadecyl column for the separation and enhanced selectivity for aromatic solutes since it provides not only hydrophobic interactions but also π-π interactions with aromatic nonpolar solutes.

Keywords: Carboxy precursor monolith ; Post polymerization functionalization ; Anthracenyl monolithic column ; Reversed -phase capillary ; electrochromatography ; Aromatic solutes

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Neequaye, Theophilus ;

Abstract: The main aim of this dissertation is to develop novel stationary phases for the chromatographic separation of a wide range of polar and nonpolar analytes by employing the capillary electrochromatography (CEC) technique. It focused on advancing the concept of post-polymerization functionalization in stationary phase preparation by using a poly(CEA-co-EDMA) precursor monolithic column to which many kinds of ligands were chemically attached. Four various types of monolithic stationary phases, including those with surface functionalized n-octadecylamine and anthracene-2-amine generating nonpolar linear C18 and aromatic surfaces, respectively, were fabricated from the above-named single precursor monolithic column and analyzed in the RP-CEC separation mode. A chiral ligand, (S)-(-)-1-(2-naphthyl)ethylamine, in a similar approach, was chemically attached to the carboxy monolith and evaluated for its dual chromatographic functionalities for enantioseparation and RP-CEC. On the other hand, tris(hydroxymethyl) aminomethane hydrochloride was grafted onto the same base monolith to obtain a polar stationary phase and analyzed using CEC under hydrophilic interaction liquid chromatography (HILIC) mode. The research findings presented in this dissertation have proved the flexibility of the carboxy monolithic column as a precursor or parent monolith to produce a variety of stationary phases. Various types of ligands were immobilized on the precursor surface using a simple and well-known amide bond formation process by using an organic soluble carbodiimide such as DCC and water-soluble carbodiimide, namely EDAC, which demonstrated that a desirable stationary phase may be customized from the carboxy monolith as needed.

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Neequaye, Theophilus ; El Rassi, Ziad ;

Abstract: A carboxy precursor monolithic column, namely poly(carboxy Et acrylate-co-ethylene glycol dimethacrylate) was first produced in a 100μm i.d. fused-silica capillary and subsequently surface bonded with n-octadecyl (C18) ligands by a post-polymerization functionalization process with octadecylamine in the presence of N,N'-dicyclohexylcarbodiimide. The bonding of octadecyl ligands was achieved via an amide linkage between the carboxy functions of the precursor monolith and the amino group of the octadecylamine compound The resulting C18 monolith exhibited a very low electroosmotic flow (EOF), a fact that required the incorporation of small amounts of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) in the polymerization solution to produce a precursor monolith with fixed neg. charges of sulfonate groups. This may indicate that the conjugation of the carboxy functions with octadecylamine occurred to a large extent so that the amount of residual carboxy functions was sparsely dispersed and not enough to produce a desirable EOF. The EOF velocity of the C18 column having fixed neg. charges provided by the incorporated AMPS increased with increasing ACN content of the mobile phase signaling an increased binding of mobile phase ions to the polar amide linkages near the monolithic surface, and a decreased viscosity of the mobile phase, both of which would result in increased EOF velocity. The C18 monolithic column constituted a novel nonpolar sorbent for reversed-phase capillary electrochromatog. for nonpolar solutes, e.g., alkylbenzenes, alkylphenyl ketones, and polyaromatic hydrocarbons, and slightly polar compounds including phenol and chlorophenols. The C18 monolithic column exhibited relatively high selectivity toward chlorophenols differing by one chloro substituent.

Keywords: Capillary electrochromatography ; Carbodiimide conjugation reaction ; Carboxy precursor monolith ; Octadecyl monolith

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Product Details of [ 538-68-1 ]

CAS No. :538-68-1
Formula : C11H16
M.W : 148.24
SMILES Code : CCCCCC1=CC=CC=C1
MDL No. :MFCD00009502
InChI Key :PWATWSYOIIXYMA-UHFFFAOYSA-N
Pubchem ID :10864

Safety of [ 538-68-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H304-H411
Precautionary Statements:P210-P273-P280-P301+P310+P331-P370+P378-P391-P403+P235-P405-P501
Class:9
UN#:3082
Packing Group:
 

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