Home Chemistry Heterocyclic Building Blocks Pyridines Pyridine-2,6-Diol
Oxidation: Pyridine-2,6-diol can undergo oxidation reactions to form various products. Oxidizing agents like chromic acid or potassium permanganate can convert the diol into corresponding ketones, aldehydes, or carboxylic acids.
Esterification: Pyridine-2,6-diol can react with carboxylic acids in the presence of acid catalysts to form esters. This reaction is similar to the esterification of alcohols.
Ether Formation: Under appropriate conditions, pyridine-2,6-diol can undergo ether formation reactions. This can occur through the reaction with alkyl halides or alkyl sulfonates in the presence of a base.
Acylation: Pyridine-2,6-diol can undergo acylation reactions where an acyl group is added to the hydroxyl group. This can be achieved using acyl chlorides or acid anhydrides in the presence of a base or acid catalyst.
Substitution Reactions: The pyridine ring in pyridine-2,6-diol can undergo substitution reactions similar to other pyridine derivatives. This could involve electrophilic aromatic substitution, nucleophilic aromatic substitution, or metal-catalyzed reactions.
Condensation Reactions: Pyridine-2,6-diol can undergo condensation reactions with carbonyl compounds or other diols to form cyclic compounds or extended chain structures.
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2,6-Dihydroxy-4-(trifluoromethyl)nicotinonitrile
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