Home Chemistry Heterocyclic Building Blocks Pyridines Pyridine 1-Oxide
Reduction: pyridine 1-oxide can undergo reduction reactions to yield the corresponding pyridine derivative. Reduction can be achieved using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: pyridine 1-oxide can be oxidized to produce various pyridine N-oxide derivatives or other oxidized products. Oxidizing agents like hydrogen peroxide (H2O2) or peracids can be employed for this purpose.
Substitution Reactions: pyridine 1-oxide can undergo substitution reactions at the nitrogen or oxygen atom. For example, nucleophilic substitution reactions at the oxygen atom can be carried out using various nucleophiles, leading to the formation of substituted pyridine N-oxide derivatives.
Cyclization: pyridine 1-oxide can participate in cyclization reactions to form heterocyclic compounds. These reactions often involve intramolecular reactions facilitated by appropriate catalysts or conditions.
Metal Complexation: pyridine 1-oxide can form complexes with transition metal ions due to its ability to act as a ligand. These complexes may exhibit unique properties and reactivities, depending on the metal ion involved.
Acid-Base Reactions: pyridine 1-oxide can undergo acid-base reactions due to the presence of the basic nitrogen atom. It can act as a base, accepting a proton from an acid, or as an acid, donating a proton to a base, depending on the reaction conditions.
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2-Mercaptopyridine N-oxide sodium
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2-(((Dimethylamino)(dimethyliminio)methyl)thio)pyridine 1-oxide tetrafluoroborate
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