KRAS Inhibitors

KRAS is one of the earliest discovered driver genes in cancer, with frequent mutations observed in lung, pancreatic, and colorectal cancers. Mutations in KRAS (such as G12C, G12D) lead to its continuous activation, driving uncontrolled cell proliferation, making it a key therapeutic target. Despite its discovery in the 1980s, KRAS was long considered "undruggable" due to the lack of a suitable binding site. In 2013, researchers discovered that the KRAS G12C mutation forms a "switch-II" pocket that can be targeted by covalent inhibitors, paving the way for KRAS-targeted drug development. Amgen and Mirati developed Sotorasib (Lumakras) and Adagrasib (Krazati), which were approved in 2021 and 2022, marking a new era in KRAS-targeted therapy. As research advances, drug development is expanding to target more challenging KRAS mutations like G12D, combining other therapeutic mechanisms (such as SHP2, EGFR inhibitors, or immunotherapy) to improve efficacy. For example, the novel drug RMC-6236 induces the formation of complexes between CypA and various RAS(ON) mutant proteins, inhibiting tumor growth and offering an innovative treatment approach. The development of KRAS-targeted drugs breaks the "undruggable" barrier, signaling a paradigm shift towards precision therapy. AMbeed offers a range of KRAS inhibitors, especially milestone novel KRAS inhibitors, to meet your research needs.

KRAS Inhibitors

BI-0474
click to sign in and save

A17029252750570-55-798%

BI-0474

$759.00/100mg Detail

BI-2493
click to sign in and save

A22886412937344-16-498%

BI-2493

$124.00/1mg Detail

ACBI3
click to sign in and save

A26354802938169-76-598%

ACBI3

$1541.00/50mg Detail

ARS-1620
click to sign in and save

A5078081698055-85-499%

ARS-1620

$99.00/10mg Detail

DCC-3116
click to sign in and save

A26922122543673-19-297%

DCC-3116

$153.00/10mg Detail

Kras4B G12D-IN-1
click to sign in and save

A22882222042365-85-398%

Kras4B G12D-IN-1

$92.00/10mg Detail

KRAS G12D inhibitor 14
click to sign in and save

A16010442765254-39-398%

KRAS G12D inhibitor 14

$337.00/10mg Detail

K-Ras(G12C) inhibitor 12
click to sign in and save

A5184821469337-95-898%

K-Ras(G12C) inhibitor 12

$529.00/100mg Detail

Oncrasin-1
click to sign in and save

A74610375629-57-198%

Oncrasin-1

$291.00/100mg Detail

LUNA18
click to sign in and save

A19541532676177-63-098%

LUNA18

$1108.00/10mg Detail

KRAS inhibitor-9
click to sign in and save

A1362939300809-71-698%

KRAS inhibitor-9

$125.00/100mg Detail

Pan KRas-IN-1
click to sign in and save

A16736692791263-84-698%

Pan KRas-IN-1

$602.00/5mg Detail

CFL-137
click to sign in and save

A176302708-06-598%

CFL-137

$271.00/1kg Detail

CFL-120
click to sign in and save

A19451318711-15-498%

CFL-120

$88.00/25g Detail

XMU-MP-9
click to sign in and save

A26716822251130-41-195%

XMU-MP-9

$175.00/100mg Detail

FTI-277 HCl
click to sign in and save

A136104180977-34-898%

FTI-277 HCl

$65.00/2mg Detail

K-Ras-IN-1
click to sign in and save

A23445684783-01-799%

K-Ras-IN-1

$123.00/50mg Detail

K-Ras G12C-IN-3
click to sign in and save

A7733421629268-19-499%

K-Ras G12C-IN-3

$609.00/50mg Detail

Sotorasib racemate
click to sign in and save

A11489612252403-56-699%

Sotorasib racemate

$290.00/250mg Detail

ARS-1323-alkyne
click to sign in and save

A13740072436544-27-198%

ARS-1323-alkyne

$2178.00/100mg Detail

1 2 3 4    page 2 of 4 Pages