Peptide Drug Intermediates

Peptide drug intermediates are building blocks formed by amino acids via peptide bonds, playing a pivotal role in peptide drug development. In peptide synthesis, amino acids are typically used as starting materials. To enhance efficiency and cost-effectiveness, protected oligopeptides can also be utilised as starting materials for complex peptides. These intermediates undergo precise sequence design and modification to optimise biological activity, stability, and pharmacokinetic properties. Typically, these intermediates are prepared via solid-phase peptide synthesis (SPPS) or liquid-phase methods, and are then subjected to rigorous purification (e.g., high-performance liquid chromatography) in order to ensure high purity (>95%) and to eliminate by-products. The market launch of GLP-1 peptide drugs such as semaglutide has substantially increased demand for peptide drug intermediates. Besides, advancements in automated synthesis technologies and green chemistry methods continue to enhance cost-effectiveness and scalability, establishing peptide drug intermediates as indispensable tools in peptide-based drug development.

Peptide Drug Intermediates

(5S,8S,11S)-5-Benzyl-11-(((S)-1-(tert-butoxy)-3-(4-(tert-butoxy)phenyl)-1-oxopropan-2-yl)carbamoyl)-1-(9H-fluoren-9-yl)-3,6,9-trioxo-8-(3-ureidopropyl)-2-oxa-4,7,10-triazapentadecan-15-oic acid
click to sign in and save

A13061551N/A95%

(5S,8S,11S)-5-Benzyl-11-(((S)-1-(tert-butoxy)-3-(4-(tert-butoxy)phenyl)-1-oxopropan-2-yl)carbamoyl)-1-(9H-fluoren-9-yl)-3,6,9-trioxo-8-(3-ureidopropyl)-2-oxa-4,7,10-triazapentadecan-15-oic acid

$0.00/25kg Detail

(S)-3-Acetamido-4-(((S)-1-(((S)-6-amino-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino)-1-oxohexan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid
click to sign in and save

A130615522243446-99-195%

(S)-3-Acetamido-4-(((S)-1-(((S)-6-amino-1-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino)-1-oxohexan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid

$0.00/25kg Detail

((S)-5-(tert-Butoxy)-2-((S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-3-methylbutanamido)-5-oxopentanoyl)glycine
click to sign in and save

A13061554N/A99%

((S)-5-(tert-Butoxy)-2-((S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-3-methylbutanamido)-5-oxopentanoyl)glycine

$0.00/1kg Detail

((59S,66S)-66-((S)-2-Amino-5-ureidopentanamido)-59-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamido)-53,60-dioxo-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-heptadecaoxa-54,61-diazaheptahexacontan-67-oyl)-L-tyrosine
click to sign in and save

A13061555N/A95%

((59S,66S)-66-((S)-2-Amino-5-ureidopentanamido)-59-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetamido)-53,60-dioxo-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-heptadecaoxa-54,61-diazaheptahexacontan-67-oyl)-L-tyrosine

$0.00/1kg Detail

Fmoc-Lys[OtBu-C18-γ-Glu(OtBu)]-OH
click to sign in and save

A29461161931109-48-698%

Fmoc-Lys[OtBu-C18-γ-Glu(OtBu)]-OH

$0.00/500kg Detail

tert-Butyl (5S,14S)-14-(tert-butoxycarbonyl)-5-(2,5-dioxopyrrolidine-1-carbonyl)-1-(9H-fluoren-9-yl)-3,11,16-trioxo-2-oxa-4,10,15-triazatritriacontan-33-oate
click to sign in and save

A13061556N/A90%

tert-Butyl (5S,14S)-14-(tert-butoxycarbonyl)-5-(2,5-dioxopyrrolidine-1-carbonyl)-1-(9H-fluoren-9-yl)-3,11,16-trioxo-2-oxa-4,10,15-triazatritriacontan-33-oate

$0.00/500kg Detail

(S)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic acid
click to sign in and save

A16621021671100-14-395%

(S)-13-(tert-Butoxycarbonyl)-34,34-dimethyl-10,15,32-trioxo-3,6,33-trioxa-9,14-diazapentatriacontanoic acid

$0.00/25kg Detail

(25S,30S,39S)-39-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-25,30-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,23,28,33-tetraoxo-3-oxa-24,29,34-triazatetracontan-40-oic acid
click to sign in and save

A13061557N/A99%

(25S,30S,39S)-39-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-25,30-bis(tert-butoxycarbonyl)-2,2-dimethyl-4,23,28,33-tetraoxo-3-oxa-24,29,34-triazatetracontan-40-oic acid

$0.00/25kg Detail

2,2-Dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid
click to sign in and save

A1681834174308-47-597%

2,2-Dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid

$40.00/100mg Detail

(S)-2-(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanamido)-3-(4-(tert-butoxy)phenyl)propanoic acid
click to sign in and save

A29379622244048-27-795%

(S)-2-(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanamido)-3-(4-(tert-butoxy)phenyl)propanoic acid

$0.00/ Detail

(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoyl)-L-valine
click to sign in and save

A19455922171152-91-195%

(3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoyl)-L-valine

$154.00/100mg Detail

Fmoc-Val-Gly-OH
click to sign in and save

A746652142810-19-398%

Fmoc-Val-Gly-OH

$121.00/5g Detail

Fmoc-L-Ile-L-Pro-OH
click to sign in and save

A271612109425-47-095%

Fmoc-L-Ile-L-Pro-OH

$835.00/5g Detail

Fmoc-His(Trt)-Aib-OH
click to sign in and save

A19420241446013-13-395%

Fmoc-His(Trt)-Aib-OH

$28.00/250mg Detail

Fmoc-L-Thr(tBu)-Gly-OH
click to sign in and save

A11574291456878-79-798%

Fmoc-L-Thr(tBu)-Gly-OH

$300.00/1g Detail

Fmoc-His(Trt)-Gly-OH
click to sign in and save

A11572891428125-83-098%

Fmoc-His(Trt)-Gly-OH

$45.00/100mg Detail

Fmoc-Gly-Pro-OH
click to sign in and save

A359820212651-48-498%

Fmoc-Gly-Pro-OH

$126.00/10g Detail

Fmoc-Ile-Ala-OH
click to sign in and save

A2267849134716-88-498%

Fmoc-Ile-Ala-OH

$0.00/ Detail

Fmoc-Ser(tBu)-Ser(tBu)-OH
click to sign in and save

A2319375110098-50-595%

Fmoc-Ser(tBu)-Ser(tBu)-OH

$87.00/250mg Detail

Fmoc-Gly-Gly-OSu
click to sign in and save

A334370114726-49-797%

Fmoc-Gly-Gly-OSu

$42.00/250mg Detail

1 2 3 4 5 6 7    page 6 of 7 Pages