During the Vitamin D signaling process, activated Vitamin D (1,25-dihydroxyvitamin D3, the most active form of Vitamin D) is transported to target cells via the bloodstream and crosses the cell membrane to enter the cell. Inside the cell, 1,25-dihydroxyvitamin D3 binds to the Vitamin D Receptor (VDR), forming an activated VDR/Vitamin D complex. This complex further dimerizes with the Retinoid X Receptor (RXR) to form a heterodimer, which can then directly bind to Vitamin D Response Elements (VDREs) on DNA, regulating the expression of various genes including those involved in cell cycle control, growth factors, and cell adhesion molecules.