Home Chemistry Heterocyclic Building Blocks Pyridines 2-(Bromomethyl)Pyridine
Nucleophilic substitution reactions: The bromine atom in the compound is susceptible to nucleophilic attack by a variety of nucleophiles, leading to substitution reactions where the bromine is replaced by the nucleophile. Common nucleophiles include amines, thiols, and hydroxide ions.
Cross-coupling reactions: 2-(bromomethyl)pyridine can participate in cross-coupling reactions, where it reacts with another organic compound (often another halide or an organometallic compound) in the presence of a catalyst to form a new carbon-carbon or carbon-heteroatom bond.
Reduction reactions: The bromine atom can be reduced to a bromide ion or completely removed from the molecule through reduction reactions. Common reducing agents include metals like zinc or tin in the presence of acid.
Nucleophilic aromatic substitution (SNAr): The electron-deficient pyridine ring can undergo nucleophilic aromatic substitution reactions, where a nucleophile attacks the ring, replacing the bromine atom.
Alkylation reactions: The pyridine ring can undergo alkylation reactions where alkyl groups are added to the ring. This can occur through Friedel-Crafts alkylation or other similar processes.
Acylation reactions: Similarly, acyl groups can be added to the pyridine ring through acylation reactions.
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2-(Bromomethyl)-6-(trifluoromethyl)pyridine
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2-(Bromomethyl)-3-chloro-5-(trifluoromethyl)pyridine
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Methyl 2-(bromomethyl)-5-(trifluoromethyl)nicotinate
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2-(Bromomethyl)-5-(trifluoromethyl)pyridine
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2-(Bromomethyl)-5-methylpyridine hydrobromide
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Methyl 6-(bromomethyl)-3-fluoropicolinate
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