Home Chemistry Heterocyclic Building Blocks Pyridines 2-Nitropyridine
Reduction: The nitro group can be reduced to an amino group (-NH2) using reducing agents like hydrogen gas over a metal catalyst, tin and hydrochloric acid, or iron and hydrochloric acid.
Electrophilic aromatic substitution: The nitro group can undergo substitution reactions, where it can be replaced by other electrophilic species. For example, it can undergo nitration, halogenation, sulfonation, or acylation reactions.
Nucleophilic substitution: The nitro group can also undergo nucleophilic substitution reactions under appropriate conditions. For instance, it can be substituted by a nucleophile such as a Grignard reagent to form a substituted pyridine derivative.
Metalation: 2-nitropyridine can be deprotonated at the alpha position relative to the nitro group under certain conditions, allowing for the introduction of various metal groups.
Oxidation: Depending on the reaction conditions, 2-nitropyridine can be oxidized to form various oxidation products.
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