Home Chemistry Heterocyclic Building Blocks Pyridines 3-Bromo-2-Methylpyridine
Nucleophilic substitution reactions: The bromine atom in the molecule can be replaced by various nucleophiles, such as amines or thiols, leading to the formation of corresponding substitution products.
Metalation reactions: The 2-methyl group can undergo metalation with strong bases such as butyllithium or Grignard reagents to form organometallic intermediates, which can subsequently undergo further reactions.
Cross-coupling reactions: The 2-methyl group can participate in cross-coupling reactions with various electrophiles in the presence of suitable catalysts, leading to the formation of biaryl or heteroaryl compounds.
Acylation reactions: The pyridine nitrogen atom can undergo acylation reactions with acyl halides or acid anhydrides, leading to the formation of N-acyl pyridinium salts.
Reduction reactions: The bromine atom can be reduced to a methyl group, for example, using metal hydrides like lithium aluminum hydride or catalytic hydrogenation conditions.
Halogenation reactions: The methyl group can be replaced with other halogen atoms under appropriate conditions, such as using N-halosuccinimide derivatives or halogenating agents.
Oxidation reactions: The methyl group or the nitrogen atom in the pyridine ring can be oxidized under certain conditions, leading to the formation of corresponding oxidation products.
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5-Bromo-2-methoxy-6-methylpyridine-3-carboxylic acid
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tert-Butyl (5-bromo-6-methylpyridin-3-yl)(tert-butoxycarbonyl)carbamate
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(5-Bromo-6-methylpyridin-3-yl)boronic acid
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