Home Chemistry Heterocyclic Building Blocks Pyridines 3-Methylpyridine
Electrophilic Substitution: Much like its parent compound pyridine, 3-methylpyridine can undergo electrophilic aromatic substitution reactions where an electrophile replaces a hydrogen atom on the aromatic ring. This could involve reactions with various electrophiles such as acyl halides, nitro groups, or alkylating agents.
Nucleophilic Substitution: 3-methylpyridine could undergo nucleophilic aromatic substitution reactions where a nucleophile replaces a leaving group on the aromatic ring. However, this is generally less favorable compared to electrophilic substitution due to the reduced electron density on the carbon atoms adjacent to the nitrogen atom.
Oxidation: 3-methylpyridine can undergo oxidation reactions, where the methyl group or the nitrogen atom may be oxidized to yield different products. Depending on the reaction conditions and reagents used, various oxidation products could be obtained.
Reduction: Conversely, 3-methylpyridine can also undergo reduction reactions, where functional groups like the nitrogen atom or the methyl group may be reduced to yield different products.
Metalation: It can undergo metalation reactions, where a metal species replaces a hydrogen atom on the aromatic ring. This could lead to the formation of organometallic complexes or facilitate further reactions with other reagents.
Alkylation/Acylation: 3-methylpyridine can undergo alkylation or acylation reactions at the nitrogen atom or at the aromatic ring under suitable conditions, leading to the introduction of alkyl or acyl groups.
Condensation Reactions: It can participate in condensation reactions with suitable reagents, forming products such as imines or enamines.
Grignard Reactions: In the presence of appropriate reagents, 3-methylpyridine can react with Grignard reagents to yield substituted products.
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2-(Chloromethyl)-5-methylpyridine hydrochloride
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(2,5-Dimethylpyridin-4-yl)boronic acid
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Methyl 2-amino-5-methylpyridine-4-carboxylate
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(4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl acetate
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