Home Chemistry Heterocyclic Building Blocks Pyridines 3-Nitropyridine
Electrophilic Aromatic Substitution (EAS): 3-Nitropyridine can undergo EAS reactions with electrophiles, such as Friedel-Crafts acylation or alkylation, where the nitro group serves as a directing group.
Reduction: The nitro group can be reduced to an amino group under various conditions, such as catalytic hydrogenation, using reducing agents like iron and acid, or with metal/acid systems like SnCl2/HCl.
Nitration: It can undergo further nitration at other positions on the pyridine ring if appropriate conditions are provided, leading to polysubstituted nitropyridines.
Amination: Through various methods like nucleophilic substitution, 3-nitropyridine can undergo amination reactions to introduce different amino groups onto the ring.
Halogenation: The pyridine ring can be halogenated at positions adjacent to the nitro group under appropriate conditions.
Oxidation: The nitrogen atom in the pyridine ring can be oxidized to form various functional groups, such as oxides or nitroso compounds.
Condensation Reactions: 3-Nitropyridine can participate in condensation reactions, such as with carbonyl compounds to form pyridine rings fused to carbocycles.
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Methyl 6-(ethylamino)-5-nitronicotinate
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Ethyl 2-methyl-5-nitro-3-pyridinecarboxylate
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