Home Chemistry Heterocyclic Building Blocks Pyridines 5-Bromopyridin-2-Ol
Substitution Reactions: The bromine atom in 5-bromopyridin-2-ol can undergo substitution reactions. For instance, it can undergo nucleophilic substitution reactions where the bromine atom is replaced by another nucleophile. This could lead to the formation of new compounds with different functional groups attached to the pyridine ring.
Acid-Base Reactions: The hydroxyl group in 5-bromopyridin-2-ol can participate in acid-base reactions. It can act as a weak acid, donating a proton to a base, or as a weak base, accepting a proton from an acid.
Oxidation Reactions: The hydroxyl group can undergo oxidation reactions, especially in the presence of strong oxidizing agents. This could result in the formation of aldehydes, ketones, or carboxylic acids depending on the reaction conditions.
Esterification Reactions: The hydroxyl group can react with carboxylic acids or acyl chlorides to form esters. This reaction typically requires an acid catalyst such as sulfuric acid.
Ether Formation: The hydroxyl group can also undergo ether formation reactions, where it reacts with alkyl halides or alkyl sulfonates to form ethers. This reaction is often catalyzed by a base such as potassium carbonate or sodium hydroxide.
Grignard Reaction: 5-bromopyridin-2-ol can react with magnesium metal to form a Grignard reagent, which can then undergo further reactions such as nucleophilic addition to carbonyl compounds.
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5-Bromo-2-hydroxy-6-methyl-3-nitropyridine
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