Benzimidazoles, which consist of two nitrogen atoms in a fused heterocyclic ring system, hold crucial therapeutic significance in the field of drug discovery. A multitude of clinically approved drugs, such as liarozole and pracinostat (for anticancer purposes), omeprazole (as proton pump inhibitors), oxfendazole (for Anthelmintic treatment), enviroxine (as an antiviral agent), ilaprazole (for antiulcer treatment), ridinilazole (with antibacterial properties), flubendazole (used against parasites), bilastine (as an antihistaminic), and many others, have been derived from benzimidazole.

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[1]Walia R, Hedaitullah M, Naaz S F, et al. Benzimidazole derivatives-an overview[J]. Int. J. Res. Pharm. Chem, 2011, 1(3): 565-74.

[2]Singh N, Pandurangan A, Rana K, et al. Benzimidazole: A short review of their antimicrobial activities[J]. Int. Current Pharm. J, 2012, 1(5): 119-127.

[3]Akhtar W, Khan M F, Verma G, et al. Therapeutic evolution of benzimidazole derivatives in the last quinquennial period[J]. European journal of medicinal chemistry, 2017, 126: 705-753.

[4]Shah K, Chhabra S, Shrivastava S K, et al. Benzimidazole: A promising pharmacophore[J]. Medicinal Chemistry Research, 2013, 22: 5077-5104.