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Chemical Structure| 989-51-5 Chemical Structure| 989-51-5

Structure of (-)-Epigallocatechin Gallate
CAS No.: 989-51-5

Chemical Structure| 989-51-5

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(-)-Epigallocatechin Gallate is a major polyphenol in green tea that inhibits cell proliferation, induces apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity, and has anticancer, antioxidant, and anti-inflammatory properties.

Synonyms: EGCG; Epigallocatechol Gallate; EGCG-Epigallocatechin Gallate)

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Product Citations

Product Citations

Krueger, Nadine ; Kronenberger, Thales ; Xie, Hang ; Rocha, Cheila ; Poehlmann, Stefan ; Su, Haixia , et al.

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chem. phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 Mpro. Several compounds were discovered to inhibit Mpro at low micromolar concentrations It was possible to crystallize robinetin together with SARS-CoV-2 Mpro, and the X-ray structure revealed covalent interaction with the protease's catalytic Cys145 site. Selected potent mols. also exhibited antiviral properties without cytotoxicity. Some of these powerful inhibitors might be utilized as lead compounds for future COVID-19 research.

Keywords: COVID-19 ; antivirals ; coronavirus ; covalent drugs ; dynamic light scattering ; inhibitors ; main protease ; natural products

Alternative Products

Product Details of (-)-Epigallocatechin Gallate

CAS No. :989-51-5
Formula : C22H18O11
M.W : 458.37
SMILES Code : O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=C(C(O)=CC(O)=C3)C1)C4=CC(O)=C(O)C(O)=C4
Synonyms :
EGCG; Epigallocatechol Gallate; EGCG-Epigallocatechin Gallate)
MDL No. :MFCD00075940
InChI Key :WMBWREPUVVBILR-WIYYLYMNSA-N
Pubchem ID :65064

Safety of (-)-Epigallocatechin Gallate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of (-)-Epigallocatechin Gallate

epigenetics
DNA

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

In Vitro:

Cell Line
Concentration Treated Time Description References
H9C2 cells 20 μM 24-hour pretreatment followed by 48-hour co-treatment with Dox EGCG pretreatment significantly reduced Dox-induced apoptosis and caspase-3 activity, decreased iron accumulation, inhibited oxidative stress and abnormal lipid metabolism, thereby alleviating Dox-induced ferroptosis and protecting cardiomyocytes. PMC8600154

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01481818 Epigallocatechin Gallate|Radio... More >> Dermatitis|Radiation Mucositis Less << PHASE1|PHASE2 UNKNOWN 2025-08-22 -
NCT00434499 Hypertension|Obesity|Type 2 Di... More >>abetes|Insulin Resistance Less << PHASE2 WITHDRAWN 2025-12-15 University of Maryland, Baltim... More >>ore, Maryland, 21201, United States Less <<
NCT05758571 Interstitial Pneumonia|Neoplas... More >>ms Malignant Less << PHASE1|PHASE2 RECRUITING 2025-12-31 Shandong Cancer Hospital, Jina... More >>n, Shandong, 250117, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.91mL

2.18mL

1.09mL

21.82mL

4.36mL

2.18mL

References

 

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